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Protein

Olfactory receptor 2V2

Gene

OR2V2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2V2
Alternative name(s):
Olfactory receptor 2V3
Olfactory receptor OR5-3
Gene namesi
Name:OR2V2
Synonyms:OR2V3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:15341. OR2V2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei274 – 29320Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32212.

Polymorphism and mutation databases

BioMutaiOR2V2.
DMDMi55977873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 2V2PRO_0000150510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R30.
PRIDEiQ96R30.

PTM databases

PhosphoSiteiQ96R30.

Expressioni

Gene expression databases

CleanExiHS_OR2V2.

Organism-specific databases

HPAiHPA049953.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332185.

Structurei

3D structure databases

ProteinModelPortaliQ96R30.
SMRiQ96R30. Positions 4-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39955.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R30.
KOiK04257.
OMAiLRKVNHF.
OrthoDBiEOG71K63J.
PhylomeDBiQ96R30.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METWVNQSYT DGFFLLGIFS HSTADLVLFS VVMAVFTVAL CGNVLLIFLI
60 70 80 90 100
YMDPHLHTPM YFFLSQLSLM DLMLVCTNVP KMAANFLSGR KSISFVGCGI
110 120 130 140 150
QIGLFVCLVG SEGLLLGLMA YDRYVAISHP LHYPILMNQR VCLQITGSSW
160 170 180 190 200
AFGIIDGLIQ MVVVMNFPYC GLRKVNHFFC EMLSLLKLAC VDTSLFEKVI
210 220 230 240 250
FACCVFMLLF PFSIIVASYA HILGTVLQMH SAQAWKKALA TCSSHLTAVT
260 270 280 290 300
LFYGAAMFIY LRPRHYRAPS HDKVASIFYT VLTPMLNPLI YSLRNREVMG
310
ALRKGLDRCR IGSQH
Length:315
Mass (Da):35,339
Last modified:November 23, 2004 - v3
Checksum:i8D84C611F9D48B74
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341A → V.
Corresponds to variant rs17617270 [ dbSNP | Ensembl ].
VAR_053160
Natural varianti221 – 2211H → R.1 Publication
Corresponds to variant rs2546423 [ dbSNP | Ensembl ].
VAR_053161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065675 Genomic DNA. Translation: BAC05900.1.
AF399614 Genomic DNA. Translation: AAK95099.1.
BK004246 Genomic DNA. Translation: DAA04644.1.
CCDSiCCDS4461.1.
RefSeqiNP_996763.1. NM_206880.1.
UniGeneiHs.553681.

Genome annotation databases

EnsembliENST00000328275; ENSP00000332185; ENSG00000182613.
GeneIDi285659.
KEGGihsa:285659.
UCSCiuc011dhj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065675 Genomic DNA. Translation: BAC05900.1.
AF399614 Genomic DNA. Translation: AAK95099.1.
BK004246 Genomic DNA. Translation: DAA04644.1.
CCDSiCCDS4461.1.
RefSeqiNP_996763.1. NM_206880.1.
UniGeneiHs.553681.

3D structure databases

ProteinModelPortaliQ96R30.
SMRiQ96R30. Positions 4-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332185.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96R30.

Polymorphism and mutation databases

BioMutaiOR2V2.
DMDMi55977873.

Proteomic databases

PaxDbiQ96R30.
PRIDEiQ96R30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328275; ENSP00000332185; ENSG00000182613.
GeneIDi285659.
KEGGihsa:285659.
UCSCiuc011dhj.2. human.

Organism-specific databases

CTDi285659.
GeneCardsiGC05P180581.
HGNCiHGNC:15341. OR2V2.
HPAiHPA049953.
neXtProtiNX_Q96R30.
PharmGKBiPA32212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39955.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R30.
KOiK04257.
OMAiLRKVNHF.
OrthoDBiEOG71K63J.
PhylomeDBiQ96R30.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2V2.
GenomeRNAii285659.
NextBioi95688.
PROiQ96R30.

Gene expression databases

CleanExiHS_OR2V2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-221.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2V2_HUMAN
AccessioniPrimary (citable) accession number: Q96R30
Secondary accession number(s): Q6IFL6, Q8NGV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 23, 2004
Last modified: June 24, 2015
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.