Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 8B4

Gene

OR8B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8B4
Alternative name(s):
Olfactory receptor OR11-315
Gene namesi
Name:OR8B4
Synonyms:OR8B4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8473. OR8B4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9823ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 30918CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32752.

Polymorphism and mutation databases

BioMutaiOR8B4.
DMDMi20532194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 8B4PRO_0000150656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RC9.
PRIDEiQ96RC9.

Expressioni

Gene expression databases

CleanExiHS_OR8B4.

Organism-specific databases

HPAiHPA049884.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348449.

Structurei

3D structure databases

ProteinModelPortaliQ96RC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF93. Eukaryota.
ENOG411183T. LUCA.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96RC9.
KOiK04257.
OMAiTYFTASF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ96RC9.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRNSSSVT EFILVGLSEQ PELQLPLFLL FLGIYVFTVV GNLGLITLIG
60 70 80 90 100
INPSLHTPMY FFLFNLSFID LCYSCVFTPK MLNDFVSESI ISYVGCMTQL
110 120 130 140 150
FFFCFFVNSE CYVLVSMAYD RYVAICNPLL YMVTMSPRVC FLLMFGSYVV
160 170 180 190 200
GFAGAMAHTG SMLRLTFCDS NVIDHYLCDV LPLLQLSCTS THVSELVFFI
210 220 230 240 250
VVGVITMLSS ISIVISYALI LSNILCIPSA EGRSKAFSTW GSHIIAVALF
260 270 280 290 300
FGSGTFTYLT TSFPGSMNHG RFASVFYTNV VPMLNPSIYS LRNKDDKLAL

GKTLKRVLF
Length:309
Mass (Da):34,404
Last modified:May 10, 2002 - v2
Checksum:iA187E1685EA59709
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221E → G.
Corresponds to variant rs10750270 [ dbSNP | Ensembl ].
VAR_053239
Natural varianti131 – 1311Y → H.1 Publication
Corresponds to variant rs4057750 [ dbSNP | Ensembl ].
VAR_024115
Natural varianti140 – 1401C → F.1 Publication
Corresponds to variant rs7116575 [ dbSNP | Ensembl ].
VAR_053240
Natural varianti178 – 1781C → R.1 Publication
Corresponds to variant rs4057749 [ dbSNP | Ensembl ].
VAR_053241

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065831 Genomic DNA. Translation: BAC06050.1.
CH471065 Genomic DNA. Translation: EAW67582.1.
BC136865 mRNA. Translation: AAI36866.1.
BC136866 mRNA. Translation: AAI36867.1.
AF399509 Genomic DNA. Translation: AAK94994.1.
BK004205 Genomic DNA. Translation: DAA04603.1.
CCDSiCCDS31710.1.
RefSeqiNP_001005196.1. NM_001005196.1.
UniGeneiHs.553671.

Genome annotation databases

EnsembliENST00000624268; ENSP00000485212; ENSG00000198657.
GeneIDi283162.
KEGGihsa:283162.
UCSCiuc010sak.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065831 Genomic DNA. Translation: BAC06050.1.
CH471065 Genomic DNA. Translation: EAW67582.1.
BC136865 mRNA. Translation: AAI36866.1.
BC136866 mRNA. Translation: AAI36867.1.
AF399509 Genomic DNA. Translation: AAK94994.1.
BK004205 Genomic DNA. Translation: DAA04603.1.
CCDSiCCDS31710.1.
RefSeqiNP_001005196.1. NM_001005196.1.
UniGeneiHs.553671.

3D structure databases

ProteinModelPortaliQ96RC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348449.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR8B4.
DMDMi20532194.

Proteomic databases

PaxDbiQ96RC9.
PRIDEiQ96RC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624268; ENSP00000485212; ENSG00000198657.
GeneIDi283162.
KEGGihsa:283162.
UCSCiuc010sak.2. human.

Organism-specific databases

CTDi283162.
GeneCardsiOR8B4.
HGNCiHGNC:8473. OR8B4.
HPAiHPA049884.
neXtProtiNX_Q96RC9.
PharmGKBiPA32752.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF93. Eukaryota.
ENOG411183T. LUCA.
GeneTreeiENSGT00760000118817.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96RC9.
KOiK04257.
OMAiTYFTASF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ96RC9.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR8B4.
GenomeRNAii283162.
PROiQ96RC9.

Gene expression databases

CleanExiHS_OR8B4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8B4_HUMAN
AccessioniPrimary (citable) accession number: Q96RC9
Secondary accession number(s): B2RNF8, Q6IFQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 10, 2002
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.