Q96R84 (OR1F2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative olfactory receptor 1F2

Alternative name(s):
OLFmf2

Gene names

Name:	OR1F2P
Synonyms:	OR1F2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Could be the product of a pseudogene.
Sequence caution	The sequence AJ003145 differs from that shown. Reason: Frameshift at position 1.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Putative olfactory receptor 1F2		PRO_0000150432
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 78	21	Helical; Name=2; Potential
	Topological domain	79 – 99	21	Extracellular Potential
	Transmembrane	100 – 119	20	Helical; Name=3; Potential
	Topological domain	120 – 138	19	Cytoplasmic Potential
	Transmembrane	139 – 157	19	Helical; Name=4; Potential
	Topological domain	158 – 195	38	Extracellular Potential
	Transmembrane	196 – 218	23	Helical; Name=5; Potential
	Topological domain	219 – 235	17	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 312	21	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	96 ↔ 188		By similarity
Experimental info
	Sequence conflict	136	1	I → T in AAK95043. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96R84 [UniParc]. Last modified October 10, 2003. Version 2. Checksum: 96B49B6DDBB11285	FASTA	312	34,944
	10 20 30 40 50 60 MERDKPVSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILAIS IDSRLHTPMY 70 80 90 100 110 120 FFLSNMSFVD NCFSTTVPKM LANHILRTQT ISFSGCLMQM YFISELADMD NFLLAVMAYD 130 140 150 160 170 180 RFVAVCRPLH YTAKMIHQLC ALLVTGSWVV ANSNALLHTL LMARLSFCAD NTIPHIFCDV 190 200 210 220 230 240 TPLLKLSCSD THLSEVMILT EAALVTITPF LCLLASYMHI TCVVLRVPST KGRWKAFSTC 250 260 270 280 290 300 GSHLAVVLLF YGTIMSPYFR TSSSHSAQRD IAAAVRFTVV TPVMNPLIYS LRNKDIKGAL 310 VKVVAVKFFS VQ

References

[1]	"A transcriptional map of the FMF region." Bernot A., Heilig R., Clepet C., Smaoui N., Da Silva C., Petit J.-L., Devaud C., Chiannilkulchai N., Fizames C., Samson D., Cruaud C., Caloustian C., Gyapay G., Delpech M., Weissenbach J. Genomics 50:147-160(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ003145 mRNA. No translation available. AF399558 Genomic DNA. Translation: AAK95043.1.
IPI	IPI00073066.
UniGene	Hs.651203.
3D structure databases
ProteinModelPortal	Q96R84.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372851.
Proteomic databases
PRIDE	Q96R84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010uwv.2. human.
Organism-specific databases
GeneCards	GC16P003267.
HGNC	HGNC:8196. OR1F2P.
neXtProt	NX_Q96R84.
PharmGKB	PA32075.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG017625.
Gene expression databases
Genevestigator	Q96R84.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OR1F2_HUMAN

Accession

Primary (citable) accession number: Q96R84

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 10, 2003
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.