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Q96R47

- O2A14_HUMAN

UniProt

Q96R47 - O2A14_HUMAN

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Protein

Olfactory receptor 2A14

Gene
OR2A14, OR2A14P, OR2A6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A14
Alternative name(s):
OST182
Olfactory receptor 2A6
Olfactory receptor OR7-12
Gene namesi
Name:OR2A14
Synonyms:OR2A14P, OR2A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:15084. OR2A14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed predictionAdd
BLAST
Transmembranei25 – 4824Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini49 – 568Cytoplasmic Reviewed prediction
Transmembranei57 – 7822Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 9921Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 11920Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei139 – 15719Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini158 – 19437Extracellular Reviewed predictionAdd
BLAST
Transmembranei195 – 21824Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini219 – 23517Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei236 – 25823Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27113Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29120Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini292 – 31019Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 2A14PRO_0000150458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R47.
PRIDEiQ96R47.

Expressioni

Gene expression databases

CleanExiHS_OR2A14.
GenevestigatoriQ96R47.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386137.

Structurei

3D structure databases

ProteinModelPortaliQ96R47.
SMRiQ96R47. Positions 32-309.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285281.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R47.
KOiK04257.
OMAiICLDCKL.
OrthoDBiEOG793B85.
PhylomeDBiQ96R47.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R47-1 [UniParc]FASTAAdd to Basket

« Hide

MEGNKTWITD ITLPRFQVGP ALEILLCGLF SAFYTLTLLG NGVIFGIICL    50
DCKLHTPMYF FLSHLAIVDI SYASNYVPKM LTNLMNQEST ISFFPCIMQT 100
FLYLAFAHVE CLILVVMSYD RYADICHPLR YNSLMSWRVC TVLAVASWVF 150
SFLLALVPLV LILSLPFCGP HEINHFFCEI LSVLKLACAD TWLNQVVIFA 200
ACVFILVGPL CLVLVSYLRI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF 250
FGSAIVTYMA PKSRHPEEQQ KVLSLFYSLF NPMLNPLIYS LRNAEVKGAL 300
RRALRKERLT 310
Length:310
Mass (Da):34,993
Last modified:May 18, 2010 - v4
Checksum:i79C30FF4D573BEC8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331S → I.2 Publications
Corresponds to variant rs2961160 [ dbSNP | Ensembl ].
VAR_060477
Natural varianti164 – 1641S → R.2 Publications
Corresponds to variant rs2961161 [ dbSNP | Ensembl ].
VAR_060478

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771Missing in AAK95081. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065693 Genomic DNA. Translation: BAC05916.1.
AF399596 Genomic DNA. Translation: AAK95081.1.
AC091768 Genomic DNA. No translation available.
BK004421 Genomic DNA. Translation: DAA04819.1.
CCDSiCCDS43672.1.
RefSeqiNP_001001659.1. NM_001001659.1.
UniGeneiHs.534547.

Genome annotation databases

EnsembliENST00000408899; ENSP00000386137; ENSG00000221938.
GeneIDi135941.
KEGGihsa:135941.
UCSCiuc011kua.2. human.

Polymorphism databases

DMDMi296439489.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065693 Genomic DNA. Translation: BAC05916.1 .
AF399596 Genomic DNA. Translation: AAK95081.1 .
AC091768 Genomic DNA. No translation available.
BK004421 Genomic DNA. Translation: DAA04819.1 .
CCDSi CCDS43672.1.
RefSeqi NP_001001659.1. NM_001001659.1.
UniGenei Hs.534547.

3D structure databases

ProteinModelPortali Q96R47.
SMRi Q96R47. Positions 32-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000386137.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 296439489.

Proteomic databases

PaxDbi Q96R47.
PRIDEi Q96R47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000408899 ; ENSP00000386137 ; ENSG00000221938 .
GeneIDi 135941.
KEGGi hsa:135941.
UCSCi uc011kua.2. human.

Organism-specific databases

CTDi 135941.
GeneCardsi GC07P143826.
H-InvDB HIX0167888.
HGNCi HGNC:15084. OR2A14.
neXtProti NX_Q96R47.
PharmGKBi PA32106.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285281.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q96R47.
KOi K04257.
OMAi ICLDCKL.
OrthoDBi EOG793B85.
PhylomeDBi Q96R47.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2A14.
GenomeRNAii 135941.
NextBioi 83532.
PROi Q96R47.

Gene expression databases

CleanExi HS_OR2A14.
Genevestigatori Q96R47.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANTS ILE-133 AND ARG-164.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION, VARIANTS ILE-133 AND ARG-164.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2A14_HUMAN
AccessioniPrimary (citable) accession number: Q96R47
Secondary accession number(s): Q6IF41, Q8NGT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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