Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

1-aminocyclopropane-1-carboxylate synthase-like protein 1

Gene

ACCS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105SubstrateBy similarity1

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • pyridoxal phosphate binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate synthase-like protein 1
Short name:
ACC synthase-like protein 1
Gene namesi
Name:ACCS
Synonyms:PHACS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110455.13.
HGNCiHGNC:23989. ACCS.

Pathology & Biotechi

Organism-specific databases

DisGeNETi84680.
OpenTargetsiENSG00000110455.
PharmGKBiPA162375284.

Chemistry databases

DrugBankiDB03214. Vinylglycine.

Polymorphism and mutation databases

BioMutaiACCS.
DMDMi74717198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003180711 – 5011-aminocyclopropane-1-carboxylate synthase-like protein 1Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei323N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiQ96QU6.
MaxQBiQ96QU6.
PaxDbiQ96QU6.
PeptideAtlasiQ96QU6.
PRIDEiQ96QU6.

PTM databases

iPTMnetiQ96QU6.
PhosphoSitePlusiQ96QU6.

Expressioni

Gene expression databases

BgeeiENSG00000110455.
CleanExiHS_ACCS.
ExpressionAtlasiQ96QU6. baseline and differential.
GenevisibleiQ96QU6. HS.

Organism-specific databases

HPAiHPA018873.
HPA021654.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi124199. 4 interactors.
IntActiQ96QU6. 3 interactors.
MINTiMINT-1470212.
STRINGi9606.ENSP00000263776.

Structurei

3D structure databases

ProteinModelPortaliQ96QU6.
SMRiQ96QU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0256. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00390000005703.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiQ96QU6.
OMAiPYYGAIT.
OrthoDBiEOG091G04H3.
PhylomeDBiQ96QU6.
TreeFamiTF354218.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiView protein in InterPro
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96QU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFTLPQKDFR APTTCLGPTC MQDLGSSHGE DLEGECSRKL DQKLPELRGV
60 70 80 90 100
GDPAMISSDT SYLSSRGRMI KWFWDSAEEG YRTYHMDEYD EDKNPSGIIN
110 120 130 140 150
LGTSENKLCF DLLSWRLSQR DMQRVEPSLL QYADWRGHLF LREEVAKFLS
160 170 180 190 200
FYCKSPVPLR PENVVVLNGG ASLFSALATV LCEAGEAFLI PTPYYGAITQ
210 220 230 240 250
HVCLYGNIRL AYVYLDSEVT GLDTRPFQLT VEKLEMALRE AHSEGVKVKG
260 270 280 290 300
LILISPQNPL GDVYSPEELQ EYLVFAKRHR LHVIVDEVYM LSVFEKSVGY
310 320 330 340 350
RSVLSLERLP DPQRTHVMWA TSKDFGMSGL RFGTLYTENQ DVATAVASLC
360 370 380 390 400
RYHGLSGLVQ YQMAQLLRDR DWINQVYLPE NHARLKAAHT YVSEELRALG
410 420 430 440 450
IPFLSRGAGF FIWVDLRKYL PKGTFEEEML LWRRFLDNKV LLSFGKAFEC
460 470 480 490 500
KEPGWFRFVF SDQVHRLCLG MQRVQQVLAG KSQVAEDPRP SQSQEPSDQR

R
Length:501
Mass (Da):57,324
Last modified:December 1, 2001 - v1
Checksum:i62C99045F0BF8D5E
GO
Isoform 2 (identifier: Q96QU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-158: LSQRDMQRVE...LSFYCKSPVP → PPGGSGQVPV...ALLCSGHGAV
     159-501: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):17,598
Checksum:i1194A3A818A0F5E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94N → S in BAB71541 (PubMed:14702039).Curated1
Sequence conflicti410F → L in BAB71541 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04822759D → N. Corresponds to variant dbSNP:rs33952257Ensembl.1
Natural variantiVAR_048228134D → E. Corresponds to variant dbSNP:rs2018795Ensembl.1
Natural variantiVAR_038685221G → E in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs35514614Ensembl.1
Natural variantiVAR_038686393S → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_038687421P → L1 PublicationCorresponds to variant dbSNP:rs3107275Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055800117 – 158LSQRD…KSPVP → PPGGSGQVPVFLLQEPSTPQ TRECGCPEWWCLALLCSGHG AV in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_055801159 – 501Missing in isoform 2. 1 PublicationAdd BLAST343

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026508 mRNA. Translation: AAK11482.1.
AK057649 mRNA. Translation: BAB71541.1.
AK304074 mRNA. Translation: BAG64981.1.
AC134775 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68072.1.
BC020197 mRNA. Translation: AAH20197.1.
CCDSiCCDS7907.1. [Q96QU6-1]
RefSeqiNP_001120691.1. NM_001127219.1. [Q96QU6-1]
NP_115981.1. NM_032592.3. [Q96QU6-1]
UniGeneiHs.126706.

Genome annotation databases

EnsembliENST00000263776; ENSP00000263776; ENSG00000110455. [Q96QU6-1]
GeneIDi84680.
KEGGihsa:84680.
UCSCiuc001mxx.3. human. [Q96QU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry namei1A1L1_HUMAN
AccessioniPrimary (citable) accession number: Q96QU6
Secondary accession number(s): B4E219, Q8WUL4, Q96LX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are necessary for activity.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families