Q96QZ7 (MAGI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Alternative name(s):
Atrophin-1-interacting protein 3
Short name=AIP-3
BAI1-associated protein 1
Short name=BAP-1
Membrane-associated guanylate kinase inverted 1
Short name=MAGI-1
Trinucleotide repeat-containing gene 19 protein
WW domain-containing protein 3
Short name=WWP3

Gene names

Name:	MAGI1
Synonyms:	AIP3, BAIAP1, BAP1, TNRC19

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1491 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface By similarity.
Subunit structure	Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 By similarity. Interacts with ASIC3 and AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex By similarity. Interacts with DDN. Isoform 3 (via PDZ domain) interacts with RAPGEF2. Ref.1 Ref.4 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12
Subcellular location	Cell junction › tight junction. Cell membrane; Peripheral membrane protein. Note: Localizes to epithelial cells tight junctions. Ref.2
Tissue specificity	Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain. Ref.1 Ref.2 Ref.4
Sequence similarities	Contains 1 guanylate kinase-like domain. Contains 6 PDZ (DHR) domains. Contains 2 WW domains.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Tight junction
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement Ref.1. Source: ProtInc cell surface receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc neuron death Inferred from mutant phenotype PubMed 22166940. Source: UniProt protein complex assembly Non-traceable author statement Ref.1. Source: ProtInc
Cellular_component	cell junction Inferred from direct assay. Source: HPA cell projection Inferred from direct assay PubMed 16464232. Source: UniProtKB cell-cell junction Traceable author statement Ref.1. Source: ProtInc cytoplasm Inferred from direct assay PubMed 16464232. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA plasma membrane Traceable author statement Ref.1. Source: ProtInc tight junction Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW alpha-actinin binding Inferred from physical interaction PubMed 16464232. Source: UniProtKB protein C-terminus binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
E6	P06463	3	EBI-924464,EBI-1186926	From a different organism.
FCHSD2	O94868	5	EBI-924464,EBI-1215612
IQGAP1	P46940	4	EBI-924464,EBI-297509
KIF1B	O60333-3	3	EBI-924464,EBI-465669
RAPGEF2	Q9Y4G8	2	EBI-8769674,EBI-307079

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q96QZ7-1)

Also known as: MAGI-1C-alpha-beta1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q96QZ7-2)

Also known as: MAGI-1C-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.

Isoform 3 (identifier: Q96QZ7-3)

Also known as: MAGI-1A-alpha-beta1;

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Isoform 4 (identifier: Q96QZ7-4)

Also known as: MAGI-1A-alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.
     1039-1094: Missing.
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Isoform 5 (identifier: Q96QZ7-5)

Also known as: MAGI-1B-alpha-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1027-1027: Missing.
     1241-1288: DPSSDRHGPA...LHKSSPHGEK → AMIPPNIAAC...PPPVHKVFRK
     1289-1491: Missing.

Isoform 6 (identifier: Q96QZ7-6)

Also known as: MAGI-1C-beta2;

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q96QZ7-7)

Also known as: MAGI-1C-beta3;

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1023-1099: GTTFAGNACV...IIPGDESSNA → VMQCQPPSWC...EVQIYSCNNP

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1491

1491

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

PRO_0000094589

Regions

Domain

17 – 105

89

PDZ 1

Domain

96 – 287

192

Guanylate kinase-like

Domain

300 – 333

34

WW 1

Domain

359 – 392

34

WW 2

Domain

472 – 554

83

PDZ 2

Domain

643 – 721

79

PDZ 3

Domain

813 – 895

83

PDZ 4

Domain

970 – 1066

97

PDZ 5

Domain

1124 – 1206

83

PDZ 6

Nucleotide binding

103 – 110

8

ATP By similarity

Region

970 – 1066

97

Interaction with FCHSD2

Compositional bias

402 – 421

20

Poly-Gln

Compositional bias

662 – 665

4

Poly-Gly

Compositional bias

978 – 988

11

Poly-Gly

Compositional bias

1341 – 1344

4

Poly-Ala

Compositional bias

1398 – 1401

4

Poly-Arg

Amino acid modifications

Modified residue

730

1

Phosphoserine Ref.13

Modified residue

741

1

Phosphoserine Ref.13

Modified residue

1361

1

Phosphoserine Ref.13

Natural variations

Alternative sequence

806 – 834

29

PMSPS…GECPI → L in isoform 2, isoform 4, isoform 6 and isoform 7.

VSP_011664

Alternative sequence

1023 – 1099

77

GTTFA…ESSNA → VMQCQPPSWCHSALGGSKHC NSVMGAASLEVQIYSCNNP in isoform 7.

VSP_011665

Alternative sequence

1027

1

Missing in isoform 2, isoform 4, isoform 5 and isoform 6.

VSP_011666

Alternative sequence

1028 – 1038

11

Missing in isoform 4 and isoform 6.

VSP_011667

Alternative sequence

1039 – 1094

56

Missing in isoform 4.

VSP_011668

Alternative sequence

1241 – 1288

48

DPSSD…PHGEK → AMIPPNIAACMRNEKLGEAC FYLMGHNQTTTPAATATAPP PVHKVFRK in isoform 5.

VSP_011669

Alternative sequence

1241 – 1256

16

DPSSD…GPQGV → GGSNYENIPSFPGMTP in isoform 3 and isoform 4.

VSP_011670

Alternative sequence

1257 – 1288

32

Missing in isoform 3 and isoform 4.

VSP_011671

Alternative sequence

1289 – 1491

203

Missing in isoform 3, isoform 4 and isoform 5.

VSP_011672

Experimental info

Sequence conflict

124

1

S → F in BAA32002. Ref.1

Sequence conflict

124

1

S → F in AAK94064. Ref.2

Sequence conflict

124

1

S → F in AAK94065. Ref.2

Sequence conflict

124

1

S → F in AAK94066. Ref.2

Sequence conflict

124

1

S → F in AAC51326. Ref.2

Sequence conflict

775

1

A → G in AAC04844. Ref.4

Secondary structure

1

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1491

Helix Strand Turn

Details...

Beta strand

304 – 310

7

Beta strand

316 – 320

5

Turn

321 – 324

4

Beta strand

325 – 329

5

Turn

331 – 333

3

Beta strand

363 – 369

7

Beta strand

371 – 373

3

Beta strand

375 – 379

5

Turn

380 – 383

4

Beta strand

384 – 388

5

Helix

390 – 398

9

Turn

463 – 465

3

Beta strand

468 – 477

10

Beta strand

479 – 481

3

Beta strand

483 – 491

9

Beta strand

494 – 501

8

Helix

506 – 510

5

Beta strand

518 – 522

5

Helix

532 – 541

10

Beta strand

546 – 554

9

Beta strand

568 – 570

3

Beta strand

640 – 647

8

Beta strand

652 – 654

3

Beta strand

656 – 659

4

Beta strand

663 – 670

8

Beta strand

685 – 689

5

Helix

699 – 707

9

Beta strand

714 – 721

8

Beta strand

839 – 845

7

Beta strand

853 – 857

5

Beta strand

865 – 870

6

Helix

875 – 879

5

Beta strand

887 – 891

5

Helix

901 – 914

14

Beta strand

916 – 922

7

Beta strand

1150 – 1156

7

Beta strand

1163 – 1168

6

Helix

1170 – 1172

3

Beta strand

1176 – 1181

6

Helix

1186 – 1189

4

Beta strand

1198 – 1202

5

Helix

1212 – 1220

9

Turn

1221 – 1224

4

Beta strand

1225 – 1231

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (MAGI-1C-alpha-beta1) [UniParc]. Last modified December 15, 2009. Version 3. Checksum: 4B2EE05243A6FA65	FASTA	1,491	164,581
	10 20 30 40 50 60 MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 70 80 90 100 110 120 GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 130 140 150 160 170 180 QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 190 200 210 220 230 240 TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 250 260 270 280 290 300 EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 310 320 330 340 350 360 PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 370 380 390 400 410 420 LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 430 440 450 460 470 480 QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 490 500 510 520 530 540 GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 550 560 570 580 590 600 SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 610 620 630 640 650 660 KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 670 680 690 700 710 720 PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 730 740 750 760 770 780 RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 790 800 810 820 830 840 TDSSGQKKPD PFKIWAQSRS MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ 850 860 870 880 890 900 DIFLWRKETG FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS 910 920 930 940 950 960 HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA SLTEEKRTPQ 970 980 990 1000 1010 1020 GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE IRRGENEGFG FVIVSSVSRP 1030 1040 1050 1060 1070 1080 EAGTTFAGNA CVAMPHKIGR IIEGSPADRC GKLKVGDRIL AVNGCSITNK SHSDIVNLIK 1090 1100 1110 1120 1130 1140 EAGNTVTLRI IPGDESSNAT LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK 1150 1160 1170 1180 1190 1200 APQATQEQDF YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL 1210 1220 1230 1240 1250 1260 EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA TGPQGVPEVR 1270 1280 1290 1300 1310 1320 AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE YSRQPNEHHT WNGTSRKPDS 1330 1340 1350 1360 1370 1380 GACRPKDRAP EGRRDAQAER AAAANGPKRR SPEKRREGTR SADNTLERRE KHEKRRDVSP 1390 1400 1410 1420 1430 1440 ERRRERSPTR RRDGSPSRRR RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR 1450 1460 1470 1480 1490 ERSLDKRNRE DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I
	Isoform 2 (MAGI-1C-beta) [UniParc]. Checksum: 09C49DDDEB792655	FASTA	1,462	161,550
	10 20 30 40 50 60 MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 70 80 90 100 110 120 GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 130 140 150 160 170 180 QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 190 200 210 220 230 240 TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 250 260 270 280 290 300 EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 310 320 330 340 350 360 PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 370 380 390 400 410 420 LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 430 440 450 460 470 480 QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 490 500 510 520 530 540 GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 550 560 570 580 590 600 SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 610 620 630 640 650 660 KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 670 680 690 700 710 720 PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 730 740 750 760 770 780 RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 790 800 810 820 830 840 TDSSGQKKPD PFKIWAQSRS MYENRLPDYQ EQDIFLWRKE TGFGFRILGG NEPGEPIYIG 850 860 870 880 890 900 HIVPLGAADT DGRLRSGDEL ICVDGTPVIG KSHQLVVQLM QQAAKQGHVN LTVRRKVVFA 910 920 930 940 950 960 VPKTENEVPS PASSHHSSNQ PASLTEEKRT PQGSQNSLNT VSSGSGSTSG IGSGGGGGSG 970 980 990 1000 1010 1020 VVSTVVQPYD VEIRRGENEG FGFVIVSSVS RPEAGTTFGN ACVAMPHKIG RIIEGSPADR 1030 1040 1050 1060 1070 1080 CGKLKVGDRI LAVNGCSITN KSHSDIVNLI KEAGNTVTLR IIPGDESSNA TLLTNAEKIA 1090 1100 1110 1120 1130 1140 TITTTHTPSQ QGTQETRNTT KPKQESQFEF KAPQATQEQD FYTVELERGA KGFGFSLRGG 1150 1160 1170 1180 1190 1200 REYNMDLYVL RLAEDGPAER CGKMRIGDEI LEINGETTKN MKHSRAIELI KNGGRRVRLF 1210 1220 1230 1240 1250 1260 LKRGDGSVPE YDPSSDRHGP ATGPQGVPEV RAGPDRRQHP SLESSYPPDL HKSSPHGEKR 1270 1280 1290 1300 1310 1320 AHARDPKGSR EYSRQPNEHH TWNGTSRKPD SGACRPKDRA PEGRRDAQAE RAAAANGPKR 1330 1340 1350 1360 1370 1380 RSPEKRREGT RSADNTLERR EKHEKRRDVS PERRRERSPT RRRDGSPSRR RRSLERLLEQ 1390 1400 1410 1420 1430 1440 RRSPERRRGG SPERRAKSTD RRRARSPERR RERSLDKRNR EDRASHRERE EANLKQDAGR 1450 1460 SSRHPPEQRR RPYKECSTDL SI
	Isoform 3 (MAGI-1A-alpha-beta1) [UniParc]. Checksum: 1D906FFCE0F8F6CE	FASTA	1,256	136,921
	10 20 30 40 50 60 MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 70 80 90 100 110 120 GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 130 140 150 160 170 180 QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 190 200 210 220 230 240 TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 250 260 270 280 290 300 EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 310 320 330 340 350 360 PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 370 380 390 400 410 420 LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 430 440 450 460 470 480 QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 490 500 510 520 530 540 GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 550 560 570 580 590 600 SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 610 620 630 640 650 660 KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 670 680 690 700 710 720 PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 730 740 750 760 770 780 RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 790 800 810 820 830 840 TDSSGQKKPD PFKIWAQSRS MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ 850 860 870 880 890 900 DIFLWRKETG FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS 910 920 930 940 950 960 HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA SLTEEKRTPQ 970 980 990 1000 1010 1020 GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE IRRGENEGFG FVIVSSVSRP 1030 1040 1050 1060 1070 1080 EAGTTFAGNA CVAMPHKIGR IIEGSPADRC GKLKVGDRIL AVNGCSITNK SHSDIVNLIK 1090 1100 1110 1120 1130 1140 EAGNTVTLRI IPGDESSNAT LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK 1150 1160 1170 1180 1190 1200 APQATQEQDF YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL 1210 1220 1230 1240 1250 EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY GGSNYENIPS FPGMTP
	Isoform 4 (MAGI-1A-alpha) [UniParc]. Checksum: 7E3FEB621B96D1B5	FASTA	1,160	126,898
	10 20 30 40 50 60 MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 70 80 90 100 110 120 GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 130 140 150 160 170 180 QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 190 200 210 220 230 240 TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 250 260 270 280 290 300 EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 310 320 330 340 350 360 PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 370 380 390 400 410 420 LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 430 440 450 460 470 480 QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 490 500 510 520 530 540 GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 550 560 570 580 590 600 SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 610 620 630 640 650 660 KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 670 680 690 700 710 720 PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 730 740 750 760 770 780 RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 790 800 810 820 830 840 TDSSGQKKPD PFKIWAQSRS MYENRLPDYQ EQDIFLWRKE TGFGFRILGG NEPGEPIYIG 850 860 870 880 890 900 HIVPLGAADT DGRLRSGDEL ICVDGTPVIG KSHQLVVQLM QQAAKQGHVN LTVRRKVVFA 910 920 930 940 950 960 VPKTENEVPS PASSHHSSNQ PASLTEEKRT PQGSQNSLNT VSSGSGSTSG IGSGGGGGSG 970 980 990 1000 1010 1020 VVSTVVQPYD VEIRRGENEG FGFVIVSSVS RPEAGTTFES SNATLLTNAE KIATITTTHT 1030 1040 1050 1060 1070 1080 PSQQGTQETR NTTKPKQESQ FEFKAPQATQ EQDFYTVELE RGAKGFGFSL RGGREYNMDL 1090 1100 1110 1120 1130 1140 YVLRLAEDGP AERCGKMRIG DEILEINGET TKNMKHSRAI ELIKNGGRRV RLFLKRGDGS 1150 1160 VPEYGGSNYE NIPSFPGMTP
	Isoform 5 (MAGI-1B-alpha-beta) [UniParc]. Checksum: 75F4654C0524B753	FASTA	1,287	140,379
	10 20 30 40 50 60 MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 70 80 90 100 110 120 GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 130 140 150 160 170 180 QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 190 200 210 220 230 240 TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 250 260 270 280 290 300 EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 310 320 330 340 350 360 PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 370 380 390 400 410 420 LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 430 440 450 460 470 480 QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 490 500 510 520 530 540 GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 550 560 570 580 590 600 SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 610 620 630 640 650 660 KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 670 680 690 700 710 720 PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 730 740 750 760 770 780 RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 790 800 810 820 830 840 TDSSGQKKPD PFKIWAQSRS MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ 850 860 870 880 890 900 DIFLWRKETG FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS 910 920 930 940 950 960 HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA SLTEEKRTPQ 970 980 990 1000 1010 1020 GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE IRRGENEGFG FVIVSSVSRP 1030 1040 1050 1060 1070 1080 EAGTTFGNAC VAMPHKIGRI IEGSPADRCG KLKVGDRILA VNGCSITNKS HSDIVNLIKE 1090 1100 1110 1120 1130 1140 AGNTVTLRII PGDESSNATL LTNAEKIATI TTTHTPSQQG TQETRNTTKP KQESQFEFKA 1150 1160 1170 1180 1190 1200 PQATQEQDFY TVELERGAKG FGFSLRGGRE YNMDLYVLRL AEDGPAERCG KMRIGDEILE 1210 1220 1230 1240 1250 1260 INGETTKNMK HSRAIELIKN GGRRVRLFLK RGDGSVPEYA MIPPNIAACM RNEKLGEACF 1270 1280 YLMGHNQTTT PAATATAPPP VHKVFRK
	Isoform 6 (MAGI-1C-beta2) [UniParc]. Checksum: 1D55FA728ED6FBA5	FASTA	1,451	160,427
	10 20 30 40 50 60 MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 70 80 90 100 110 120 GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 130 140 150 160 170 180 QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 190 200 210 220 230 240 TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 250 260 270 280 290 300 EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 310 320 330 340 350 360 PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 370 380 390 400 410 420 LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 430 440 450 460 470 480 QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 490 500 510 520 530 540 GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 550 560 570 580 590 600 SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 610 620 630 640 650 660 KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 670 680 690 700 710 720 PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 730 740 750 760 770 780 RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 790 800 810 820 830 840 TDSSGQKKPD PFKIWAQSRS MYENRLPDYQ EQDIFLWRKE TGFGFRILGG NEPGEPIYIG 850 860 870 880 890 900 HIVPLGAADT DGRLRSGDEL ICVDGTPVIG KSHQLVVQLM QQAAKQGHVN LTVRRKVVFA 910 920 930 940 950 960 VPKTENEVPS PASSHHSSNQ PASLTEEKRT PQGSQNSLNT VSSGSGSTSG IGSGGGGGSG 970 980 990 1000 1010 1020 VVSTVVQPYD VEIRRGENEG FGFVIVSSVS RPEAGTTFGR IIEGSPADRC GKLKVGDRIL 1030 1040 1050 1060 1070 1080 AVNGCSITNK SHSDIVNLIK EAGNTVTLRI IPGDESSNAT LLTNAEKIAT ITTTHTPSQQ 1090 1100 1110 1120 1130 1140 GTQETRNTTK PKQESQFEFK APQATQEQDF YTVELERGAK GFGFSLRGGR EYNMDLYVLR 1150 1160 1170 1180 1190 1200 LAEDGPAERC GKMRIGDEIL EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY 1210 1220 1230 1240 1250 1260 DPSSDRHGPA TGPQGVPEVR AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE 1270 1280 1290 1300 1310 1320 YSRQPNEHHT WNGTSRKPDS GACRPKDRAP EGRRDAQAER AAAANGPKRR SPEKRREGTR 1330 1340 1350 1360 1370 1380 SADNTLERRE KHEKRRDVSP ERRRERSPTR RRDGSPSRRR RSLERLLEQR RSPERRRGGS 1390 1400 1410 1420 1430 1440 PERRAKSTDR RRARSPERRR ERSLDKRNRE DRASHREREE ANLKQDAGRS SRHPPEQRRR 1450 PYKECSTDLS I
	Isoform 7 (MAGI-1C-beta3) [UniParc]. Checksum: 5F60A23E79301C1E	FASTA	1,425	157,781
	10 20 30 40 50 60 MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 70 80 90 100 110 120 GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 130 140 150 160 170 180 QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 190 200 210 220 230 240 TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 250 260 270 280 290 300 EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 310 320 330 340 350 360 PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 370 380 390 400 410 420 LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 430 440 450 460 470 480 QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 490 500 510 520 530 540 GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 550 560 570 580 590 600 SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 610 620 630 640 650 660 KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 670 680 690 700 710 720 PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 730 740 750 760 770 780 RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 790 800 810 820 830 840 TDSSGQKKPD PFKIWAQSRS MYENRLPDYQ EQDIFLWRKE TGFGFRILGG NEPGEPIYIG 850 860 870 880 890 900 HIVPLGAADT DGRLRSGDEL ICVDGTPVIG KSHQLVVQLM QQAAKQGHVN LTVRRKVVFA 910 920 930 940 950 960 VPKTENEVPS PASSHHSSNQ PASLTEEKRT PQGSQNSLNT VSSGSGSTSG IGSGGGGGSG 970 980 990 1000 1010 1020 VVSTVVQPYD VEIRRGENEG FGFVIVSSVS RPEAVMQCQP PSWCHSALGG SKHCNSVMGA 1030 1040 1050 1060 1070 1080 ASLEVQIYSC NNPTLLTNAE KIATITTTHT PSQQGTQETR NTTKPKQESQ FEFKAPQATQ 1090 1100 1110 1120 1130 1140 EQDFYTVELE RGAKGFGFSL RGGREYNMDL YVLRLAEDGP AERCGKMRIG DEILEINGET 1150 1160 1170 1180 1190 1200 TKNMKHSRAI ELIKNGGRRV RLFLKRGDGS VPEYDPSSDR HGPATGPQGV PEVRAGPDRR 1210 1220 1230 1240 1250 1260 QHPSLESSYP PDLHKSSPHG EKRAHARDPK GSREYSRQPN EHHTWNGTSR KPDSGACRPK 1270 1280 1290 1300 1310 1320 DRAPEGRRDA QAERAAAANG PKRRSPEKRR EGTRSADNTL ERREKHEKRR DVSPERRRER 1330 1340 1350 1360 1370 1380 SPTRRRDGSP SRRRRSLERL LEQRRSPERR RGGSPERRAK STDRRRARSP ERRRERSLDK 1390 1400 1410 1420 RNREDRASHR EREEANLKQD AGRSSRHPPE QRRRPYKECS TDLSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1." Shiratsuchi T., Futamura M., Oda K., Nishimori H., Nakamura Y., Tokino T. Biochem. Biophys. Res. Commun. 247:597-604(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH BAI1. Tissue: Brain.
[2]	"MAGI-1: a widely expressed, alternatively spliced tight junction protein." Laura R.P., Ross S., Koeppen H., Lasky L.A. Exp. Cell Res. 275:155-170(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 5), ALTERNATIVE SPLICING (ISOFORMS 6 AND 7), SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins." Wood J.D., Yuan J., Margolis R.L., Colomer V., Duan K., Kushi J., Kaminsky Z., Kleiderlein J.J. Jr., Sharp A.H., Ross C.A. Mol. Cell. Neurosci. 11:149-160(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-826 (ISOFORMS 1/3), TISSUE SPECIFICITY, INTERACTION WITH DRPLA.
[5]	"Identification of novel human WW domain-containing proteins by cloning of ligand targets." Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M. J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-371.
[6]	"Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions." Mino A., Ohtsuka T., Inoue E., Takai Y. Genes Cells 5:1009-1016(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RAPGEF2.
[7]	"Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1." Patrie K.M., Drescher A.J., Welihinda A., Mundel P., Margolis B. J. Biol. Chem. 277:30183-30190(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SYNPO AND ACTN4.
[8]	"JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1." Hirabayashi S., Tajima M., Yao I., Nishimura W., Mori H., Hata Y. Mol. Cell. Biol. 23:4267-4282(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IGSF5.
[9]	"Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains." Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y. Oncogene 22:8422-8431(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FCHSD2.
[10]	"PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current." Hruska-Hageman A.M., Benson C.J., Leonard A.S., Price M.P., Welsh M.J. J. Biol. Chem. 279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ASIC3.
[11]	"Angiomotin regulates endothelial cell-cell junctions and cell motility." Bratt A., Birot O., Sinha I., Veitonmaeki N., Aase K., Ernkvist M., Holmgren L. J. Biol. Chem. 280:34859-34869(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AMOT.
[12]	"CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin." Kawata A., Iida J., Ikeda M., Sato Y., Mori H., Kansaku A., Sumita K., Fujiwara N., Rokukawa C., Hamano M., Hirabayashi S., Hata Y. J. Biochem. 139:931-939(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DDN.
[13]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730; SER-741 AND SER-1361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"Solution structure of WW domains from the human membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1. MAGI-1." RIKEN structural genomics initiative (RSGI) Submitted (APR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 295-401.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB010894 mRNA. Translation: BAA32002.1.
AF401655 mRNA. Translation: AAK94065.1.
AF401656 mRNA. Translation: AAK94066.1.
AF401654 mRNA. Translation: AAK94064.1.
AC104438 Genomic DNA. No translation available.
AC112516 Genomic DNA. No translation available.
AC121493 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
U80754 mRNA. Translation: AAC04844.1.
U96115 mRNA. Translation: AAC51326.1. Different termination.

PIR

JE0209.

RefSeq

NP_001028229.1. NM_001033057.1.
NP_004733.2. NM_004742.2.
NP_056335.1. NM_015520.1.
XP_005265621.1. XM_005265564.1.

UniGene

Hs.476636.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KPK	NMR	-	A	455-580	[»]
2KPL	NMR	-	A	455-580	[»]
2Q9V	X-ray	2.00	A	839-922	[»]
2R4H	X-ray	2.05	A/B/C	1149-1233	[»]
2YSD	NMR	-	A	295-338	[»]
2YSE	NMR	-	A	355-401	[»]
2ZAJ	NMR	-	A	355-390	[»]
3BPU	X-ray	1.60	A	640-721	[»]

ProteinModelPortal

Q96QZ7.

SMR

Q96QZ7. Positions 138-190, 295-401, 455-580, 640-721, 839-1237.

ModBase

Search...

MobiDB

Search...

Protein-protein interaction databases

BioGrid

114655. 24 interactions.

IntAct

Q96QZ7. 23 interactions.

MINT

MINT-215167.

STRING

9606.ENSP00000385450.

PTM databases

PhosphoSite

Q96QZ7.

Polymorphism databases

DMDM

281185501.

Proteomic databases

PaxDb

Q96QZ7.

PRIDE

Q96QZ7.

Protocols and materials databases

DNASU

9223.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000330909; ENSP00000331157; ENSG00000151276. [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276. [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276. [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276. [Q96QZ7-4]

GeneID

9223.

KEGG

hsa:9223.

UCSC

uc003dmm.3. human. [Q96QZ7-5]
uc003dmn.3. human. [Q96QZ7-2]
uc003dmo.3. human. [Q96QZ7-3]
uc003dmp.3. human. [Q96QZ7-4]

Organism-specific databases

CTD

9223.

GeneCards

GC03M065318.

H-InvDB

HIX0003428.
HIX0163431.

HGNC

HGNC:946. MAGI1.

HPA

HPA031851.
HPA031852.
HPA031853.
HPA031854.

MIM

602625. gene.

neXtProt

NX_Q96QZ7.

PharmGKB

PA164742006.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5021.

HOVERGEN

HBG007091.

KO

K05631.

OMA

YQEQDIF.

PhylomeDB

Q96QZ7.

TreeFam

TF316816.

Enzyme and pathway databases

SignaLink

Q96QZ7.

Gene expression databases

ArrayExpress

Q96QZ7.

Bgee

Q96QZ7.

CleanEx

HS_BAP1.
HS_MAGI1.

Genevestigator

Q96QZ7.

Family and domain databases

Gene3D

2.30.42.10. 6 hits.

InterPro

IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
[Graphical view]

Pfam

PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 5 hits.
PF00397. WW. 1 hit.
[Graphical view]

SMART

SM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
[Graphical view]

SUPFAM

SSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 2 hits.
SSF52540. SSF52540. 1 hit.

PROSITE

PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

MAGI1. human.

EvolutionaryTrace

Q96QZ7.

GeneWiki

MAGI1.

GenomeRNAi

9223.

NextBio

34575.

PRO

Q96QZ7.

SOURCE

Search...

Entry information

Entry name

MAGI1_HUMAN

Accession

Primary (citable) accession number: Q96QZ7
Secondary accession number(s): O00309 , O43863, O75085, Q96QZ8, Q96QZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	December 15, 2009
Last modified:	April 16, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.