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Q96R84

- OR1F2_HUMAN

UniProt

Q96R84 - OR1F2_HUMAN

Protein

Putative olfactory receptor 1F2

Gene

OR1F2P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative olfactory receptor 1F2
    Alternative name(s):
    OLFmf2
    Gene namesi
    Name:OR1F2P
    Synonyms:OR1F2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:8196. OR1F2P.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32075.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Putative olfactory receptor 1F2PRO_0000150432Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ96R84.

    Expressioni

    Gene expression databases

    GenevestigatoriQ96R84.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96R84.
    SMRiQ96R84. Positions 36-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 19538ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21823Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG017625.
    PhylomeDBiQ96R84.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96R84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERDKPVSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILAIS    50
    IDSRLHTPMY FFLSNMSFVD NCFSTTVPKM LANHILRTQT ISFSGCLMQM 100
    YFISELADMD NFLLAVMAYD RFVAVCRPLH YTAKMIHQLC ALLVTGSWVV 150
    ANSNALLHTL LMARLSFCAD NTIPHIFCDV TPLLKLSCSD THLSEVMILT 200
    EAALVTITPF LCLLASYMHI TCVVLRVPST KGRWKAFSTC GSHLAVVLLF 250
    YGTIMSPYFR TSSSHSAQRD IAAAVRFTVV TPVMNPLIYS LRNKDIKGAL 300
    VKVVAVKFFS VQ 312
    Length:312
    Mass (Da):34,944
    Last modified:October 10, 2003 - v2
    Checksum:i96B49B6DDBB11285
    GO

    Sequence cautioni

    The sequence AJ003145 differs from that shown. Reason: Frameshift at position 1.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti136 – 1361I → T in AAK95043. (PubMed:12213199)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ003145 mRNA. No translation available.
    AF399558 Genomic DNA. Translation: AAK95043.1.
    UniGeneiHs.651203.

    Genome annotation databases

    UCSCiuc010uwv.2. human.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ003145 mRNA. No translation available.
    AF399558 Genomic DNA. Translation: AAK95043.1 .
    UniGenei Hs.651203.

    3D structure databases

    ProteinModelPortali Q96R84.
    SMRi Q96R84. Positions 36-157.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q96R84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc010uwv.2. human.

    Organism-specific databases

    GeneCardsi GC16P003267.
    HGNCi HGNC:8196. OR1F2P.
    neXtProti NX_Q96R84.
    PharmGKBi PA32075.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG017625.
    PhylomeDBi Q96R84.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    PROi Q96R84.

    Gene expression databases

    Genevestigatori Q96R84.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.

    Entry informationi

    Entry nameiOR1F2_HUMAN
    AccessioniPrimary (citable) accession number: Q96R84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3