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Q96RD0

- OR8B2_HUMAN

UniProt

Q96RD0 - OR8B2_HUMAN

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Protein

Olfactory receptor 8B2

Gene

OR8B2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8B2
Alternative name(s):
Olfactory receptor OR11-309
Gene namesi
Name:OR8B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8471. OR8B2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 8B2PRO_0000150654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RD0.
PRIDEiQ96RD0.

PTM databases

PhosphoSiteiQ96RD0.

Expressioni

Gene expression databases

BgeeiQ96RD0.
CleanExiHS_OR8B2.
GenevestigatoriQ96RD0.

Interactioni

Protein-protein interaction databases

BioGridi117761. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96RD0.
SMRiQ96RD0. Positions 31-153.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27012ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 31322CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282622.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96RD0.
KOiK04257.
OMAiMTRLFFF.
OrthoDBiEOG71K63J.
PhylomeDBiQ96RD0.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARNNSLVT EFILAGLTDH PEFRQPLFFL FLVIYIVTMV GNLGLITLFG
60 70 80 90 100
LNSHLHTPMY YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR
110 120 130 140 150
LFFFLFFVIS ECYMLTSMAY DRYVAICNPL LYKVTMSHQV CSMLTFAAYI
160 170 180 190 200
MGLAGATAHT GCMLRLTFCS ANIINHYLCD ILPLLQLSCT STYVNEVVVL
210 220 230 240 250
IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST CSSHVIALSL
260 270 280 290 300
FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL
310
RKALIKIQRR NIF
Length:313
Mass (Da):35,272
Last modified:May 5, 2009 - v3
Checksum:i6FA6C2FC8DD4BE5F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201H → R.
Corresponds to variant rs28373946 [ dbSNP | Ensembl ].
VAR_062058
Natural varianti27 – 271L → F.
Corresponds to variant rs530740 [ dbSNP | Ensembl ].
VAR_055147
Natural varianti164 – 1641L → F.
Corresponds to variant rs886202 [ dbSNP | Ensembl ].
VAR_060011
Natural varianti273 – 2731S → F.
Corresponds to variant rs503220 [ dbSNP | Ensembl ].
VAR_062059

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065826 Genomic DNA. Translation: BAC06045.1.
CH471065 Genomic DNA. Translation: EAW67580.1.
AF399508 Genomic DNA. Translation: AAK94993.1.
BK004500 Genomic DNA. Translation: DAA04898.1.
CCDSiCCDS31708.1.
RefSeqiNP_001005468.1. NM_001005468.1.
XP_005271557.1. XM_005271500.1.
UniGeneiHs.450608.
Hs.576944.

Genome annotation databases

EnsembliENST00000375013; ENSP00000364152; ENSG00000204293.
GeneIDi26595.
KEGGihsa:26595.
UCSCiuc010sai.2. human.

Polymorphism databases

DMDMi229462942.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065826 Genomic DNA. Translation: BAC06045.1 .
CH471065 Genomic DNA. Translation: EAW67580.1 .
AF399508 Genomic DNA. Translation: AAK94993.1 .
BK004500 Genomic DNA. Translation: DAA04898.1 .
CCDSi CCDS31708.1.
RefSeqi NP_001005468.1. NM_001005468.1.
XP_005271557.1. XM_005271500.1.
UniGenei Hs.450608.
Hs.576944.

3D structure databases

ProteinModelPortali Q96RD0.
SMRi Q96RD0. Positions 31-153.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117761. 1 interaction.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q96RD0.

Polymorphism databases

DMDMi 229462942.

Proteomic databases

PaxDbi Q96RD0.
PRIDEi Q96RD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375013 ; ENSP00000364152 ; ENSG00000204293 .
GeneIDi 26595.
KEGGi hsa:26595.
UCSCi uc010sai.2. human.

Organism-specific databases

CTDi 26595.
GeneCardsi GC11M124252.
H-InvDB HIX0171292.
HGNCi HGNC:8471. OR8B2.
neXtProti NX_Q96RD0.
PharmGKBi PA32750.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282622.
GeneTreei ENSGT00760000118817.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q96RD0.
KOi K04257.
OMAi MTRLFFF.
OrthoDBi EOG71K63J.
PhylomeDBi Q96RD0.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR8B2.
GenomeRNAii 26595.
NextBioi 48972.
PROi Q96RD0.

Gene expression databases

Bgeei Q96RD0.
CleanExi HS_OR8B2.
Genevestigatori Q96RD0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
  4. Cited for: IDENTIFICATION.

Entry informationi

Entry nameiOR8B2_HUMAN
AccessioniPrimary (citable) accession number: Q96RD0
Secondary accession number(s): Q8NGH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3