Q96R47 (O2A14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2A14

Alternative name(s):
OST182
Olfactory receptor 2A6
Olfactory receptor OR7-12

Gene names

Name:	OR2A14
Synonyms:	OR2A14P, OR2A6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Olfactory receptor 2A14		PRO_0000150458
Regions
	Topological domain	1 – 24	24	Extracellular Potential
	Transmembrane	25 – 48	24	Helical; Name=1; Potential
	Topological domain	49 – 56	8	Cytoplasmic Potential
	Transmembrane	57 – 78	22	Helical; Name=2; Potential
	Topological domain	79 – 99	21	Extracellular Potential
	Transmembrane	100 – 119	20	Helical; Name=3; Potential
	Topological domain	120 – 138	19	Cytoplasmic Potential
	Transmembrane	139 – 157	19	Helical; Name=4; Potential
	Topological domain	158 – 194	37	Extracellular Potential
	Transmembrane	195 – 218	24	Helical; Name=5; Potential
	Topological domain	219 – 235	17	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 310	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 188		By similarity
Natural variations
	Natural variant	133	1	S → I. Ref.2 Ref.4 Corresponds to variant rs2961160 [ dbSNP | Ensembl ].		VAR_060477
	Natural variant	164	1	S → R. Ref.2 Ref.4 Corresponds to variant rs2961161 [ dbSNP | Ensembl ].		VAR_060478
Experimental info
	Sequence conflict	177	1	Missing in AAK95081. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96R47 [UniParc]. Last modified May 18, 2010. Version 4. Checksum: 79C30FF4D573BEC8	FASTA	310	34,993
	10 20 30 40 50 60 MEGNKTWITD ITLPRFQVGP ALEILLCGLF SAFYTLTLLG NGVIFGIICL DCKLHTPMYF 70 80 90 100 110 120 FLSHLAIVDI SYASNYVPKM LTNLMNQEST ISFFPCIMQT FLYLAFAHVE CLILVVMSYD 130 140 150 160 170 180 RYADICHPLR YNSLMSWRVC TVLAVASWVF SFLLALVPLV LILSLPFCGP HEINHFFCEI 190 200 210 220 230 240 LSVLKLACAD TWLNQVVIFA ACVFILVGPL CLVLVSYLRI LAAILRIQSG EGRRKAFSTC 250 260 270 280 290 300 SSHLCVVGLF FGSAIVTYMA PKSRHPEEQQ KVLSLFYSLF NPMLNPLIYS LRNAEVKGAL 310 RRALRKERLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANTS ILE-133 AND ARG-164.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, VARIANTS ILE-133 AND ARG-164.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065693 Genomic DNA. Translation: BAC05916.1. AF399596 Genomic DNA. Translation: AAK95081.1. AC091768 Genomic DNA. No translation available. BK004421 Genomic DNA. Translation: DAA04819.1.
IPI	IPI00455038.
RefSeq	NP_001001659.1. NM_001001659.1.
UniGene	Hs.534547.
3D structure databases
ProteinModelPortal	Q96R47.
SMR	Q96R47. Positions 32-309.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000386137.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	296439489.
Proteomic databases
PaxDb	Q96R47.
PRIDE	Q96R47.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000408899; ENSP00000386137; ENSG00000221938.
GeneID	135941.
KEGG	hsa:135941.
UCSC	uc011kua.2. human.
Organism-specific databases
CTD	135941.
GeneCards	GC07P143826.
H-InvDB	HIX0167888.
HGNC	HGNC:15084. OR2A14.
neXtProt	NX_Q96R47.
PharmGKB	PA32106.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG285281.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q96R47.
KO	K04257.
OMA	ICLDCKL.
OrthoDB	EOG473PRX.
PhylomeDB	Q96R47.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR2A14.
Genevestigator	Q96R47.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	135941.
NextBio	83532.

Entry information

Entry name

O2A14_HUMAN

Accession

Primary (citable) accession number: Q96R47
Secondary accession number(s): Q6IF41, Q8NGT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 94 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.