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Protein

Exportin-6

Gene

XPO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.1 Publication

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • protein export from nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-6
Short name:
Exp6
Alternative name(s):
Ran-binding protein 20
Gene namesi
Name:XPO6
Synonyms:KIAA0370, RANBP20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19733. XPO6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23214.
OpenTargetsiENSG00000169180.
PharmGKBiPA134989996.

Polymorphism and mutation databases

DMDMi74724278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002353012 – 1125Exportin-6Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei199PhosphoserineBy similarity1
Modified residuei201PhosphothreonineCombined sources1
Modified residuei204PhosphothreonineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96QU8.
MaxQBiQ96QU8.
PaxDbiQ96QU8.
PeptideAtlasiQ96QU8.
PRIDEiQ96QU8.

PTM databases

iPTMnetiQ96QU8.
PhosphoSitePlusiQ96QU8.

Expressioni

Gene expression databases

BgeeiENSG00000169180.
CleanExiHS_XPO6.
ExpressionAtlasiQ96QU8. baseline and differential.
GenevisibleiQ96QU8. HS.

Organism-specific databases

HPAiHPA038246.

Interactioni

Subunit structurei

Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP62P371983EBI-10293124,EBI-347978

Protein-protein interaction databases

BioGridi116821. 39 interactors.
IntActiQ96QU8. 4 interactors.
MINTiMINT-1452541.
STRINGi9606.ENSP00000302790.

Structurei

3D structure databases

ProteinModelPortaliQ96QU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 97Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2020. Eukaryota.
COG5101. LUCA.
GeneTreeiENSGT00390000002810.
HOVERGENiHBG054104.
InParanoidiQ96QU8.
OMAiEYVMMYS.
OrthoDBiEOG091G040W.
PhylomeDBiQ96QU8.
TreeFamiTF323443.

Family and domain databases

Gene3Di1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96QU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QIGAWRFCLY
60 70 80 90 100
FLSSTRNDYV MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK
110 120 130 140 150
TLPYFIRNKL CKVIVDIGRQ DWPMFYHDFF TNILQLIQSP VTTPLGLIML
160 170 180 190 200
KTTSEELACP REDLSVARKE ELRKLLLDQV QTVLGLLTGI LETVWDKHSV
210 220 230 240 250
TAATPPPSPT SGESGDLLSN LLQSPSSAKL LNQPIPILDV ESEYICSLAL
260 270 280 290 300
ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDIRARKMA SVNGSSQNCV
310 320 330 340 350
SGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD
360 370 380 390 400
NNAHTVKSRL EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL
410 420 430 440 450
LFKYTFHQPT HEGYFSCLDI WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL
460 470 480 490 500
VLLLTEVLNR IQFRYNQAQL EELDDETLDD DQQTEWQRYL RQSLEVVAKV
510 520 530 540 550
MELLPTHAFS TLFPVLQDNL EVYLGLQQFI VTSGSGHRLN ITAENDCRRL
560 570 580 590 600
HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI
610 620 630 640 650
KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCS EVHRQNTQQF
660 670 680 690 700
VTLISTTMDA ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ
710 720 730 740 750
KVFNRITDAS ALRLVDKAQV LVCRALSNIL LLPWPNLPEN EQQWPVRSIN
760 770 780 790 800
HASLISALSR DYRNLKPSAV APQRKMPLDD TKLIIHQTLS VLEDIVENIS
810 820 830 840 850
GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS FFLTLFRGLR
860 870 880 890 900
VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV
910 920 930 940 950
QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW
960 970 980 990 1000
RYFFKSTVLA SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL
1010 1020 1030 1040 1050
FYLETLNTKQ KLYHKKIFRT AMLFQFVNVL LQVLVHKSHD LLQEEIGIAI
1060 1070 1080 1090 1100
YNMASVDFDG FFAAFLPEFL TSCDGVDANQ KSVLGRNFKM DRDLPSFTQN
1110 1120
VHRLVNDLRY YRLCNDSLPP GTVKL
Length:1,125
Mass (Da):128,883
Last modified:December 1, 2001 - v1
Checksum:i753D5F815EC110A2
GO
Isoform 2 (identifier: Q96QU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Show »
Length:1,111
Mass (Da):127,394
Checksum:iEF0366D01A789C85
GO

Sequence cautioni

The sequence BAA20825 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti378 – 379FV → L in AAI08287 (PubMed:15489334).Curated2
Sequence conflicti811Y → H in AAH78674 (PubMed:15489334).Curated1
Sequence conflicti891K → R in BAD96763 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0489611029V → L.Corresponds to variant rs14672dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557561 – 14Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026388 mRNA. Translation: AAK01471.1.
AB002368 mRNA. Translation: BAA20825.3. Different initiation.
AK123846 mRNA. No translation available.
AC136611 Genomic DNA. No translation available.
CH471145 Genomic DNA. Translation: EAW55736.1.
CH471145 Genomic DNA. Translation: EAW55738.1.
CH471145 Genomic DNA. Translation: EAW55739.1.
BC004403 mRNA. Translation: AAH04403.1.
BC014071 mRNA. Translation: AAH14071.2.
BC078674 mRNA. Translation: AAH78674.1.
BC108286 mRNA. Translation: AAI08287.1.
BC130304 mRNA. Translation: AAI30305.1.
AK223043 mRNA. Translation: BAD96763.1.
CCDSiCCDS42135.1. [Q96QU8-1]
CCDS59266.1. [Q96QU8-2]
RefSeqiNP_001257869.1. NM_001270940.1. [Q96QU8-2]
NP_055986.1. NM_015171.3. [Q96QU8-1]
UniGeneiHs.460468.

Genome annotation databases

EnsembliENST00000304658; ENSP00000302790; ENSG00000169180. [Q96QU8-1]
ENST00000565698; ENSP00000457341; ENSG00000169180. [Q96QU8-2]
GeneIDi23214.
KEGGihsa:23214.
UCSCiuc002dpa.4. human. [Q96QU8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026388 mRNA. Translation: AAK01471.1.
AB002368 mRNA. Translation: BAA20825.3. Different initiation.
AK123846 mRNA. No translation available.
AC136611 Genomic DNA. No translation available.
CH471145 Genomic DNA. Translation: EAW55736.1.
CH471145 Genomic DNA. Translation: EAW55738.1.
CH471145 Genomic DNA. Translation: EAW55739.1.
BC004403 mRNA. Translation: AAH04403.1.
BC014071 mRNA. Translation: AAH14071.2.
BC078674 mRNA. Translation: AAH78674.1.
BC108286 mRNA. Translation: AAI08287.1.
BC130304 mRNA. Translation: AAI30305.1.
AK223043 mRNA. Translation: BAD96763.1.
CCDSiCCDS42135.1. [Q96QU8-1]
CCDS59266.1. [Q96QU8-2]
RefSeqiNP_001257869.1. NM_001270940.1. [Q96QU8-2]
NP_055986.1. NM_015171.3. [Q96QU8-1]
UniGeneiHs.460468.

3D structure databases

ProteinModelPortaliQ96QU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116821. 39 interactors.
IntActiQ96QU8. 4 interactors.
MINTiMINT-1452541.
STRINGi9606.ENSP00000302790.

PTM databases

iPTMnetiQ96QU8.
PhosphoSitePlusiQ96QU8.

Polymorphism and mutation databases

DMDMi74724278.

Proteomic databases

EPDiQ96QU8.
MaxQBiQ96QU8.
PaxDbiQ96QU8.
PeptideAtlasiQ96QU8.
PRIDEiQ96QU8.

Protocols and materials databases

DNASUi23214.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304658; ENSP00000302790; ENSG00000169180. [Q96QU8-1]
ENST00000565698; ENSP00000457341; ENSG00000169180. [Q96QU8-2]
GeneIDi23214.
KEGGihsa:23214.
UCSCiuc002dpa.4. human. [Q96QU8-1]

Organism-specific databases

CTDi23214.
DisGeNETi23214.
GeneCardsiXPO6.
HGNCiHGNC:19733. XPO6.
HPAiHPA038246.
MIMi608411. gene.
neXtProtiNX_Q96QU8.
OpenTargetsiENSG00000169180.
PharmGKBiPA134989996.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2020. Eukaryota.
COG5101. LUCA.
GeneTreeiENSGT00390000002810.
HOVERGENiHBG054104.
InParanoidiQ96QU8.
OMAiEYVMMYS.
OrthoDBiEOG091G040W.
PhylomeDBiQ96QU8.
TreeFamiTF323443.

Miscellaneous databases

ChiTaRSiXPO6. human.
GeneWikiiXPO6.
GenomeRNAii23214.
PROiQ96QU8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169180.
CleanExiHS_XPO6.
ExpressionAtlasiQ96QU8. baseline and differential.
GenevisibleiQ96QU8. HS.

Family and domain databases

Gene3Di1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXPO6_HUMAN
AccessioniPrimary (citable) accession number: Q96QU8
Secondary accession number(s): A1L3W4
, D3DWF9, Q2YDX3, Q53G88, Q68G50, Q76N88, Q96CP8, Q9BT21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.