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Protein

Olfactory receptor 4K3

Gene

OR4K3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176290-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K3
Alternative name(s):
Olfactory receptor OR14-14
Gene namesi
Name:OR4K3
Synonyms:OR4K3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14731. OR4K3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 315CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32318.

Polymorphism and mutation databases

DMDMi166215048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505541 – 315Olfactory receptor 4K3Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96R72.
PeptideAtlasiQ96R72.
PRIDEiQ96R72.

PTM databases

PhosphoSitePlusiQ96R72.

Interactioni

Protein-protein interaction databases

IntActiQ96R72. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ96R72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ96R72.
PhylomeDBiQ96R72.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSNQSAVT EFILRGLSSS LELQIFYFLF FSIVYAATVL GNLLIVVTIA
60 70 80 90 100
SEPHLHSPMY FLLGNLSFID MSLASFATPK MIADFLREHK AISFEGCMTQ
110 120 130 140 150
MFFLHLLGGA EIVLLISMSF DRYVAICKPL HYLTIMSRRM CVGLVILSWI
160 170 180 190 200
VGIFHALSQL AFTVNLPFCG PNEVDSFFCD LPLVIKLACV DTYILGVFMI
210 220 230 240 250
STSGMIALVC FILLVISYTI ILVTVRQRSS GGSSKALSTC SAHFTVVTLF
260 270 280 290 300
FGPCTFIYVW PFTNFPIDKV LSVFYTIYTP LLNPVIYTVR NKDVKYSMRK
310
LSSHIFKSRK TDHTP
Length:315
Mass (Da):35,408
Last modified:January 15, 2008 - v3
Checksum:i5039C16DB3A0820E
GO

Sequence cautioni

The sequence DAA04756 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59M → T in AC024399 (PubMed:12508121).Curated1

Polymorphismi

A single nucleotide deletion at position Met-205 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024399 Genomic DNA. No translation available.
AF399571 Genomic DNA. Translation: AAK95056.1.
BK004358 Genomic DNA. Translation: DAA04756.1. Different initiation.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024399 Genomic DNA. No translation available.
AF399571 Genomic DNA. Translation: AAK95056.1.
BK004358 Genomic DNA. Translation: DAA04756.1. Different initiation.

3D structure databases

ProteinModelPortaliQ96R72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96R72. 1 interactor.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ96R72.

Polymorphism and mutation databases

DMDMi166215048.

Proteomic databases

MaxQBiQ96R72.
PeptideAtlasiQ96R72.
PRIDEiQ96R72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR4K3.
HGNCiHGNC:14731. OR4K3.
neXtProtiNX_Q96R72.
PharmGKBiPA32318.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ96R72.
PhylomeDBiQ96R72.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176290-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ96R72.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4K3_HUMAN
AccessioniPrimary (citable) accession number: Q96R72
Secondary accession number(s): Q6IFA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.