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Protein

Olfactory receptor 4F4

Gene

OR4F4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4F4
Alternative name(s):
HS14a-1-A
Olfactory receptor OR19-3
Gene namesi
Name:OR4F4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:8301. OR4F4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818ExtracellularSequence analysisAdd
BLAST
Transmembranei19 – 4224Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini43 – 508CytoplasmicSequence analysis
Transmembranei51 – 7222Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini73 – 9321ExtracellularSequence analysisAdd
BLAST
Transmembranei94 – 11320Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini114 – 13219CytoplasmicSequence analysisAdd
BLAST
Transmembranei133 – 15119Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini152 – 18837ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 21224Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini213 – 22816CytoplasmicSequence analysisAdd
BLAST
Transmembranei229 – 25123Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini252 – 26211ExtracellularSequence analysisAdd
BLAST
Transmembranei263 – 28220Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini283 – 30523CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32290.

Polymorphism and mutation databases

BioMutaiOR4F4.
DMDMi38372849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Olfactory receptor 4F4PRO_0000150546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96R69.
PRIDEiQ96R69.

PTM databases

iPTMnetiQ96R69.
PhosphoSiteiQ96R69.

Expressioni

Gene expression databases

CleanExiHS_OR4F4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317482.

Structurei

3D structure databases

ProteinModelPortaliQ96R69.
SMRiQ96R69. Positions 32-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9XX. Eukaryota.
ENOG411192Y. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ96R69.
KOiK04257.
OMAiLRKWDVH.
OrthoDBiEOG7J9VPZ.
PhylomeDBiQ96R69.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEFIFLGL SDSQELQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS
60 70 80 90 100
PMYFLLANLS LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF
110 120 130 140 150
GGSEMVILIA MGFDRYIAIC KPLHYTTIMC GNACVGIMAV AWGIGFLHSV
160 170 180 190 200
SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL ACTDTYRLDI MVIANSGVLT
210 220 230 240 250
VCSFVLLIIS YTIILMTIQH CPLDKSSKAL STLTAHITVV LLFFGPCVFI
260 270 280 290 300
YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRRLRKWDAH

SSVKF
Length:305
Mass (Da):34,259
Last modified:October 10, 2003 - v2
Checksum:i903D4D8E98EA07F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78442 Genomic DNA. No translation available.
BC136907 mRNA. Translation: AAI36908.1.
BC136908 mRNA. Translation: AAI36909.1.
AF399574 Genomic DNA. Translation: AAK95059.1.
BK004223 Genomic DNA. Translation: DAA04621.1.
CCDSiCCDS32343.1.
RefSeqiNP_001004195.2. NM_001004195.2.
UniGeneiHs.554420.

Genome annotation databases

EnsembliENST00000326183; ENSP00000317482; ENSG00000177693.
GeneIDi26682.
KEGGihsa:26682.
UCSCiuc002cdf.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78442 Genomic DNA. No translation available.
BC136907 mRNA. Translation: AAI36908.1.
BC136908 mRNA. Translation: AAI36909.1.
AF399574 Genomic DNA. Translation: AAK95059.1.
BK004223 Genomic DNA. Translation: DAA04621.1.
CCDSiCCDS32343.1.
RefSeqiNP_001004195.2. NM_001004195.2.
UniGeneiHs.554420.

3D structure databases

ProteinModelPortaliQ96R69.
SMRiQ96R69. Positions 32-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317482.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96R69.
PhosphoSiteiQ96R69.

Polymorphism and mutation databases

BioMutaiOR4F4.
DMDMi38372849.

Proteomic databases

PaxDbiQ96R69.
PRIDEiQ96R69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326183; ENSP00000317482; ENSG00000177693.
GeneIDi26682.
KEGGihsa:26682.
UCSCiuc002cdf.2. human.

Organism-specific databases

CTDi26682.
GeneCardsiOR4F4.
HGNCiHGNC:8301. OR4F4.
neXtProtiNX_Q96R69.
PharmGKBiPA32290.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9XX. Eukaryota.
ENOG411192Y. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ96R69.
KOiK04257.
OMAiLRKWDVH.
OrthoDBiEOG7J9VPZ.
PhylomeDBiQ96R69.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii26682.
PROiQ96R69.

Gene expression databases

CleanExiHS_OR4F4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes."
    Trask B.J., Friedman C., Martin-Gallardo A., Rowen L., Akinbami C., Blankenship J., Collins C., Giorgi D., Iadonato S., Johnson F., Kuo W.L., Massa H., Morrish T., Naylor S., Nguyen O.T., Rouquier S., Smith T., Wong D.J., Youngblom J., van den Engh G.
    Hum. Mol. Genet. 7:13-26(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-274.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4F4_HUMAN
AccessioniPrimary (citable) accession number: Q96R69
Secondary accession number(s): B2RNI5, Q6IFN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.