ID   OR8B2_HUMAN             Reviewed;         313 AA.
AC   Q96RD0; Q8NGH2;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 3.
DT   24-JAN-2024, entry version 169.
DE   RecName: Full=Olfactory receptor 8B2;
DE   AltName: Full=Olfactory receptor OR11-309;
GN   Name=OR8B2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR8B2";
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DR   EMBL; AB065826; BAC06045.1; -; Genomic_DNA.
DR   EMBL; CH471065; EAW67580.1; -; Genomic_DNA.
DR   EMBL; AF399508; AAK94993.1; -; Genomic_DNA.
DR   EMBL; BK004500; DAA04898.1; -; Genomic_DNA.
DR   CCDS; CCDS31708.1; -.
DR   RefSeq; NP_001005468.1; NM_001005468.1.
DR   RefSeq; XP_016873024.1; XM_017017535.1.
DR   RefSeq; XP_016873025.1; XM_017017536.1.
DR   AlphaFoldDB; Q96RD0; -.
DR   SMR; Q96RD0; -.
DR   BioGRID; 117761; 1.
DR   STRING; 9606.ENSP00000493235; -.
DR   GlyCosmos; Q96RD0; 1 site, No reported glycans.
DR   GlyGen; Q96RD0; 1 site.
DR   BioMuta; OR8B2; -.
DR   DMDM; 229462942; -.
DR   MassIVE; Q96RD0; -.
DR   PaxDb; 9606-ENSP00000364152; -.
DR   Antibodypedia; 78415; 19 antibodies from 9 providers.
DR   DNASU; 26595; -.
DR   Ensembl; ENST00000641451.2; ENSP00000493235.1; ENSG00000284680.3.
DR   GeneID; 26595; -.
DR   KEGG; hsa:26595; -.
DR   MANE-Select; ENST00000641451.2; ENSP00000493235.1; NM_001005468.2; NP_001005468.1.
DR   UCSC; uc010sai.3; human.
DR   AGR; HGNC:8471; -.
DR   CTD; 26595; -.
DR   GeneCards; OR8B2; -.
DR   HGNC; HGNC:8471; OR8B2.
DR   HPA; ENSG00000284680; Tissue enriched (testis).
DR   neXtProt; NX_Q96RD0; -.
DR   PharmGKB; PA32750; -.
DR   VEuPathDB; HostDB:ENSG00000284680; -.
DR   eggNOG; ENOG502RTZT; Eukaryota.
DR   GeneTree; ENSGT01010000222320; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q96RD0; -.
DR   OMA; FQQPFFF; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q96RD0; -.
DR   TreeFam; TF352753; -.
DR   PathwayCommons; Q96RD0; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26595; 7 hits in 639 CRISPR screens.
DR   GeneWiki; OR8B2; -.
DR   GenomeRNAi; 26595; -.
DR   Pharos; Q96RD0; Tdark.
DR   PRO; PR:Q96RD0; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q96RD0; Protein.
DR   Bgee; ENSG00000284680; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 2 other cell types or tissues.
DR   ExpressionAtlas; Q96RD0; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15405; 7tmA_OR8B-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48018:SF61; OLFACTORY RECEPTOR 8B2-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q96RD0; HS.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..313
FT                   /note="Olfactory receptor 8B2"
FT                   /id="PRO_0000150654"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..313
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         20
FT                   /note="H -> R (in dbSNP:rs28373946)"
FT                   /id="VAR_062058"
FT   VARIANT         27
FT                   /note="L -> F (in dbSNP:rs530740)"
FT                   /id="VAR_055147"
FT   VARIANT         164
FT                   /note="L -> F (in dbSNP:rs886202)"
FT                   /id="VAR_060011"
FT   VARIANT         273
FT                   /note="S -> F (in dbSNP:rs503220)"
FT                   /id="VAR_062059"
SQ   SEQUENCE   313 AA;  35272 MW;  6FA6C2FC8DD4BE5F CRC64;
     MLARNNSLVT EFILAGLTDH PEFRQPLFFL FLVIYIVTMV GNLGLITLFG LNSHLHTPMY
     YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR LFFFLFFVIS ECYMLTSMAY
     DRYVAICNPL LYKVTMSHQV CSMLTFAAYI MGLAGATAHT GCMLRLTFCS ANIINHYLCD
     ILPLLQLSCT STYVNEVVVL IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST
     CSSHVIALSL FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL
     RKALIKIQRR NIF
//