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Protein

Pannexin-3

Gene

PANX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Structural component of the gap junctions and the hemichannels.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.25.2.3. the gap junction-forming innexin (innexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Pannexin-3
Gene namesi
Name:PANX3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:20573. PANX3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939CytoplasmicSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini61 – 11353ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini135 – 21581CytoplasmicSequence analysisAdd
BLAST
Transmembranei216 – 23621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini237 – 26731ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini289 – 392104CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920643.

Polymorphism and mutation databases

BioMutaiPANX3.
DMDMi20139071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Pannexin-3PRO_0000208491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96QZ0.
PaxDbiQ96QZ0.
PRIDEiQ96QZ0.

PTM databases

iPTMnetiQ96QZ0.
PhosphoSiteiQ96QZ0.

Expressioni

Gene expression databases

BgeeiQ96QZ0.
CleanExiHS_PANX3.
GenevisibleiQ96QZ0. HS.

Interactioni

Protein-protein interaction databases

BioGridi125498. 1 interaction.
IntActiQ96QZ0. 1 interaction.
STRINGi9606.ENSP00000284288.

Structurei

3D structure databases

ProteinModelPortaliQ96QZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pannexin family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE65. Eukaryota.
ENOG410ZSQN. LUCA.
GeneTreeiENSGT00390000009703.
HOGENOMiHOG000063721.
HOVERGENiHBG053497.
InParanoidiQ96QZ0.
KOiK03443.
OMAiKMFPYSL.
OrthoDBiEOG74N5G9.
PhylomeDBiQ96QZ0.
TreeFamiTF333142.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAHTAAEY MLSDALLPDR RGPRLKGLRL ELPLDRIVKF VAVGSPLLLM
60 70 80 90 100
SLAFAQEFSS GSPISCFSPS NFSIRQAAYV DSSCWDSLLH HKQDGPGQDK
110 120 130 140 150
MKSLWPHKAL PYSLLALALL MYLPVLLWQY AAVPALSSDL LFIISELDKS
160 170 180 190 200
YNRSIRLVQH MLKIRQKSSD PYVFWNELEK ARKERYFEFP LLERYLACKQ
210 220 230 240 250
RSHSLVATYL LRNSLLLIFT SATYLYLGHF HLDVFFQEEF SCSIKTGLLS
260 270 280 290 300
DETHVPNLIT CRLTSLSIFQ IVSLSSVAIY TILVPVIIYN LTRLCRWDKR
310 320 330 340 350
LLSVYEMLPA FDLLSRKMLG CPINDLNVIL LFLRANISEL ISFSWLSVLC
360 370 380 390
VLKDTTTQKH NIDTVVDFMT LLAGLEPSKP KHLTNSACDE HP
Length:392
Mass (Da):44,683
Last modified:December 1, 2001 - v1
Checksum:i8988F5DCC6E1B050
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951G → R.
Corresponds to variant rs34498516 [ dbSNP | Ensembl ].
VAR_034367
Natural varianti208 – 2081T → A.
Corresponds to variant rs35569094 [ dbSNP | Ensembl ].
VAR_034368

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406650 mRNA. Translation: AAK95655.1.
CCDSiCCDS8447.1.
RefSeqiNP_443191.1. NM_052959.2.
UniGeneiHs.99235.

Genome annotation databases

EnsembliENST00000284288; ENSP00000284288; ENSG00000154143.
GeneIDi116337.
KEGGihsa:116337.
UCSCiuc001qah.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Pannexin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406650 mRNA. Translation: AAK95655.1.
CCDSiCCDS8447.1.
RefSeqiNP_443191.1. NM_052959.2.
UniGeneiHs.99235.

3D structure databases

ProteinModelPortaliQ96QZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125498. 1 interaction.
IntActiQ96QZ0. 1 interaction.
STRINGi9606.ENSP00000284288.

Protein family/group databases

TCDBi1.A.25.2.3. the gap junction-forming innexin (innexin) family.

PTM databases

iPTMnetiQ96QZ0.
PhosphoSiteiQ96QZ0.

Polymorphism and mutation databases

BioMutaiPANX3.
DMDMi20139071.

Proteomic databases

EPDiQ96QZ0.
PaxDbiQ96QZ0.
PRIDEiQ96QZ0.

Protocols and materials databases

DNASUi116337.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284288; ENSP00000284288; ENSG00000154143.
GeneIDi116337.
KEGGihsa:116337.
UCSCiuc001qah.4. human.

Organism-specific databases

CTDi116337.
GeneCardsiPANX3.
HGNCiHGNC:20573. PANX3.
MIMi608422. gene.
neXtProtiNX_Q96QZ0.
PharmGKBiPA134920643.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE65. Eukaryota.
ENOG410ZSQN. LUCA.
GeneTreeiENSGT00390000009703.
HOGENOMiHOG000063721.
HOVERGENiHBG053497.
InParanoidiQ96QZ0.
KOiK03443.
OMAiKMFPYSL.
OrthoDBiEOG74N5G9.
PhylomeDBiQ96QZ0.
TreeFamiTF333142.

Miscellaneous databases

GenomeRNAii116337.
PROiQ96QZ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ96QZ0.
CleanExiHS_PANX3.
GenevisibleiQ96QZ0. HS.

Family and domain databases

InterProiIPR000990. Innexin.
[Graphical view]
PfamiPF00876. Innexin. 1 hit.
[Graphical view]
PROSITEiPS51013. PANNEXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPANX3_HUMAN
AccessioniPrimary (citable) accession number: Q96QZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.