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Protein

Olfactory receptor 4C12

Gene

OR4C12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33908-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C12
Alternative name(s):
Olfactory receptor OR11-259
Gene namesi
Name:OR4C12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15168. OR4C12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 309CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283093.
OpenTargetsiENSG00000221954.
PharmGKBiPA32254.

Polymorphism and mutation databases

DMDMi38372848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505331 – 309Olfactory receptor 4C12Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R67.
PeptideAtlasiQ96R67.
PRIDEiQ96R67.
TopDownProteomicsiQ96R67.

PTM databases

iPTMnetiQ96R67.
PhosphoSitePlusiQ96R67.

Expressioni

Gene expression databases

CleanExiHS_OR4C12.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334418.

Structurei

3D structure databases

ProteinModelPortaliQ96R67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKHV. Eukaryota.
ENOG4111834. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ96R67.
KOiK04257.
OMAiLYMITLS.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ96R67.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKKKNVTEF ILIGLTQNPI MEKVTFVVFL VLYMITLSGN LLIVVTITTS
60 70 80 90 100
QALSSPMYFF LTHLSLIDTV YSSSSAPKLI VDSFQEKKII SFNGCMAQAY
110 120 130 140 150
AEHIFGATEI ILLTVMACDC YVAICKPLNY TTIMSHSLCI LLVAVAWVGG
160 170 180 190 200
FLHATIQILF TVWLPFCGPN VIGHFMCDLY PLLKLVCIDT HTLGLFVAVN
210 220 230 240 250
SGFICLLNFL ILVVSYVIIL RSLKNNSLEG RCKALSTCIS HIIVVVLFFV
260 270 280 290 300
PCIFVYLRSV TTLPIDKAVA VFYTMVVPML NPVVYTLRNA EVKSAIRKLW

RKKVTSDND
Length:309
Mass (Da):34,491
Last modified:October 10, 2003 - v2
Checksum:i3C6AD9FA309457C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034192283V → L.1 PublicationCorresponds to variant rs4598671dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136850 mRNA. Translation: AAI36851.1.
BC136851 mRNA. Translation: AAI36852.1.
AF399576 Genomic DNA. Translation: AAK95061.1.
BK004413 Genomic DNA. Translation: DAA04811.1.
CCDSiCCDS31496.1.
RefSeqiNP_001005270.3. NM_001005270.4.
UniGeneiHs.553669.

Genome annotation databases

EnsembliENST00000335238; ENSP00000334418; ENSG00000221954.
GeneIDi283093.
KEGGihsa:283093.
UCSCiuc010ria.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136850 mRNA. Translation: AAI36851.1.
BC136851 mRNA. Translation: AAI36852.1.
AF399576 Genomic DNA. Translation: AAK95061.1.
BK004413 Genomic DNA. Translation: DAA04811.1.
CCDSiCCDS31496.1.
RefSeqiNP_001005270.3. NM_001005270.4.
UniGeneiHs.553669.

3D structure databases

ProteinModelPortaliQ96R67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334418.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96R67.
PhosphoSitePlusiQ96R67.

Polymorphism and mutation databases

DMDMi38372848.

Proteomic databases

PaxDbiQ96R67.
PeptideAtlasiQ96R67.
PRIDEiQ96R67.
TopDownProteomicsiQ96R67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335238; ENSP00000334418; ENSG00000221954.
GeneIDi283093.
KEGGihsa:283093.
UCSCiuc010ria.2. human.

Organism-specific databases

CTDi283093.
DisGeNETi283093.
GeneCardsiOR4C12.
HGNCiHGNC:15168. OR4C12.
neXtProtiNX_Q96R67.
OpenTargetsiENSG00000221954.
PharmGKBiPA32254.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKHV. Eukaryota.
ENOG4111834. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ96R67.
KOiK04257.
OMAiLYMITLS.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ96R67.
TreeFamiTF337350.

Enzyme and pathway databases

BioCyciZFISH:G66-33908-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4C12.
GenomeRNAii283093.
PROiQ96R67.

Gene expression databases

CleanExiHS_OR4C12.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4CC_HUMAN
AccessioniPrimary (citable) accession number: Q96R67
Secondary accession number(s): B2RNF0, Q6IF49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.