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Protein

Olfactory receptor 2M4

Gene

OR2M4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2M4
Alternative name(s):
HTPCRX18
OST710
Olfactory receptor OR1-55
Olfactory receptor TPCR100
Gene namesi
Name:OR2M4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8270. OR2M4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31119CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32194.

Polymorphism and mutation databases

BioMutaiOR2M4.
DMDMi55977872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Olfactory receptor 2M4PRO_0000150493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R27.
PRIDEiQ96R27.

PTM databases

PhosphoSiteiQ96R27.

Expressioni

Gene expression databases

CleanExiHS_OR2M4.
GenevestigatoriQ96R27.

Organism-specific databases

HPAiHPA051308.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306688.

Structurei

3D structure databases

ProteinModelPortaliQ96R27.
SMRiQ96R27. Positions 27-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251852.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R27.
KOiK04257.
OMAiQKLCVLM.
OrthoDBiEOG7FV3QP.
PhylomeDBiQ96R27.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWENQTFNS IFILLGIFNH SPTHTFLFSL VLGIFSLALM ENISMVLLIY
60 70 80 90 100
IEKQLHTPMY FLLSQLSLMD LMLICTTLPK MIFSYLSGKK SISLAGCGTQ
110 120 130 140 150
IFFYVSLLGA ECFLLAVMAY DRYVAICHPL QYTILMNPKL CVFMTVASWT
160 170 180 190 200
LGSLDGIIVL AAVLSFSYCS SLEIHHFFCD VAALLPLSCT ETSAFERLLV
210 220 230 240 250
ICCVVMLIFP VSVIILSYSH VLRAVIHMGS GESRRKAFTT CSSHLSVVGL
260 270 280 290 300
YYGAAMFMYM RPASKHTPDQ DKMVSAFYTI LTPMLNPLIY SLRNKEVFRA
310
LQKVLKKRKL I
Length:311
Mass (Da):35,071
Last modified:November 23, 2004 - v2
Checksum:i5FAF7E97B922F580
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391K → E (PubMed:12213199).Curated
Sequence conflicti139 – 1391K → E (PubMed:9119360).Curated
Sequence conflicti139 – 1391K → E (PubMed:1370859).Curated
Sequence conflicti245 – 2451L → P (PubMed:12213199).Curated
Sequence conflicti245 – 2451L → P (PubMed:9119360).Curated
Sequence conflicti280 – 2801I → N (PubMed:12213199).Curated
Sequence conflicti280 – 2801I → N (PubMed:9119360).Curated
Sequence conflicti281 – 2822LT → SH (PubMed:9119360).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065953 Genomic DNA. Translation: BAC06166.1.
AL450303 Genomic DNA. Translation: CAH71663.1.
AF399617 Genomic DNA. Translation: AAK95102.1.
X89666 mRNA. Translation: CAA61813.1.
X64992 mRNA. No translation available.
BK004483 Genomic DNA. Translation: DAA04881.1.
CCDSiCCDS31108.1.
PIRiS58011.
RefSeqiNP_059974.1. NM_017504.1.
UniGeneiHs.381309.

Genome annotation databases

EnsembliENST00000306687; ENSP00000306688; ENSG00000171180.
GeneIDi26245.
KEGGihsa:26245.
UCSCiuc010pzh.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065953 Genomic DNA. Translation: BAC06166.1.
AL450303 Genomic DNA. Translation: CAH71663.1.
AF399617 Genomic DNA. Translation: AAK95102.1.
X89666 mRNA. Translation: CAA61813.1.
X64992 mRNA. No translation available.
BK004483 Genomic DNA. Translation: DAA04881.1.
CCDSiCCDS31108.1.
PIRiS58011.
RefSeqiNP_059974.1. NM_017504.1.
UniGeneiHs.381309.

3D structure databases

ProteinModelPortaliQ96R27.
SMRiQ96R27. Positions 27-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306688.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96R27.

Polymorphism and mutation databases

BioMutaiOR2M4.
DMDMi55977872.

Proteomic databases

PaxDbiQ96R27.
PRIDEiQ96R27.

Protocols and materials databases

DNASUi26245.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306687; ENSP00000306688; ENSG00000171180.
GeneIDi26245.
KEGGihsa:26245.
UCSCiuc010pzh.2. human.

Organism-specific databases

CTDi26245.
GeneCardsiGC01P248402.
HGNCiHGNC:8270. OR2M4.
HPAiHPA051308.
neXtProtiNX_Q96R27.
PharmGKBiPA32194.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG251852.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ96R27.
KOiK04257.
OMAiQKLCVLM.
OrthoDBiEOG7FV3QP.
PhylomeDBiQ96R27.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2M4.
GenomeRNAii26245.
NextBioi48445.
PROiQ96R27.

Gene expression databases

CleanExiHS_OR2M4.
GenevestigatoriQ96R27.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
  4. "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species."
    Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.
    Genomics 39:239-246(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-282.
    Tissue: Testis.
  5. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
    Tissue: Testis.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2M4_HUMAN
AccessioniPrimary (citable) accession number: Q96R27
Secondary accession number(s): Q15611, Q8NG82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 23, 2004
Last modified: May 27, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.