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Protein

Olfactory receptor 2A14

Gene

OR2A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A14
Alternative name(s):
OST182
Olfactory receptor 2A6
Olfactory receptor OR7-12
Gene namesi
Name:OR2A14
Synonyms:OR2A14P, OR2A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15084. OR2A14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 2A14PRO_0000150458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R47.
PRIDEiQ96R47.

Expressioni

Gene expression databases

CleanExiHS_OR2A14.
GenevestigatoriQ96R47.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386137.

Structurei

3D structure databases

ProteinModelPortaliQ96R47.
SMRiQ96R47. Positions 32-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285281.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R47.
KOiK04257.
OMAiNKTWITD.
OrthoDBiEOG793B85.
PhylomeDBiQ96R47.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGNKTWITD ITLPRFQVGP ALEILLCGLF SAFYTLTLLG NGVIFGIICL
60 70 80 90 100
DCKLHTPMYF FLSHLAIVDI SYASNYVPKM LTNLMNQEST ISFFPCIMQT
110 120 130 140 150
FLYLAFAHVE CLILVVMSYD RYADICHPLR YNSLMSWRVC TVLAVASWVF
160 170 180 190 200
SFLLALVPLV LILSLPFCGP HEINHFFCEI LSVLKLACAD TWLNQVVIFA
210 220 230 240 250
ACVFILVGPL CLVLVSYLRI LAAILRIQSG EGRRKAFSTC SSHLCVVGLF
260 270 280 290 300
FGSAIVTYMA PKSRHPEEQQ KVLSLFYSLF NPMLNPLIYS LRNAEVKGAL
310
RRALRKERLT
Length:310
Mass (Da):34,993
Last modified:May 18, 2010 - v4
Checksum:i79C30FF4D573BEC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771Missing in AAK95081 (PubMed:12213199).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331S → I.2 Publications
Corresponds to variant rs2961160 [ dbSNP | Ensembl ].
VAR_060477
Natural varianti164 – 1641S → R.2 Publications
Corresponds to variant rs2961161 [ dbSNP | Ensembl ].
VAR_060478

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065693 Genomic DNA. Translation: BAC05916.1.
AF399596 Genomic DNA. Translation: AAK95081.1.
AC091768 Genomic DNA. No translation available.
BK004421 Genomic DNA. Translation: DAA04819.1.
CCDSiCCDS43672.1.
RefSeqiNP_001001659.1. NM_001001659.1.
UniGeneiHs.534547.

Genome annotation databases

EnsembliENST00000408899; ENSP00000386137; ENSG00000221938.
GeneIDi135941.
KEGGihsa:135941.
UCSCiuc011kua.2. human.

Polymorphism databases

DMDMi296439489.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065693 Genomic DNA. Translation: BAC05916.1.
AF399596 Genomic DNA. Translation: AAK95081.1.
AC091768 Genomic DNA. No translation available.
BK004421 Genomic DNA. Translation: DAA04819.1.
CCDSiCCDS43672.1.
RefSeqiNP_001001659.1. NM_001001659.1.
UniGeneiHs.534547.

3D structure databases

ProteinModelPortaliQ96R47.
SMRiQ96R47. Positions 32-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386137.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi296439489.

Proteomic databases

PaxDbiQ96R47.
PRIDEiQ96R47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408899; ENSP00000386137; ENSG00000221938.
GeneIDi135941.
KEGGihsa:135941.
UCSCiuc011kua.2. human.

Organism-specific databases

CTDi135941.
GeneCardsiGC07P143826.
H-InvDBHIX0167888.
HGNCiHGNC:15084. OR2A14.
neXtProtiNX_Q96R47.
PharmGKBiPA32106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG285281.
GeneTreeiENSGT00760000119029.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R47.
KOiK04257.
OMAiNKTWITD.
OrthoDBiEOG793B85.
PhylomeDBiQ96R47.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2A14.
GenomeRNAii135941.
NextBioi83532.
PROiQ96R47.

Gene expression databases

CleanExiHS_OR2A14.
GenevestigatoriQ96R47.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANTS ILE-133 AND ARG-164.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION, VARIANTS ILE-133 AND ARG-164.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiO2A14_HUMAN
AccessioniPrimary (citable) accession number: Q96R47
Secondary accession number(s): Q6IF41, Q8NGT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.