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Q96QZ7 (MAGI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Alternative name(s):
Atrophin-1-interacting protein 3
Short name=AIP-3
BAI1-associated protein 1
Short name=BAP-1
Membrane-associated guanylate kinase inverted 1
Short name=MAGI-1
Trinucleotide repeat-containing gene 19 protein
WW domain-containing protein 3
Short name=WWP3
Gene names
Name:MAGI1
Synonyms:AIP3, BAIAP1, BAP1, TNRC19
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1491 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface By similarity.

Subunit structure

Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 By similarity. Interacts with ASIC3 and AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex By similarity. Interacts with DDN. Isoform 3 (via PDZ domain) interacts with RAPGEF2. Ref.1 Ref.5 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13

Subcellular location

Cell junctiontight junction. Cell membrane; Peripheral membrane protein. Note: Localizes to epithelial cells tight junctions. Ref.2

Tissue specificity

Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain. Ref.1 Ref.2 Ref.5

Sequence similarities

Contains 1 guanylate kinase-like domain.

Contains 6 PDZ (DHR) domains.

Contains 2 WW domains.

Binary interactions

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q96QZ7-1)

Also known as: MAGI-1C-alpha-beta1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q96QZ7-2)

Also known as: MAGI-1C-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
Isoform 3 (identifier: Q96QZ7-3)

Also known as: MAGI-1A-alpha-beta1;

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.
Isoform 4 (identifier: Q96QZ7-4)

Also known as: MAGI-1A-alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.
     1039-1094: Missing.
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.
Isoform 5 (identifier: Q96QZ7-5)

Also known as: MAGI-1B-alpha-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1027-1027: Missing.
     1241-1288: DPSSDRHGPA...LHKSSPHGEK → AMIPPNIAAC...PPPVHKVFRK
     1289-1491: Missing.
Isoform 6 (identifier: Q96QZ7-6)

Also known as: MAGI-1C-beta2;

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: Q96QZ7-7)

Also known as: MAGI-1C-beta3;

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1023-1099: GTTFAGNACV...IIPGDESSNA → VMQCQPPSWC...EVQIYSCNNP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14911491Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
PRO_0000094589

Regions

Domain17 – 10589PDZ 1
Domain96 – 287192Guanylate kinase-like
Domain300 – 33334WW 1
Domain359 – 39234WW 2
Domain472 – 55483PDZ 2
Domain643 – 72179PDZ 3
Domain813 – 89583PDZ 4
Domain970 – 106697PDZ 5
Domain1124 – 120683PDZ 6
Nucleotide binding103 – 1108ATP By similarity
Region970 – 106697Interaction with FCHSD2
Compositional bias402 – 42120Poly-Gln
Compositional bias662 – 6654Poly-Gly
Compositional bias978 – 98811Poly-Gly
Compositional bias1341 – 13444Poly-Ala
Compositional bias1398 – 14014Poly-Arg

Amino acid modifications

Modified residue7301Phosphoserine Ref.14
Modified residue7411Phosphoserine Ref.14
Modified residue13611Phosphoserine Ref.14

Natural variations

Alternative sequence806 – 83429PMSPS…GECPI → L in isoform 2, isoform 4, isoform 6 and isoform 7.
VSP_011664
Alternative sequence1023 – 109977GTTFA…ESSNA → VMQCQPPSWCHSALGGSKHC NSVMGAASLEVQIYSCNNP in isoform 7.
VSP_011665
Alternative sequence10271Missing in isoform 2, isoform 4, isoform 5 and isoform 6.
VSP_011666
Alternative sequence1028 – 103811Missing in isoform 4 and isoform 6.
VSP_011667
Alternative sequence1039 – 109456Missing in isoform 4.
VSP_011668
Alternative sequence1241 – 128848DPSSD…PHGEK → AMIPPNIAACMRNEKLGEAC FYLMGHNQTTTPAATATAPP PVHKVFRK in isoform 5.
VSP_011669
Alternative sequence1241 – 125616DPSSD…GPQGV → GGSNYENIPSFPGMTP in isoform 3 and isoform 4.
VSP_011670
Alternative sequence1257 – 128832Missing in isoform 3 and isoform 4.
VSP_011671
Alternative sequence1289 – 1491203Missing in isoform 3, isoform 4 and isoform 5.
VSP_011672

Experimental info

Sequence conflict1241S → F in BAA32002. Ref.1
Sequence conflict1241S → F in AAK94064. Ref.2
Sequence conflict1241S → F in AAK94065. Ref.2
Sequence conflict1241S → F in AAK94066. Ref.2
Sequence conflict1241S → F in AAC51326. Ref.2
Sequence conflict4281D → H in BAF82492. Ref.3
Sequence conflict7751A → G in AAC04844. Ref.5
Sequence conflict10011I → T in BAF82492. Ref.3

Secondary structure

................................................................................... 1491
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (MAGI-1C-alpha-beta1) [UniParc].

Last modified December 15, 2009. Version 3.
Checksum: 4B2EE05243A6FA65

FASTA1,491164,581
        10         20         30         40         50         60 
MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV EAAGLPGGGE 

        70         80         90        100        110        120 
GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK AVRQGGRLNK DLRHFLNQRF 

       130        140        150        160        170        180 
QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG 

       190        200        210        220        230        240 
TYEGNYYGTP KPPSQPVSGK VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE 

       250        260        270        280        290        300 
EDDVPEMNSS FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 

       310        320        330        340        350        360 
PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV HTEELDSELE 

       370        380        390        400        410        420 
LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL EQQQQQQQQQ QQQQQQQQQQ 

       430        440        450        460        470        480 
QTEEWTEDHS ALVPPVIPNH PPSNPEPARE VPLQGKPFFT RNPSELKGKF IHTKLRKSSR 

       490        500        510        520        530        540 
GFGFTVVGGD EPDEFLQIKS LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ 

       550        560        570        580        590        600 
SIPIGASVDL ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 

       610        620        630        640        650        660 
KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP MGFGFTIADS 

       670        680        690        700        710        720 
PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN QVVDMLVECP KGSEVTLLVQ 

       730        740        750        760        770        780 
RGGLPVPKKS PKSQPLERKD SQNSSQHSVS SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ 

       790        800        810        820        830        840 
TDSSGQKKPD PFKIWAQSRS MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ 

       850        860        870        880        890        900 
DIFLWRKETG FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS 

       910        920        930        940        950        960 
HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA SLTEEKRTPQ 

       970        980        990       1000       1010       1020 
GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE IRRGENEGFG FVIVSSVSRP 

      1030       1040       1050       1060       1070       1080 
EAGTTFAGNA CVAMPHKIGR IIEGSPADRC GKLKVGDRIL AVNGCSITNK SHSDIVNLIK 

      1090       1100       1110       1120       1130       1140 
EAGNTVTLRI IPGDESSNAT LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK 

      1150       1160       1170       1180       1190       1200 
APQATQEQDF YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL 

      1210       1220       1230       1240       1250       1260 
EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA TGPQGVPEVR 

      1270       1280       1290       1300       1310       1320 
AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE YSRQPNEHHT WNGTSRKPDS 

      1330       1340       1350       1360       1370       1380 
GACRPKDRAP EGRRDAQAER AAAANGPKRR SPEKRREGTR SADNTLERRE KHEKRRDVSP 

      1390       1400       1410       1420       1430       1440 
ERRRERSPTR RRDGSPSRRR RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR 

      1450       1460       1470       1480       1490 
ERSLDKRNRE DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I 

« Hide

Isoform 2 (MAGI-1C-beta) [UniParc].

Checksum: 09C49DDDEB792655
Show »

FASTA1,462161,550
Isoform 3 (MAGI-1A-alpha-beta1) [UniParc].

Checksum: 1D906FFCE0F8F6CE
Show »

FASTA1,256136,921
Isoform 4 (MAGI-1A-alpha) [UniParc].

Checksum: 7E3FEB621B96D1B5
Show »

FASTA1,160126,898
Isoform 5 (MAGI-1B-alpha-beta) [UniParc].

Checksum: 75F4654C0524B753
Show »

FASTA1,287140,379
Isoform 6 (MAGI-1C-beta2) [UniParc].

Checksum: 1D55FA728ED6FBA5
Show »

FASTA1,451160,427
Isoform 7 (MAGI-1C-beta3) [UniParc].

Checksum: 5F60A23E79301C1E
Show »

FASTA1,425157,781

References

« Hide 'large scale' references
[1]"Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1."
Shiratsuchi T., Futamura M., Oda K., Nishimori H., Nakamura Y., Tokino T.
Biochem. Biophys. Res. Commun. 247:597-604(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH BAI1.
Tissue: Brain.
[2]"MAGI-1: a widely expressed, alternatively spliced tight junction protein."
Laura R.P., Ross S., Koeppen H., Lasky L.A.
Exp. Cell Res. 275:155-170(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 5), ALTERNATIVE SPLICING (ISOFORMS 6 AND 7), SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins."
Wood J.D., Yuan J., Margolis R.L., Colomer V., Duan K., Kushi J., Kaminsky Z., Kleiderlein J.J. Jr., Sharp A.H., Ross C.A.
Mol. Cell. Neurosci. 11:149-160(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-826 (ISOFORMS 1/3), TISSUE SPECIFICITY, INTERACTION WITH DRPLA.
[6]"Identification of novel human WW domain-containing proteins by cloning of ligand targets."
Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M.
J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-371.
[7]"Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions."
Mino A., Ohtsuka T., Inoue E., Takai Y.
Genes Cells 5:1009-1016(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAPGEF2.
[8]"Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."
Patrie K.M., Drescher A.J., Welihinda A., Mundel P., Margolis B.
J. Biol. Chem. 277:30183-30190(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SYNPO AND ACTN4.
[9]"JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1."
Hirabayashi S., Tajima M., Yao I., Nishimura W., Mori H., Hata Y.
Mol. Cell. Biol. 23:4267-4282(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH IGSF5.
[10]"Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains."
Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y.
Oncogene 22:8422-8431(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FCHSD2.
[11]"PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."
Hruska-Hageman A.M., Benson C.J., Leonard A.S., Price M.P., Welsh M.J.
J. Biol. Chem. 279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ASIC3.
[12]"Angiomotin regulates endothelial cell-cell junctions and cell motility."
Bratt A., Birot O., Sinha I., Veitonmaeki N., Aase K., Ernkvist M., Holmgren L.
J. Biol. Chem. 280:34859-34869(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AMOT.
[13]"CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin."
Kawata A., Iida J., Ikeda M., Sato Y., Mori H., Kansaku A., Sumita K., Fujiwara N., Rokukawa C., Hamano M., Hirabayashi S., Hata Y.
J. Biochem. 139:931-939(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DDN.
[14]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730; SER-741 AND SER-1361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"Solution structure of WW domains from the human membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1. MAGI-1."
RIKEN structural genomics initiative (RSGI)
Submitted (APR-2008) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 295-401.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB010894 mRNA. Translation: BAA32002.1.
AF401655 mRNA. Translation: AAK94065.1.
AF401656 mRNA. Translation: AAK94066.1.
AF401654 mRNA. Translation: AAK94064.1.
AK289803 mRNA. Translation: BAF82492.1.
AC104438 Genomic DNA. No translation available.
AC112516 Genomic DNA. No translation available.
AC121493 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
U80754 mRNA. Translation: AAC04844.1.
U96115 mRNA. Translation: AAC51326.1. Different termination.
CCDSCCDS2904.1. [Q96QZ7-3]
CCDS33780.1. [Q96QZ7-2]
CCDS33781.1. [Q96QZ7-5]
PIRJE0209.
RefSeqNP_001028229.1. NM_001033057.1. [Q96QZ7-2]
NP_004733.2. NM_004742.2. [Q96QZ7-3]
NP_056335.1. NM_015520.1. [Q96QZ7-5]
XP_005265621.1. XM_005265564.1. [Q96QZ7-1]
UniGeneHs.476636.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WBPX-ray2.40B1382-1390[»]
2KPKNMR-A455-580[»]
2KPLNMR-A455-580[»]
2Q9VX-ray2.00A839-922[»]
2R4HX-ray2.05A/B/C1149-1233[»]
2YSDNMR-A295-338[»]
2YSENMR-A355-401[»]
2ZAJNMR-A355-390[»]
3BPUX-ray1.60A640-721[»]
ProteinModelPortalQ96QZ7.
SMRQ96QZ7. Positions 17-103, 138-190, 295-401, 455-580, 640-721, 839-923, 994-1237.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114655. 24 interactions.
IntActQ96QZ7. 23 interactions.
MINTMINT-215167.
STRING9606.ENSP00000385450.

PTM databases

PhosphoSiteQ96QZ7.

Polymorphism databases

DMDM281185501.

Proteomic databases

MaxQBQ96QZ7.
PaxDbQ96QZ7.
PRIDEQ96QZ7.

Protocols and materials databases

DNASU9223.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330909; ENSP00000331157; ENSG00000151276. [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276. [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276. [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276. [Q96QZ7-4]
GeneID9223.
KEGGhsa:9223.
UCSCuc003dmm.3. human. [Q96QZ7-5]
uc003dmn.3. human. [Q96QZ7-2]
uc003dmo.3. human. [Q96QZ7-3]
uc003dmp.3. human. [Q96QZ7-4]

Organism-specific databases

CTD9223.
GeneCardsGC03M065318.
H-InvDBHIX0003428.
HIX0163431.
HGNCHGNC:946. MAGI1.
HPAHPA031851.
HPA031852.
HPA031853.
HPA031854.
MIM602625. gene.
neXtProtNX_Q96QZ7.
PharmGKBPA164742006.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5021.
HOVERGENHBG007091.
KOK05631.
OMAIPDYQEQ.
PhylomeDBQ96QZ7.
TreeFamTF316816.

Enzyme and pathway databases

SignaLinkQ96QZ7.

Gene expression databases

ArrayExpressQ96QZ7.
BgeeQ96QZ7.
CleanExHS_BAP1.
HS_MAGI1.
GenevestigatorQ96QZ7.

Family and domain databases

Gene3D2.30.42.10. 6 hits.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 5 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMSSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMAGI1. human.
EvolutionaryTraceQ96QZ7.
GeneWikiMAGI1.
GenomeRNAi9223.
NextBio34575.
PROQ96QZ7.
SOURCESearch...

Entry information

Entry nameMAGI1_HUMAN
AccessionPrimary (citable) accession number: Q96QZ7
Secondary accession number(s): A8K188 expand/collapse secondary AC list , O00309, O43863, O75085, Q96QZ8, Q96QZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 15, 2009
Last modified: July 9, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM