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Protein

Exportin-6

Gene

XPO6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.1 Publication

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB
  • Ran GTPase binding Source: InterPro

GO - Biological processi

  • protein export from nucleus Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-6
Short name:
Exp6
Alternative name(s):
Ran-binding protein 20
Gene namesi
Name:XPO6
Synonyms:KIAA0370, RANBP20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169180.11
HGNCiHGNC:19733 XPO6
MIMi608411 gene
neXtProtiNX_Q96QU8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23214
OpenTargetsiENSG00000169180
PharmGKBiPA134989996

Polymorphism and mutation databases

DMDMi74724278

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002353012 – 1125Exportin-6Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei199PhosphoserineBy similarity1
Modified residuei201PhosphothreonineCombined sources1
Modified residuei204PhosphothreonineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96QU8
MaxQBiQ96QU8
PaxDbiQ96QU8
PeptideAtlasiQ96QU8
PRIDEiQ96QU8
ProteomicsDBi77908

PTM databases

CarbonylDBiQ96QU8
iPTMnetiQ96QU8
PhosphoSitePlusiQ96QU8

Expressioni

Gene expression databases

BgeeiENSG00000169180
CleanExiHS_XPO6
ExpressionAtlasiQ96QU8 baseline and differential
GenevisibleiQ96QU8 HS

Organism-specific databases

HPAiHPA038246

Interactioni

Subunit structurei

Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP62P371983EBI-10293124,EBI-347978

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116821, 50 interactors
IntActiQ96QU8, 5 interactors
MINTiQ96QU8
STRINGi9606.ENSP00000302790

Structurei

3D structure databases

ProteinModelPortaliQ96QU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 97Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000002810
HOVERGENiHBG054104
InParanoidiQ96QU8
OMAiWQRYLRQ
OrthoDBiEOG091G040W
PhylomeDBiQ96QU8
TreeFamiTF323443

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 6 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96QU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEEASLRA LESLMTEFFH DCTTNERKRE IEELLNNFAQ QIGAWRFCLY
60 70 80 90 100
FLSSTRNDYV MMYSLTVFEN LINKMWLGVP SQDKMEIRSC LPKLLLAHHK
110 120 130 140 150
TLPYFIRNKL CKVIVDIGRQ DWPMFYHDFF TNILQLIQSP VTTPLGLIML
160 170 180 190 200
KTTSEELACP REDLSVARKE ELRKLLLDQV QTVLGLLTGI LETVWDKHSV
210 220 230 240 250
TAATPPPSPT SGESGDLLSN LLQSPSSAKL LNQPIPILDV ESEYICSLAL
260 270 280 290 300
ECLAHLFSWI PLSASITPSL LTTIFHFARF GCDIRARKMA SVNGSSQNCV
310 320 330 340 350
SGQERGRLGV LAMSCINELM SKNCVPMEFE EYLLRMFQQT FYLLQKITKD
360 370 380 390 400
NNAHTVKSRL EELDESYIEK FTDFLRLFVS VHLRRIESYS QFPVVEFLTL
410 420 430 440 450
LFKYTFHQPT HEGYFSCLDI WTLFLDYLTS KIKSRLGDKE AVLNRYEDAL
460 470 480 490 500
VLLLTEVLNR IQFRYNQAQL EELDDETLDD DQQTEWQRYL RQSLEVVAKV
510 520 530 540 550
MELLPTHAFS TLFPVLQDNL EVYLGLQQFI VTSGSGHRLN ITAENDCRRL
560 570 580 590 600
HCSLRDLSSL LQAVGRLAEY FIGDVFAARF NDALTVVERL VKVTLYGSQI
610 620 630 640 650
KLYNIETAVP SVLKPDLIDV HAQSLAALQA YSHWLAQYCS EVHRQNTQQF
660 670 680 690 700
VTLISTTMDA ITPLISTKVQ DKLLLSACHL LVSLATTVRP VFLISIPAVQ
710 720 730 740 750
KVFNRITDAS ALRLVDKAQV LVCRALSNIL LLPWPNLPEN EQQWPVRSIN
760 770 780 790 800
HASLISALSR DYRNLKPSAV APQRKMPLDD TKLIIHQTLS VLEDIVENIS
810 820 830 840 850
GESTKSRQIC YQSLQESVQV SLALFPAFIH QSDVTDEMLS FFLTLFRGLR
860 870 880 890 900
VQMGVPFTEQ IIQTFLNMFT REQLAESILH EGSTGCRVVE KFLKILQVVV
910 920 930 940 950
QEPGQVFKPF LPSIIALCME QVYPIIAERP SPDVKAELFE LLFRTLHHNW
960 970 980 990 1000
RYFFKSTVLA SVQRGIAEEQ MENEPQFSAI MQAFGQSFLQ PDIHLFKQNL
1010 1020 1030 1040 1050
FYLETLNTKQ KLYHKKIFRT AMLFQFVNVL LQVLVHKSHD LLQEEIGIAI
1060 1070 1080 1090 1100
YNMASVDFDG FFAAFLPEFL TSCDGVDANQ KSVLGRNFKM DRDLPSFTQN
1110 1120
VHRLVNDLRY YRLCNDSLPP GTVKL
Length:1,125
Mass (Da):128,883
Last modified:December 1, 2001 - v1
Checksum:i753D5F815EC110A2
GO
Isoform 2 (identifier: Q96QU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Show »
Length:1,111
Mass (Da):127,394
Checksum:iEF0366D01A789C85
GO

Sequence cautioni

The sequence BAA20825 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti378 – 379FV → L in AAI08287 (PubMed:15489334).Curated2
Sequence conflicti811Y → H in AAH78674 (PubMed:15489334).Curated1
Sequence conflicti891K → R in BAD96763 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0489611029V → L. Corresponds to variant dbSNP:rs14672Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557561 – 14Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026388 mRNA Translation: AAK01471.1
AB002368 mRNA Translation: BAA20825.3 Different initiation.
AK123846 mRNA No translation available.
AC136611 Genomic DNA No translation available.
CH471145 Genomic DNA Translation: EAW55736.1
CH471145 Genomic DNA Translation: EAW55738.1
CH471145 Genomic DNA Translation: EAW55739.1
BC004403 mRNA Translation: AAH04403.1
BC014071 mRNA Translation: AAH14071.2
BC078674 mRNA Translation: AAH78674.1
BC108286 mRNA Translation: AAI08287.1
BC130304 mRNA Translation: AAI30305.1
AK223043 mRNA Translation: BAD96763.1
CCDSiCCDS42135.1 [Q96QU8-1]
CCDS59266.1 [Q96QU8-2]
RefSeqiNP_001257869.1, NM_001270940.1 [Q96QU8-2]
NP_055986.1, NM_015171.3 [Q96QU8-1]
UniGeneiHs.460468

Genome annotation databases

EnsembliENST00000304658; ENSP00000302790; ENSG00000169180 [Q96QU8-1]
ENST00000565698; ENSP00000457341; ENSG00000169180 [Q96QU8-2]
GeneIDi23214
KEGGihsa:23214
UCSCiuc002dpa.4 human [Q96QU8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiXPO6_HUMAN
AccessioniPrimary (citable) accession number: Q96QU8
Secondary accession number(s): A1L3W4
, D3DWF9, Q2YDX3, Q53G88, Q68G50, Q76N88, Q96CP8, Q9BT21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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