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Protein

Olfactory receptor 14A2

Gene

OR14A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14A2
Alternative name(s):
Olfactory receptor 5AX1
Olfactory receptor OR1-31
Gene namesi
Name:OR14A2
Synonyms:OR5AX1, OR5AX1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15024. OR14A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9115ExtracellularSequence analysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini113 – 13624CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 19336ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini215 – 23723CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 2679ExtracellularSequence analysis
Transmembranei268 – 29023Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 31424CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi206558302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 14A2PRO_0000344440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R54.
PRIDEiQ96R54.

Expressioni

Gene expression databases

BgeeiQ96R54.

Organism-specific databases

HPAiHPA052685.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355441.

Structurei

3D structure databases

ProteinModelPortaliQ96R54.
SMRiQ96R54. Positions 24-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96R54.
OMAiSVIPQFF.
OrthoDBiEOG7M98H6.
PhylomeDBiQ96R54.
TreeFamiTF352740.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVTLVTGF LLMGFSNIQK LRILYGVLFL LIYLAALMSN LLIITLITLD
60 70 80 90 100
VKLQTPMYFF LKNLSFLDVF LVSVPIPKFI VNNLTHNNSI SILGCAFQLL
110 120 130 140 150
LMTSFSAGEI FILTAMSYDR YVAICCPLNY EVIMNTGVCV LMASVSWAIG
160 170 180 190 200
GLFGTAYTAG TFSMPFCGSS VIPQFFCDVP SLLRISCSET LMVIYAGIGV
210 220 230 240 250
GACLSISCFI CIVISYIYIF STVLKIPTTK GQSKAFSTCF PHLTVFTVFI
260 270 280 290 300
ITAYFVYLKP PSNSPSVIDR LLSVIYTVMP PVFNPVTYSL RNNDMKCALI
310
RLLQKTYGQE AYFI
Length:314
Mass (Da):34,780
Last modified:July 22, 2008 - v2
Checksum:i8EE5299FF6898842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065620 Genomic DNA. No translation available.
AF399589 Genomic DNA. Translation: AAK95074.1.
BK004620 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000366485; ENSP00000355441; ENSG00000241128.
UCSCiuc057rau.1. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065620 Genomic DNA. No translation available.
AF399589 Genomic DNA. Translation: AAK95074.1.
BK004620 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ96R54.
SMRiQ96R54. Positions 24-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355441.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi206558302.

Proteomic databases

PaxDbiQ96R54.
PRIDEiQ96R54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366485; ENSP00000355441; ENSG00000241128.
UCSCiuc057rau.1. human.

Organism-specific databases

GeneCardsiOR14A2.
HGNCiHGNC:15024. OR14A2.
HPAiHPA052685.
neXtProtiNX_Q96R54.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96R54.
OMAiSVIPQFF.
OrthoDBiEOG7M98H6.
PhylomeDBiQ96R54.
TreeFamiTF352740.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ96R54.

Gene expression databases

BgeeiQ96R54.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO14A2_HUMAN
AccessioniPrimary (citable) accession number: Q96R54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: March 16, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.