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Q96RD0 (OR8B2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 8B2
Alternative name(s):
Olfactory receptor OR11-309
Gene names
Name:OR8B2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Olfactory receptor 8B2
PRO_0000150654

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27012Extracellular Potential
Transmembrane271 – 29121Helical; Name=7; Potential
Topological domain292 – 31322Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant201H → R.
Corresponds to variant rs28373946 [ dbSNP | Ensembl ].
VAR_062058
Natural variant271L → F.
Corresponds to variant rs530740 [ dbSNP | Ensembl ].
VAR_055147
Natural variant1641L → F.
Corresponds to variant rs886202 [ dbSNP | Ensembl ].
VAR_060011
Natural variant2731S → F.
Corresponds to variant rs503220 [ dbSNP | Ensembl ].
VAR_062059

Sequences

Sequence LengthMass (Da)Tools
Q96RD0 [UniParc].

Last modified May 5, 2009. Version 3.
Checksum: 6FA6C2FC8DD4BE5F

FASTA31335,272
        10         20         30         40         50         60 
MLARNNSLVT EFILAGLTDH PEFRQPLFFL FLVIYIVTMV GNLGLITLFG LNSHLHTPMY 

        70         80         90        100        110        120 
YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR LFFFLFFVIS ECYMLTSMAY 

       130        140        150        160        170        180 
DRYVAICNPL LYKVTMSHQV CSMLTFAAYI MGLAGATAHT GCMLRLTFCS ANIINHYLCD 

       190        200        210        220        230        240 
ILPLLQLSCT STYVNEVVVL IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST 

       250        260        270        280        290        300 
CSSHVIALSL FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL 

       310 
RKALIKIQRR NIF 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065826 Genomic DNA. Translation: BAC06045.1.
CH471065 Genomic DNA. Translation: EAW67580.1.
AF399508 Genomic DNA. Translation: AAK94993.1.
BK004500 Genomic DNA. Translation: DAA04898.1.
CCDSCCDS31708.1.
RefSeqNP_001005468.1. NM_001005468.1.
XP_005271557.1. XM_005271500.1.
UniGeneHs.450608.
Hs.576944.

3D structure databases

ProteinModelPortalQ96RD0.
SMRQ96RD0. Positions 31-153, 278-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117761. 1 interaction.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ96RD0.

Polymorphism databases

DMDM229462942.

Proteomic databases

PaxDbQ96RD0.
PRIDEQ96RD0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375013; ENSP00000364152; ENSG00000204293.
GeneID26595.
KEGGhsa:26595.
UCSCuc010sai.2. human.

Organism-specific databases

CTD26595.
GeneCardsGC11M124252.
H-InvDBHIX0171292.
HGNCHGNC:8471. OR8B2.
neXtProtNX_Q96RD0.
PharmGKBPA32750.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282622.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ96RD0.
KOK04257.
OMAMTRLFFF.
OrthoDBEOG71K63J.
PhylomeDBQ96RD0.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ96RD0.
CleanExHS_OR8B2.
GenevestigatorQ96RD0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR8B2.
GenomeRNAi26595.
NextBio48972.
PROQ96RD0.

Entry information

Entry nameOR8B2_HUMAN
AccessionPrimary (citable) accession number: Q96RD0
Secondary accession number(s): Q8NGH2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries