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Protein

Olfactory receptor 5B12

Gene

OR5B12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5B12
Alternative name(s):
Olfactory receptor 5B16
Olfactory receptor OR11-241
Gene namesi
Name:OR5B12
Synonyms:OR5B12P, OR5B16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172362.2.
HGNCiHGNC:15432. OR5B12.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 314CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32481.

Polymorphism and mutation databases

BioMutaiOR5B12.
DMDMi20532192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505871 – 314Olfactory receptor 5B12Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R08.
PeptideAtlasiQ96R08.
PRIDEiQ96R08.

PTM databases

iPTMnetiQ96R08.
PhosphoSitePlusiQ96R08.

Expressioni

Gene expression databases

BgeeiENSG00000172362.
CleanExiHS_OR5B12.

Interactioni

Protein-protein interaction databases

BioGridi133437. 2 interactors.
STRINGi9606.ENSP00000306657.

Structurei

3D structure databases

ProteinModelPortaliQ96R08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00890000139366.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96R08.
KOiK04257.
OMAiNACVTQF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ96R08.
TreeFamiTF352753.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96R08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENNTEVTEF ILVGLTDDPE LQIPLFIVFL FIYLITLVGN LGMIELILLD
60 70 80 90 100
SCLHTPMYFF LSNLSLVDFG YSSAVTPKVM VGFLTGDKFI LYNACATQFF
110 120 130 140 150
FFVAFITAES FLLASMAYDR YAALCKPLHY TTTMTTNVCA CLAIGSYICG
160 170 180 190 200
FLNASIHTGN TFRLSFCRSN VVEHFFCDAP PLLTLSCSDN YISEMVIFFV
210 220 230 240 250
VGFNDLFSIL VILISYLFIF ITIMKMRSPE GRQKAFSTCA SHLTAVSIFY
260 270 280 290 300
GTGIFMYLRP NSSHFMGTDK MASVFYAIVI PMLNPLVYSL RNKEVKSAFK
310
KTVGKAKASI GFIF
Length:314
Mass (Da):35,182
Last modified:May 10, 2002 - v2
Checksum:i93BB84F1CACA68F1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053191141C → R2 PublicationsCorresponds to variant dbSNP:rs4938895Ensembl.1
Natural variantiVAR_053192141C → Y. Corresponds to variant dbSNP:rs11229457Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065851 Genomic DNA. Translation: BAC06069.1.
CH471076 Genomic DNA. Translation: EAW73806.1.
BC136947 mRNA. Translation: AAI36948.1.
BC136948 mRNA. Translation: AAI36949.1.
AF399637 Genomic DNA. Translation: AAK95122.1.
BK004507 Genomic DNA. Translation: DAA04905.1.
CCDSiCCDS31551.1.
RefSeqiNP_001004733.1. NM_001004733.2.
UniGeneiHs.553754.

Genome annotation databases

EnsembliENST00000302572; ENSP00000306657; ENSG00000172362.
GeneIDi390191.
KEGGihsa:390191.
UCSCiuc010rkh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR5BC_HUMAN
AccessioniPrimary (citable) accession number: Q96R08
Secondary accession number(s): B2RNL2, Q6IEV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 10, 2002
Last modified: September 27, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families