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Protein
Submitted name:

DJ576K7.1 (FK506 binding protein 12-rapamycin associated protein 1)

Gene

FRAP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
DJ576K7.1 (FK506 binding protein 12-rapamycin associated protein 1)Imported
Gene namesi
Name:FRAP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ96QW8.
PeptideAtlasiQ96QW8.

Structurei

3D structure databases

ProteinModelPortaliQ96QW8.
SMRiQ96QW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 539FATInterPro annotationAdd BLAST539
Domaini739 – 895PI3K/PI4KInterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.20.120.150. 1 hit.
1.25.10.10. 1 hit.
1.25.40.10. 2 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR009076. FRB_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR026683. TOR.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR11139:SF85. PTHR11139:SF85. 1 hit.
PfamiView protein in Pfam
PF02259. FAT. 1 hit.
PF08771. FRB_dom. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
SMARTiView protein in SMART
SM00146. PI3Kc. 1 hit.
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS51189. FAT. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q96QW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EIQATWYEKL HEWEDALVAY DKKMDTNKDD PELMLGRMRC LEALGEWGQL
60 70 80 90 100
HQQCCEKWTL VNDETQAKMA RMAAAAAWGL GQWDSMEEYT CMIPRDTHDG
110 120 130 140 150
AFYRAVLALH QDLFSLAQQC IDKARDLLDA ELTAMAGESY SRAYGAMVSC
160 170 180 190 200
HMLSELEEVI QYKLVPERRE IIRQIWWERL QGCQRIVEDW QKILMVRSLV
210 220 230 240 250
VSPHEDMRTW LKYASLCGKS GRLALAHKTL VLLLGVDPSR QLDHPLPTVH
260 270 280 290 300
PQVTYAYMKN MWKSARKIDA FQHMQHFVQT MQQQAQHAIA TEDQQHKQEL
310 320 330 340 350
HKLMARCFLK LGEWQLNLQG INESTIPKVL QYYSAATEHD RSWYKAWHAW
360 370 380 390 400
AVMNFEAVLH YKHQNQARDE KKKLRHASGA NITNATTAAT TAATATTTAS
410 420 430 440 450
TEGSNSESEA ESTENSPTPS PLQKKVTEDL SKTLLMYTVP AVQGFFRSIS
460 470 480 490 500
LSRGNNLQDT LRVLTLWFDY GHWPDVNEAL VEGVKAIQID TWLQVIPQLI
510 520 530 540 550
ARIDTPRPLV GRLIHQLLTD IGRYHPQALI YPLTVASKST TTARHNAANK
560 570 580 590 600
ILKNMCEHSN TLVQQAMMVS EELIRVAILW HEMWHEGLEE ASRLYFGERN
610 620 630 640 650
VKGMFEVLEP LHAMMERGPQ TLKETSFNQA YGRDLMEAQE WCRKYMKSGN
660 670 680 690 700
VKDLTQAWDL YYHVFRRISK QLPQLTSLEL QYVSPKLLMC RDLELAVPGT
710 720 730 740 750
YDPNQPIIRI QSIAPSLQVI TSKQRPRKLT LMGSNGHEFV FLLKGHEDLR
760 770 780 790 800
QDERVMQLFG LVNTLLANDP TSLRKNLSIQ RYAVIPLSTN SGLIGWVPHC
810 820 830 840 850
DTLHALIRDY REKKKILLNI EHRIMLRMAP DYDHLTLMQK VEVFEHAVNN
860 870 880 890
TAGDDLAKLL WLKSPSSEVW FDRRTNYTRS LAVMSMVGYI LGLGD
Length:895
Mass (Da):102,975
Last modified:December 1, 2001 - v1
Checksum:i93D61DB2396815A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei895Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359082 Genomic DNA. Translation: CAC42395.1.
UniGeneiHs.338207.

Similar proteinsi

Entry informationi

Entry nameiQ96QW8_HUMAN
AccessioniPrimary (citable) accession number: Q96QW8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.