Q96QU8 (XPO6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exportin-6
Short name=Exp6

Alternative name(s):
Ran-binding protein 20

Gene names

Name:	XPO6
Synonyms:	KIAA0370, RANBP20

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1125 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. Ref.1
Subunit structure	Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner. Ref.1
Subcellular location	Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm.
Sequence similarities	Belongs to the exportin family. Contains 1 importin N-terminal domain.
Sequence caution	The sequence BAA20825.3 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein export from nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Cellular component	cytoplasm Inferred by curator Ref.1. Source: UniProtKB nucleolus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: UniProtKB protein transporter activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1125	1125	Exportin-6		PRO_0000235301
Regions
	Domain	31 – 97	67	Importin N-terminal
Amino acid modifications
	Modified residue	199	1	Phosphoserine Ref.11
	Modified residue	201	1	Phosphothreonine Ref.11
	Modified residue	204	1	Phosphothreonine Ref.7 Ref.8 Ref.9 Ref.10 Ref.11
	Modified residue	208	1	Phosphoserine Ref.7 Ref.10
	Modified residue	210	1	Phosphothreonine Ref.8 Ref.9
	Modified residue	214	1	Phosphoserine Ref.7
	Modified residue	224	1	Phosphoserine Ref.8 Ref.9 Ref.11
Natural variations
	Natural variant	1029	1	V → L. Corresponds to variant rs14672 [ dbSNP | Ensembl ].		VAR_048961
Experimental info
	Sequence conflict	378 – 379	2	FV → L in AAI08287. Ref.5
	Sequence conflict	811	1	Y → H in AAH78674. Ref.5
	Sequence conflict	891	1	K → R in BAD96763. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q96QU8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 753D5F815EC110A2	FASTA	1,125	128,883
	10 20 30 40 50 60 MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QIGAWRFCLY FLSSTRNDYV 70 80 90 100 110 120 MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK TLPYFIRNKL CKVIVDIGRQ 130 140 150 160 170 180 DWPMFYHDFF TNILQLIQSP VTTPLGLIML KTTSEELACP REDLSVARKE ELRKLLLDQV 190 200 210 220 230 240 QTVLGLLTGI LETVWDKHSV TAATPPPSPT SGESGDLLSN LLQSPSSAKL LNQPIPILDV 250 260 270 280 290 300 ESEYICSLAL ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDIRARKMA SVNGSSQNCV 310 320 330 340 350 360 SGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD NNAHTVKSRL 370 380 390 400 410 420 EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL LFKYTFHQPT HEGYFSCLDI 430 440 450 460 470 480 WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL VLLLTEVLNR IQFRYNQAQL EELDDETLDD 490 500 510 520 530 540 DQQTEWQRYL RQSLEVVAKV MELLPTHAFS TLFPVLQDNL EVYLGLQQFI VTSGSGHRLN 550 560 570 580 590 600 ITAENDCRRL HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI 610 620 630 640 650 660 KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCS EVHRQNTQQF VTLISTTMDA 670 680 690 700 710 720 ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ KVFNRITDAS ALRLVDKAQV 730 740 750 760 770 780 LVCRALSNIL LLPWPNLPEN EQQWPVRSIN HASLISALSR DYRNLKPSAV APQRKMPLDD 790 800 810 820 830 840 TKLIIHQTLS VLEDIVENIS GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS 850 860 870 880 890 900 FFLTLFRGLR VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV 910 920 930 940 950 960 QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW RYFFKSTVLA 970 980 990 1000 1010 1020 SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL FYLETLNTKQ KLYHKKIFRT 1030 1040 1050 1060 1070 1080 AMLFQFVNVL LQVLVHKSHD LLQEEIGIAI YNMASVDFDG FFAAFLPEFL TSCDGVDANQ 1090 1100 1110 1120 KSVLGRNFKM DRDLPSFTQN VHRLVNDLRY YRLCNDSLPP GTVKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes." Stueven T., Hartmann E., Goerlich D. EMBO J. 22:5928-5940(2003) [PubMed: 14592989] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN ACTIN AND PROFILIN-ACTIN COMPLEXES EXPORT, IDENTIFICATION IN A COMPLEX WITH RAN; ACTB AND PFN1, INTERACTION WITH ACTB. Tissue: Cervix carcinoma.
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Choriocarcinoma, Skin and Testis.
[6]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 715-1125. Tissue: Thyroid.
[7]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-204; THR-204; SER-208 AND SER-214, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-204; THR-210 AND SER-224, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-204; THR-210 AND SER-224, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-204 AND SER-208, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199; THR-201; THR-204 AND SER-224, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY026388 mRNA. Translation: AAK01471.1. AB002368 mRNA. Translation: BAA20825.3. Different initiation. CH471145 Genomic DNA. Translation: EAW55739.1. BC004403 mRNA. Translation: AAH04403.1. BC014071 mRNA. Translation: AAH14071.2. BC078674 mRNA. Translation: AAH78674.1. BC108286 mRNA. Translation: AAI08287.1. BC130304 mRNA. Translation: AAI30305.1. AK223043 mRNA. Translation: BAD96763.1.
IPI	IPI00465296.
RefSeq	NP_055986.1. NM_015171.2.
UniGene	Hs.460468.
3D structure databases
ProteinModelPortal	Q96QU8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96QU8. 1 interaction.
MINT	MINT-1452541.
STRING	Q96QU8.
PTM databases
PhosphoSite	Q96QU8.
Polymorphism databases
DMDM	74724278.
Proteomic databases
PRIDE	Q96QU8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304658; ENSP00000302790; ENSG00000169180.
GeneID	23214.
KEGG	hsa:23214.
UCSC	uc002dpa.1. human.
Organism-specific databases
CTD	23214.
GeneCards	GC16M028016.
H-InvDB	HIX0012918.
HGNC	HGNC:19733. XPO6.
HPA	HPA038246.
MIM	608411. gene.
neXtProt	NX_Q96QU8.
PharmGKB	PA134989996.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000002810.
HOVERGEN	HBG054104.
InParanoid	Q96QU8.
OMA	SQDKMEI.
OrthoDB	EOG4D7Z4W.
PhylomeDB	Q96QU8.
Gene expression databases
ArrayExpress	Q96QU8.
Bgee	Q96QU8.
CleanEx	HS_XPO6.
Genevestigator	Q96QU8.
GermOnline	ENSG00000169180. Homo sapiens.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR013598. Exportin-1/Importin-b-like. IPR001494. Importin-beta_N. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 5 hits.
Pfam	PF03810. IBN_N. 1 hit. PF08389. Xpo1. 1 hit. [Graphical view]
SMART	SM00913. IBN_N. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50166. IMPORTIN_B_NT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	44775.
SOURCE	Search...

Entry information

Entry name

XPO6_HUMAN

Accession

Primary (citable) accession number: Q96QU8
Secondary accession number(s): A1L3W4 , Q2YDX3, Q53G88, Q68G50, Q76N88, Q96CP8, Q9BT21

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.