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UniProtKB - Q96QZ7 (MAGI1_HUMAN)

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Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Gene

MAGI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi103 – 110ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • alpha-actinin binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • protein complex scaffold Source: InterPro
  • protein C-terminus binding Source: ProtInc
Complete GO annotation...

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • neuron death Source: UniProtKB
  • protein complex assembly Source: ProtInc
Complete GO annotation...

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96QZ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Alternative name(s):
Atrophin-1-interacting protein 3
Short name:
AIP-3
BAI1-associated protein 1
Short name:
BAP-1
Membrane-associated guanylate kinase inverted 1
Short name:
MAGI-1
Trinucleotide repeat-containing gene 19 protein
WW domain-containing protein 3
Short name:
WWP3
Gene namesi
Name:MAGI1
Synonyms:AIP3, BAIAP1, BAP1, TNRC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:946. MAGI1.

Subcellular locationi

  • Cell junction › tight junction 1 Publication
  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

    • Note: Localizes to epithelial cells tight junctions.

GO - Cellular componenti

  • adherens junction Source: UniProtKB
  • bicellular tight junction Source: UniProtKB-SubCell
  • cell-cell junction Source: ProtInc
  • cell junction Source: HPA
  • cell projection Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi9223.
OpenTargetsiENSG00000151276.
PharmGKBiPA164742006.

Polymorphism and mutation databases

BioMutaiMAGI1.
DMDMi281185501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945891 – 1491Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1Add BLAST1491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei357PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei800PhosphoserineBy similarity1
Modified residuei1071PhosphoserineCombined sources1
Modified residuei1361PhosphoserineCombined sources1
Modified residuei1412PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96QZ7.
MaxQBiQ96QZ7.
PaxDbiQ96QZ7.
PeptideAtlasiQ96QZ7.
PRIDEiQ96QZ7.

PTM databases

iPTMnetiQ96QZ7.
PhosphoSitePlusiQ96QZ7.

Expressioni

Tissue specificityi

Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain.3 Publications

Gene expression databases

BgeeiENSG00000151276.
CleanExiHS_BAP1.
HS_MAGI1.
ExpressionAtlasiQ96QZ7. baseline and differential.
GenevisibleiQ96QZ7. HS.

Organism-specific databases

HPAiHPA031851.
HPA031852.
HPA031853.

Interactioni

Subunit structurei

Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4 (PubMed:12042308). Interacts with cytoplasmic domain of BAI1 (PubMed:9647739). Interacts via its WW domains with DRPLA (PubMed:9647693). Interacts with ESAM, LRP2 and CXADR (By similarity). May interact with CTNNB1 (By similarity). Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ASIC3 and AMOT (PubMed:15317815, PubMed:16043488). Interacts with FCHSD2 (PubMed:14627983). Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity) (PubMed:12773569). Interacts with DDN (PubMed:16751601). Isoform 3 (via PDZ domain) interacts with RAPGEF2 (PubMed:11168587). Interacts with DLL1 (By similarity). Interacts with KCNJ10 and possibly with KCNJ10/KCNJ16 heterodimer; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney tubular cells.By similarity9 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • alpha-actinin binding Source: UniProtKB
  • protein complex scaffold Source: InterPro
  • protein C-terminus binding Source: ProtInc
Complete GO annotation...

Protein-protein interaction databases

BioGridi114655. 28 interactors.
IntActiQ96QZ7. 24 interactors.
MINTiMINT-215167.
STRINGi9606.ENSP00000385450.

Structurei

Secondary structure

11491
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi304 – 310Combined sources7
Beta strandi316 – 320Combined sources5
Turni321 – 324Combined sources4
Beta strandi325 – 329Combined sources5
Turni331 – 333Combined sources3
Beta strandi363 – 369Combined sources7
Beta strandi371 – 373Combined sources3
Beta strandi375 – 379Combined sources5
Turni380 – 383Combined sources4
Beta strandi384 – 388Combined sources5
Helixi390 – 398Combined sources9
Turni463 – 465Combined sources3
Beta strandi468 – 477Combined sources10
Beta strandi479 – 481Combined sources3
Beta strandi483 – 491Combined sources9
Beta strandi494 – 501Combined sources8
Helixi506 – 510Combined sources5
Beta strandi518 – 522Combined sources5
Helixi532 – 541Combined sources10
Beta strandi546 – 554Combined sources9
Beta strandi568 – 570Combined sources3
Beta strandi640 – 647Combined sources8
Beta strandi652 – 654Combined sources3
Beta strandi656 – 659Combined sources4
Beta strandi663 – 670Combined sources8
Beta strandi685 – 689Combined sources5
Helixi699 – 707Combined sources9
Beta strandi714 – 721Combined sources8
Beta strandi839 – 845Combined sources7
Beta strandi853 – 857Combined sources5
Beta strandi865 – 870Combined sources6
Helixi875 – 879Combined sources5
Beta strandi887 – 891Combined sources5
Helixi901 – 914Combined sources14
Beta strandi916 – 922Combined sources7
Beta strandi1150 – 1156Combined sources7
Beta strandi1163 – 1168Combined sources6
Helixi1170 – 1172Combined sources3
Beta strandi1176 – 1181Combined sources6
Helixi1186 – 1189Combined sources4
Beta strandi1198 – 1202Combined sources5
Helixi1212 – 1220Combined sources9
Turni1221 – 1224Combined sources4
Beta strandi1225 – 1231Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WBPX-ray2.40B1382-1390[»]
2KPKNMR-A455-580[»]
2KPLNMR-A455-580[»]
2Q9VX-ray2.00A839-922[»]
2R4HX-ray2.05A/B/C1149-1233[»]
2YSDNMR-A295-338[»]
2YSENMR-A355-401[»]
2ZAJNMR-A355-390[»]
3BPUX-ray1.60A640-721[»]
ProteinModelPortaliQ96QZ7.
SMRiQ96QZ7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96QZ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 105PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini96 – 287Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST192
Domaini300 – 333WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini359 – 392WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini472 – 554PDZ 2PROSITE-ProRule annotationAdd BLAST83
Domaini643 – 721PDZ 3PROSITE-ProRule annotationAdd BLAST79
Domaini813 – 895PDZ 4PROSITE-ProRule annotationAdd BLAST83
Domaini970 – 1066PDZ 5PROSITE-ProRule annotationAdd BLAST97
Domaini1124 – 1206PDZ 6PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni970 – 1066Interaction with FCHSD21 PublicationAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi402 – 421Poly-GlnAdd BLAST20
Compositional biasi662 – 665Poly-Gly4
Compositional biasi978 – 988Poly-GlyAdd BLAST11
Compositional biasi1341 – 1344Poly-Ala4
Compositional biasi1398 – 1401Poly-Arg4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3209. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00650000092997.
HOGENOMiHOG000113463.
HOVERGENiHBG007091.
InParanoidiQ96QZ7.
KOiK05631.
OMAiIPDYQEQ.
OrthoDBiEOG091G0NSY.
PhylomeDBiQ96QZ7.
TreeFamiTF316816.

Family and domain databases

InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR030033. MAGI1.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
PANTHERiPTHR10316:SF54. PTHR10316:SF54. 1 hit.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 5 hits.
PF00397. WW. 2 hits.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
SUPFAMiSSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q96QZ7-1) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-alpha-beta1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV 
        60         70         80         90        100
EAAGLPGGGE GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK 
       110        120        130        140        150
AVRQGGRLNK DLRHFLNQRF QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR 
       160        170        180        190        200
EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG TYEGNYYGTP KPPSQPVSGK 
       210        220        230        240        250
VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE EDDVPEMNSS 
       260        270        280        290        300
FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 
       310        320        330        340        350
PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV 
       360        370        380        390        400
HTEELDSELE LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL 
       410        420        430        440        450
EQQQQQQQQQ QQQQQQQQQQ QTEEWTEDHS ALVPPVIPNH PPSNPEPARE 
       460        470        480        490        500
VPLQGKPFFT RNPSELKGKF IHTKLRKSSR GFGFTVVGGD EPDEFLQIKS 
       510        520        530        540        550
LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ SIPIGASVDL 
       560        570        580        590        600
ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 
       610        620        630        640        650
KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP 
       660        670        680        690        700
MGFGFTIADS PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN 
       710        720        730        740        750
QVVDMLVECP KGSEVTLLVQ RGGLPVPKKS PKSQPLERKD SQNSSQHSVS 
       760        770        780        790        800
SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ TDSSGQKKPD PFKIWAQSRS 
       810        820        830        840        850
MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ DIFLWRKETG 
       860        870        880        890        900
FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS 
       910        920        930        940        950
HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA 
       960        970        980        990       1000
SLTEEKRTPQ GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE 
      1010       1020       1030       1040       1050
IRRGENEGFG FVIVSSVSRP EAGTTFAGNA CVAMPHKIGR IIEGSPADRC 
      1060       1070       1080       1090       1100
GKLKVGDRIL AVNGCSITNK SHSDIVNLIK EAGNTVTLRI IPGDESSNAT 
      1110       1120       1130       1140       1150
LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK APQATQEQDF 
      1160       1170       1180       1190       1200
YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL 
      1210       1220       1230       1240       1250
EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA 
      1260       1270       1280       1290       1300
TGPQGVPEVR AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE 
      1310       1320       1330       1340       1350
YSRQPNEHHT WNGTSRKPDS GACRPKDRAP EGRRDAQAER AAAANGPKRR 
      1360       1370       1380       1390       1400
SPEKRREGTR SADNTLERRE KHEKRRDVSP ERRRERSPTR RRDGSPSRRR 
      1410       1420       1430       1440       1450
RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR ERSLDKRNRE 
      1460       1470       1480       1490 
DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I
Note: No experimental confirmation available.
Length:1,491
Mass (Da):164,581
Last modified:December 15, 2009 - v3
Checksum:i4B2EE05243A6FA65
GO
Isoform 2 (identifier: Q96QZ7-2) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.

Show »
Length:1,462
Mass (Da):161,550
Checksum:i09C49DDDEB792655
GO
Isoform 3 (identifier: Q96QZ7-3) [UniParc]FASTAAdd to basket
Also known as: MAGI-1A-alpha-beta1

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Show »
Length:1,256
Mass (Da):136,921
Checksum:i1D906FFCE0F8F6CE
GO
Isoform 4 (identifier: Q96QZ7-4) [UniParc]FASTAAdd to basket
Also known as: MAGI-1A-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.
     1039-1094: Missing.
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Show »
Length:1,160
Mass (Da):126,898
Checksum:i7E3FEB621B96D1B5
GO
Isoform 5 (identifier: Q96QZ7-5) [UniParc]FASTAAdd to basket
Also known as: MAGI-1B-alpha-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1027-1027: Missing.
     1241-1288: DPSSDRHGPA...LHKSSPHGEK → AMIPPNIAAC...PPPVHKVFRK
     1289-1491: Missing.

Show »
Length:1,287
Mass (Da):140,379
Checksum:i75F4654C0524B753
GO
Isoform 6 (identifier: Q96QZ7-6) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta2

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.

Note: No experimental confirmation available.
Show »
Length:1,451
Mass (Da):160,427
Checksum:i1D55FA728ED6FBA5
GO
Isoform 7 (identifier: Q96QZ7-7) [UniParc]FASTAAdd to basket
Also known as: MAGI-1C-beta3

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1023-1099: GTTFAGNACV...IIPGDESSNA → VMQCQPPSWC...EVQIYSCNNP

Note: No experimental confirmation available.
Show »
Length:1,425
Mass (Da):157,781
Checksum:i5F60A23E79301C1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124S → F in BAA32002 (PubMed:9647739).Curated1
Sequence conflicti124S → F in AAK94064 (PubMed:11969287).Curated1
Sequence conflicti124S → F in AAK94065 (PubMed:11969287).Curated1
Sequence conflicti124S → F in AAK94066 (PubMed:11969287).Curated1
Sequence conflicti124S → F in AAC51326 (PubMed:11969287).Curated1
Sequence conflicti428D → H in BAF82492 (PubMed:14702039).Curated1
Sequence conflicti775A → G in AAC04844 (PubMed:9647693).Curated1
Sequence conflicti1001I → T in BAF82492 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011664806 – 834PMSPS…GECPI → L in isoform 2, isoform 4, isoform 6 and isoform 7. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0116651023 – 1099GTTFA…ESSNA → VMQCQPPSWCHSALGGSKHC NSVMGAASLEVQIYSCNNP in isoform 7. CuratedAdd BLAST77
Alternative sequenceiVSP_0116661027Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_0116671028 – 1038Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0116681039 – 1094Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_0116691241 – 1288DPSSD…PHGEK → AMIPPNIAACMRNEKLGEAC FYLMGHNQTTTPAATATAPP PVHKVFRK in isoform 5. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0116701241 – 1256DPSSD…GPQGV → GGSNYENIPSFPGMTP in isoform 3 and isoform 4. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0116711257 – 1288Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST32
Alternative sequenceiVSP_0116721289 – 1491Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010894 mRNA. Translation: BAA32002.1.
AF401655 mRNA. Translation: AAK94065.1.
AF401656 mRNA. Translation: AAK94066.1.
AF401654 mRNA. Translation: AAK94064.1.
AK289803 mRNA. Translation: BAF82492.1.
AC104438 Genomic DNA. No translation available.
AC112516 Genomic DNA. No translation available.
AC121493 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
U80754 mRNA. Translation: AAC04844.1.
U96115 mRNA. Translation: AAC51326.1. Different termination.
CCDSiCCDS2904.1. [Q96QZ7-3]
CCDS33780.1. [Q96QZ7-2]
CCDS33781.1. [Q96QZ7-5]
PIRiJE0209.
RefSeqiNP_001028229.1. NM_001033057.1. [Q96QZ7-2]
NP_004733.2. NM_004742.2. [Q96QZ7-3]
NP_056335.1. NM_015520.1. [Q96QZ7-5]
XP_005265621.1. XM_005265564.1. [Q96QZ7-1]
UniGeneiHs.476636.

Genome annotation databases

EnsembliENST00000330909; ENSP00000331157; ENSG00000151276. [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276. [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276. [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276. [Q96QZ7-4]
ENST00000634409; ENSP00000489444; ENSG00000282956. [Q96QZ7-2]
ENST00000634774; ENSP00000489393; ENSG00000282956. [Q96QZ7-5]
ENST00000635378; ENSP00000489391; ENSG00000282956. [Q96QZ7-3]
ENST00000635471; ENSP00000489322; ENSG00000282956. [Q96QZ7-4]
GeneIDi9223.
KEGGihsa:9223.
UCSCiuc003dmm.4. human. [Q96QZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010894 mRNA. Translation: BAA32002.1.
AF401655 mRNA. Translation: AAK94065.1.
AF401656 mRNA. Translation: AAK94066.1.
AF401654 mRNA. Translation: AAK94064.1.
AK289803 mRNA. Translation: BAF82492.1.
AC104438 Genomic DNA. No translation available.
AC112516 Genomic DNA. No translation available.
AC121493 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
U80754 mRNA. Translation: AAC04844.1.
U96115 mRNA. Translation: AAC51326.1. Different termination.
CCDSiCCDS2904.1. [Q96QZ7-3]
CCDS33780.1. [Q96QZ7-2]
CCDS33781.1. [Q96QZ7-5]
PIRiJE0209.
RefSeqiNP_001028229.1. NM_001033057.1. [Q96QZ7-2]
NP_004733.2. NM_004742.2. [Q96QZ7-3]
NP_056335.1. NM_015520.1. [Q96QZ7-5]
XP_005265621.1. XM_005265564.1. [Q96QZ7-1]
UniGeneiHs.476636.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WBPX-ray2.40B1382-1390[»]
2KPKNMR-A455-580[»]
2KPLNMR-A455-580[»]
2Q9VX-ray2.00A839-922[»]
2R4HX-ray2.05A/B/C1149-1233[»]
2YSDNMR-A295-338[»]
2YSENMR-A355-401[»]
2ZAJNMR-A355-390[»]
3BPUX-ray1.60A640-721[»]
ProteinModelPortaliQ96QZ7.
SMRiQ96QZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114655. 28 interactors.
IntActiQ96QZ7. 24 interactors.
MINTiMINT-215167.
STRINGi9606.ENSP00000385450.

PTM databases

iPTMnetiQ96QZ7.
PhosphoSitePlusiQ96QZ7.

Polymorphism and mutation databases

BioMutaiMAGI1.
DMDMi281185501.

Proteomic databases

EPDiQ96QZ7.
MaxQBiQ96QZ7.
PaxDbiQ96QZ7.
PeptideAtlasiQ96QZ7.
PRIDEiQ96QZ7.

Protocols and materials databases

DNASUi9223.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330909; ENSP00000331157; ENSG00000151276. [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276. [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276. [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276. [Q96QZ7-4]
ENST00000634409; ENSP00000489444; ENSG00000282956. [Q96QZ7-2]
ENST00000634774; ENSP00000489393; ENSG00000282956. [Q96QZ7-5]
ENST00000635378; ENSP00000489391; ENSG00000282956. [Q96QZ7-3]
ENST00000635471; ENSP00000489322; ENSG00000282956. [Q96QZ7-4]
GeneIDi9223.
KEGGihsa:9223.
UCSCiuc003dmm.4. human. [Q96QZ7-1]

Organism-specific databases

CTDi9223.
DisGeNETi9223.
GeneCardsiMAGI1.
H-InvDBiHIX0003428.
HIX0163431.
HGNCiHGNC:946. MAGI1.
HPAiHPA031851.
HPA031852.
HPA031853.
MIMi602625. gene.
neXtProtiNX_Q96QZ7.
OpenTargetsiENSG00000151276.
PharmGKBiPA164742006.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3209. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00650000092997.
HOGENOMiHOG000113463.
HOVERGENiHBG007091.
InParanoidiQ96QZ7.
KOiK05631.
OMAiIPDYQEQ.
OrthoDBiEOG091G0NSY.
PhylomeDBiQ96QZ7.
TreeFamiTF316816.

Enzyme and pathway databases

SignaLinkiQ96QZ7.

Miscellaneous databases

ChiTaRSiMAGI1. human.
EvolutionaryTraceiQ96QZ7.
GeneWikiiMAGI1.
GenomeRNAii9223.
PROiPR:Q96QZ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151276.
CleanExiHS_BAP1.
HS_MAGI1.
ExpressionAtlasiQ96QZ7. baseline and differential.
GenevisibleiQ96QZ7. HS.

Family and domain databases

InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR030033. MAGI1.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
PANTHERiPTHR10316:SF54. PTHR10316:SF54. 1 hit.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 5 hits.
PF00397. WW. 2 hits.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
SUPFAMiSSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMAGI1_HUMAN
AccessioniPrimary (citable) accession number: Q96QZ7
Secondary accession number(s): A8K188
, O00309, O43863, O75085, Q96QZ8, Q96QZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 15, 2009
Last modified: May 10, 2017
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.