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Q96R27

- OR2M4_HUMAN

UniProt

Q96R27 - OR2M4_HUMAN

Protein

Olfactory receptor 2M4

Gene

OR2M4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2M4
    Alternative name(s):
    HTPCRX18
    OST710
    Olfactory receptor OR1-55
    Olfactory receptor TPCR100
    Gene namesi
    Name:OR2M4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8270. OR2M4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32194.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Olfactory receptor 2M4PRO_0000150493Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96R27.
    PRIDEiQ96R27.

    PTM databases

    PhosphoSiteiQ96R27.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2M4.
    GenevestigatoriQ96R27.

    Organism-specific databases

    HPAiHPA051308.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000306688.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96R27.
    SMRiQ96R27. Positions 27-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31119CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251852.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ96R27.
    KOiK04257.
    OMAiIFPVSVI.
    OrthoDBiEOG7FV3QP.
    PhylomeDBiQ96R27.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96R27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVWENQTFNS IFILLGIFNH SPTHTFLFSL VLGIFSLALM ENISMVLLIY    50
    IEKQLHTPMY FLLSQLSLMD LMLICTTLPK MIFSYLSGKK SISLAGCGTQ 100
    IFFYVSLLGA ECFLLAVMAY DRYVAICHPL QYTILMNPKL CVFMTVASWT 150
    LGSLDGIIVL AAVLSFSYCS SLEIHHFFCD VAALLPLSCT ETSAFERLLV 200
    ICCVVMLIFP VSVIILSYSH VLRAVIHMGS GESRRKAFTT CSSHLSVVGL 250
    YYGAAMFMYM RPASKHTPDQ DKMVSAFYTI LTPMLNPLIY SLRNKEVFRA 300
    LQKVLKKRKL I 311
    Length:311
    Mass (Da):35,071
    Last modified:November 23, 2004 - v2
    Checksum:i5FAF7E97B922F580
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391K → E(PubMed:12213199)Curated
    Sequence conflicti139 – 1391K → E(PubMed:9119360)Curated
    Sequence conflicti139 – 1391K → E(PubMed:1370859)Curated
    Sequence conflicti245 – 2451L → P(PubMed:12213199)Curated
    Sequence conflicti245 – 2451L → P(PubMed:9119360)Curated
    Sequence conflicti280 – 2801I → N(PubMed:12213199)Curated
    Sequence conflicti280 – 2801I → N(PubMed:9119360)Curated
    Sequence conflicti281 – 2822LT → SH(PubMed:9119360)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065953 Genomic DNA. Translation: BAC06166.1.
    AL450303 Genomic DNA. Translation: CAH71663.1.
    AF399617 Genomic DNA. Translation: AAK95102.1.
    X89666 mRNA. Translation: CAA61813.1.
    X64992 mRNA. No translation available.
    BK004483 Genomic DNA. Translation: DAA04881.1.
    CCDSiCCDS31108.1.
    PIRiS58011.
    RefSeqiNP_059974.1. NM_017504.1.
    UniGeneiHs.381309.

    Genome annotation databases

    EnsembliENST00000306687; ENSP00000306688; ENSG00000171180.
    GeneIDi26245.
    KEGGihsa:26245.
    UCSCiuc010pzh.2. human.

    Polymorphism databases

    DMDMi55977872.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065953 Genomic DNA. Translation: BAC06166.1 .
    AL450303 Genomic DNA. Translation: CAH71663.1 .
    AF399617 Genomic DNA. Translation: AAK95102.1 .
    X89666 mRNA. Translation: CAA61813.1 .
    X64992 mRNA. No translation available.
    BK004483 Genomic DNA. Translation: DAA04881.1 .
    CCDSi CCDS31108.1.
    PIRi S58011.
    RefSeqi NP_059974.1. NM_017504.1.
    UniGenei Hs.381309.

    3D structure databases

    ProteinModelPortali Q96R27.
    SMRi Q96R27. Positions 27-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000306688.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96R27.

    Polymorphism databases

    DMDMi 55977872.

    Proteomic databases

    PaxDbi Q96R27.
    PRIDEi Q96R27.

    Protocols and materials databases

    DNASUi 26245.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306687 ; ENSP00000306688 ; ENSG00000171180 .
    GeneIDi 26245.
    KEGGi hsa:26245.
    UCSCi uc010pzh.2. human.

    Organism-specific databases

    CTDi 26245.
    GeneCardsi GC01P248402.
    HGNCi HGNC:8270. OR2M4.
    HPAi HPA051308.
    neXtProti NX_Q96R27.
    PharmGKBi PA32194.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251852.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q96R27.
    KOi K04257.
    OMAi IFPVSVI.
    OrthoDBi EOG7FV3QP.
    PhylomeDBi Q96R27.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2M4.
    GenomeRNAii 26245.
    NextBioi 48445.
    PROi Q96R27.

    Gene expression databases

    CleanExi HS_OR2M4.
    Genevestigatori Q96R27.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
    4. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
      Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
      Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
      Tissue: Testis.
    5. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
      Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
      Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
      Tissue: Testis.
    6. Cited for: IDENTIFICATION.
    7. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2M4_HUMAN
    AccessioniPrimary (citable) accession number: Q96R27
    Secondary accession number(s): Q15611, Q8NG82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3