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Q96R47

- O2A14_HUMAN

UniProt

Q96R47 - O2A14_HUMAN

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Protein

Olfactory receptor 2A14

Gene

OR2A14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A14
Alternative name(s):
OST182
Olfactory receptor 2A6
Olfactory receptor OR7-12
Gene namesi
Name:OR2A14
Synonyms:OR2A14P, OR2A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:15084. OR2A14.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 2A14PRO_0000150458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R47.
PRIDEiQ96R47.

Expressioni

Gene expression databases

CleanExiHS_OR2A14.
GenevestigatoriQ96R47.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386137.

Structurei

3D structure databases

ProteinModelPortaliQ96R47.
SMRiQ96R47. Positions 32-309.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285281.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R47.
KOiK04257.
OMAiICLDCKL.
OrthoDBiEOG793B85.
PhylomeDBiQ96R47.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R47 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGNKTWITD ITLPRFQVGP ALEILLCGLF SAFYTLTLLG NGVIFGIICL
60 70 80 90 100
DCKLHTPMYF FLSHLAIVDI SYASNYVPKM LTNLMNQEST ISFFPCIMQT
110 120 130 140 150
FLYLAFAHVE CLILVVMSYD RYADICHPLR YNSLMSWRVC TVLAVASWVF
160 170 180 190 200
SFLLALVPLV LILSLPFCGP HEINHFFCEI LSVLKLACAD TWLNQVVIFA
210 220 230 240 250
ACVFILVGPL CLVLVSYLRI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF
260 270 280 290 300
FGSAIVTYMA PKSRHPEEQQ KVLSLFYSLF NPMLNPLIYS LRNAEVKGAL
310
RRALRKERLT
Length:310
Mass (Da):34,993
Last modified:May 18, 2010 - v4
Checksum:i79C30FF4D573BEC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771Missing in AAK95081. (PubMed:12213199)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331S → I.2 Publications
Corresponds to variant rs2961160 [ dbSNP | Ensembl ].
VAR_060477
Natural varianti164 – 1641S → R.2 Publications
Corresponds to variant rs2961161 [ dbSNP | Ensembl ].
VAR_060478

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065693 Genomic DNA. Translation: BAC05916.1.
AF399596 Genomic DNA. Translation: AAK95081.1.
AC091768 Genomic DNA. No translation available.
BK004421 Genomic DNA. Translation: DAA04819.1.
CCDSiCCDS43672.1.
RefSeqiNP_001001659.1. NM_001001659.1.
UniGeneiHs.534547.

Genome annotation databases

EnsembliENST00000408899; ENSP00000386137; ENSG00000221938.
GeneIDi135941.
KEGGihsa:135941.
UCSCiuc011kua.2. human.

Polymorphism databases

DMDMi296439489.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065693 Genomic DNA. Translation: BAC05916.1 .
AF399596 Genomic DNA. Translation: AAK95081.1 .
AC091768 Genomic DNA. No translation available.
BK004421 Genomic DNA. Translation: DAA04819.1 .
CCDSi CCDS43672.1.
RefSeqi NP_001001659.1. NM_001001659.1.
UniGenei Hs.534547.

3D structure databases

ProteinModelPortali Q96R47.
SMRi Q96R47. Positions 32-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000386137.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 296439489.

Proteomic databases

PaxDbi Q96R47.
PRIDEi Q96R47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000408899 ; ENSP00000386137 ; ENSG00000221938 .
GeneIDi 135941.
KEGGi hsa:135941.
UCSCi uc011kua.2. human.

Organism-specific databases

CTDi 135941.
GeneCardsi GC07P143826.
H-InvDB HIX0167888.
HGNCi HGNC:15084. OR2A14.
neXtProti NX_Q96R47.
PharmGKBi PA32106.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285281.
GeneTreei ENSGT00760000119029.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q96R47.
KOi K04257.
OMAi ICLDCKL.
OrthoDBi EOG793B85.
PhylomeDBi Q96R47.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2A14.
GenomeRNAii 135941.
NextBioi 83532.
PROi Q96R47.

Gene expression databases

CleanExi HS_OR2A14.
Genevestigatori Q96R47.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANTS ILE-133 AND ARG-164.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION, VARIANTS ILE-133 AND ARG-164.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2A14_HUMAN
AccessioniPrimary (citable) accession number: Q96R47
Secondary accession number(s): Q6IF41, Q8NGT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 105 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3