Reviewed, UniProtKB/Swiss-Prot Q96QU6 (1A1L1_HUMAN)

Names and origin

Protein names

Recommended name:
    1-aminocyclopropane-1-carboxylate synthase-like protein 1
      Short name=ACC synthase-like protein

Gene names

Name:	ACCS
Synonyms:	PHACS

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine. Ref.1
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Caution	Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are necessary for activity. Ref.1

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Pyridoxal phosphate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Ref.1 Inferred from electronic annotation. Source: InterPro protein homodimerization activity Ref.1 Non-traceable author statement. Source: UniProtKB pyridoxal phosphate binding Ref.1 Non-traceable author statement. Source: UniProtKB transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	1-aminocyclopropane-1-carboxylate synthase-like protein 1		PRO_0000318071
Sites
	Binding site	105	1	Substrate By similarity
Amino acid modifications
	Modified residue	323	1	N6-(pyridoxal phosphate)lysine By similarity
Natural variations
	Natural variant	59	1	D → N: dbSNP rs33952257.		VAR_048227
	Natural variant	134	1	D → E: dbSNP rs2018795.		VAR_048228
	Natural variant	221	1	G → E in a breast cancer sample; somatic mutation. dbSNP rs35514614. Ref.5		VAR_038685
	Natural variant	393	1	S → L in a breast cancer sample; somatic mutation. Ref.5		VAR_038686
	Natural variant	421	1	P → L: dbSNP rs3107275. Ref.4		VAR_038687
Experimental info
	Sequence conflict	94	1	N → S in BAB71541. Ref.2
	Sequence conflict	410	1	F → L in BAB71541. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96QU6-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 62C99045F0BF8D5E	FASTA	501	57,324
	10 20 30 40 50 60 MFTLPQKDFR APTTCLGPTC MQDLGSSHGE DLEGECSRKL DQKLPELRGV GDPAMISSDT 70 80 90 100 110 120 SYLSSRGRMI KWFWDSAEEG YRTYHMDEYD EDKNPSGIIN LGTSENKLCF DLLSWRLSQR 130 140 150 160 170 180 DMQRVEPSLL QYADWRGHLF LREEVAKFLS FYCKSPVPLR PENVVVLNGG ASLFSALATV 190 200 210 220 230 240 LCEAGEAFLI PTPYYGAITQ HVCLYGNIRL AYVYLDSEVT GLDTRPFQLT VEKLEMALRE 250 260 270 280 290 300 AHSEGVKVKG LILISPQNPL GDVYSPEELQ EYLVFAKRHR LHVIVDEVYM LSVFEKSVGY 310 320 330 340 350 360 RSVLSLERLP DPQRTHVMWA TSKDFGMSGL RFGTLYTENQ DVATAVASLC RYHGLSGLVQ 370 380 390 400 410 420 YQMAQLLRDR DWINQVYLPE NHARLKAAHT YVSEELRALG IPFLSRGAGF FIWVDLRKYL 430 440 450 460 470 480 PKGTFEEEML LWRRFLDNKV LLSFGKAFEC KEPGWFRFVF SDQVHRLCLG MQRVQQVLAG 490 500 KSQVAEDPRP SQSQEPSDQR R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human cDNA for a homologue of the plant enzyme 1-aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity." Koch K.A., Capitani G., Gruetter M.G., Kirsch J.F. Gene 272:75-84(2001) [PubMed: 11470512] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Trachea.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-421. Tissue: Uterus.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-221 AND LEU-393.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY026508 mRNA. Translation: AAK11482.1. AK057649 mRNA. Translation: BAB71541.1. CH471064 Genomic DNA. Translation: EAW68072.1. BC020197 mRNA. Translation: AAH20197.1.
IPI	IPI00411817.
RefSeq	NP_001120691.1. NP_115981.1.
UniGene	Hs.126706
3D structure databases
HSSP	HSSP built from PDB template 1M4N based on UniProtKB P37821.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96QU6. 1 interaction.
STRING	Q96QU6.
Genome annotation databases
Ensembl	ENST00000263776; ENSP00000263776; ENSG00000110455; Homo sapiens. [Genome view] ENST00000448099; ENSP00000402569; ENSG00000110455; Homo sapiens. [Genome view]
GeneID	84680.
KEGG	hsa:84680.
UCSC	uc001mxx.2. human.
Organism-specific databases
CTD	84680.
GeneCards	GC11P044045.
HGNC	HGNC:23989. ACCS.
HPA	HPA018873. HPA021654.
MIM	608405. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96QU6.
OMA	PYYGAIT
OrthoDB	EOG9RNDVP
Gene expression databases
ArrayExpress	Q96QU6.
Bgee	Q96QU6.
CleanEx	HS_ACCS.
Genevestigator	Q96QU6.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase_major. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	74721.
SOURCE	Search...

Entry information

Entry name

1A1L1_HUMAN

Accession

Primary (citable) accession number: Q96QU6
Secondary accession number(s): Q8WUL4, Q96LX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 1, 2001
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.