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Protein

Olfactory receptor 5M11

Gene

OR5M11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31581-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5M11
Gene namesi
Name:OR5M11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15291. OR5M11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 98ExtracellularSequence analysisAdd BLAST23
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 195ExtracellularSequence analysisAdd BLAST36
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 305CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255223.
PharmGKBiPA32548.

Polymorphism and mutation databases

BioMutaiOR5M11.
DMDMi38372852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506091 – 305Olfactory receptor 5M11Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RB7.
PRIDEiQ96RB7.

PTM databases

iPTMnetiQ96RB7.
PhosphoSitePlusiQ96RB7.

Expressioni

Gene expression databases

CleanExiHS_OR5M11.
ExpressionAtlasiQ96RB7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000432417.

Structurei

3D structure databases

ProteinModelPortaliQ96RB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVK3. Eukaryota.
ENOG41118NH. LUCA.
GeneTreeiENSGT00810000125401.
HOVERGENiHBG017625.
InParanoidiQ96RB7.
KOiK04257.
OMAiELYMLAA.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ96RB7.
TreeFamiTF352751.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTNGSAIT EFILLGLTDC PELQSLLFVL FLVVYLVTLL GNLGMIMLMR
60 70 80 90 100
LDSRLHTPMY FFLTNLAFVD LCYTSNATPQ MSTNIVSEKT ISFAGCFTQC
110 120 130 140 150
YIFIALLLTE FYMLAAMAYD RYVAIYDPLR YSVKTSRRVC ICLATFPYVY
160 170 180 190 200
GFSDGLFQAI LTFRLTFCRS SVINHFYCAD PPLIKLSCSD TYVKEHAMFI
210 220 230 240 250
SAGFNLSSSL TIVLVSYAFI LAAILRIKSA EGRHKAFSTC GSHMMAVTLF
260 270 280 290 300
YGTLFCMYIR PPTDKTVEES KIIAVFYTFV SPVLNPLIYS LRNKDVKQAL

KNVLR
Length:305
Mass (Da):34,450
Last modified:October 10, 2003 - v2
Checksum:iC846F0070FD9FF0E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034231171S → N.2 PublicationsCorresponds to variant rs628524dbSNPEnsembl.1
Natural variantiVAR_034232280V → L.Corresponds to variant rs17547207dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW73717.1.
BC136951 mRNA. Translation: AAI36952.1.
BC136953 mRNA. Translation: AAI36954.1.
AF399521 Genomic DNA. Translation: AAK95006.1.
CCDSiCCDS53629.1.
RefSeqiNP_001005245.1. NM_001005245.1.
UniGeneiHs.553632.

Genome annotation databases

EnsembliENST00000528616; ENSP00000432417; ENSG00000255223.
GeneIDi219487.
KEGGihsa:219487.
UCSCiuc010rjl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW73717.1.
BC136951 mRNA. Translation: AAI36952.1.
BC136953 mRNA. Translation: AAI36954.1.
AF399521 Genomic DNA. Translation: AAK95006.1.
CCDSiCCDS53629.1.
RefSeqiNP_001005245.1. NM_001005245.1.
UniGeneiHs.553632.

3D structure databases

ProteinModelPortaliQ96RB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000432417.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96RB7.
PhosphoSitePlusiQ96RB7.

Polymorphism and mutation databases

BioMutaiOR5M11.
DMDMi38372852.

Proteomic databases

PaxDbiQ96RB7.
PRIDEiQ96RB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528616; ENSP00000432417; ENSG00000255223.
GeneIDi219487.
KEGGihsa:219487.
UCSCiuc010rjl.2. human.

Organism-specific databases

CTDi219487.
GeneCardsiOR5M11.
HGNCiHGNC:15291. OR5M11.
neXtProtiNX_Q96RB7.
OpenTargetsiENSG00000255223.
PharmGKBiPA32548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVK3. Eukaryota.
ENOG41118NH. LUCA.
GeneTreeiENSGT00810000125401.
HOVERGENiHBG017625.
InParanoidiQ96RB7.
KOiK04257.
OMAiELYMLAA.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ96RB7.
TreeFamiTF352751.

Enzyme and pathway databases

BioCyciZFISH:G66-31581-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5M11.
GenomeRNAii219487.
PROiQ96RB7.

Gene expression databases

CleanExiHS_OR5M11.
ExpressionAtlasiQ96RB7. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5MB_HUMAN
AccessioniPrimary (citable) accession number: Q96RB7
Secondary accession number(s): B2RNL5, B2RNL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.