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Q96RD0

- OR8B2_HUMAN

UniProt

Q96RD0 - OR8B2_HUMAN

Protein

Olfactory receptor 8B2

Gene

OR8B2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 8B2
    Alternative name(s):
    Olfactory receptor OR11-309
    Gene namesi
    Name:OR8B2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8471. OR8B2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32750.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Olfactory receptor 8B2PRO_0000150654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96RD0.
    PRIDEiQ96RD0.

    PTM databases

    PhosphoSiteiQ96RD0.

    Expressioni

    Gene expression databases

    BgeeiQ96RD0.
    CleanExiHS_OR8B2.
    GenevestigatoriQ96RD0.

    Interactioni

    Protein-protein interaction databases

    BioGridi117761. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96RD0.
    SMRiQ96RD0. Positions 31-153, 278-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31322CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG282622.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ96RD0.
    KOiK04257.
    OMAiMTRLFFF.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ96RD0.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96RD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLARNNSLVT EFILAGLTDH PEFRQPLFFL FLVIYIVTMV GNLGLITLFG    50
    LNSHLHTPMY YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR 100
    LFFFLFFVIS ECYMLTSMAY DRYVAICNPL LYKVTMSHQV CSMLTFAAYI 150
    MGLAGATAHT GCMLRLTFCS ANIINHYLCD ILPLLQLSCT STYVNEVVVL 200
    IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST CSSHVIALSL 250
    FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL 300
    RKALIKIQRR NIF 313
    Length:313
    Mass (Da):35,272
    Last modified:May 5, 2009 - v3
    Checksum:i6FA6C2FC8DD4BE5F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201H → R.
    Corresponds to variant rs28373946 [ dbSNP | Ensembl ].
    VAR_062058
    Natural varianti27 – 271L → F.
    Corresponds to variant rs530740 [ dbSNP | Ensembl ].
    VAR_055147
    Natural varianti164 – 1641L → F.
    Corresponds to variant rs886202 [ dbSNP | Ensembl ].
    VAR_060011
    Natural varianti273 – 2731S → F.
    Corresponds to variant rs503220 [ dbSNP | Ensembl ].
    VAR_062059

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065826 Genomic DNA. Translation: BAC06045.1.
    CH471065 Genomic DNA. Translation: EAW67580.1.
    AF399508 Genomic DNA. Translation: AAK94993.1.
    BK004500 Genomic DNA. Translation: DAA04898.1.
    CCDSiCCDS31708.1.
    RefSeqiNP_001005468.1. NM_001005468.1.
    XP_005271557.1. XM_005271500.1.
    UniGeneiHs.450608.
    Hs.576944.

    Genome annotation databases

    EnsembliENST00000375013; ENSP00000364152; ENSG00000204293.
    GeneIDi26595.
    KEGGihsa:26595.
    UCSCiuc010sai.2. human.

    Polymorphism databases

    DMDMi229462942.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065826 Genomic DNA. Translation: BAC06045.1 .
    CH471065 Genomic DNA. Translation: EAW67580.1 .
    AF399508 Genomic DNA. Translation: AAK94993.1 .
    BK004500 Genomic DNA. Translation: DAA04898.1 .
    CCDSi CCDS31708.1.
    RefSeqi NP_001005468.1. NM_001005468.1.
    XP_005271557.1. XM_005271500.1.
    UniGenei Hs.450608.
    Hs.576944.

    3D structure databases

    ProteinModelPortali Q96RD0.
    SMRi Q96RD0. Positions 31-153, 278-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117761. 1 interaction.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96RD0.

    Polymorphism databases

    DMDMi 229462942.

    Proteomic databases

    PaxDbi Q96RD0.
    PRIDEi Q96RD0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375013 ; ENSP00000364152 ; ENSG00000204293 .
    GeneIDi 26595.
    KEGGi hsa:26595.
    UCSCi uc010sai.2. human.

    Organism-specific databases

    CTDi 26595.
    GeneCardsi GC11M124252.
    H-InvDB HIX0171292.
    HGNCi HGNC:8471. OR8B2.
    neXtProti NX_Q96RD0.
    PharmGKBi PA32750.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282622.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q96RD0.
    KOi K04257.
    OMAi MTRLFFF.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q96RD0.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR8B2.
    GenomeRNAii 26595.
    NextBioi 48972.
    PROi Q96RD0.

    Gene expression databases

    Bgeei Q96RD0.
    CleanExi HS_OR8B2.
    Genevestigatori Q96RD0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
    4. Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiOR8B2_HUMAN
    AccessioniPrimary (citable) accession number: Q96RD0
    Secondary accession number(s): Q8NGH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2002
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3