Q96RD0 (OR8B2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 8B2

Alternative name(s):
Olfactory receptor OR11-309

Gene names

Name:

OR8B2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Olfactory receptor 8B2		PRO_0000150654
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 270	12	Extracellular Potential
	Transmembrane	271 – 291	21	Helical; Name=7; Potential
	Topological domain	292 – 313	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	20	1	H → R. Corresponds to variant rs28373946 [ dbSNP | Ensembl ].		VAR_062058
	Natural variant	27	1	L → F. Corresponds to variant rs530740 [ dbSNP | Ensembl ].		VAR_055147
	Natural variant	164	1	L → F. Corresponds to variant rs886202 [ dbSNP | Ensembl ].		VAR_060011
	Natural variant	273	1	S → F. Corresponds to variant rs503220 [ dbSNP | Ensembl ].		VAR_062059

Sequences

	Sequence		Length	Mass (Da)
	Q96RD0 [UniParc]. Last modified May 5, 2009. Version 3. Checksum: 6FA6C2FC8DD4BE5F	FASTA	313	35,272
	10 20 30 40 50 60 MLARNNSLVT EFILAGLTDH PEFRQPLFFL FLVIYIVTMV GNLGLITLFG LNSHLHTPMY 70 80 90 100 110 120 YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR LFFFLFFVIS ECYMLTSMAY 130 140 150 160 170 180 DRYVAICNPL LYKVTMSHQV CSMLTFAAYI MGLAGATAHT GCMLRLTFCS ANIINHYLCD 190 200 210 220 230 240 ILPLLQLSCT STYVNEVVVL IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST 250 260 270 280 290 300 CSSHVIALSL FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL 310 RKALIKIQRR NIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065826 Genomic DNA. Translation: BAC06045.1. CH471065 Genomic DNA. Translation: EAW67580.1. AF399508 Genomic DNA. Translation: AAK94993.1. BK004500 Genomic DNA. Translation: DAA04898.1.
IPI	IPI00382709.
RefSeq	NP_001005468.1. NM_001005468.1.
UniGene	Hs.576944.
3D structure databases
ProteinModelPortal	Q96RD0.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q96RD0.
Polymorphism databases
DMDM	229462942.
Proteomic databases
PaxDb	Q96RD0.
PRIDE	Q96RD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375013; ENSP00000364152; ENSG00000204293.
GeneID	26595.
KEGG	hsa:26595.
UCSC	uc010sai.2. human.
Organism-specific databases
CTD	26595.
GeneCards	GC11M124252.
H-InvDB	HIX0171292.
HGNC	HGNC:8471. OR8B2.
neXtProt	NX_Q96RD0.
PharmGKB	PA32750.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG282622.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q96RD0.
KO	K04257.
OMA	TRLFFFL.
OrthoDB	EOG4PZJ7C.
Gene expression databases
Bgee	Q96RD0.
CleanEx	HS_OR8B2.
Genevestigator	Q96RD0.
GermOnline	ENSG00000204293. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26595.
NextBio	48972.

Entry information

Entry name

OR8B2_HUMAN

Accession

Primary (citable) accession number: Q96RD0
Secondary accession number(s): Q8NGH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.