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Q96QZ7

- MAGI1_HUMAN

UniProt

Q96QZ7 - MAGI1_HUMAN

Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Gene

MAGI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 3 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi103 – 1108ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. alpha-actinin binding Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. protein C-terminus binding Source: ProtInc

    GO - Biological processi

    1. cell adhesion Source: ProtInc
    2. cell surface receptor signaling pathway Source: ProtInc
    3. neuron death Source: UniProt
    4. protein complex assembly Source: ProtInc

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ96QZ7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
    Alternative name(s):
    Atrophin-1-interacting protein 3
    Short name:
    AIP-3
    BAI1-associated protein 1
    Short name:
    BAP-1
    Membrane-associated guanylate kinase inverted 1
    Short name:
    MAGI-1
    Trinucleotide repeat-containing gene 19 protein
    WW domain-containing protein 3
    Short name:
    WWP3
    Gene namesi
    Name:MAGI1
    Synonyms:AIP3, BAIAP1, BAP1, TNRC19
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:946. MAGI1.

    Subcellular locationi

    Cell junctiontight junction 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Localizes to epithelial cells tight junctions.

    GO - Cellular componenti

    1. cell-cell junction Source: ProtInc
    2. cell junction Source: HPA
    3. cell projection Source: UniProtKB
    4. cytoplasm Source: UniProtKB
    5. nucleus Source: HPA
    6. plasma membrane Source: ProtInc
    7. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164742006.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14911491Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1PRO_0000094589Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei730 – 7301Phosphoserine2 Publications
    Modified residuei741 – 7411Phosphoserine2 Publications
    Modified residuei1361 – 13611Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96QZ7.
    PaxDbiQ96QZ7.
    PRIDEiQ96QZ7.

    PTM databases

    PhosphoSiteiQ96QZ7.

    Expressioni

    Tissue specificityi

    Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain.3 Publications

    Gene expression databases

    ArrayExpressiQ96QZ7.
    BgeeiQ96QZ7.
    CleanExiHS_BAP1.
    HS_MAGI1.
    GenevestigatoriQ96QZ7.

    Organism-specific databases

    HPAiHPA031851.
    HPA031852.
    HPA031853.
    HPA031854.

    Interactioni

    Subunit structurei

    Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 By similarity. Interacts with ASIC3 and AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex By similarity. Interacts with DDN. Isoform 3 (via PDZ domain) interacts with RAPGEF2.By similarity9 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    E6P064633EBI-924464,EBI-1186926From a different organism.
    FCHSD2O948685EBI-924464,EBI-1215612
    IQGAP1P469404EBI-924464,EBI-297509
    KIF1BO60333-33EBI-924464,EBI-465669
    RAPGEF2Q9Y4G82EBI-8769674,EBI-307079

    Protein-protein interaction databases

    BioGridi114655. 24 interactions.
    IntActiQ96QZ7. 23 interactions.
    MINTiMINT-215167.
    STRINGi9606.ENSP00000385450.

    Structurei

    Secondary structure

    1
    1491
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi304 – 3107
    Beta strandi316 – 3205
    Turni321 – 3244
    Beta strandi325 – 3295
    Turni331 – 3333
    Beta strandi363 – 3697
    Beta strandi371 – 3733
    Beta strandi375 – 3795
    Turni380 – 3834
    Beta strandi384 – 3885
    Helixi390 – 3989
    Turni463 – 4653
    Beta strandi468 – 47710
    Beta strandi479 – 4813
    Beta strandi483 – 4919
    Beta strandi494 – 5018
    Helixi506 – 5105
    Beta strandi518 – 5225
    Helixi532 – 54110
    Beta strandi546 – 5549
    Beta strandi568 – 5703
    Beta strandi640 – 6478
    Beta strandi652 – 6543
    Beta strandi656 – 6594
    Beta strandi663 – 6708
    Beta strandi685 – 6895
    Helixi699 – 7079
    Beta strandi714 – 7218
    Beta strandi839 – 8457
    Beta strandi853 – 8575
    Beta strandi865 – 8706
    Helixi875 – 8795
    Beta strandi887 – 8915
    Helixi901 – 91414
    Beta strandi916 – 9227
    Beta strandi1150 – 11567
    Beta strandi1163 – 11686
    Helixi1170 – 11723
    Beta strandi1176 – 11816
    Helixi1186 – 11894
    Beta strandi1198 – 12025
    Helixi1212 – 12209
    Turni1221 – 12244
    Beta strandi1225 – 12317

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WBPX-ray2.40B1382-1390[»]
    2KPKNMR-A455-580[»]
    2KPLNMR-A455-580[»]
    2Q9VX-ray2.00A839-922[»]
    2R4HX-ray2.05A/B/C1149-1233[»]
    2YSDNMR-A295-338[»]
    2YSENMR-A355-401[»]
    2ZAJNMR-A355-390[»]
    3BPUX-ray1.60A640-721[»]
    ProteinModelPortaliQ96QZ7.
    SMRiQ96QZ7. Positions 17-103, 138-190, 295-401, 455-580, 640-721, 839-923, 994-1237.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96QZ7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 10589PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 287192Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini300 – 33334WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini359 – 39234WW 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 55483PDZ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini643 – 72179PDZ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini813 – 89583PDZ 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini970 – 106697PDZ 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1124 – 120683PDZ 6PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni970 – 106697Interaction with FCHSD2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi402 – 42120Poly-GlnAdd
    BLAST
    Compositional biasi662 – 6654Poly-Gly
    Compositional biasi978 – 98811Poly-GlyAdd
    BLAST
    Compositional biasi1341 – 13444Poly-Ala
    Compositional biasi1398 – 14014Poly-Arg

    Sequence similaritiesi

    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 6 PDZ (DHR) domains.PROSITE-ProRule annotation
    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5021.
    HOVERGENiHBG007091.
    KOiK05631.
    OMAiIPDYQEQ.
    PhylomeDBiQ96QZ7.
    TreeFamiTF316816.

    Family and domain databases

    Gene3Di2.30.42.10. 6 hits.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF00595. PDZ. 5 hits.
    PF00397. WW. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00228. PDZ. 6 hits.
    SM00456. WW. 2 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 6 hits.
    SSF51045. SSF51045. 2 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 6 hits.
    PS01159. WW_DOMAIN_1. 2 hits.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q96QZ7-1) [UniParc]FASTAAdd to Basket

    Also known as: MAGI-1C-alpha-beta1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKVIQKKNH WTSRVHECTV KRGPQGELGV TVLGGAEHGE FPYVGAVAAV     50
    EAAGLPGGGE GPRLGEGELL LEVQGVRVSG LPRYDVLGVI DSCKEAVTFK 100
    AVRQGGRLNK DLRHFLNQRF QKGSPDHELQ QTIRDNLYRH AVPCTTRSPR 150
    EGEVPGVDYN FLTVKEFLDL EQSGTLLEVG TYEGNYYGTP KPPSQPVSGK 200
    VITTDALHSL QSGSKQSTPK RTKSYNDMQN AGIVHAENEE EDDVPEMNSS 250
    FTADSGEQEE HTLQETALPP VNSSIIAAPI TDPSQKFPQY LPLSAEDNLG 300
    PLPENWEMAY TENGEVYFID HNTKTTSWLD PRCLNKQQKP LEECEDDEGV 350
    HTEELDSELE LPAGWEKIED PVYGIYYVDH INRKTQYENP VLEAKRKKQL 400
    EQQQQQQQQQ QQQQQQQQQQ QTEEWTEDHS ALVPPVIPNH PPSNPEPARE 450
    VPLQGKPFFT RNPSELKGKF IHTKLRKSSR GFGFTVVGGD EPDEFLQIKS 500
    LVLDGPAALD GKMETGDVIV SVNDTCVLGH THAQVVKIFQ SIPIGASVDL 550
    ELCRGYPLPF DPDDPNTSLV TSVAILDKEP IIVNGQETYD SPASHSSKTG 600
    KVNGMKDARP SSPADVASNS SHGYPNDTVS LASSIATQPE LITVHIVKGP 650
    MGFGFTIADS PGGGGQRVKQ IVDSPRCRGL KEGDLIVEVN KKNVQALTHN 700
    QVVDMLVECP KGSEVTLLVQ RGGLPVPKKS PKSQPLERKD SQNSSQHSVS 750
    SHRSLHTASP SHSTQVLPEF PPAEAQAPDQ TDSSGQKKPD PFKIWAQSRS 800
    MYENRPMSPS PASGLSKGER EREINSTNFG ECPIPDYQEQ DIFLWRKETG 850
    FGFRILGGNE PGEPIYIGHI VPLGAADTDG RLRSGDELIC VDGTPVIGKS 900
    HQLVVQLMQQ AAKQGHVNLT VRRKVVFAVP KTENEVPSPA SSHHSSNQPA 950
    SLTEEKRTPQ GSQNSLNTVS SGSGSTSGIG SGGGGGSGVV STVVQPYDVE 1000
    IRRGENEGFG FVIVSSVSRP EAGTTFAGNA CVAMPHKIGR IIEGSPADRC 1050
    GKLKVGDRIL AVNGCSITNK SHSDIVNLIK EAGNTVTLRI IPGDESSNAT 1100
    LLTNAEKIAT ITTTHTPSQQ GTQETRNTTK PKQESQFEFK APQATQEQDF 1150
    YTVELERGAK GFGFSLRGGR EYNMDLYVLR LAEDGPAERC GKMRIGDEIL 1200
    EINGETTKNM KHSRAIELIK NGGRRVRLFL KRGDGSVPEY DPSSDRHGPA 1250
    TGPQGVPEVR AGPDRRQHPS LESSYPPDLH KSSPHGEKRA HARDPKGSRE 1300
    YSRQPNEHHT WNGTSRKPDS GACRPKDRAP EGRRDAQAER AAAANGPKRR 1350
    SPEKRREGTR SADNTLERRE KHEKRRDVSP ERRRERSPTR RRDGSPSRRR 1400
    RSLERLLEQR RSPERRRGGS PERRAKSTDR RRARSPERRR ERSLDKRNRE 1450
    DRASHREREE ANLKQDAGRS SRHPPEQRRR PYKECSTDLS I 1491

    Note: No experimental confirmation available.

    Length:1,491
    Mass (Da):164,581
    Last modified:December 15, 2009 - v3
    Checksum:i4B2EE05243A6FA65
    GO
    Isoform 2 (identifier: Q96QZ7-2) [UniParc]FASTAAdd to Basket

    Also known as: MAGI-1C-beta

    The sequence of this isoform differs from the canonical sequence as follows:
         806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
         1027-1027: Missing.

    Show »
    Length:1,462
    Mass (Da):161,550
    Checksum:i09C49DDDEB792655
    GO
    Isoform 3 (identifier: Q96QZ7-3) [UniParc]FASTAAdd to Basket

    Also known as: MAGI-1A-alpha-beta1

    The sequence of this isoform differs from the canonical sequence as follows:
         1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
         1257-1288: Missing.
         1289-1491: Missing.

    Show »
    Length:1,256
    Mass (Da):136,921
    Checksum:i1D906FFCE0F8F6CE
    GO
    Isoform 4 (identifier: Q96QZ7-4) [UniParc]FASTAAdd to Basket

    Also known as: MAGI-1A-alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
         1027-1027: Missing.
         1028-1038: Missing.
         1039-1094: Missing.
         1241-1256: DPSSDRHGPATGPQGV → GGSNYENIPSFPGMTP
         1257-1288: Missing.
         1289-1491: Missing.

    Show »
    Length:1,160
    Mass (Da):126,898
    Checksum:i7E3FEB621B96D1B5
    GO
    Isoform 5 (identifier: Q96QZ7-5) [UniParc]FASTAAdd to Basket

    Also known as: MAGI-1B-alpha-beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1027-1027: Missing.
         1241-1288: DPSSDRHGPA...LHKSSPHGEK → AMIPPNIAAC...PPPVHKVFRK
         1289-1491: Missing.

    Show »
    Length:1,287
    Mass (Da):140,379
    Checksum:i75F4654C0524B753
    GO
    Isoform 6 (identifier: Q96QZ7-6) [UniParc]FASTAAdd to Basket

    Also known as: MAGI-1C-beta2

    The sequence of this isoform differs from the canonical sequence as follows:
         806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
         1027-1027: Missing.
         1028-1038: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,451
    Mass (Da):160,427
    Checksum:i1D55FA728ED6FBA5
    GO
    Isoform 7 (identifier: Q96QZ7-7) [UniParc]FASTAAdd to Basket

    Also known as: MAGI-1C-beta3

    The sequence of this isoform differs from the canonical sequence as follows:
         806-834: PMSPSPASGLSKGEREREINSTNFGECPI → L
         1023-1099: GTTFAGNACV...IIPGDESSNA → VMQCQPPSWC...EVQIYSCNNP

    Note: No experimental confirmation available.

    Show »
    Length:1,425
    Mass (Da):157,781
    Checksum:i5F60A23E79301C1E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241S → F in BAA32002. (PubMed:9647739)Curated
    Sequence conflicti124 – 1241S → F in AAK94064. (PubMed:11969287)Curated
    Sequence conflicti124 – 1241S → F in AAK94065. (PubMed:11969287)Curated
    Sequence conflicti124 – 1241S → F in AAK94066. (PubMed:11969287)Curated
    Sequence conflicti124 – 1241S → F in AAC51326. (PubMed:11969287)Curated
    Sequence conflicti428 – 4281D → H in BAF82492. (PubMed:14702039)Curated
    Sequence conflicti775 – 7751A → G in AAC04844. (PubMed:9647693)Curated
    Sequence conflicti1001 – 10011I → T in BAF82492. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei806 – 83429PMSPS…GECPI → L in isoform 2, isoform 4, isoform 6 and isoform 7. 1 PublicationVSP_011664Add
    BLAST
    Alternative sequencei1023 – 109977GTTFA…ESSNA → VMQCQPPSWCHSALGGSKHC NSVMGAASLEVQIYSCNNP in isoform 7. CuratedVSP_011665Add
    BLAST
    Alternative sequencei1027 – 10271Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_011666
    Alternative sequencei1028 – 103811Missing in isoform 4 and isoform 6. 1 PublicationVSP_011667Add
    BLAST
    Alternative sequencei1039 – 109456Missing in isoform 4. 1 PublicationVSP_011668Add
    BLAST
    Alternative sequencei1241 – 128848DPSSD…PHGEK → AMIPPNIAACMRNEKLGEAC FYLMGHNQTTTPAATATAPP PVHKVFRK in isoform 5. 1 PublicationVSP_011669Add
    BLAST
    Alternative sequencei1241 – 125616DPSSD…GPQGV → GGSNYENIPSFPGMTP in isoform 3 and isoform 4. 3 PublicationsVSP_011670Add
    BLAST
    Alternative sequencei1257 – 128832Missing in isoform 3 and isoform 4. 3 PublicationsVSP_011671Add
    BLAST
    Alternative sequencei1289 – 1491203Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_011672Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010894 mRNA. Translation: BAA32002.1.
    AF401655 mRNA. Translation: AAK94065.1.
    AF401656 mRNA. Translation: AAK94066.1.
    AF401654 mRNA. Translation: AAK94064.1.
    AK289803 mRNA. Translation: BAF82492.1.
    AC104438 Genomic DNA. No translation available.
    AC112516 Genomic DNA. No translation available.
    AC121493 Genomic DNA. No translation available.
    AC145425 Genomic DNA. No translation available.
    U80754 mRNA. Translation: AAC04844.1.
    U96115 mRNA. Translation: AAC51326.1. Different termination.
    CCDSiCCDS2904.1. [Q96QZ7-3]
    CCDS33780.1. [Q96QZ7-2]
    CCDS33781.1. [Q96QZ7-5]
    PIRiJE0209.
    RefSeqiNP_001028229.1. NM_001033057.1. [Q96QZ7-2]
    NP_004733.2. NM_004742.2. [Q96QZ7-3]
    NP_056335.1. NM_015520.1. [Q96QZ7-5]
    XP_005265621.1. XM_005265564.1. [Q96QZ7-1]
    UniGeneiHs.476636.

    Genome annotation databases

    EnsembliENST00000330909; ENSP00000331157; ENSG00000151276. [Q96QZ7-5]
    ENST00000402939; ENSP00000385450; ENSG00000151276. [Q96QZ7-2]
    ENST00000483466; ENSP00000420323; ENSG00000151276. [Q96QZ7-3]
    ENST00000497477; ENSP00000424369; ENSG00000151276. [Q96QZ7-4]
    GeneIDi9223.
    KEGGihsa:9223.
    UCSCiuc003dmm.3. human. [Q96QZ7-5]
    uc003dmn.3. human. [Q96QZ7-2]
    uc003dmo.3. human. [Q96QZ7-3]
    uc003dmp.3. human. [Q96QZ7-4]

    Polymorphism databases

    DMDMi281185501.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010894 mRNA. Translation: BAA32002.1 .
    AF401655 mRNA. Translation: AAK94065.1 .
    AF401656 mRNA. Translation: AAK94066.1 .
    AF401654 mRNA. Translation: AAK94064.1 .
    AK289803 mRNA. Translation: BAF82492.1 .
    AC104438 Genomic DNA. No translation available.
    AC112516 Genomic DNA. No translation available.
    AC121493 Genomic DNA. No translation available.
    AC145425 Genomic DNA. No translation available.
    U80754 mRNA. Translation: AAC04844.1 .
    U96115 mRNA. Translation: AAC51326.1 . Different termination.
    CCDSi CCDS2904.1. [Q96QZ7-3 ]
    CCDS33780.1. [Q96QZ7-2 ]
    CCDS33781.1. [Q96QZ7-5 ]
    PIRi JE0209.
    RefSeqi NP_001028229.1. NM_001033057.1. [Q96QZ7-2 ]
    NP_004733.2. NM_004742.2. [Q96QZ7-3 ]
    NP_056335.1. NM_015520.1. [Q96QZ7-5 ]
    XP_005265621.1. XM_005265564.1. [Q96QZ7-1 ]
    UniGenei Hs.476636.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WBP X-ray 2.40 B 1382-1390 [» ]
    2KPK NMR - A 455-580 [» ]
    2KPL NMR - A 455-580 [» ]
    2Q9V X-ray 2.00 A 839-922 [» ]
    2R4H X-ray 2.05 A/B/C 1149-1233 [» ]
    2YSD NMR - A 295-338 [» ]
    2YSE NMR - A 355-401 [» ]
    2ZAJ NMR - A 355-390 [» ]
    3BPU X-ray 1.60 A 640-721 [» ]
    ProteinModelPortali Q96QZ7.
    SMRi Q96QZ7. Positions 17-103, 138-190, 295-401, 455-580, 640-721, 839-923, 994-1237.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114655. 24 interactions.
    IntActi Q96QZ7. 23 interactions.
    MINTi MINT-215167.
    STRINGi 9606.ENSP00000385450.

    PTM databases

    PhosphoSitei Q96QZ7.

    Polymorphism databases

    DMDMi 281185501.

    Proteomic databases

    MaxQBi Q96QZ7.
    PaxDbi Q96QZ7.
    PRIDEi Q96QZ7.

    Protocols and materials databases

    DNASUi 9223.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330909 ; ENSP00000331157 ; ENSG00000151276 . [Q96QZ7-5 ]
    ENST00000402939 ; ENSP00000385450 ; ENSG00000151276 . [Q96QZ7-2 ]
    ENST00000483466 ; ENSP00000420323 ; ENSG00000151276 . [Q96QZ7-3 ]
    ENST00000497477 ; ENSP00000424369 ; ENSG00000151276 . [Q96QZ7-4 ]
    GeneIDi 9223.
    KEGGi hsa:9223.
    UCSCi uc003dmm.3. human. [Q96QZ7-5 ]
    uc003dmn.3. human. [Q96QZ7-2 ]
    uc003dmo.3. human. [Q96QZ7-3 ]
    uc003dmp.3. human. [Q96QZ7-4 ]

    Organism-specific databases

    CTDi 9223.
    GeneCardsi GC03M065318.
    H-InvDB HIX0003428.
    HIX0163431.
    HGNCi HGNC:946. MAGI1.
    HPAi HPA031851.
    HPA031852.
    HPA031853.
    HPA031854.
    MIMi 602625. gene.
    neXtProti NX_Q96QZ7.
    PharmGKBi PA164742006.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5021.
    HOVERGENi HBG007091.
    KOi K05631.
    OMAi IPDYQEQ.
    PhylomeDBi Q96QZ7.
    TreeFami TF316816.

    Enzyme and pathway databases

    SignaLinki Q96QZ7.

    Miscellaneous databases

    ChiTaRSi MAGI1. human.
    EvolutionaryTracei Q96QZ7.
    GeneWikii MAGI1.
    GenomeRNAii 9223.
    NextBioi 34575.
    PROi Q96QZ7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96QZ7.
    Bgeei Q96QZ7.
    CleanExi HS_BAP1.
    HS_MAGI1.
    Genevestigatori Q96QZ7.

    Family and domain databases

    Gene3Di 2.30.42.10. 6 hits.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF00595. PDZ. 5 hits.
    PF00397. WW. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00228. PDZ. 6 hits.
    SM00456. WW. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 6 hits.
    SSF51045. SSF51045. 2 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 6 hits.
    PS01159. WW_DOMAIN_1. 2 hits.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1."
      Shiratsuchi T., Futamura M., Oda K., Nishimori H., Nakamura Y., Tokino T.
      Biochem. Biophys. Res. Commun. 247:597-604(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, INTERACTION WITH BAI1.
      Tissue: Brain.
    2. "MAGI-1: a widely expressed, alternatively spliced tight junction protein."
      Laura R.P., Ross S., Koeppen H., Lasky L.A.
      Exp. Cell Res. 275:155-170(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 5), ALTERNATIVE SPLICING (ISOFORMS 6 AND 7), SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins."
      Wood J.D., Yuan J., Margolis R.L., Colomer V., Duan K., Kushi J., Kaminsky Z., Kleiderlein J.J. Jr., Sharp A.H., Ross C.A.
      Mol. Cell. Neurosci. 11:149-160(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 150-826 (ISOFORMS 1/3), TISSUE SPECIFICITY, INTERACTION WITH DRPLA.
    6. "Identification of novel human WW domain-containing proteins by cloning of ligand targets."
      Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B., Kay B.K., Fowlkes D.M.
      J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 152-371.
    7. "Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions."
      Mino A., Ohtsuka T., Inoue E., Takai Y.
      Genes Cells 5:1009-1016(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAPGEF2.
    8. "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."
      Patrie K.M., Drescher A.J., Welihinda A., Mundel P., Margolis B.
      J. Biol. Chem. 277:30183-30190(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYNPO AND ACTN4.
    9. "JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1."
      Hirabayashi S., Tajima M., Yao I., Nishimura W., Mori H., Hata Y.
      Mol. Cell. Biol. 23:4267-4282(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IGSF5.
    10. "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains."
      Ohno H., Hirabayashi S., Kansaku A., Yao I., Tajima M., Nishimura W., Ohnishi H., Mashima H., Fujita T., Omata M., Hata Y.
      Oncogene 22:8422-8431(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FCHSD2.
    11. "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."
      Hruska-Hageman A.M., Benson C.J., Leonard A.S., Price M.P., Welsh M.J.
      J. Biol. Chem. 279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ASIC3.
    12. "Angiomotin regulates endothelial cell-cell junctions and cell motility."
      Bratt A., Birot O., Sinha I., Veitonmaeki N., Aase K., Ernkvist M., Holmgren L.
      J. Biol. Chem. 280:34859-34869(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AMOT.
    13. "CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin."
      Kawata A., Iida J., Ikeda M., Sato Y., Mori H., Kansaku A., Sumita K., Fujiwara N., Rokukawa C., Hamano M., Hirabayashi S., Hata Y.
      J. Biochem. 139:931-939(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DDN.
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730; SER-741 AND SER-1361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Solution structure of WW domains from the human membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1. MAGI-1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (APR-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 295-401.

    Entry informationi

    Entry nameiMAGI1_HUMAN
    AccessioniPrimary (citable) accession number: Q96QZ7
    Secondary accession number(s): A8K188
    , O00309, O43863, O75085, Q96QZ8, Q96QZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3