DJ576K7.1 (FK506 binding protein 12-rapamycin associated protein 1)

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Unreviewed, UniProtKB/TrEMBL Q96QW8 (Q96QW8_HUMAN)

Last modified January 19, 2010. Version 55. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
DJ576K7.1 (FK506 binding protein 12-rapamycin associated protein 1) EMBL CAC42395.1

Gene names

Name:

FRAP1 EMBL CAC42395.1

Organism

Homo sapiens (Human) EMBL CAC42395.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	895 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Sequence similarities

Contains 1 PI3K/PI4K domain.

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Ontologies

Keywords
Molecular function	Kinase Spearmint SPM000403 Transferase
Gene Ontology (GO)
Biological process	germ cell development Inferred from electronic annotation. Source: Compara negative regulation of cell size Inferred from electronic annotation. Source: Compara negative regulation of macroautophagy Inferred from electronic annotation. Source: Compara peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of actin filament polymerization Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of lamellipodium assembly Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of stress fiber assembly Inferred from electronic annotation. Source: Compara positive regulation of translation Inferred from electronic annotation. Source: Compara protein amino acid autophosphorylation Inferred from electronic annotation. Source: Compara regulation of Rac GTPase activity Inferred from electronic annotation. Source: Compara regulation of carbohydrate utilization Inferred from electronic annotation. Source: Compara regulation of fatty acid beta-oxidation Inferred from electronic annotation. Source: Compara regulation of glycogen biosynthetic process Inferred from electronic annotation. Source: Compara regulation of protein kinase activity Inferred from electronic annotation. Source: Compara regulation of response to food Inferred from electronic annotation. Source: Compara response to amino acid stimulus Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara ruffle organization Inferred from electronic annotation. Source: Compara
Cellular component	TORC1 complex Inferred from electronic annotation. Source: Compara TORC2 complex Inferred from electronic annotation. Source: Compara cell soma Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara soluble fraction Inferred from electronic annotation. Source: Compara
Molecular function	drug binding Inferred from electronic annotation. Source: Compara protein binding Inferred from electronic annotation. Source: Compara protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

EMBL CAC42395.1

Non-terminal residue

895

EMBL CAC42395.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q96QW8-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 93D61DB2396815A3
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FASTA

895

102,975

        10         20         30         40         50         60 
EIQATWYEKL HEWEDALVAY DKKMDTNKDD PELMLGRMRC LEALGEWGQL HQQCCEKWTL 

        70         80         90        100        110        120 
VNDETQAKMA RMAAAAAWGL GQWDSMEEYT CMIPRDTHDG AFYRAVLALH QDLFSLAQQC 

       130        140        150        160        170        180 
IDKARDLLDA ELTAMAGESY SRAYGAMVSC HMLSELEEVI QYKLVPERRE IIRQIWWERL 

       190        200        210        220        230        240 
QGCQRIVEDW QKILMVRSLV VSPHEDMRTW LKYASLCGKS GRLALAHKTL VLLLGVDPSR 

       250        260        270        280        290        300 
QLDHPLPTVH PQVTYAYMKN MWKSARKIDA FQHMQHFVQT MQQQAQHAIA TEDQQHKQEL 

       310        320        330        340        350        360 
HKLMARCFLK LGEWQLNLQG INESTIPKVL QYYSAATEHD RSWYKAWHAW AVMNFEAVLH 

       370        380        390        400        410        420 
YKHQNQARDE KKKLRHASGA NITNATTAAT TAATATTTAS TEGSNSESEA ESTENSPTPS 

       430        440        450        460        470        480 
PLQKKVTEDL SKTLLMYTVP AVQGFFRSIS LSRGNNLQDT LRVLTLWFDY GHWPDVNEAL 

       490        500        510        520        530        540 
VEGVKAIQID TWLQVIPQLI ARIDTPRPLV GRLIHQLLTD IGRYHPQALI YPLTVASKST 

       550        560        570        580        590        600 
TTARHNAANK ILKNMCEHSN TLVQQAMMVS EELIRVAILW HEMWHEGLEE ASRLYFGERN 

       610        620        630        640        650        660 
VKGMFEVLEP LHAMMERGPQ TLKETSFNQA YGRDLMEAQE WCRKYMKSGN VKDLTQAWDL 

       670        680        690        700        710        720 
YYHVFRRISK QLPQLTSLEL QYVSPKLLMC RDLELAVPGT YDPNQPIIRI QSIAPSLQVI 

       730        740        750        760        770        780 
TSKQRPRKLT LMGSNGHEFV FLLKGHEDLR QDERVMQLFG LVNTLLANDP TSLRKNLSIQ 

       790        800        810        820        830        840 
RYAVIPLSTN SGLIGWVPHC DTLHALIRDY REKKKILLNI EHRIMLRMAP DYDHLTLMQK 

       850        860        870        880        890 
VEVFEHAVNN TAGDDLAKLL WLKSPSSEVW FDRRTNYTRS LAVMSMVGYI LGLGD

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References

[1]	Hall R. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AL359082 Genomic DNA. Translation: CAC42395.1.
IPI	IPI00031410.
UniGene	Hs.338207
3D structure databases
HSSP	HSSP built from PDB template 1FAP based on UniProtKB P42345.
SMR	Q96QW8. Positions 572-671.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96QW8.
Genome annotation databases
Ensembl	ENST00000361445; ENSP00000354558; ENSG00000198793; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:3942. FRAP1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96QW8.
Gene expression databases
ArrayExpress	Q96QW8.
Bgee	Q96QW8.
Family and domain databases
InterPro	IPR009076. FKBP_rapamycin-assoc_FKBP12-bd. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR003151. PIK-rel_kinase_FAT. IPR014009. PIK_FAT. [Graphical view]
Gene3D	G3DSA:1.20.120.150. FRAP_FKBP12_bd. 1 hit. G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
Pfam	PF02259. FAT. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. PF08771. Rapamycin_bind. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
PROSITE	PS51189. FAT. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

Q96QW8_HUMAN

Accession

Primary (citable) accession number: Q96QW8

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information