Q96R27 (OR2M4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2M4

Alternative name(s):
HTPCRX18
OST710
Olfactory receptor OR1-55
Olfactory receptor TPCR100

Gene names

Name:

OR2M4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.4. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Olfactory receptor 2M4		PRO_0000150493
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 219	24	Helical; Name=5; Potential
	Topological domain	220 – 236	17	Cytoplasmic Potential
	Transmembrane	237 – 259	23	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 292	20	Helical; Name=7; Potential
	Topological domain	293 – 311	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Experimental info
	Sequence conflict	139	1	K → E Ref.3
	Sequence conflict	139	1	K → E Ref.4
	Sequence conflict	139	1	K → E Ref.5
	Sequence conflict	245	1	L → P Ref.3
	Sequence conflict	245	1	L → P Ref.4
	Sequence conflict	280	1	I → N Ref.3
	Sequence conflict	280	1	I → N Ref.4
	Sequence conflict	281 – 282	2	LT → SH Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q96R27 [UniParc]. Last modified November 23, 2004. Version 2. Checksum: 5FAF7E97B922F580	FASTA	311	35,071
	10 20 30 40 50 60 MVWENQTFNS IFILLGIFNH SPTHTFLFSL VLGIFSLALM ENISMVLLIY IEKQLHTPMY 70 80 90 100 110 120 FLLSQLSLMD LMLICTTLPK MIFSYLSGKK SISLAGCGTQ IFFYVSLLGA ECFLLAVMAY 130 140 150 160 170 180 DRYVAICHPL QYTILMNPKL CVFMTVASWT LGSLDGIIVL AAVLSFSYCS SLEIHHFFCD 190 200 210 220 230 240 VAALLPLSCT ETSAFERLLV ICCVVMLIFP VSVIILSYSH VLRAVIHMGS GESRRKAFTT 250 260 270 280 290 300 CSSHLSVVGL YYGAAMFMYM RPASKHTPDQ DKMVSAFYTI LTPMLNPLIY SLRNKEVFRA 310 LQKVLKKRKL I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
[4]	"Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species." Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M. Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282. Tissue: Testis.
[5]	"Expression of members of the putative olfactory receptor gene family in mammalian germ cells." Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G. Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239. Tissue: Testis.
[6]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065953 Genomic DNA. Translation: BAC06166.1. AL450303 Genomic DNA. Translation: CAH71663.1. AF399617 Genomic DNA. Translation: AAK95102.1. X89666 mRNA. Translation: CAA61813.1. X64992 mRNA. No translation available. BK004483 Genomic DNA. Translation: DAA04881.1.
IPI	IPI00168939.
PIR	S58011.
RefSeq	NP_059974.1. NM_017504.1.
UniGene	Hs.381309.
3D structure databases
ProteinModelPortal	Q96R27.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000306688.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q96R27.
Polymorphism databases
DMDM	55977872.
Proteomic databases
PaxDb	Q96R27.
PRIDE	Q96R27.
Protocols and materials databases
DNASU	26245.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306687; ENSP00000306688; ENSG00000171180.
GeneID	26245.
KEGG	hsa:26245.
UCSC	uc010pzh.2. human.
Organism-specific databases
CTD	26245.
GeneCards	GC01P248402.
HGNC	HGNC:8270. OR2M4.
HPA	HPA051308.
neXtProt	NX_Q96R27.
PharmGKB	PA32194.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG251852.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q96R27.
KO	K04257.
OMA	QKLCVLM.
OrthoDB	EOG4BP1C6.
PhylomeDB	Q96R27.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR2M4.
Genevestigator	Q96R27.
GermOnline	ENSG00000171180. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26245.
NextBio	48445.

Entry information

Entry name

OR2M4_HUMAN

Accession

Primary (citable) accession number: Q96R27
Secondary accession number(s): Q15611, Q8NG82

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.