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Q96R30

- OR2V2_HUMAN

UniProt

Q96R30 - OR2V2_HUMAN

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Protein
Olfactory receptor 2V2
Gene
OR2V2, OR2V3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2V2
Alternative name(s):
Olfactory receptor 2V3
Olfactory receptor OR5-3
Gene namesi
Name:OR2V2
Synonyms:OR2V3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:15341. OR2V2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Extracellular Reviewed prediction
Add
BLAST
Transmembranei27 – 5024Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini51 – 588Cytoplasmic Reviewed prediction
Transmembranei59 – 8022Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini81 – 10121Extracellular Reviewed prediction
Add
BLAST
Transmembranei102 – 12120Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini122 – 14019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei141 – 15919Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini160 – 19637Extracellular Reviewed prediction
Add
BLAST
Transmembranei197 – 22024Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini221 – 23717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei238 – 26023Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini261 – 27313Extracellular Reviewed prediction
Add
BLAST
Transmembranei274 – 29320Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini294 – 31522Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 2V2
PRO_0000150510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 190 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R30.
PRIDEiQ96R30.

PTM databases

PhosphoSiteiQ96R30.

Expressioni

Gene expression databases

CleanExiHS_OR2V2.
GenevestigatoriQ96R30.

Organism-specific databases

HPAiHPA049953.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332185.

Structurei

3D structure databases

ProteinModelPortaliQ96R30.
SMRiQ96R30. Positions 4-164.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39955.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R30.
KOiK04257.
OMAiIFACCVF.
OrthoDBiEOG71K63J.
PhylomeDBiQ96R30.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R30-1 [UniParc]FASTAAdd to Basket

« Hide

METWVNQSYT DGFFLLGIFS HSTADLVLFS VVMAVFTVAL CGNVLLIFLI    50
YMDPHLHTPM YFFLSQLSLM DLMLVCTNVP KMAANFLSGR KSISFVGCGI 100
QIGLFVCLVG SEGLLLGLMA YDRYVAISHP LHYPILMNQR VCLQITGSSW 150
AFGIIDGLIQ MVVVMNFPYC GLRKVNHFFC EMLSLLKLAC VDTSLFEKVI 200
FACCVFMLLF PFSIIVASYA HILGTVLQMH SAQAWKKALA TCSSHLTAVT 250
LFYGAAMFIY LRPRHYRAPS HDKVASIFYT VLTPMLNPLI YSLRNREVMG 300
ALRKGLDRCR IGSQH 315
Length:315
Mass (Da):35,339
Last modified:November 23, 2004 - v3
Checksum:i8D84C611F9D48B74
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341A → V.
Corresponds to variant rs17617270 [ dbSNP | Ensembl ].
VAR_053160
Natural varianti221 – 2211H → R.1 Publication
Corresponds to variant rs2546423 [ dbSNP | Ensembl ].
VAR_053161

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065675 Genomic DNA. Translation: BAC05900.1.
AF399614 Genomic DNA. Translation: AAK95099.1.
BK004246 Genomic DNA. Translation: DAA04644.1.
CCDSiCCDS4461.1.
RefSeqiNP_996763.1. NM_206880.1.
UniGeneiHs.553681.

Genome annotation databases

EnsembliENST00000328275; ENSP00000332185; ENSG00000182613.
GeneIDi285659.
KEGGihsa:285659.
UCSCiuc011dhj.2. human.

Polymorphism databases

DMDMi55977873.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065675 Genomic DNA. Translation: BAC05900.1 .
AF399614 Genomic DNA. Translation: AAK95099.1 .
BK004246 Genomic DNA. Translation: DAA04644.1 .
CCDSi CCDS4461.1.
RefSeqi NP_996763.1. NM_206880.1.
UniGenei Hs.553681.

3D structure databases

ProteinModelPortali Q96R30.
SMRi Q96R30. Positions 4-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000332185.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q96R30.

Polymorphism databases

DMDMi 55977873.

Proteomic databases

PaxDbi Q96R30.
PRIDEi Q96R30.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328275 ; ENSP00000332185 ; ENSG00000182613 .
GeneIDi 285659.
KEGGi hsa:285659.
UCSCi uc011dhj.2. human.

Organism-specific databases

CTDi 285659.
GeneCardsi GC05P180581.
HGNCi HGNC:15341. OR2V2.
HPAi HPA049953.
neXtProti NX_Q96R30.
PharmGKBi PA32212.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39955.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q96R30.
KOi K04257.
OMAi IFACCVF.
OrthoDBi EOG71K63J.
PhylomeDBi Q96R30.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2V2.
GenomeRNAii 285659.
NextBioi 95688.
PROi Q96R30.

Gene expression databases

CleanExi HS_OR2V2.
Genevestigatori Q96R30.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-221.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2V2_HUMAN
AccessioniPrimary (citable) accession number: Q96R30
Secondary accession number(s): Q6IFL6, Q8NGV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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