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Protein

Olfactory receptor 2A7

Gene

OR2A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A7
Alternative name(s):
Olfactory receptor OR7-18
Gene namesi
Name:OR2A7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:8234. OR2A7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7822Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 31019CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32120.

Polymorphism and mutation databases

BioMutaiOR2A7.
DMDMi152031651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 2A7PRO_0000150456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96R45.
PRIDEiQ96R45.

PTM databases

PhosphoSiteiQ96R45.

Expressioni

Gene expression databases

BgeeiQ96R45.
CleanExiHS_OR2A7.
GenevisibleiQ96R45. HS.

Organism-specific databases

HPAiHPA058272.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000420502.

Structurei

3D structure databases

ProteinModelPortaliQ96R45.
SMRiQ96R45. Positions 108-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIT7. Eukaryota.
ENOG41118P9. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R45.
KOiK04257.
OMAiITEFTLL.
OrthoDBiEOG793B85.
PhylomeDBiQ96R45.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDNITSITE FLLLGFPVGP RIQMLLFGLF SLFYVFTLLG NGTILGLISL
60 70 80 90 100
DSRLHAPMYF FLSHLAVVDI AYACNTVPRM LVNLLHPAKP ISFAGRMMQT
110 120 130 140 150
FLFSTFAVTE CLLLVVMSYD LYVAICHPLR YLAIMTWRVC ITLAVTSWTT
160 170 180 190 200
GVLLSLIHLV LLLPLPFCRP QKIYHFFCEI LAVLKLACAD THINENMVLA
210 220 230 240 250
GAISGLVGPL STIVVSYMCI LCAILQIQSR EVQRKAFCTC FSHLCVIGLF
260 270 280 290 300
YGTAIIMYVG PRYGNPKEQK KYLLLFHSLF NPMLNPLICS LRNSEVKNTL
310
KRVLGVERAL
Length:310
Mass (Da):34,742
Last modified:July 10, 2007 - v3
Checksum:iCEC80375FA7E6CF4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti274 – 2741L → P in AAK95083 (PubMed:12213199).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004889 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48048.1.
BC136704 mRNA. Translation: AAI36705.1.
BC136711 mRNA. Translation: AAI36712.1.
AF399598 Genomic DNA. Translation: AAK95083.1.
BK004218 Genomic DNA. Translation: DAA04616.1.
CCDSiCCDS55177.1.
RefSeqiNP_001005328.1. NM_001005328.1.
UniGeneiHs.658609.
Hs.745042.

Genome annotation databases

EnsembliENST00000493325; ENSP00000420502; ENSG00000243896.
GeneIDi401427.
KEGGihsa:401427.
UCSCiuc011kuc.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004889 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48048.1.
BC136704 mRNA. Translation: AAI36705.1.
BC136711 mRNA. Translation: AAI36712.1.
AF399598 Genomic DNA. Translation: AAK95083.1.
BK004218 Genomic DNA. Translation: DAA04616.1.
CCDSiCCDS55177.1.
RefSeqiNP_001005328.1. NM_001005328.1.
UniGeneiHs.658609.
Hs.745042.

3D structure databases

ProteinModelPortaliQ96R45.
SMRiQ96R45. Positions 108-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000420502.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96R45.

Polymorphism and mutation databases

BioMutaiOR2A7.
DMDMi152031651.

Proteomic databases

PaxDbiQ96R45.
PRIDEiQ96R45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493325; ENSP00000420502; ENSG00000243896.
GeneIDi401427.
KEGGihsa:401427.
UCSCiuc011kuc.3. human.

Organism-specific databases

CTDi401427.
GeneCardsiOR2A7.
HGNCiHGNC:8234. OR2A7.
HPAiHPA058272.
neXtProtiNX_Q96R45.
PharmGKBiPA32120.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIT7. Eukaryota.
ENOG41118P9. LUCA.
GeneTreeiENSGT00820000127003.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R45.
KOiK04257.
OMAiITEFTLL.
OrthoDBiEOG793B85.
PhylomeDBiQ96R45.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii401427.
NextBioi106824.
PROiQ96R45.

Gene expression databases

BgeeiQ96R45.
CleanExiHS_OR2A7.
GenevisibleiQ96R45. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2A7_HUMAN
AccessioniPrimary (citable) accession number: Q96R45
Secondary accession number(s): B2RN57, Q6IFP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: July 10, 2007
Last modified: April 13, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.