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Q96R28

- OR2M2_HUMAN

UniProt

Q96R28 - OR2M2_HUMAN

Protein

Olfactory receptor 2M2

Gene

OR2M2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2M2
    Alternative name(s):
    OST423
    Gene namesi
    Name:OR2M2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8268. OR2M2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32192.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Olfactory receptor 2M2PRO_0000150491Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96R28.
    PRIDEiQ96R28.

    PTM databases

    PhosphoSiteiQ96R28.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2M2.
    GenevestigatoriQ96R28.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352710.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96R28.
    SMRiQ96R28. Positions 32-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 34755CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42540.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ96R28.
    KOiK04257.
    OMAiICGLMAT.
    OrthoDBiEOG7FV3QP.
    PhylomeDBiQ96R28.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96R28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWENQTFNS DFILLGIFNH SPPHTFLFFL VLGIFLVAFM GNSVMVLLIY    50
    LDTQLHTPMY FLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCVTQ 100
    IFFYISLSGS ECFLLAVMAY DRYIAICHPL RYTNLMNPKI CGLMATFSWI 150
    LGSTDGIIDA VATFSFSFCG SREIAHFFCE FPSLLILSCN DTSIFEEVIF 200
    ICCIVMLVFP VAIIIASYAR VILAVIHMGS GEGRCKAFTT CSSHLMVVGM 250
    YYGAALFMYI RPTSDHSPTQ DKMVSVFYTI LTPMLNPLIY SLRNKEVTRA 300
    FMKILGKGKS ESELPHKLYV LLFAKFFFLI SIFFYDVKIL ALIMYIA 347
    Length:347
    Mass (Da):39,177
    Last modified:January 10, 2006 - v2
    Checksum:i3432AA0B3EC8F474
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti72 – 721M → K in AAK95101. (PubMed:12213199)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871S → C.
    Corresponds to variant rs61156873 [ dbSNP | Ensembl ].
    VAR_062026
    Natural varianti220 – 2201R → G.
    Corresponds to variant rs4244171 [ dbSNP | Ensembl ].
    VAR_059990
    Natural varianti235 – 2351C → R.
    Corresponds to variant rs4916104 [ dbSNP | Ensembl ].
    VAR_059991
    Natural varianti237 – 2371A → T.
    Corresponds to variant rs9435890 [ dbSNP | Ensembl ].
    VAR_034179

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL592313 Genomic DNA. Translation: CAM45730.1.
    AF399616 Genomic DNA. Translation: AAK95101.1.
    CCDSiCCDS31106.1.
    RefSeqiNP_001004688.1. NM_001004688.1.
    UniGeneiHs.534728.

    Genome annotation databases

    EnsembliENST00000359682; ENSP00000352710; ENSG00000198601.
    GeneIDi391194.
    KEGGihsa:391194.
    UCSCiuc010pzf.2. human.

    Polymorphism databases

    DMDMi85541044.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL592313 Genomic DNA. Translation: CAM45730.1 .
    AF399616 Genomic DNA. Translation: AAK95101.1 .
    CCDSi CCDS31106.1.
    RefSeqi NP_001004688.1. NM_001004688.1.
    UniGenei Hs.534728.

    3D structure databases

    ProteinModelPortali Q96R28.
    SMRi Q96R28. Positions 32-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000352710.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96R28.

    Polymorphism databases

    DMDMi 85541044.

    Proteomic databases

    PaxDbi Q96R28.
    PRIDEi Q96R28.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359682 ; ENSP00000352710 ; ENSG00000198601 .
    GeneIDi 391194.
    KEGGi hsa:391194.
    UCSCi uc010pzf.2. human.

    Organism-specific databases

    CTDi 391194.
    GeneCardsi GC01P248343.
    H-InvDB HIX0028950.
    HGNCi HGNC:8268. OR2M2.
    neXtProti NX_Q96R28.
    PharmGKBi PA32192.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42540.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q96R28.
    KOi K04257.
    OMAi ICGLMAT.
    OrthoDBi EOG7FV3QP.
    PhylomeDBi Q96R28.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2M2.
    GenomeRNAii 391194.
    NextBioi 104453.
    PROi Q96R28.

    Gene expression databases

    CleanExi HS_OR2M2.
    Genevestigatori Q96R28.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.

    Entry informationi

    Entry nameiOR2M2_HUMAN
    AccessioniPrimary (citable) accession number: Q96R28
    Secondary accession number(s): A3KFT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3