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Protein

Olfactory receptor 4F4

Gene

OR4F4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-30717-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4F4
Alternative name(s):
HS14a-1-A
Olfactory receptor OR19-3
Gene namesi
Name:OR4F4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:8301. OR4F4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18ExtracellularSequence analysisAdd BLAST18
Transmembranei19 – 42Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini43 – 50CytoplasmicSequence analysis8
Transmembranei51 – 72Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini73 – 93ExtracellularSequence analysisAdd BLAST21
Transmembranei94 – 113Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini114 – 132CytoplasmicSequence analysisAdd BLAST19
Transmembranei133 – 151Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini152 – 188ExtracellularSequence analysisAdd BLAST37
Transmembranei189 – 212Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini213 – 228CytoplasmicSequence analysisAdd BLAST16
Transmembranei229 – 251Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini252 – 262ExtracellularSequence analysisAdd BLAST11
Transmembranei263 – 282Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini283 – 305CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177693.
PharmGKBiPA32290.

Polymorphism and mutation databases

BioMutaiOR4F4.
DMDMi38372849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505461 – 305Olfactory receptor 4F4Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi90 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96R69.
PRIDEiQ96R69.

PTM databases

iPTMnetiQ96R69.
PhosphoSitePlusiQ96R69.

Expressioni

Gene expression databases

CleanExiHS_OR4F4.

Organism-specific databases

HPAiCAB026377.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317482.

Structurei

3D structure databases

ProteinModelPortaliQ96R69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9XX. Eukaryota.
ENOG411192Y. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ96R69.
KOiK04257.
OMAiLRKWDVH.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ96R69.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTEFIFLGL SDSQELQTFL FMLFFVFYGG IVFGNLLIVI TVVSDSHLHS
60 70 80 90 100
PMYFLLANLS LIDLSLSSVT APKMITDFFS QRKVISFKGC LVQIFLLHFF
110 120 130 140 150
GGSEMVILIA MGFDRYIAIC KPLHYTTIMC GNACVGIMAV AWGIGFLHSV
160 170 180 190 200
SQLAFAVHLP FCGPNEVDSF YCDLPRVIKL ACTDTYRLDI MVIANSGVLT
210 220 230 240 250
VCSFVLLIIS YTIILMTIQH CPLDKSSKAL STLTAHITVV LLFFGPCVFI
260 270 280 290 300
YAWPFPIKSL DKFLAVFYSV ITPLLNPIIY TLRNKDMKTA IRRLRKWDAH

SSVKF
Length:305
Mass (Da):34,259
Last modified:October 10, 2003 - v2
Checksum:i903D4D8E98EA07F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78442 Genomic DNA. No translation available.
BC136907 mRNA. Translation: AAI36908.1.
BC136908 mRNA. Translation: AAI36909.1.
AF399574 Genomic DNA. Translation: AAK95059.1.
BK004223 Genomic DNA. Translation: DAA04621.1.
CCDSiCCDS32343.1.
RefSeqiNP_001004195.2. NM_001004195.2.
UniGeneiHs.554420.

Genome annotation databases

EnsembliENST00000326183; ENSP00000317482; ENSG00000177693.
GeneIDi26682.
KEGGihsa:26682.
UCSCiuc002cdf.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78442 Genomic DNA. No translation available.
BC136907 mRNA. Translation: AAI36908.1.
BC136908 mRNA. Translation: AAI36909.1.
AF399574 Genomic DNA. Translation: AAK95059.1.
BK004223 Genomic DNA. Translation: DAA04621.1.
CCDSiCCDS32343.1.
RefSeqiNP_001004195.2. NM_001004195.2.
UniGeneiHs.554420.

3D structure databases

ProteinModelPortaliQ96R69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317482.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96R69.
PhosphoSitePlusiQ96R69.

Polymorphism and mutation databases

BioMutaiOR4F4.
DMDMi38372849.

Proteomic databases

PaxDbiQ96R69.
PRIDEiQ96R69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326183; ENSP00000317482; ENSG00000177693.
GeneIDi26682.
KEGGihsa:26682.
UCSCiuc002cdf.2. human.

Organism-specific databases

CTDi26682.
GeneCardsiOR4F4.
HGNCiHGNC:8301. OR4F4.
HPAiCAB026377.
neXtProtiNX_Q96R69.
OpenTargetsiENSG00000177693.
PharmGKBiPA32290.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9XX. Eukaryota.
ENOG411192Y. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ96R69.
KOiK04257.
OMAiLRKWDVH.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ96R69.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:G66-30717-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii26682.
PROiQ96R69.

Gene expression databases

CleanExiHS_OR4F4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4F4_HUMAN
AccessioniPrimary (citable) accession number: Q96R69
Secondary accession number(s): B2RNI5, Q6IFN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.