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Q96QZ7

- MAGI1_HUMAN

UniProt

Q96QZ7 - MAGI1_HUMAN

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Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Gene

MAGI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 1108ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. alpha-actinin binding Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. protein C-terminus binding Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: ProtInc
  2. cell surface receptor signaling pathway Source: ProtInc
  3. neuron death Source: UniProt
  4. protein complex assembly Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96QZ7.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Alternative name(s):
Atrophin-1-interacting protein 3
Short name:
AIP-3
BAI1-associated protein 1
Short name:
BAP-1
Membrane-associated guanylate kinase inverted 1
Short name:
MAGI-1
Trinucleotide repeat-containing gene 19 protein
WW domain-containing protein 3
Short name:
WWP3
Gene namesi
Name:MAGI1
Synonyms:AIP3, BAIAP1, BAP1, TNRC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:946. MAGI1.

Subcellular locationi

Cell junctiontight junction 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Localizes to epithelial cells tight junctions.

GO - Cellular componenti

  1. cell-cell junction Source: ProtInc
  2. cell junction Source: HPA
  3. cell projection Source: UniProtKB
  4. cytoplasm Source: UniProtKB
  5. nucleus Source: HPA
  6. plasma membrane Source: ProtInc
  7. tight junction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14911491Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1PRO_0000094589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei730 – 7301Phosphoserine1 Publication
Modified residuei741 – 7411Phosphoserine1 Publication
Modified residuei1361 – 13611Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96QZ7.
PaxDbiQ96QZ7.
PRIDEiQ96QZ7.

PTM databases

PhosphoSiteiQ96QZ7.

Expressioni

Tissue specificityi

Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain.3 Publications

Gene expression databases

BgeeiQ96QZ7.
CleanExiHS_BAP1.
HS_MAGI1.
ExpressionAtlasiQ96QZ7. baseline and differential.
GenevestigatoriQ96QZ7.

Organism-specific databases

HPAiHPA031851.
HPA031852.
HPA031853.
HPA031854.

Interactioni

Subunit structurei

Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ASIC3 and AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity). Interacts with DDN. Isoform 3 (via PDZ domain) interacts with RAPGEF2.By similarity9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
E6P064633EBI-924464,EBI-1186926From a different organism.
FCHSD2O948685EBI-924464,EBI-1215612
IQGAP1P469404EBI-924464,EBI-297509
KIF1BO60333-33EBI-924464,EBI-465669
RAPGEF2Q9Y4G82EBI-8769674,EBI-307079

Protein-protein interaction databases

BioGridi114655. 26 interactions.
IntActiQ96QZ7. 23 interactions.
MINTiMINT-215167.
STRINGi9606.ENSP00000385450.

Structurei

Secondary structure

1
1491
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi304 – 3107Combined sources
Beta strandi316 – 3205Combined sources
Turni321 – 3244Combined sources
Beta strandi325 – 3295Combined sources
Turni331 – 3333Combined sources
Beta strandi363 – 3697Combined sources
Beta strandi371 – 3733Combined sources
Beta strandi375 – 3795Combined sources
Turni380 – 3834Combined sources
Beta strandi384 – 3885Combined sources
Helixi390 – 3989Combined sources
Turni463 – 4653Combined sources
Beta strandi468 – 47710Combined sources
Beta strandi479 – 4813Combined sources
Beta strandi483 – 4919Combined sources
Beta strandi494 – 5018Combined sources
Helixi506 – 5105Combined sources
Beta strandi518 – 5225Combined sources
Helixi532 – 54110Combined sources
Beta strandi546 – 5549Combined sources
Beta strandi568 – 5703Combined sources
Beta strandi640 – 6478Combined sources
Beta strandi652 – 6543Combined sources
Beta strandi656 – 6594Combined sources
Beta strandi663 – 6708Combined sources
Beta strandi685 – 6895Combined sources
Helixi699 – 7079Combined sources
Beta strandi714 – 7218Combined sources
Beta strandi839 – 8457Combined sources
Beta strandi853 – 8575Combined sources
Beta strandi865 – 8706Combined sources
Helixi875 – 8795Combined sources
Beta strandi887 – 8915Combined sources
Helixi901 – 91414Combined sources
Beta strandi916 – 9227Combined sources
Beta strandi1150 – 11567Combined sources
Beta strandi1163 – 11686Combined sources
Helixi1170 – 11723Combined sources
Beta strandi1176 – 11816Combined sources
Helixi1186 – 11894Combined sources
Beta strandi1198 – 12025Combined sources
Helixi1212 – 12209Combined sources
Turni1221 – 12244Combined sources
Beta strandi1225 – 12317Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WBPX-ray2.40B1382-1390[»]
2KPKNMR-A455-580[»]
2KPLNMR-A455-580[»]
2Q9VX-ray2.00A839-922[»]
2R4HX-ray2.05A/B/C1149-1233[»]
2YSDNMR-A295-338[»]
2YSENMR-A355-401[»]
2ZAJNMR-A355-390[»]
3BPUX-ray1.60A640-721[»]
ProteinModelPortaliQ96QZ7.
SMRiQ96QZ7. Positions 138-190, 295-401, 455-580, 640-721, 839-923, 994-1237.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96QZ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 10589PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 287192Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST
Domaini300 – 33334WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini359 – 39234WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini472 – 55483PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini643 – 72179PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini813 – 89583PDZ 4PROSITE-ProRule annotationAdd
BLAST
Domaini970 – 106697PDZ 5PROSITE-ProRule annotationAdd
BLAST
Domaini1124 – 120683PDZ 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni970 – 106697Interaction with FCHSD2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi402 – 42120Poly-GlnAdd
BLAST
Compositional biasi662 – 6654Poly-Gly
Compositional biasi978 – 98811Poly-GlyAdd
BLAST
Compositional biasi1341 – 13444Poly-Ala
Compositional biasi1398 – 14014Poly-Arg

Sequence similaritiesi

Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 6 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5021.
GeneTreeiENSGT00650000092997.
HOVERGENiHBG007091.
InParanoidiQ96QZ7.
KOiK05631.
OMAiIPDYQEQ.
PhylomeDBiQ96QZ7.
TreeFamiTF316816.

Family and domain databases

Gene3Di2.30.42.10. 6 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 5 hits.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q96QZ7-1) [UniParc]FASTAAdd to Basket

Also known as: MAGI-1C-alpha-beta1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV
60 70 80 90 100
EAAGLPGGGE GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK
110 120 130 140 150
AVRQGGRLNK DLRHFLNQRF QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR
160 170 180 190 200
EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG TYEGNYYGTP KPPSQPVSGK
210 220 230 240 250
VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE EDDVPEMNSS
260 270 280 290 300
FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG
310 320 330 340 350
PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV
360 370 380 390 400
HTEELDSELE LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL
410 420 430 440 450
EQQQQQQQQQ QQQQQQQQQQ QTEEWTEDHS ALVPPVIPNH PPSNPEPARE
460 470 480 490 500
VPLQGKPFFT RNPSELKGKF IHTKLRKSSR GFGFTVVGGD EPDEFLQIKS
510 520 530 540 550
LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ SIPIGASVDL
560 570 580 590 600
ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG
610 620 630 640 650
KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP
660 670 680 690 700
MGFGFTIADS PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN
710 720 730 740 750
QVVDMLVECP KGSEVTLLVQ RGGLPVPKKS PKSQPLERKD SQNSSQHSVS
760 770 780 790 800
SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ TDSSGQKKPD PFKIWAQSRS
810 820 830 840 850
MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ DIFLWRKETG
860 870 880 890 900
FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS
910 920 930 940 950
HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA
960 970 980 990 1000
SLTEEKRTPQ GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE
1010 1020 1030 1040 1050
IRRGENEGFG FVIVSSVSRP EAGTTFAGNA CVAMPHKIGR IIEGSPADRC
1060 1070 1080 1090 1100
GKLKVGDRIL AVNGCSITNK SHSDIVNLIK EAGNTVTLRI IPGDESSNAT
1110 1120 1130 1140 1150
LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK APQATQEQDF
1160 1170 1180 1190 1200
YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL
1210 1220 1230 1240 1250
EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA
1260 1270 1280 1290 1300
TGPQGVPEVR AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE
1310 1320 1330 1340 1350
YSRQPNEHHT WNGTSRKPDS GACRPKDRAP EGRRDAQAER AAAANGPKRR
1360 1370 1380 1390 1400
SPEKRREGTR SADNTLERRE KHEKRRDVSP ERRRERSPTR RRDGSPSRRR
1410 1420 1430 1440 1450
RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR ERSLDKRNRE
1460 1470 1480 1490
DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I

Note: No experimental confirmation available.

Length:1,491
Mass (Da):164,581
Last modified:December 15, 2009 - v3
Checksum:i4B2EE05243A6FA65
GO
Isoform 2 (identifier: Q96QZ7-2) [UniParc]FASTAAdd to Basket

Also known as: MAGI-1C-beta

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.

Show »
Length:1,462
Mass (Da):161,550
Checksum:i09C49DDDEB792655
GO
Isoform 3 (identifier: Q96QZ7-3) [UniParc]FASTAAdd to Basket

Also known as: MAGI-1A-alpha-beta1

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Show »
Length:1,256
Mass (Da):136,921
Checksum:i1D906FFCE0F8F6CE
GO
Isoform 4 (identifier: Q96QZ7-4) [UniParc]FASTAAdd to Basket

Also known as: MAGI-1A-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.
     1039-1094: Missing.
     1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
     1257-1288: Missing.
     1289-1491: Missing.

Show »
Length:1,160
Mass (Da):126,898
Checksum:i7E3FEB621B96D1B5
GO
Isoform 5 (identifier: Q96QZ7-5) [UniParc]FASTAAdd to Basket

Also known as: MAGI-1B-alpha-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1027-1027: Missing.
     1241-1288: DPSSDRHGPA...LHKSSPHGEK → AMIPPNIAAC...PPPVHKVFRK
     1289-1491: Missing.

Show »
Length:1,287
Mass (Da):140,379
Checksum:i75F4654C0524B753
GO
Isoform 6 (identifier: Q96QZ7-6) [UniParc]FASTAAdd to Basket

Also known as: MAGI-1C-beta2

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1027-1027: Missing.
     1028-1038: Missing.

Note: No experimental confirmation available.

Show »
Length:1,451
Mass (Da):160,427
Checksum:i1D55FA728ED6FBA5
GO
Isoform 7 (identifier: Q96QZ7-7) [UniParc]FASTAAdd to Basket

Also known as: MAGI-1C-beta3

The sequence of this isoform differs from the canonical sequence as follows:
     806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
     1023-1099: GTTFAGNACV...IIPGDESSNA → VMQCQPPSWC...EVQIYSCNNP

Note: No experimental confirmation available.

Show »
Length:1,425
Mass (Da):157,781
Checksum:i5F60A23E79301C1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241S → F in BAA32002. (PubMed:9647739)Curated
Sequence conflicti124 – 1241S → F in AAK94064. (PubMed:11969287)Curated
Sequence conflicti124 – 1241S → F in AAK94065. (PubMed:11969287)Curated
Sequence conflicti124 – 1241S → F in AAK94066. (PubMed:11969287)Curated
Sequence conflicti124 – 1241S → F in AAC51326. (PubMed:11969287)Curated
Sequence conflicti428 – 4281D → H in BAF82492. (PubMed:14702039)Curated
Sequence conflicti775 – 7751A → G in AAC04844. (PubMed:9647693)Curated
Sequence conflicti1001 – 10011I → T in BAF82492. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei806 – 83429PMSPS…GECPI → L in isoform 2, isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_011664Add
BLAST
Alternative sequencei1023 – 109977GTTFA…ESSNA → VMQCQPPSWCHSALGGSKHC NSVMGAASLEVQIYSCNNP in isoform 7. CuratedVSP_011665Add
BLAST
Alternative sequencei1027 – 10271Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_011666
Alternative sequencei1028 – 103811Missing in isoform 4 and isoform 6. 1 PublicationVSP_011667Add
BLAST
Alternative sequencei1039 – 109456Missing in isoform 4. 1 PublicationVSP_011668Add
BLAST
Alternative sequencei1241 – 128848DPSSD…PHGEK → AMIPPNIAACMRNEKLGEAC FYLMGHNQTTTPAATATAPP PVHKVFRK in isoform 5. 1 PublicationVSP_011669Add
BLAST
Alternative sequencei1241 – 125616DPSSD…GPQGV → GGSNYENIPSFPGMTP in isoform 3 and isoform 4. 3 PublicationsVSP_011670Add
BLAST
Alternative sequencei1257 – 128832Missing in isoform 3 and isoform 4. 3 PublicationsVSP_011671Add
BLAST
Alternative sequencei1289 – 1491203Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_011672Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010894 mRNA. Translation: BAA32002.1.
AF401655 mRNA. Translation: AAK94065.1.
AF401656 mRNA. Translation: AAK94066.1.
AF401654 mRNA. Translation: AAK94064.1.
AK289803 mRNA. Translation: BAF82492.1.
AC104438 Genomic DNA. No translation available.
AC112516 Genomic DNA. No translation available.
AC121493 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
U80754 mRNA. Translation: AAC04844.1.
U96115 mRNA. Translation: AAC51326.1. Different termination.
CCDSiCCDS2904.1. [Q96QZ7-3]
CCDS33780.1. [Q96QZ7-2]
CCDS33781.1. [Q96QZ7-5]
PIRiJE0209.
RefSeqiNP_001028229.1. NM_001033057.1. [Q96QZ7-2]
NP_004733.2. NM_004742.2. [Q96QZ7-3]
NP_056335.1. NM_015520.1. [Q96QZ7-5]
XP_005265621.1. XM_005265564.1. [Q96QZ7-1]
UniGeneiHs.476636.

Genome annotation databases

EnsembliENST00000330909; ENSP00000331157; ENSG00000151276. [Q96QZ7-5]
ENST00000402939; ENSP00000385450; ENSG00000151276. [Q96QZ7-2]
ENST00000483466; ENSP00000420323; ENSG00000151276. [Q96QZ7-3]
ENST00000497477; ENSP00000424369; ENSG00000151276. [Q96QZ7-4]
GeneIDi9223.
KEGGihsa:9223.
UCSCiuc003dmm.3. human. [Q96QZ7-5]
uc003dmn.3. human. [Q96QZ7-2]
uc003dmo.3. human. [Q96QZ7-3]
uc003dmp.3. human. [Q96QZ7-4]

Polymorphism databases

DMDMi281185501.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010894 mRNA. Translation: BAA32002.1 .
AF401655 mRNA. Translation: AAK94065.1 .
AF401656 mRNA. Translation: AAK94066.1 .
AF401654 mRNA. Translation: AAK94064.1 .
AK289803 mRNA. Translation: BAF82492.1 .
AC104438 Genomic DNA. No translation available.
AC112516 Genomic DNA. No translation available.
AC121493 Genomic DNA. No translation available.
AC145425 Genomic DNA. No translation available.
U80754 mRNA. Translation: AAC04844.1 .
U96115 mRNA. Translation: AAC51326.1 . Different termination.
CCDSi CCDS2904.1. [Q96QZ7-3 ]
CCDS33780.1. [Q96QZ7-2 ]
CCDS33781.1. [Q96QZ7-5 ]
PIRi JE0209.
RefSeqi NP_001028229.1. NM_001033057.1. [Q96QZ7-2 ]
NP_004733.2. NM_004742.2. [Q96QZ7-3 ]
NP_056335.1. NM_015520.1. [Q96QZ7-5 ]
XP_005265621.1. XM_005265564.1. [Q96QZ7-1 ]
UniGenei Hs.476636.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WBP X-ray 2.40 B 1382-1390 [» ]
2KPK NMR - A 455-580 [» ]
2KPL NMR - A 455-580 [» ]
2Q9V X-ray 2.00 A 839-922 [» ]
2R4H X-ray 2.05 A/B/C 1149-1233 [» ]
2YSD NMR - A 295-338 [» ]
2YSE NMR - A 355-401 [» ]
2ZAJ NMR - A 355-390 [» ]
3BPU X-ray 1.60 A 640-721 [» ]
ProteinModelPortali Q96QZ7.
SMRi Q96QZ7. Positions 138-190, 295-401, 455-580, 640-721, 839-923, 994-1237.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114655. 26 interactions.
IntActi Q96QZ7. 23 interactions.
MINTi MINT-215167.
STRINGi 9606.ENSP00000385450.

PTM databases

PhosphoSitei Q96QZ7.

Polymorphism databases

DMDMi 281185501.

Proteomic databases

MaxQBi Q96QZ7.
PaxDbi Q96QZ7.
PRIDEi Q96QZ7.

Protocols and materials databases

DNASUi 9223.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330909 ; ENSP00000331157 ; ENSG00000151276 . [Q96QZ7-5 ]
ENST00000402939 ; ENSP00000385450 ; ENSG00000151276 . [Q96QZ7-2 ]
ENST00000483466 ; ENSP00000420323 ; ENSG00000151276 . [Q96QZ7-3 ]
ENST00000497477 ; ENSP00000424369 ; ENSG00000151276 . [Q96QZ7-4 ]
GeneIDi 9223.
KEGGi hsa:9223.
UCSCi uc003dmm.3. human. [Q96QZ7-5 ]
uc003dmn.3. human. [Q96QZ7-2 ]
uc003dmo.3. human. [Q96QZ7-3 ]
uc003dmp.3. human. [Q96QZ7-4 ]

Organism-specific databases

CTDi 9223.
GeneCardsi GC03M065318.
H-InvDB HIX0003428.
HIX0163431.
HGNCi HGNC:946. MAGI1.
HPAi HPA031851.
HPA031852.
HPA031853.
HPA031854.
MIMi 602625. gene.
neXtProti NX_Q96QZ7.
PharmGKBi PA164742006.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5021.
GeneTreei ENSGT00650000092997.
HOVERGENi HBG007091.
InParanoidi Q96QZ7.
KOi K05631.
OMAi IPDYQEQ.
PhylomeDBi Q96QZ7.
TreeFami TF316816.

Enzyme and pathway databases

SignaLinki Q96QZ7.

Miscellaneous databases

ChiTaRSi MAGI1. human.
EvolutionaryTracei Q96QZ7.
GeneWikii MAGI1.
GenomeRNAii 9223.
NextBioi 34575.
PROi Q96QZ7.
SOURCEi Search...

Gene expression databases

Bgeei Q96QZ7.
CleanExi HS_BAP1.
HS_MAGI1.
ExpressionAtlasi Q96QZ7. baseline and differential.
Genevestigatori Q96QZ7.

Family and domain databases

Gene3Di 2.30.42.10. 6 hits.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
PF00595. PDZ. 5 hits.
PF00397. WW. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00228. PDZ. 6 hits.
SM00456. WW. 2 hits.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 6 hits.
SSF51045. SSF51045. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 6 hits.
PS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1."
    Shiratsuchi T., Futamura M., Oda K., Nishimori H., Nakamura Y., Tokino T.
    Biochem. Biophys. Res. Commun. 247:597-604(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH BAI1.
    Tissue: Brain.
  2. "MAGI-1: a widely expressed, alternatively spliced tight junction protein."
    Laura R.P., Ross S., Koeppen H., Lasky L.A.
    Exp. Cell Res. 275:155-170(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 5), ALTERNATIVE SPLICING (ISOFORMS 6 AND 7), SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins."
    Wood J.D., Yuan J., Margolis R.L., Colomer V., Duan K., Kushi J., Kaminsky Z., Kleiderlein J.J. Jr., Sharp A.H., Ross C.A.
    Mol. Cell. Neurosci. 11:149-160(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-826 (ISOFORMS 1/3), TISSUE SPECIFICITY, INTERACTION WITH DRPLA.
  6. "Identification of novel human WW domain-containing proteins by cloning of ligand targets."
    Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M.
    J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-371.
  7. "Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions."
    Mino A., Ohtsuka T., Inoue E., Takai Y.
    Genes Cells 5:1009-1016(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAPGEF2.
  8. "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."
    Patrie K.M., Drescher A.J., Welihinda A., Mundel P., Margolis B.
    J. Biol. Chem. 277:30183-30190(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SYNPO AND ACTN4.
  9. "JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1."
    Hirabayashi S., Tajima M., Yao I., Nishimura W., Mori H., Hata Y.
    Mol. Cell. Biol. 23:4267-4282(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGSF5.
  10. "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains."
    Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y.
    Oncogene 22:8422-8431(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FCHSD2.
  11. "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."
    Hruska-Hageman A.M., Benson C.J., Leonard A.S., Price M.P., Welsh M.J.
    J. Biol. Chem. 279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ASIC3.
  12. "Angiomotin regulates endothelial cell-cell junctions and cell motility."
    Bratt A., Birot O., Sinha I., Veitonmaeki N., Aase K., Ernkvist M., Holmgren L.
    J. Biol. Chem. 280:34859-34869(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AMOT.
  13. "CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin."
    Kawata A., Iida J., Ikeda M., Sato Y., Mori H., Kansaku A., Sumita K., Fujiwara N., Rokukawa C., Hamano M., Hirabayashi S., Hata Y.
    J. Biochem. 139:931-939(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDN.
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730; SER-741 AND SER-1361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Solution structure of WW domains from the human membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1. MAGI-1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 295-401.

Entry informationi

Entry nameiMAGI1_HUMAN
AccessioniPrimary (citable) accession number: Q96QZ7
Secondary accession number(s): A8K188
, O00309, O43863, O75085, Q96QZ8, Q96QZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 15, 2009
Last modified: November 26, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3