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Protein

Olfactory receptor 5B12

Gene

OR5B12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5B12
Alternative name(s):
Olfactory receptor 5B16
Olfactory receptor OR11-241
Gene namesi
Name:OR5B12
Synonyms:OR5B12P, OR5B16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15432. OR5B12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence analysis
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19436ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 23520CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 26913ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 31424CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32481.

Polymorphism and mutation databases

BioMutaiOR5B12.
DMDMi20532192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 5B12PRO_0000150587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96R08.
PRIDEiQ96R08.

PTM databases

iPTMnetiQ96R08.
PhosphoSiteiQ96R08.

Expressioni

Gene expression databases

CleanExiHS_OR5B12.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306657.

Structurei

3D structure databases

ProteinModelPortaliQ96R08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96R08.
KOiK04257.
OMAiLVMGCYV.
OrthoDBiEOG71K63J.
PhylomeDBiQ96R08.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96R08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENNTEVTEF ILVGLTDDPE LQIPLFIVFL FIYLITLVGN LGMIELILLD
60 70 80 90 100
SCLHTPMYFF LSNLSLVDFG YSSAVTPKVM VGFLTGDKFI LYNACATQFF
110 120 130 140 150
FFVAFITAES FLLASMAYDR YAALCKPLHY TTTMTTNVCA CLAIGSYICG
160 170 180 190 200
FLNASIHTGN TFRLSFCRSN VVEHFFCDAP PLLTLSCSDN YISEMVIFFV
210 220 230 240 250
VGFNDLFSIL VILISYLFIF ITIMKMRSPE GRQKAFSTCA SHLTAVSIFY
260 270 280 290 300
GTGIFMYLRP NSSHFMGTDK MASVFYAIVI PMLNPLVYSL RNKEVKSAFK
310
KTVGKAKASI GFIF
Length:314
Mass (Da):35,182
Last modified:May 10, 2002 - v2
Checksum:i93BB84F1CACA68F1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411C → R.2 Publications
Corresponds to variant rs4938895 [ dbSNP | Ensembl ].
VAR_053191
Natural varianti141 – 1411C → Y.
Corresponds to variant rs11229457 [ dbSNP | Ensembl ].
VAR_053192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065851 Genomic DNA. Translation: BAC06069.1.
CH471076 Genomic DNA. Translation: EAW73806.1.
BC136947 mRNA. Translation: AAI36948.1.
BC136948 mRNA. Translation: AAI36949.1.
AF399637 Genomic DNA. Translation: AAK95122.1.
BK004507 Genomic DNA. Translation: DAA04905.1.
CCDSiCCDS31551.1.
RefSeqiNP_001004733.1. NM_001004733.2.
UniGeneiHs.553754.

Genome annotation databases

EnsembliENST00000302572; ENSP00000306657; ENSG00000172362.
GeneIDi390191.
KEGGihsa:390191.
UCSCiuc010rkh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065851 Genomic DNA. Translation: BAC06069.1.
CH471076 Genomic DNA. Translation: EAW73806.1.
BC136947 mRNA. Translation: AAI36948.1.
BC136948 mRNA. Translation: AAI36949.1.
AF399637 Genomic DNA. Translation: AAK95122.1.
BK004507 Genomic DNA. Translation: DAA04905.1.
CCDSiCCDS31551.1.
RefSeqiNP_001004733.1. NM_001004733.2.
UniGeneiHs.553754.

3D structure databases

ProteinModelPortaliQ96R08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306657.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96R08.
PhosphoSiteiQ96R08.

Polymorphism and mutation databases

BioMutaiOR5B12.
DMDMi20532192.

Proteomic databases

PaxDbiQ96R08.
PRIDEiQ96R08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302572; ENSP00000306657; ENSG00000172362.
GeneIDi390191.
KEGGihsa:390191.
UCSCiuc010rkh.2. human.

Organism-specific databases

CTDi390191.
GeneCardsiOR5B12.
HGNCiHGNC:15432. OR5B12.
neXtProtiNX_Q96R08.
PharmGKBiPA32481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ96R08.
KOiK04257.
OMAiLVMGCYV.
OrthoDBiEOG71K63J.
PhylomeDBiQ96R08.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5B12.
GenomeRNAii390191.
PROiQ96R08.

Gene expression databases

CleanExiHS_OR5B12.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-141.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-141.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5BC_HUMAN
AccessioniPrimary (citable) accession number: Q96R08
Secondary accession number(s): B2RNL2, Q6IEV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 10, 2002
Last modified: July 6, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.