ID   OR2M4_HUMAN             Reviewed;         311 AA.
AC   Q96R27; Q15611; Q8NG82;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 2.
DT   24-JAN-2024, entry version 164.
DE   RecName: Full=Olfactory receptor 2M4;
DE   AltName: Full=HTPCRX18;
DE   AltName: Full=OST710;
DE   AltName: Full=Olfactory receptor OR1-55;
DE   AltName: Full=Olfactory receptor TPCR100;
GN   Name=OR2M4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
RC   TISSUE=Testis;
RX   PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA   Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT   "Specific repertoire of olfactory receptor genes in the male germ cells of
RT   several mammalian species.";
RL   Genomics 39:239-246(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
RC   TISSUE=Testis;
RX   PubMed=1370859; DOI=10.1038/355453a0;
RA   Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA   Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA   Vassart G.;
RT   "Expression of members of the putative olfactory receptor gene family in
RT   mammalian germ cells.";
RL   Nature 355:453-455(1992).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [7]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR2M4";
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DR   EMBL; AB065953; BAC06166.1; -; Genomic_DNA.
DR   EMBL; AL450303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF399617; AAK95102.1; -; Genomic_DNA.
DR   EMBL; X89666; CAA61813.1; -; mRNA.
DR   EMBL; X64992; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK004483; DAA04881.1; -; Genomic_DNA.
DR   CCDS; CCDS31108.1; -.
DR   PIR; S58011; S58011.
DR   RefSeq; NP_059974.1; NM_017504.1.
DR   AlphaFoldDB; Q96R27; -.
DR   SMR; Q96R27; -.
DR   STRING; 9606.ENSP00000492992; -.
DR   GlyCosmos; Q96R27; 1 site, No reported glycans.
DR   GlyGen; Q96R27; 2 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; Q96R27; -.
DR   PhosphoSitePlus; Q96R27; -.
DR   BioMuta; OR2M4; -.
DR   DMDM; 55977872; -.
DR   MassIVE; Q96R27; -.
DR   PaxDb; 9606-ENSP00000306688; -.
DR   PeptideAtlas; Q96R27; -.
DR   Antibodypedia; 64187; 31 antibodies from 15 providers.
DR   DNASU; 26245; -.
DR   Ensembl; ENST00000641868.1; ENSP00000492992.1; ENSG00000171180.3.
DR   GeneID; 26245; -.
DR   KEGG; hsa:26245; -.
DR   MANE-Select; ENST00000641868.1; ENSP00000492992.1; NM_017504.2; NP_059974.1.
DR   UCSC; uc010pzh.2; human.
DR   AGR; HGNC:8270; -.
DR   CTD; 26245; -.
DR   DisGeNET; 26245; -.
DR   GeneCards; OR2M4; -.
DR   HGNC; HGNC:8270; OR2M4.
DR   HPA; ENSG00000171180; Not detected.
DR   neXtProt; NX_Q96R27; -.
DR   OpenTargets; ENSG00000171180; -.
DR   PharmGKB; PA32194; -.
DR   VEuPathDB; HostDB:ENSG00000171180; -.
DR   eggNOG; ENOG502R1AD; Eukaryota.
DR   GeneTree; ENSGT01090000259995; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q96R27; -.
DR   OMA; LQAVIHM; -.
DR   OrthoDB; 3784606at2759; -.
DR   PhylomeDB; Q96R27; -.
DR   TreeFam; TF337295; -.
DR   PathwayCommons; Q96R27; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26245; 10 hits in 750 CRISPR screens.
DR   ChiTaRS; OR2M4; human.
DR   GeneWiki; OR2M4; -.
DR   GenomeRNAi; 26245; -.
DR   Pharos; Q96R27; Tdark.
DR   PRO; PR:Q96R27; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q96R27; Protein.
DR   Bgee; ENSG00000171180; Expressed in prefrontal cortex and 2 other cell types or tissues.
DR   ExpressionAtlas; Q96R27; baseline and differential.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   CDD; cd15421; 7tmA_OR2T-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF91; OLFACTORY RECEPTOR 2M4; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q96R27; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 2M4"
FT                   /id="PRO_0000150493"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        139
FT                   /note="K -> E (in Ref. 3, 4 and 5)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        245
FT                   /note="L -> P (in Ref. 3 and 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        280
FT                   /note="I -> N (in Ref. 3 and 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        281..282
FT                   /note="LT -> SH (in Ref. 4)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   311 AA;  35071 MW;  5FAF7E97B922F580 CRC64;
     MVWENQTFNS IFILLGIFNH SPTHTFLFSL VLGIFSLALM ENISMVLLIY IEKQLHTPMY
     FLLSQLSLMD LMLICTTLPK MIFSYLSGKK SISLAGCGTQ IFFYVSLLGA ECFLLAVMAY
     DRYVAICHPL QYTILMNPKL CVFMTVASWT LGSLDGIIVL AAVLSFSYCS SLEIHHFFCD
     VAALLPLSCT ETSAFERLLV ICCVVMLIFP VSVIILSYSH VLRAVIHMGS GESRRKAFTT
     CSSHLSVVGL YYGAAMFMYM RPASKHTPDQ DKMVSAFYTI LTPMLNPLIY SLRNKEVFRA
     LQKVLKKRKL I
//