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Q96R30

- OR2V2_HUMAN

UniProt

Q96R30 - OR2V2_HUMAN

Protein

Olfactory receptor 2V2

Gene

OR2V2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 3 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2V2
    Alternative name(s):
    Olfactory receptor 2V3
    Olfactory receptor OR5-3
    Gene namesi
    Name:OR2V2
    Synonyms:OR2V3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:15341. OR2V2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32212.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 2V2PRO_0000150510Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96R30.
    PRIDEiQ96R30.

    PTM databases

    PhosphoSiteiQ96R30.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2V2.
    GenevestigatoriQ96R30.

    Organism-specific databases

    HPAiHPA049953.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000332185.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96R30.
    SMRiQ96R30. Positions 4-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 588CytoplasmicSequence Analysis
    Topological domaini81 – 10121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 23717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 5024Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 8022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 15919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 22024Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 26023Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29320Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39955.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ96R30.
    KOiK04257.
    OMAiIFACCVF.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ96R30.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96R30-1 [UniParc]FASTAAdd to Basket

    « Hide

    METWVNQSYT DGFFLLGIFS HSTADLVLFS VVMAVFTVAL CGNVLLIFLI    50
    YMDPHLHTPM YFFLSQLSLM DLMLVCTNVP KMAANFLSGR KSISFVGCGI 100
    QIGLFVCLVG SEGLLLGLMA YDRYVAISHP LHYPILMNQR VCLQITGSSW 150
    AFGIIDGLIQ MVVVMNFPYC GLRKVNHFFC EMLSLLKLAC VDTSLFEKVI 200
    FACCVFMLLF PFSIIVASYA HILGTVLQMH SAQAWKKALA TCSSHLTAVT 250
    LFYGAAMFIY LRPRHYRAPS HDKVASIFYT VLTPMLNPLI YSLRNREVMG 300
    ALRKGLDRCR IGSQH 315
    Length:315
    Mass (Da):35,339
    Last modified:November 23, 2004 - v3
    Checksum:i8D84C611F9D48B74
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341A → V.
    Corresponds to variant rs17617270 [ dbSNP | Ensembl ].
    VAR_053160
    Natural varianti221 – 2211H → R.1 Publication
    Corresponds to variant rs2546423 [ dbSNP | Ensembl ].
    VAR_053161

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065675 Genomic DNA. Translation: BAC05900.1.
    AF399614 Genomic DNA. Translation: AAK95099.1.
    BK004246 Genomic DNA. Translation: DAA04644.1.
    CCDSiCCDS4461.1.
    RefSeqiNP_996763.1. NM_206880.1.
    UniGeneiHs.553681.

    Genome annotation databases

    EnsembliENST00000328275; ENSP00000332185; ENSG00000182613.
    GeneIDi285659.
    KEGGihsa:285659.
    UCSCiuc011dhj.2. human.

    Polymorphism databases

    DMDMi55977873.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065675 Genomic DNA. Translation: BAC05900.1 .
    AF399614 Genomic DNA. Translation: AAK95099.1 .
    BK004246 Genomic DNA. Translation: DAA04644.1 .
    CCDSi CCDS4461.1.
    RefSeqi NP_996763.1. NM_206880.1.
    UniGenei Hs.553681.

    3D structure databases

    ProteinModelPortali Q96R30.
    SMRi Q96R30. Positions 4-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000332185.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96R30.

    Polymorphism databases

    DMDMi 55977873.

    Proteomic databases

    PaxDbi Q96R30.
    PRIDEi Q96R30.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328275 ; ENSP00000332185 ; ENSG00000182613 .
    GeneIDi 285659.
    KEGGi hsa:285659.
    UCSCi uc011dhj.2. human.

    Organism-specific databases

    CTDi 285659.
    GeneCardsi GC05P180581.
    HGNCi HGNC:15341. OR2V2.
    HPAi HPA049953.
    neXtProti NX_Q96R30.
    PharmGKBi PA32212.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39955.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q96R30.
    KOi K04257.
    OMAi IFACCVF.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q96R30.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2V2.
    GenomeRNAii 285659.
    NextBioi 95688.
    PROi Q96R30.

    Gene expression databases

    CleanExi HS_OR2V2.
    Genevestigatori Q96R30.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-221.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2V2_HUMAN
    AccessioniPrimary (citable) accession number: Q96R30
    Secondary accession number(s): Q6IFL6, Q8NGV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3