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Q96R30 (OR2V2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2V2
Alternative name(s):
Olfactory receptor 2V3
Olfactory receptor OR5-3
Gene names
Name:OR2V2
Synonyms:OR2V3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 2V2
PRO_0000150510

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 5024Helical; Name=1; Potential
Topological domain51 – 588Cytoplasmic Potential
Transmembrane59 – 8022Helical; Name=2; Potential
Topological domain81 – 10121Extracellular Potential
Transmembrane102 – 12120Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 15919Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 22024Helical; Name=5; Potential
Topological domain221 – 23717Cytoplasmic Potential
Transmembrane238 – 26023Helical; Name=6; Potential
Topological domain261 – 27313Extracellular Potential
Transmembrane274 – 29320Helical; Name=7; Potential
Topological domain294 – 31522Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant341A → V.
Corresponds to variant rs17617270 [ dbSNP | Ensembl ].
VAR_053160
Natural variant2211H → R. Ref.1
Corresponds to variant rs2546423 [ dbSNP | Ensembl ].
VAR_053161

Sequences

Sequence LengthMass (Da)Tools
Q96R30 [UniParc].

Last modified November 23, 2004. Version 3.
Checksum: 8D84C611F9D48B74

FASTA31535,339
        10         20         30         40         50         60 
METWVNQSYT DGFFLLGIFS HSTADLVLFS VVMAVFTVAL CGNVLLIFLI YMDPHLHTPM 

        70         80         90        100        110        120 
YFFLSQLSLM DLMLVCTNVP KMAANFLSGR KSISFVGCGI QIGLFVCLVG SEGLLLGLMA 

       130        140        150        160        170        180 
YDRYVAISHP LHYPILMNQR VCLQITGSSW AFGIIDGLIQ MVVVMNFPYC GLRKVNHFFC 

       190        200        210        220        230        240 
EMLSLLKLAC VDTSLFEKVI FACCVFMLLF PFSIIVASYA HILGTVLQMH SAQAWKKALA 

       250        260        270        280        290        300 
TCSSHLTAVT LFYGAAMFIY LRPRHYRAPS HDKVASIFYT VLTPMLNPLI YSLRNREVMG 

       310 
ALRKGLDRCR IGSQH 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-221.
[2]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065675 Genomic DNA. Translation: BAC05900.1.
AF399614 Genomic DNA. Translation: AAK95099.1.
BK004246 Genomic DNA. Translation: DAA04644.1.
CCDSCCDS4461.1.
RefSeqNP_996763.1. NM_206880.1.
UniGeneHs.553681.

3D structure databases

ProteinModelPortalQ96R30.
SMRQ96R30. Positions 4-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000332185.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ96R30.

Polymorphism databases

DMDM55977873.

Proteomic databases

PaxDbQ96R30.
PRIDEQ96R30.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328275; ENSP00000332185; ENSG00000182613.
GeneID285659.
KEGGhsa:285659.
UCSCuc011dhj.2. human.

Organism-specific databases

CTD285659.
GeneCardsGC05P180581.
HGNCHGNC:15341. OR2V2.
HPAHPA049953.
neXtProtNX_Q96R30.
PharmGKBPA32212.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39955.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ96R30.
KOK04257.
OMAIFACCVF.
OrthoDBEOG71K63J.
PhylomeDBQ96R30.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2V2.
GenevestigatorQ96R30.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2V2.
GenomeRNAi285659.
NextBio95688.
PROQ96R30.

Entry information

Entry nameOR2V2_HUMAN
AccessionPrimary (citable) accession number: Q96R30
Secondary accession number(s): Q6IFL6, Q8NGV1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries