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Q96R47

- O2A14_HUMAN

UniProt

Q96R47 - O2A14_HUMAN

Protein

Olfactory receptor 2A14

Gene

OR2A14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 4 (18 May 2010)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2A14
    Alternative name(s):
    OST182
    Olfactory receptor 2A6
    Olfactory receptor OR7-12
    Gene namesi
    Name:OR2A14
    Synonyms:OR2A14P, OR2A6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:15084. OR2A14.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32106.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Olfactory receptor 2A14PRO_0000150458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96R47.
    PRIDEiQ96R47.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2A14.
    GenevestigatoriQ96R47.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000386137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96R47.
    SMRiQ96R47. Positions 32-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285281.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ96R47.
    KOiK04257.
    OMAiICLDCKL.
    OrthoDBiEOG793B85.
    PhylomeDBiQ96R47.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96R47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGNKTWITD ITLPRFQVGP ALEILLCGLF SAFYTLTLLG NGVIFGIICL    50
    DCKLHTPMYF FLSHLAIVDI SYASNYVPKM LTNLMNQEST ISFFPCIMQT 100
    FLYLAFAHVE CLILVVMSYD RYADICHPLR YNSLMSWRVC TVLAVASWVF 150
    SFLLALVPLV LILSLPFCGP HEINHFFCEI LSVLKLACAD TWLNQVVIFA 200
    ACVFILVGPL CLVLVSYLRI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF 250
    FGSAIVTYMA PKSRHPEEQQ KVLSLFYSLF NPMLNPLIYS LRNAEVKGAL 300
    RRALRKERLT 310
    Length:310
    Mass (Da):34,993
    Last modified:May 18, 2010 - v4
    Checksum:i79C30FF4D573BEC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1771Missing in AAK95081. (PubMed:12213199)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331S → I.2 Publications
    Corresponds to variant rs2961160 [ dbSNP | Ensembl ].
    VAR_060477
    Natural varianti164 – 1641S → R.2 Publications
    Corresponds to variant rs2961161 [ dbSNP | Ensembl ].
    VAR_060478

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065693 Genomic DNA. Translation: BAC05916.1.
    AF399596 Genomic DNA. Translation: AAK95081.1.
    AC091768 Genomic DNA. No translation available.
    BK004421 Genomic DNA. Translation: DAA04819.1.
    CCDSiCCDS43672.1.
    RefSeqiNP_001001659.1. NM_001001659.1.
    UniGeneiHs.534547.

    Genome annotation databases

    EnsembliENST00000408899; ENSP00000386137; ENSG00000221938.
    GeneIDi135941.
    KEGGihsa:135941.
    UCSCiuc011kua.2. human.

    Polymorphism databases

    DMDMi296439489.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065693 Genomic DNA. Translation: BAC05916.1 .
    AF399596 Genomic DNA. Translation: AAK95081.1 .
    AC091768 Genomic DNA. No translation available.
    BK004421 Genomic DNA. Translation: DAA04819.1 .
    CCDSi CCDS43672.1.
    RefSeqi NP_001001659.1. NM_001001659.1.
    UniGenei Hs.534547.

    3D structure databases

    ProteinModelPortali Q96R47.
    SMRi Q96R47. Positions 32-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000386137.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 296439489.

    Proteomic databases

    PaxDbi Q96R47.
    PRIDEi Q96R47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000408899 ; ENSP00000386137 ; ENSG00000221938 .
    GeneIDi 135941.
    KEGGi hsa:135941.
    UCSCi uc011kua.2. human.

    Organism-specific databases

    CTDi 135941.
    GeneCardsi GC07P143826.
    H-InvDB HIX0167888.
    HGNCi HGNC:15084. OR2A14.
    neXtProti NX_Q96R47.
    PharmGKBi PA32106.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285281.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q96R47.
    KOi K04257.
    OMAi ICLDCKL.
    OrthoDBi EOG793B85.
    PhylomeDBi Q96R47.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2A14.
    GenomeRNAii 135941.
    NextBioi 83532.
    PROi Q96R47.

    Gene expression databases

    CleanExi HS_OR2A14.
    Genevestigatori Q96R47.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANTS ILE-133 AND ARG-164.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: IDENTIFICATION, VARIANTS ILE-133 AND ARG-164.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO2A14_HUMAN
    AccessioniPrimary (citable) accession number: Q96R47
    Secondary accession number(s): Q6IF41, Q8NGT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3