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UniProtKB - Q96QZ7 (MAGI1_HUMAN)

UniProt

Q96QZ7 - MAGI1_HUMAN

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Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Gene

MAGI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 1108ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • alpha-actinin binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • protein C-terminus binding Source: ProtInc

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • neuron death Source: UniProtKB
  • protein complex assembly Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96QZ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Alternative name(s):
Atrophin-1-interacting protein 3
Short name:
AIP-3
BAI1-associated protein 1
Short name:
BAP-1
Membrane-associated guanylate kinase inverted 1
Short name:
MAGI-1
Trinucleotide repeat-containing gene 19 protein
WW domain-containing protein 3
Short name:
WWP3
Gene namesi
Name:MAGI1
Synonyms:AIP3, BAIAP1, BAP1, TNRC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componentsi: Chromosome 3, Chromosome 5

Organism-specific databases

HGNCiHGNC:946. MAGI1.

Subcellular locationi

  • Cell junction › tight junction 1 Publication
  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

    • Note: Localizes to epithelial cells tight junctions.

GO - Cellular componenti

  • adherens junction Source: UniProtKB
  • bicellular tight junction Source: UniProtKB-SubCell
  • cell-cell junction Source: ProtInc
  • cell junction Source: HPA
  • cell projection Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742006.

Polymorphism and mutation databases

BioMutaiMAGI1.
DMDMi281185501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14911491Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1PRO_0000094589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei357 – 3571PhosphoserineCombined sources
Modified residuei730 – 7301PhosphoserineCombined sources
Modified residuei741 – 7411PhosphoserineCombined sources
Modified residuei800 – 8001PhosphoserineBy similarity
Modified residuei1071 – 10711PhosphoserineCombined sources
Modified residuei1361 – 13611PhosphoserineCombined sources
Modified residuei1412 – 14121PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96QZ7.
MaxQBiQ96QZ7.
PaxDbiQ96QZ7.
PeptideAtlasiQ96QZ7.
PRIDEiQ96QZ7.

PTM databases

iPTMnetiQ96QZ7.
PhosphoSiteiQ96QZ7.

Expressioni

Tissue specificityi

Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain.3 Publications

Gene expression databases

BgeeiENSG00000151276.
CleanExiHS_BAP1.
HS_MAGI1.
ExpressionAtlasiQ96QZ7. baseline and differential.
GenevisibleiQ96QZ7. HS.

Organism-specific databases

HPAiHPA031851.
HPA031852.
HPA031853.

Interactioni

Subunit structurei

Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4 (PubMed:12042308). Interacts with cytoplasmic domain of BAI1 (PubMed:9647739). Interacts via its WW domains with DRPLA (PubMed:9647693). Interacts with ESAM, LRP2 and CXADR (By similarity). May interact with CTNNB1 (By similarity). Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ASIC3 and AMOT (PubMed:15317815, PubMed:16043488). Interacts with FCHSD2 (PubMed:14627983). Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity) (PubMed:12773569). Interacts with DDN (PubMed:16751601). Isoform 3 (via PDZ domain) interacts with RAPGEF2 (PubMed:11168587). Interacts with DLL1 (By similarity). Interacts with KCNJ10 and possibly with KCNJ10/KCNJ16 heterodimer; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney tubular cells.By similarity9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
E6P064633EBI-924464,EBI-1186926From a different organism.
FCHSD2O948685EBI-924464,EBI-1215612
IQGAP1P469404EBI-924464,EBI-297509
KIF1BO60333-33EBI-924464,EBI-465669
RAPGEF2Q9Y4G82EBI-8769674,EBI-307079

GO - Molecular functioni

  • alpha-actinin binding Source: UniProtKB
  • protein C-terminus binding Source: ProtInc

Protein-protein interaction databases

BioGridi114655. 28 interactions.
IntActiQ96QZ7. 23 interactions.
MINTiMINT-215167.
STRINGi9606.ENSP00000385450.

Structurei

Secondary structure

1
1491
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi304 – 3107Combined sources
Beta strandi316 – 3205Combined sources
Turni321 – 3244Combined sources
Beta strandi325 – 3295Combined sources
Turni331 – 3333Combined sources
Beta strandi363 – 3697Combined sources
Beta strandi371 – 3733Combined sources
Beta strandi375 – 3795Combined sources
Turni380 – 3834Combined sources
Beta strandi384 – 3885Combined sources
Helixi390 – 3989Combined sources
Turni463 – 4653Combined sources
Beta strandi468 – 47710Combined sources
Beta strandi479 – 4813Combined sources
Beta strandi483 – 4919Combined sources
Beta strandi494 – 5018Combined sources
Helixi506 – 5105Combined sources
Beta strandi518 – 5225Combined sources
Helixi532 – 54110Combined sources
Beta strandi546 – 5549Combined sources
Beta strandi568 – 5703Combined sources
Beta strandi640 – 6478Combined sources
Beta strandi652 – 6543Combined sources
Beta strandi656 – 6594Combined sources
Beta strandi663 – 6708Combined sources
Beta strandi685 – 6895Combined sources
Helixi699 – 7079Combined sources
Beta strandi714 – 7218Combined sources
Beta strandi839 – 8457Combined sources
Beta strandi853 – 8575Combined sources
Beta strandi865 – 8706Combined sources
Helixi875 – 8795Combined sources
Beta strandi887 – 8915Combined sources
Helixi901 – 91414Combined sources
Beta strandi916 – 9227Combined sources
Beta strandi1150 – 11567Combined sources
Beta strandi1163 – 11686Combined sources
Helixi1170 – 11723Combined sources
Beta strandi1176 – 11816Combined sources
Helixi1186 – 11894Combined sources
Beta strandi1198 – 12025Combined sources
Helixi1212 – 12209Combined sources
Turni1221 – 12244Combined sources
Beta strandi1225 – 12317Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WBPX-ray2.40B1382-1390[»]
2KPKNMR-A455-580[»]
2KPLNMR-A455-580[»]
2Q9VX-ray2.00A839-922[»]
2R4HX-ray2.05A/B/C1149-1233[»]
2YSDNMR-A295-338[»]
2YSENMR-A355-401[»]
2ZAJNMR-A355-390[»]
3BPUX-ray1.60A640-721[»]
ProteinModelPortaliQ96QZ7.
SMRiQ96QZ7. Positions 295-338, 355-401, 455-580, 640-721, 839-923, 994-1095, 1149-1237.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96QZ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 10589PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 287192Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST
Domaini300 – 33334WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini359 – 39234WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini472 – 55483PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini643 – 72179PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini813 – 89583PDZ 4PROSITE-ProRule annotationAdd
BLAST
Domaini970 – 106697PDZ 5PROSITE-ProRule annotationAdd
BLAST
Domaini1124 – 120683PDZ 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni970 – 106697Interaction with FCHSD2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi402 – 42120Poly-GlnAdd
BLAST
Compositional biasi662 – 6654Poly-Gly
Compositional biasi978 – 98811Poly-GlyAdd
BLAST
Compositional biasi1341 – 13444Poly-Ala
Compositional biasi1398 – 14014Poly-Arg

Sequence similaritiesi

Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 6 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3209. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00650000092997.
HOGENOMiHOG000113463.
HOVERGENiHBG007091.
InParanoidiQ96QZ7.
KOiK05631.
OMAiIPDYQEQ.
OrthoDBiEOG091G0NSY.
PhylomeDBiQ96QZ7.
TreeFamiTF316816.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR030033. MAGI1.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
[Graphical view]
PANTHERiPTHR10316:SF12. PTHR10316:SF12. 3 hits.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 5 hits.
PF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q96QZ7-1) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-alpha-beta1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV 
        60         70         80         90        100
EAAGLPGGGE GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK 
       110        120        130        140        150
AVRQGGRLNK DLRHFLNQRF QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR 
       160        170        180        190        200
EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG TYEGNYYGTP KPPSQPVSGK 
       210        220        230        240        250
VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE EDDVPEMNSS 
       260        270        280        290        300
FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 
       310        320        330        340        350
PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV 
       360        370        380        390        400
HTEELDSELE LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL 
       410        420        430        440        450
EQQQQQQQQQ QQQQQQQQQQ QTEEWTEDHS ALVPPVIPNH PPSNPEPARE 
       460        470        480        490        500
VPLQGKPFFT RNPSELKGKF IHTKLRKSSR GFGFTVVGGD EPDEFLQIKS 
       510        520        530        540        550
LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ SIPIGASVDL 
       560        570        580        590        600
ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 
       610        620        630        640        650
KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP 
       660        670        680        690        700
MGFGFTIADS PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN 
       710        720        730        740        750
QVVDMLVECP KGSEVTLLVQ RGGLPVPKKS PKSQPLERKD SQNSSQHSVS 
       760        770        780        790        800
SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ TDSSGQKKPD PFKIWAQSRS 
       810        820        830        840        850
MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ DIFLWRKETG 
       860        870        880        890        900
FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS 
       910        920        930        940        950
HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA 
       960        970        980        990       1000
SLTEEKRTPQ GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE 
      1010       1020       1030       1040       1050
IRRGENEGFG FVIVSSVSRP EAGTTFAGNA CVAMPHKIGR IIEGSPADRC 
      1060       1070       1080       1090       1100
GKLKVGDRIL AVNGCSITNK SHSDIVNLIK EAGNTVTLRI IPGDESSNAT 
      1110       1120       1130       1140       1150
LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK APQATQEQDF 
      1160       1170       1180       1190       1200
YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL 
      1210       1220       1230       1240       1250
EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA 
      1260       1270       1280       1290       1300
TGPQGVPEVR AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE 
      1310       1320       1330       1340       1350
YSRQPNEHHT WNGTSRKPDS GACRPKDRAP EGRRDAQAER AAAANGPKRR 
      1360       1370       1380       1390       1400
SPEKRREGTR SADNTLERRE KHEKRRDVSP ERRRERSPTR RRDGSPSRRR 
      1410       1420       1430       1440       1450
RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR ERSLDKRNRE 
      1460       1470       1480       1490 
DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I
Note: No experimental confirmation available.
Length:1,491
Mass (Da):164,581
Last modified:December 15, 2009 - v3
Checksum:i4B2EE05243A6FA65
GO
Isoform 2 (identifier: Q96QZ7-2) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.

Show »
Length:1,462
Mass (Da):161,550
Checksum:i09C49DDDEB792655
GO
Isoform 3 (identifier: Q96QZ7-3) [UniParc]FASTAAdd to basket
Also known as: MAGI-1A-alpha-beta1

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Show »
Length:1,256
Mass (Da):136,921
Checksum:i1D906FFCE0F8F6CE
GO
Isoform 4 (identifier: Q96QZ7-4) [UniParc]FASTAAdd to basket
Also known as: MAGI-1A-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.
     1039-1094: Missing.
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Show »
Length:1,160
Mass (Da):126,898
Checksum:i7E3FEB621B96D1B5
GO
Isoform 5 (identifier: Q96QZ7-5) [UniParc]FASTAAdd to basket
Also known as: MAGI-1B-alpha-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1027-1027: Missing.
     1241-1288: DPSSDRHGPA...LHKSSPHGEK → AMIPPNIAAC...PPPVHKVFRK
     1289-1491: Missing.

Show »
Length:1,287
Mass (Da):140,379
Checksum:i75F4654C0524B753
GO
Isoform 6 (identifier: Q96QZ7-6) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta2

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.

Note: No experimental confirmation available.
Show »
Length:1,451
Mass (Da):160,427
Checksum:i1D55FA728ED6FBA5
GO
Isoform 7 (identifier: Q96QZ7-7) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta3

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1023-1099: GTTFAGNACV...IIPGDESSNA → VMQCQPPSWC...EVQIYSCNNP

Note: No experimental confirmation available.
Show »
Length:1,425
Mass (Da):157,781
Checksum:i5F60A23E79301C1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241S → F in BAA32002 (PubMed:9647739).Curated
Sequence conflicti124 – 1241S → F in AAK94064 (PubMed:11969287).Curated
Sequence conflicti124 – 1241S → F in AAK94065 (PubMed:11969287).Curated
Sequence conflicti124 – 1241S → F in AAK94066 (PubMed:11969287).Curated
Sequence conflicti124 – 1241S → F in AAC51326 (PubMed:11969287).Curated
Sequence conflicti428 – 4281D → H in BAF82492 (PubMed:14702039).Curated
Sequence conflicti775 – 7751A → G in AAC04844 (PubMed:9647693).Curated
Sequence conflicti1001 – 10011I → T in BAF82492 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei806 – 83429PMSPS…GECPI → L in isoform 2, isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_011664Add
BLAST
Alternative sequencei1023 – 109977GTTFA…ESSNA → VMQCQPPSWCHSALGGSKHC NSVMGAASLEVQIYSCNNP in isoform 7. CuratedVSP_011665Add
BLAST
Alternative sequencei1027 – 10271Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_011666
Alternative sequencei1028 – 103811Missing in isoform 4 and isoform 6. 1 PublicationVSP_011667Add
BLAST
Alternative sequencei1039 – 109456Missing in isoform 4. 1 PublicationVSP_011668Add
BLAST
Alternative sequencei1241 – 128848DPSSD…PHGEK → AMIPPNIAACMRNEKLGEAC FYLMGHNQTTTPAATATAPP PVHKVFRK in isoform 5. 1 PublicationVSP_011669Add
BLAST
Alternative sequencei1241 – 125616DPSSD…GPQGV → GGSNYENIPSFPGMTP in isoform 3 and isoform 4. 3 PublicationsVSP_011670Add
BLAST
Alternative sequencei1257 – 128832Missing in isoform 3 and isoform 4. 3 PublicationsVSP_011671Add
BLAST
Alternative sequencei1289 – 1491203Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_011672Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010894 mRNA. Translation: BAA32002.1.
AF401655 mRNA. Translation: AAK94065.1.
AF401656 mRNA. Translation: AAK94066.1.
AF401654 mRNA. Translation: AAK94064.1.
AK289803 mRNA. Translation: BAF82492.1.
AC104438 Genomic DNA. No translation available.
AC112516 Genomic DNA. No translation available.
AC121493 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
U80754 mRNA. Translation: AAC04844.1.
U96115 mRNA. Translation: AAC51326.1. Different termination.
CCDSiCCDS2904.1. [Q96QZ7-3]
CCDS33780.1. [Q96QZ7-2]
CCDS33781.1. [Q96QZ7-5]
PIRiJE0209.
RefSeqiNP_001028229.1. NM_001033057.1. [Q96QZ7-2]
NP_004733.2. NM_004742.2. [Q96QZ7-3]
NP_056335.1. NM_015520.1. [Q96QZ7-5]
XP_005265621.1. XM_005265564.1. [Q96QZ7-1]
UniGeneiHs.476636.

Genome annotation databases

EnsembliENST00000330909; ENSP00000331157; ENSG00000151276. [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276. [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276. [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276. [Q96QZ7-4]
ENST00000634409; ENSP00000489444; ENSG00000282956. [Q96QZ7-2]
ENST00000634774; ENSP00000489393; ENSG00000282956. [Q96QZ7-5]
ENST00000635378; ENSP00000489391; ENSG00000282956. [Q96QZ7-3]
ENST00000635471; ENSP00000489322; ENSG00000282956. [Q96QZ7-4]
GeneIDi9223.
KEGGihsa:9223.
UCSCiuc003dmm.4. human. [Q96QZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010894 mRNA. Translation: BAA32002.1.
AF401655 mRNA. Translation: AAK94065.1.
AF401656 mRNA. Translation: AAK94066.1.
AF401654 mRNA. Translation: AAK94064.1.
AK289803 mRNA. Translation: BAF82492.1.
AC104438 Genomic DNA. No translation available.
AC112516 Genomic DNA. No translation available.
AC121493 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
U80754 mRNA. Translation: AAC04844.1.
U96115 mRNA. Translation: AAC51326.1. Different termination.
CCDSiCCDS2904.1. [Q96QZ7-3]
CCDS33780.1. [Q96QZ7-2]
CCDS33781.1. [Q96QZ7-5]
PIRiJE0209.
RefSeqiNP_001028229.1. NM_001033057.1. [Q96QZ7-2]
NP_004733.2. NM_004742.2. [Q96QZ7-3]
NP_056335.1. NM_015520.1. [Q96QZ7-5]
XP_005265621.1. XM_005265564.1. [Q96QZ7-1]
UniGeneiHs.476636.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WBPX-ray2.40B1382-1390[»]
2KPKNMR-A455-580[»]
2KPLNMR-A455-580[»]
2Q9VX-ray2.00A839-922[»]
2R4HX-ray2.05A/B/C1149-1233[»]
2YSDNMR-A295-338[»]
2YSENMR-A355-401[»]
2ZAJNMR-A355-390[»]
3BPUX-ray1.60A640-721[»]
ProteinModelPortaliQ96QZ7.
SMRiQ96QZ7. Positions 295-338, 355-401, 455-580, 640-721, 839-923, 994-1095, 1149-1237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114655. 28 interactions.
IntActiQ96QZ7. 23 interactions.
MINTiMINT-215167.
STRINGi9606.ENSP00000385450.

PTM databases

iPTMnetiQ96QZ7.
PhosphoSiteiQ96QZ7.

Polymorphism and mutation databases

BioMutaiMAGI1.
DMDMi281185501.

Proteomic databases

EPDiQ96QZ7.
MaxQBiQ96QZ7.
PaxDbiQ96QZ7.
PeptideAtlasiQ96QZ7.
PRIDEiQ96QZ7.

Protocols and materials databases

DNASUi9223.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330909; ENSP00000331157; ENSG00000151276. [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276. [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276. [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276. [Q96QZ7-4]
ENST00000634409; ENSP00000489444; ENSG00000282956. [Q96QZ7-2]
ENST00000634774; ENSP00000489393; ENSG00000282956. [Q96QZ7-5]
ENST00000635378; ENSP00000489391; ENSG00000282956. [Q96QZ7-3]
ENST00000635471; ENSP00000489322; ENSG00000282956. [Q96QZ7-4]
GeneIDi9223.
KEGGihsa:9223.
UCSCiuc003dmm.4. human. [Q96QZ7-1]

Organism-specific databases

CTDi9223.
GeneCardsiMAGI1.
H-InvDBHIX0003428.
HIX0163431.
HGNCiHGNC:946. MAGI1.
HPAiHPA031851.
HPA031852.
HPA031853.
MIMi602625. gene.
neXtProtiNX_Q96QZ7.
PharmGKBiPA164742006.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3209. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00650000092997.
HOGENOMiHOG000113463.
HOVERGENiHBG007091.
InParanoidiQ96QZ7.
KOiK05631.
OMAiIPDYQEQ.
OrthoDBiEOG091G0NSY.
PhylomeDBiQ96QZ7.
TreeFamiTF316816.

Enzyme and pathway databases

SignaLinkiQ96QZ7.

Miscellaneous databases

ChiTaRSiMAGI1. human.
EvolutionaryTraceiQ96QZ7.
GeneWikiiMAGI1.
GenomeRNAii9223.
PROiQ96QZ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151276.
CleanExiHS_BAP1.
HS_MAGI1.
ExpressionAtlasiQ96QZ7. baseline and differential.
GenevisibleiQ96QZ7. HS.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR030033. MAGI1.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
[Graphical view]
PANTHERiPTHR10316:SF12. PTHR10316:SF12. 3 hits.
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 5 hits.
PF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGI1_HUMAN
AccessioniPrimary (citable) accession number: Q96QZ7
Secondary accession number(s): A8K188
, O00309, O43863, O75085, Q96QZ8, Q96QZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 15, 2009
Last modified: September 7, 2016
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.