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Q96R47 (O2A14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2A14
Alternative name(s):
OST182
Olfactory receptor 2A6
Olfactory receptor OR7-12
Gene names
Name:OR2A14
Synonyms:OR2A14P, OR2A6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Olfactory receptor 2A14
PRO_0000150458

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4824Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7822Helical; Name=2; Potential
Topological domain79 – 9921Extracellular Potential
Transmembrane100 – 11920Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15719Helical; Name=4; Potential
Topological domain158 – 19437Extracellular Potential
Transmembrane195 – 21824Helical; Name=5; Potential
Topological domain219 – 23517Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 31019Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Natural variations

Natural variant1331S → I. Ref.2 Ref.4
Corresponds to variant rs2961160 [ dbSNP | Ensembl ].
VAR_060477
Natural variant1641S → R. Ref.2 Ref.4
Corresponds to variant rs2961161 [ dbSNP | Ensembl ].
VAR_060478

Experimental info

Sequence conflict1771Missing in AAK95081. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q96R47 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: 79C30FF4D573BEC8

FASTA31034,993
        10         20         30         40         50         60 
MEGNKTWITD ITLPRFQVGP ALEILLCGLF SAFYTLTLLG NGVIFGIICL DCKLHTPMYF 

        70         80         90        100        110        120 
FLSHLAIVDI SYASNYVPKM LTNLMNQEST ISFFPCIMQT FLYLAFAHVE CLILVVMSYD 

       130        140        150        160        170        180 
RYADICHPLR YNSLMSWRVC TVLAVASWVF SFLLALVPLV LILSLPFCGP HEINHFFCEI 

       190        200        210        220        230        240 
LSVLKLACAD TWLNQVVIFA ACVFILVGPL CLVLVSYLRI LAAILRIQSG EGRRKAFSTC 

       250        260        270        280        290        300 
SSHLCVVGLF FGSAIVTYMA PKSRHPEEQQ KVLSLFYSLF NPMLNPLIYS LRNAEVKGAL 

       310 
RRALRKERLT 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANTS ILE-133 AND ARG-164.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, VARIANTS ILE-133 AND ARG-164.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065693 Genomic DNA. Translation: BAC05916.1.
AF399596 Genomic DNA. Translation: AAK95081.1.
AC091768 Genomic DNA. No translation available.
BK004421 Genomic DNA. Translation: DAA04819.1.
CCDSCCDS43672.1.
RefSeqNP_001001659.1. NM_001001659.1.
UniGeneHs.534547.

3D structure databases

ProteinModelPortalQ96R47.
SMRQ96R47. Positions 32-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000386137.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM296439489.

Proteomic databases

PaxDbQ96R47.
PRIDEQ96R47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000408899; ENSP00000386137; ENSG00000221938.
GeneID135941.
KEGGhsa:135941.
UCSCuc011kua.2. human.

Organism-specific databases

CTD135941.
GeneCardsGC07P143826.
H-InvDBHIX0167888.
HGNCHGNC:15084. OR2A14.
neXtProtNX_Q96R47.
PharmGKBPA32106.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285281.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ96R47.
KOK04257.
OMAICLDCKL.
OrthoDBEOG793B85.
PhylomeDBQ96R47.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2A14.
GenevestigatorQ96R47.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2A14.
GenomeRNAi135941.
NextBio83532.
PROQ96R47.

Entry information

Entry nameO2A14_HUMAN
AccessionPrimary (citable) accession number: Q96R47
Secondary accession number(s): Q6IF41, Q8NGT8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries