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Protein

Olfactory receptor 2A5

Gene

OR2A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32027-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A5
Alternative name(s):
Olfactory receptor 2A26
Olfactory receptor 2A8
Olfactory receptor 7-138/7-141
Short name:
OR7-138
Short name:
OR7-141
Gene namesi
Name:OR2A5
Synonyms:OR2A26, OR2A8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:8232. OR2A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 100ExtracellularSequence analysisAdd BLAST22
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 196ExtracellularSequence analysisAdd BLAST38
Transmembranei197 – 219Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 311CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221836.
PharmGKBiPA32118.

Polymorphism and mutation databases

BioMutaiOR2A5.
DMDMi85692724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504551 – 311Olfactory receptor 2A5Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R48.
PeptideAtlasiQ96R48.
PRIDEiQ96R48.

PTM databases

iPTMnetiQ96R48.
PhosphoSitePlusiQ96R48.

Expressioni

Gene expression databases

CleanExiHS_OR2A5.
ExpressionAtlasiQ96R48. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386208.

Structurei

3D structure databases

ProteinModelPortaliQ96R48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHHV. Eukaryota.
ENOG410Z9E8. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R48.
KOiK04257.
OMAiVLWKERS.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ96R48.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKNQTWVTE FILLGFPLSL RIQMLLSGLF SLLYVFTLLG NGAILGLIWL
60 70 80 90 100
DSRLHTPMYF FLSHLAIIDI SYASNNVPKM LTNLGLNKRK TISFVPCTMQ
110 120 130 140 150
TFLYMAFAHT ECLILVMMSY DRYMAICHPL QYSVIMRWGV CTVLAVTSWA
160 170 180 190 200
CGSLLALVHV VLILRLPFCG PHEINHFFCE ILSVLKLACA DTWLNQVVIF
210 220 230 240 250
AASVFILVGP LCLVLVSYSR ILAAILRIQS GEGRRKAFST CSSHLCMVGL
260 270 280 290 300
FFGSAIVMYM APKSRHPEEQ QKVLSLFYSL FNPMLNPLIY SLRNAEVKGA
310
LKRVLWKQRS K
Length:311
Mass (Da):35,207
Last modified:January 10, 2006 - v2
Checksum:i0E515A53AEF1A950
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti76N → K in AAC39633 (PubMed:9500546).Curated1
Sequence conflicti76N → K in AAK95080 (PubMed:12213199).Curated1
Sequence conflicti227R → G in AAC39630 (PubMed:9500546).Curated1
Sequence conflicti227R → G in AAK95080 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053129126I → V.Corresponds to variant rs2961144dbSNPEnsembl.1
Natural variantiVAR_053130202A → S.Corresponds to variant rs6464573dbSNPEnsembl.1
Natural variantiVAR_059984255A → T.Corresponds to variant rs6464574dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091768 Genomic DNA. No translation available.
BC136860 mRNA. Translation: AAI36861.1.
U86278 Genomic DNA. Translation: AAC39630.1.
U86281 Genomic DNA. Translation: AAC39633.1.
AF399595 Genomic DNA. Translation: AAK95080.1.
CCDSiCCDS43668.1.
RefSeqiNP_036497.1. NM_012365.1.
UniGeneiHs.553793.

Genome annotation databases

EnsembliENST00000408906; ENSP00000386208; ENSG00000221836.
GeneIDi393046.
KEGGihsa:393046.
UCSCiuc011ktw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091768 Genomic DNA. No translation available.
BC136860 mRNA. Translation: AAI36861.1.
U86278 Genomic DNA. Translation: AAC39630.1.
U86281 Genomic DNA. Translation: AAC39633.1.
AF399595 Genomic DNA. Translation: AAK95080.1.
CCDSiCCDS43668.1.
RefSeqiNP_036497.1. NM_012365.1.
UniGeneiHs.553793.

3D structure databases

ProteinModelPortaliQ96R48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386208.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96R48.
PhosphoSitePlusiQ96R48.

Polymorphism and mutation databases

BioMutaiOR2A5.
DMDMi85692724.

Proteomic databases

PaxDbiQ96R48.
PeptideAtlasiQ96R48.
PRIDEiQ96R48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408906; ENSP00000386208; ENSG00000221836.
GeneIDi393046.
KEGGihsa:393046.
UCSCiuc011ktw.3. human.

Organism-specific databases

CTDi393046.
GeneCardsiOR2A5.
H-InvDBHIX0033736.
HGNCiHGNC:8232. OR2A5.
neXtProtiNX_Q96R48.
OpenTargetsiENSG00000221836.
PharmGKBiPA32118.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHV. Eukaryota.
ENOG410Z9E8. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R48.
KOiK04257.
OMAiVLWKERS.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ96R48.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:G66-32027-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2A5.
GenomeRNAii393046.
PROiQ96R48.

Gene expression databases

CleanExiHS_OR2A5.
ExpressionAtlasiQ96R48. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2A5_HUMAN
AccessioniPrimary (citable) accession number: Q96R48
Secondary accession number(s): B9EGX2, O43885, O43888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.