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Protein

Olfactory receptor 14A2

Gene

OR14A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14A2
Alternative name(s):
Olfactory receptor 5AX1
Olfactory receptor OR1-31
Gene namesi
Name:OR14A2
Synonyms:OR5AX1, OR5AX1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000241128.1.
HGNCiHGNC:15024. OR14A2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 91ExtracellularSequence analysisAdd BLAST15
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 136CytoplasmicSequence analysisAdd BLAST24
Transmembranei137 – 157Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini158 – 193ExtracellularSequence analysisAdd BLAST36
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 237CytoplasmicSequence analysisAdd BLAST23
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 267ExtracellularSequence analysis9
Transmembranei268 – 290Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini291 – 314CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi206558302.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003444401 – 314Olfactory receptor 14A2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R54.
PRIDEiQ96R54.

Expressioni

Gene expression databases

BgeeiENSG00000241128.
ExpressionAtlasiQ96R54. baseline.

Organism-specific databases

HPAiHPA052685.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355441.

Structurei

3D structure databases

ProteinModelPortaliQ96R54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96R54.
OMAiTAYFVYL.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ96R54.
TreeFamiTF352740.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96R54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVTLVTGF LLMGFSNIQK LRILYGVLFL LIYLAALMSN LLIITLITLD
60 70 80 90 100
VKLQTPMYFF LKNLSFLDVF LVSVPIPKFI VNNLTHNNSI SILGCAFQLL
110 120 130 140 150
LMTSFSAGEI FILTAMSYDR YVAICCPLNY EVIMNTGVCV LMASVSWAIG
160 170 180 190 200
GLFGTAYTAG TFSMPFCGSS VIPQFFCDVP SLLRISCSET LMVIYAGIGV
210 220 230 240 250
GACLSISCFI CIVISYIYIF STVLKIPTTK GQSKAFSTCF PHLTVFTVFI
260 270 280 290 300
ITAYFVYLKP PSNSPSVIDR LLSVIYTVMP PVFNPVTYSL RNNDMKCALI
310
RLLQKTYGQE AYFI
Length:314
Mass (Da):34,780
Last modified:July 22, 2008 - v2
Checksum:i8EE5299FF6898842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065620 Genomic DNA. No translation available.
AF399589 Genomic DNA. Translation: AAK95074.1.
BK004620 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000366485; ENSP00000355441; ENSG00000241128.
UCSCiuc057rau.1. human.

Similar proteinsi

Entry informationi

Entry nameiO14A2_HUMAN
AccessioniPrimary (citable) accession number: Q96R54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 27, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families