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Q96R27

- OR2M4_HUMAN

UniProt

Q96R27 - OR2M4_HUMAN

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Protein
Olfactory receptor 2M4
Gene
OR2M4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2M4
Alternative name(s):
HTPCRX18
OST710
Olfactory receptor OR1-55
Olfactory receptor TPCR100
Gene namesi
Name:OR2M4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8270. OR2M4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini80 – 10021Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini159 – 19537Extracellular Reviewed prediction
Add
BLAST
Transmembranei196 – 21924Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini220 – 23617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei237 – 25923Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini260 – 27213Extracellular Reviewed prediction
Add
BLAST
Transmembranei273 – 29220Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini293 – 31119Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 2M4
PRO_0000150493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R27.
PRIDEiQ96R27.

PTM databases

PhosphoSiteiQ96R27.

Expressioni

Gene expression databases

CleanExiHS_OR2M4.
GenevestigatoriQ96R27.

Organism-specific databases

HPAiHPA051308.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306688.

Structurei

3D structure databases

ProteinModelPortaliQ96R27.
SMRiQ96R27. Positions 27-296.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251852.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R27.
KOiK04257.
OMAiIFPVSVI.
OrthoDBiEOG7FV3QP.
PhylomeDBiQ96R27.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R27-1 [UniParc]FASTAAdd to Basket

« Hide

MVWENQTFNS IFILLGIFNH SPTHTFLFSL VLGIFSLALM ENISMVLLIY    50
IEKQLHTPMY FLLSQLSLMD LMLICTTLPK MIFSYLSGKK SISLAGCGTQ 100
IFFYVSLLGA ECFLLAVMAY DRYVAICHPL QYTILMNPKL CVFMTVASWT 150
LGSLDGIIVL AAVLSFSYCS SLEIHHFFCD VAALLPLSCT ETSAFERLLV 200
ICCVVMLIFP VSVIILSYSH VLRAVIHMGS GESRRKAFTT CSSHLSVVGL 250
YYGAAMFMYM RPASKHTPDQ DKMVSAFYTI LTPMLNPLIY SLRNKEVFRA 300
LQKVLKKRKL I 311
Length:311
Mass (Da):35,071
Last modified:November 23, 2004 - v2
Checksum:i5FAF7E97B922F580
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391K → E1 Publication
Sequence conflicti139 – 1391K → E1 Publication
Sequence conflicti139 – 1391K → E1 Publication
Sequence conflicti245 – 2451L → P1 Publication
Sequence conflicti245 – 2451L → P1 Publication
Sequence conflicti280 – 2801I → N1 Publication
Sequence conflicti280 – 2801I → N1 Publication
Sequence conflicti281 – 2822LT → SH1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065953 Genomic DNA. Translation: BAC06166.1.
AL450303 Genomic DNA. Translation: CAH71663.1.
AF399617 Genomic DNA. Translation: AAK95102.1.
X89666 mRNA. Translation: CAA61813.1.
X64992 mRNA. No translation available.
BK004483 Genomic DNA. Translation: DAA04881.1.
CCDSiCCDS31108.1.
PIRiS58011.
RefSeqiNP_059974.1. NM_017504.1.
UniGeneiHs.381309.

Genome annotation databases

EnsembliENST00000306687; ENSP00000306688; ENSG00000171180.
GeneIDi26245.
KEGGihsa:26245.
UCSCiuc010pzh.2. human.

Polymorphism databases

DMDMi55977872.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065953 Genomic DNA. Translation: BAC06166.1 .
AL450303 Genomic DNA. Translation: CAH71663.1 .
AF399617 Genomic DNA. Translation: AAK95102.1 .
X89666 mRNA. Translation: CAA61813.1 .
X64992 mRNA. No translation available.
BK004483 Genomic DNA. Translation: DAA04881.1 .
CCDSi CCDS31108.1.
PIRi S58011.
RefSeqi NP_059974.1. NM_017504.1.
UniGenei Hs.381309.

3D structure databases

ProteinModelPortali Q96R27.
SMRi Q96R27. Positions 27-296.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000306688.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q96R27.

Polymorphism databases

DMDMi 55977872.

Proteomic databases

PaxDbi Q96R27.
PRIDEi Q96R27.

Protocols and materials databases

DNASUi 26245.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306687 ; ENSP00000306688 ; ENSG00000171180 .
GeneIDi 26245.
KEGGi hsa:26245.
UCSCi uc010pzh.2. human.

Organism-specific databases

CTDi 26245.
GeneCardsi GC01P248402.
HGNCi HGNC:8270. OR2M4.
HPAi HPA051308.
neXtProti NX_Q96R27.
PharmGKBi PA32194.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251852.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q96R27.
KOi K04257.
OMAi IFPVSVI.
OrthoDBi EOG7FV3QP.
PhylomeDBi Q96R27.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2M4.
GenomeRNAii 26245.
NextBioi 48445.
PROi Q96R27.

Gene expression databases

CleanExi HS_OR2M4.
Genevestigatori Q96R27.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  4. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
    Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
    Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
    Tissue: Testis.
  5. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
    Tissue: Testis.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2M4_HUMAN
AccessioniPrimary (citable) accession number: Q96R27
Secondary accession number(s): Q15611, Q8NG82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi