ID   O2A14_HUMAN             Reviewed;         310 AA.
AC   Q96R47; A4D2G5; Q6IF41; Q8NGT8;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 4.
DT   24-JAN-2024, entry version 160.
DE   RecName: Full=Olfactory receptor 2A14;
DE   AltName: Full=OST182;
DE   AltName: Full=Olfactory receptor 2A6;
DE   AltName: Full=Olfactory receptor OR7-12;
GN   Name=OR2A14; Synonyms=OR2A14P, OR2A6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-133.
RX   PubMed=25977809; DOI=10.1038/sdata.2015.2;
RA   Mainland J.D., Li Y.R., Zhou T., Liu W.L., Matsunami H.;
RT   "Human olfactory receptor responses to odorants.";
RL   Sci. Data 2:150002-150002(2015).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, AND VARIANTS ILE-133 AND
RP   ARG-164.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-133.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-133.
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-133.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [8]
RP   IDENTIFICATION, AND VARIANTS ILE-133 AND ARG-164.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [9]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2A14";
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DR   EMBL; AB065693; BAC05916.1; -; Genomic_DNA.
DR   EMBL; AF399596; AAK95081.1; -; Genomic_DNA.
DR   EMBL; KP290564; ALI87723.1; -; Genomic_DNA.
DR   EMBL; AC091768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236959; EAL23799.1; -; Genomic_DNA.
DR   EMBL; CH878732; EAW55633.1; -; Genomic_DNA.
DR   EMBL; BC136889; AAI36890.1; -; mRNA.
DR   EMBL; BK004421; DAA04819.1; -; Genomic_DNA.
DR   CCDS; CCDS43672.1; -.
DR   RefSeq; NP_001001659.1; NM_001001659.1.
DR   AlphaFoldDB; Q96R47; -.
DR   SMR; Q96R47; -.
DR   STRING; 9606.ENSP00000493353; -.
DR   GlyCosmos; Q96R47; 1 site, No reported glycans.
DR   GlyGen; Q96R47; 1 site.
DR   iPTMnet; Q96R47; -.
DR   PhosphoSitePlus; Q96R47; -.
DR   BioMuta; OR2A14; -.
DR   DMDM; 296439489; -.
DR   MassIVE; Q96R47; -.
DR   PaxDb; 9606-ENSP00000386137; -.
DR   PeptideAtlas; Q96R47; -.
DR   Antibodypedia; 64089; 17 antibodies from 8 providers.
DR   DNASU; 135941; -.
DR   Ensembl; ENST00000408899.2; ENSP00000386137.2; ENSG00000221938.5.
DR   Ensembl; ENST00000641068.1; ENSP00000493353.1; ENSG00000221938.5.
DR   GeneID; 135941; -.
DR   KEGG; hsa:135941; -.
DR   MANE-Select; ENST00000641068.1; ENSP00000493353.1; NM_001001659.3; NP_001001659.1.
DR   UCSC; uc011kua.3; human.
DR   AGR; HGNC:15084; -.
DR   CTD; 135941; -.
DR   GeneCards; OR2A14; -.
DR   HGNC; HGNC:15084; OR2A14.
DR   HPA; ENSG00000221938; Not detected.
DR   neXtProt; NX_Q96R47; -.
DR   PharmGKB; PA32106; -.
DR   VEuPathDB; HostDB:ENSG00000221938; -.
DR   eggNOG; ENOG502SIA2; Eukaryota.
DR   GeneTree; ENSGT00940000153255; -.
DR   InParanoid; Q96R47; -.
DR   OMA; GLFCLFY; -.
DR   OrthoDB; 5259681at2759; -.
DR   PhylomeDB; Q96R47; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q96R47; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 135941; 6 hits in 735 CRISPR screens.
DR   GeneWiki; OR2A14; -.
DR   GenomeRNAi; 135941; -.
DR   Pharos; Q96R47; Tdark.
DR   PRO; PR:Q96R47; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q96R47; Protein.
DR   Bgee; ENSG00000221938; Expressed in primordial germ cell in gonad and 2 other cell types or tissues.
DR   ExpressionAtlas; Q96R47; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15420; 7tmA_OR2A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF27; OLFACTORY RECEPTOR-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..310
FT                   /note="Olfactory receptor 2A14"
FT                   /id="PRO_0000150458"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..157
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..310
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         133
FT                   /note="S -> I (in dbSNP:rs2961160)"
FT                   /evidence="ECO:0000269|PubMed:12213199,
FT                   ECO:0000269|PubMed:12690205, ECO:0000269|PubMed:14983052,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:25977809"
FT                   /id="VAR_060477"
FT   VARIANT         164
FT                   /note="S -> R (in dbSNP:rs2961161)"
FT                   /evidence="ECO:0000269|PubMed:12213199,
FT                   ECO:0000269|PubMed:14983052"
FT                   /id="VAR_060478"
FT   CONFLICT        177
FT                   /note="Missing (in Ref. 2; ALI87723, 3; AAK95081, 5;
FT                   EAL23799 and 6; AAI36890)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   310 AA;  34993 MW;  79C30FF4D573BEC8 CRC64;
     MEGNKTWITD ITLPRFQVGP ALEILLCGLF SAFYTLTLLG NGVIFGIICL DCKLHTPMYF
     FLSHLAIVDI SYASNYVPKM LTNLMNQEST ISFFPCIMQT FLYLAFAHVE CLILVVMSYD
     RYADICHPLR YNSLMSWRVC TVLAVASWVF SFLLALVPLV LILSLPFCGP HEINHFFCEI
     LSVLKLACAD TWLNQVVIFA ACVFILVGPL CLVLVSYLRI LAAILRIQSG EGRRKAFSTC
     SSHLCVVGLF FGSAIVTYMA PKSRHPEEQQ KVLSLFYSLF NPMLNPLIYS LRNAEVKGAL
     RRALRKERLT
//