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Protein

Putative olfactory receptor 1F2

Gene

OR1F2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 1F2
Alternative name(s):
OLFmf2
Gene namesi
Name:OR1F2P
Synonyms:OR1F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:8196. OR1F2P.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 19538ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21823Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Putative olfactory receptor 1F2PRO_0000150432Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ96R84.

Expressioni

Gene expression databases

GenevestigatoriQ96R84.

Structurei

3D structure databases

ProteinModelPortaliQ96R84.
SMRiQ96R84. Positions 36-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ96R84.
PhylomeDBiQ96R84.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R84-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERDKPVSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILAIS
60 70 80 90 100
IDSRLHTPMY FFLSNMSFVD NCFSTTVPKM LANHILRTQT ISFSGCLMQM
110 120 130 140 150
YFISELADMD NFLLAVMAYD RFVAVCRPLH YTAKMIHQLC ALLVTGSWVV
160 170 180 190 200
ANSNALLHTL LMARLSFCAD NTIPHIFCDV TPLLKLSCSD THLSEVMILT
210 220 230 240 250
EAALVTITPF LCLLASYMHI TCVVLRVPST KGRWKAFSTC GSHLAVVLLF
260 270 280 290 300
YGTIMSPYFR TSSSHSAQRD IAAAVRFTVV TPVMNPLIYS LRNKDIKGAL
310
VKVVAVKFFS VQ
Length:312
Mass (Da):34,944
Last modified:October 10, 2003 - v2
Checksum:i96B49B6DDBB11285
GO

Sequence cautioni

The sequence AJ003145 differs from that shown. Reason: Frameshift at position 1. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361I → T in AAK95043. (PubMed:12213199)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003145 mRNA. No translation available.
AF399558 Genomic DNA. Translation: AAK95043.1.
UniGeneiHs.651203.

Genome annotation databases

UCSCiuc010uwv.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003145 mRNA. No translation available.
AF399558 Genomic DNA. Translation: AAK95043.1.
UniGeneiHs.651203.

3D structure databases

ProteinModelPortaliQ96R84.
SMRiQ96R84. Positions 36-157.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ96R84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc010uwv.2. human.

Organism-specific databases

GeneCardsiGC16P003271.
HGNCiHGNC:8196. OR1F2P.
neXtProtiNX_Q96R84.
PharmGKBiPA32075.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ96R84.
PhylomeDBiQ96R84.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ96R84.

Gene expression databases

GenevestigatoriQ96R84.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.

Entry informationi

Entry nameiOR1F2_HUMAN
AccessioniPrimary (citable) accession number: Q96R84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: January 7, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.