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Protein

Olfactory receptor 7D2

Gene

OR7D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-30937-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7D2
Alternative name(s):
HTPCRH03
Olfactory receptor 19-4
Short name:
OR19-4
Olfactory receptor OR19-10
Gene namesi
Name:OR7D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8378. OR7D2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188000.
PharmGKBiPA32627.

Polymorphism and mutation databases

BioMutaiOR7D2.
DMDMi37081386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506481 – 312Olfactory receptor 7D2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96RA2.
PRIDEiQ96RA2.

PTM databases

iPTMnetiQ96RA2.
PhosphoSitePlusiQ96RA2.

Expressioni

Gene expression databases

BgeeiENSG00000188000.
CleanExiHS_OR7D2.
GenevisibleiQ96RA2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345563.

Structurei

3D structure databases

ProteinModelPortaliQ96RA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96RA2.
KOiK04257.
OMAiVHFTSAV.
OrthoDBiEOG091G0B53.
PhylomeDBiQ96RA2.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96RA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAGNQTGFL EFILLGLSED PELQPFIFGL FLSMYLVTVL GNLLIILAIS
60 70 80 90 100
SDSHLHTPMY FFLSNLSWVD ICFSTCIVPK MLVNIQTENK AISYMDCLTQ
110 120 130 140 150
VYFSMFFPIL DTLLLTVMAY DRFVAVCHPL HYMIIMNPHL CGLLVFVTWL
160 170 180 190 200
IGVMTSLLHI SLMMHLIFCK DFEIPHFFCE LTYILQLACS DTFLNSTLIY
210 220 230 240 250
FMTGVLGVFP LLGIIFSYSR IASSIRKMSS SGGKQKALST CGSHLSVVSL
260 270 280 290 300
FYGTGIGVHF TSAVTHSSQK ISVASVMYTV VTPMLNPFIY SLRNKDVKGA
310
LGSLLSRAAS CL
Length:312
Mass (Da):34,747
Last modified:September 26, 2003 - v2
Checksum:i4EB05A7BA9BBB0F5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053235197T → M.Corresponds to variant rs13345452dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065928 Genomic DNA. Translation: BAC06143.1.
AK095468 mRNA. Translation: BAC04554.1.
AF399537 Genomic DNA. Translation: AAK95022.1.
BK004265 Genomic DNA. Translation: DAA04663.1.
CCDSiCCDS32900.1.
RefSeqiNP_787079.1. NM_175883.2.
UniGeneiHs.531755.

Genome annotation databases

EnsembliENST00000344248; ENSP00000345563; ENSG00000188000.
GeneIDi162998.
KEGGihsa:162998.
UCSCiuc002mkz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065928 Genomic DNA. Translation: BAC06143.1.
AK095468 mRNA. Translation: BAC04554.1.
AF399537 Genomic DNA. Translation: AAK95022.1.
BK004265 Genomic DNA. Translation: DAA04663.1.
CCDSiCCDS32900.1.
RefSeqiNP_787079.1. NM_175883.2.
UniGeneiHs.531755.

3D structure databases

ProteinModelPortaliQ96RA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345563.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96RA2.
PhosphoSitePlusiQ96RA2.

Polymorphism and mutation databases

BioMutaiOR7D2.
DMDMi37081386.

Proteomic databases

PaxDbiQ96RA2.
PRIDEiQ96RA2.

Protocols and materials databases

DNASUi162998.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344248; ENSP00000345563; ENSG00000188000.
GeneIDi162998.
KEGGihsa:162998.
UCSCiuc002mkz.1. human.

Organism-specific databases

CTDi162998.
GeneCardsiOR7D2.
H-InvDBHIX0022836.
HGNCiHGNC:8378. OR7D2.
neXtProtiNX_Q96RA2.
OpenTargetsiENSG00000188000.
PharmGKBiPA32627.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96RA2.
KOiK04257.
OMAiVHFTSAV.
OrthoDBiEOG091G0B53.
PhylomeDBiQ96RA2.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:G66-30937-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7D2.
GenomeRNAii162998.
PROiQ96RA2.

Gene expression databases

BgeeiENSG00000188000.
CleanExiHS_OR7D2.
GenevisibleiQ96RA2. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR7D2_HUMAN
AccessioniPrimary (citable) accession number: Q96RA2
Secondary accession number(s): Q6IFJ7, Q8N133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.