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Protein

Olfactory receptor 4K3

Gene

OR4K3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K3
Alternative name(s):
Olfactory receptor OR14-14
Gene namesi
Name:OR4K3
Synonyms:OR4K3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14731. OR4K3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 31526CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32318.

Polymorphism and mutation databases

DMDMi166215048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 4K3PRO_0000150554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ96R72.
PRIDEiQ96R72.

PTM databases

PhosphoSiteiQ96R72.

Interactioni

Protein-protein interaction databases

IntActiQ96R72. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96R72.
SMRiQ96R72. Positions 42-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ96R72.
PhylomeDBiQ96R72.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSNQSAVT EFILRGLSSS LELQIFYFLF FSIVYAATVL GNLLIVVTIA
60 70 80 90 100
SEPHLHSPMY FLLGNLSFID MSLASFATPK MIADFLREHK AISFEGCMTQ
110 120 130 140 150
MFFLHLLGGA EIVLLISMSF DRYVAICKPL HYLTIMSRRM CVGLVILSWI
160 170 180 190 200
VGIFHALSQL AFTVNLPFCG PNEVDSFFCD LPLVIKLACV DTYILGVFMI
210 220 230 240 250
STSGMIALVC FILLVISYTI ILVTVRQRSS GGSSKALSTC SAHFTVVTLF
260 270 280 290 300
FGPCTFIYVW PFTNFPIDKV LSVFYTIYTP LLNPVIYTVR NKDVKYSMRK
310
LSSHIFKSRK TDHTP
Length:315
Mass (Da):35,408
Last modified:January 15, 2008 - v3
Checksum:i5039C16DB3A0820E
GO

Sequence cautioni

The sequence DAA04756 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591M → T in AC024399 (PubMed:12508121).Curated

Polymorphismi

A single nucleotide deletion at position Met-205 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024399 Genomic DNA. No translation available.
AF399571 Genomic DNA. Translation: AAK95056.1.
BK004358 Genomic DNA. Translation: DAA04756.1. Different initiation.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024399 Genomic DNA. No translation available.
AF399571 Genomic DNA. Translation: AAK95056.1.
BK004358 Genomic DNA. Translation: DAA04756.1. Different initiation.

3D structure databases

ProteinModelPortaliQ96R72.
SMRiQ96R72. Positions 42-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96R72. 1 interaction.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96R72.

Polymorphism and mutation databases

DMDMi166215048.

Proteomic databases

PeptideAtlasiQ96R72.
PRIDEiQ96R72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR4K3.
HGNCiHGNC:14731. OR4K3.
neXtProtiNX_Q96R72.
PharmGKBiPA32318.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ96R72.
PhylomeDBiQ96R72.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ96R72.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4K3_HUMAN
AccessioniPrimary (citable) accession number: Q96R72
Secondary accession number(s): Q6IFA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.