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Protein

Olfactory receptor 8B2

Gene

OR8B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32246-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8B2
Alternative name(s):
Olfactory receptor OR11-309
Gene namesi
Name:OR8B2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8471. OR8B2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 270ExtracellularSequence analysisAdd BLAST12
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 313CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204293.
PharmGKBiPA32750.

Polymorphism and mutation databases

BioMutaiOR8B2.
DMDMi229462942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506541 – 313Olfactory receptor 8B2Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RD0.
PRIDEiQ96RD0.

Expressioni

Gene expression databases

BgeeiENSG00000204293.
CleanExiHS_OR8B2.
ExpressionAtlasiQ96RD0. baseline and differential.
GenevisibleiQ96RD0. HS.

Interactioni

Protein-protein interaction databases

BioGridi117761. 1 interactor.
STRINGi9606.ENSP00000364152.

Structurei

3D structure databases

ProteinModelPortaliQ96RD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF93. Eukaryota.
ENOG411183T. LUCA.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96RD0.
KOiK04257.
OMAiMTRLFFF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ96RD0.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARNNSLVT EFILAGLTDH PEFRQPLFFL FLVIYIVTMV GNLGLITLFG
60 70 80 90 100
LNSHLHTPMY YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR
110 120 130 140 150
LFFFLFFVIS ECYMLTSMAY DRYVAICNPL LYKVTMSHQV CSMLTFAAYI
160 170 180 190 200
MGLAGATAHT GCMLRLTFCS ANIINHYLCD ILPLLQLSCT STYVNEVVVL
210 220 230 240 250
IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST CSSHVIALSL
260 270 280 290 300
FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL
310
RKALIKIQRR NIF
Length:313
Mass (Da):35,272
Last modified:May 5, 2009 - v3
Checksum:i6FA6C2FC8DD4BE5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06205820H → R.Corresponds to variant rs28373946dbSNPEnsembl.1
Natural variantiVAR_05514727L → F.Corresponds to variant rs530740dbSNPEnsembl.1
Natural variantiVAR_060011164L → F.Corresponds to variant rs886202dbSNPEnsembl.1
Natural variantiVAR_062059273S → F.Corresponds to variant rs503220dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065826 Genomic DNA. Translation: BAC06045.1.
CH471065 Genomic DNA. Translation: EAW67580.1.
AF399508 Genomic DNA. Translation: AAK94993.1.
BK004500 Genomic DNA. Translation: DAA04898.1.
CCDSiCCDS31708.1.
RefSeqiNP_001005468.1. NM_001005468.1.
XP_016873024.1. XM_017017535.1.
XP_016873025.1. XM_017017536.1.
UniGeneiHs.576944.

Genome annotation databases

EnsembliENST00000375013; ENSP00000364152; ENSG00000204293.
GeneIDi26595.
KEGGihsa:26595.
UCSCiuc010sai.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065826 Genomic DNA. Translation: BAC06045.1.
CH471065 Genomic DNA. Translation: EAW67580.1.
AF399508 Genomic DNA. Translation: AAK94993.1.
BK004500 Genomic DNA. Translation: DAA04898.1.
CCDSiCCDS31708.1.
RefSeqiNP_001005468.1. NM_001005468.1.
XP_016873024.1. XM_017017535.1.
XP_016873025.1. XM_017017536.1.
UniGeneiHs.576944.

3D structure databases

ProteinModelPortaliQ96RD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117761. 1 interactor.
STRINGi9606.ENSP00000364152.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR8B2.
DMDMi229462942.

Proteomic databases

PaxDbiQ96RD0.
PRIDEiQ96RD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375013; ENSP00000364152; ENSG00000204293.
GeneIDi26595.
KEGGihsa:26595.
UCSCiuc010sai.3. human.

Organism-specific databases

CTDi26595.
GeneCardsiOR8B2.
H-InvDBHIX0171292.
HGNCiHGNC:8471. OR8B2.
neXtProtiNX_Q96RD0.
OpenTargetsiENSG00000204293.
PharmGKBiPA32750.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF93. Eukaryota.
ENOG411183T. LUCA.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96RD0.
KOiK04257.
OMAiMTRLFFF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ96RD0.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:G66-32246-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8B2.
GenomeRNAii26595.
PROiQ96RD0.

Gene expression databases

BgeeiENSG00000204293.
CleanExiHS_OR8B2.
ExpressionAtlasiQ96RD0. baseline and differential.
GenevisibleiQ96RD0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8B2_HUMAN
AccessioniPrimary (citable) accession number: Q96RD0
Secondary accession number(s): Q8NGH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.