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Protein

1-aminocyclopropane-1-carboxylate synthase-like protein 1

Gene

ACCS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051SubstrateBy similarity

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • protein homodimerization activity Source: UniProtKB
  • pyridoxal phosphate binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate synthase-like protein 1
Short name:
ACC synthase-like protein 1
Gene namesi
Name:ACCS
Synonyms:PHACS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23989. ACCS.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375284.

Polymorphism and mutation databases

BioMutaiACCS.
DMDMi74717198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5015011-aminocyclopropane-1-carboxylate synthase-like protein 1PRO_0000318071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei323 – 3231N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

EPDiQ96QU6.
MaxQBiQ96QU6.
PaxDbiQ96QU6.
PeptideAtlasiQ96QU6.
PRIDEiQ96QU6.

PTM databases

iPTMnetiQ96QU6.
PhosphoSiteiQ96QU6.

Expressioni

Gene expression databases

BgeeiQ96QU6.
CleanExiHS_ACCS.
ExpressionAtlasiQ96QU6. baseline and differential.
GenevisibleiQ96QU6. HS.

Organism-specific databases

HPAiHPA018873.
HPA021654.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UQCRBP149273EBI-743387,EBI-743128

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi124199. 4 interactions.
IntActiQ96QU6. 1 interaction.
MINTiMINT-1470212.
STRINGi9606.ENSP00000263776.

Structurei

3D structure databases

ProteinModelPortaliQ96QU6.
SMRiQ96QU6. Positions 80-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0256. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00390000005703.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiQ96QU6.
OMAiRIIPVEC.
PhylomeDBiQ96QU6.
TreeFamiTF354218.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96QU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFTLPQKDFR APTTCLGPTC MQDLGSSHGE DLEGECSRKL DQKLPELRGV
60 70 80 90 100
GDPAMISSDT SYLSSRGRMI KWFWDSAEEG YRTYHMDEYD EDKNPSGIIN
110 120 130 140 150
LGTSENKLCF DLLSWRLSQR DMQRVEPSLL QYADWRGHLF LREEVAKFLS
160 170 180 190 200
FYCKSPVPLR PENVVVLNGG ASLFSALATV LCEAGEAFLI PTPYYGAITQ
210 220 230 240 250
HVCLYGNIRL AYVYLDSEVT GLDTRPFQLT VEKLEMALRE AHSEGVKVKG
260 270 280 290 300
LILISPQNPL GDVYSPEELQ EYLVFAKRHR LHVIVDEVYM LSVFEKSVGY
310 320 330 340 350
RSVLSLERLP DPQRTHVMWA TSKDFGMSGL RFGTLYTENQ DVATAVASLC
360 370 380 390 400
RYHGLSGLVQ YQMAQLLRDR DWINQVYLPE NHARLKAAHT YVSEELRALG
410 420 430 440 450
IPFLSRGAGF FIWVDLRKYL PKGTFEEEML LWRRFLDNKV LLSFGKAFEC
460 470 480 490 500
KEPGWFRFVF SDQVHRLCLG MQRVQQVLAG KSQVAEDPRP SQSQEPSDQR

R
Length:501
Mass (Da):57,324
Last modified:December 1, 2001 - v1
Checksum:i62C99045F0BF8D5E
GO
Isoform 2 (identifier: Q96QU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-158: LSQRDMQRVE...LSFYCKSPVP → PPGGSGQVPV...ALLCSGHGAV
     159-501: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):17,598
Checksum:i1194A3A818A0F5E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941N → S in BAB71541 (PubMed:14702039).Curated
Sequence conflicti410 – 4101F → L in BAB71541 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591D → N.
Corresponds to variant rs33952257 [ dbSNP | Ensembl ].
VAR_048227
Natural varianti134 – 1341D → E.
Corresponds to variant rs2018795 [ dbSNP | Ensembl ].
VAR_048228
Natural varianti221 – 2211G → E in a breast cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs35514614 [ dbSNP | Ensembl ].
VAR_038685
Natural varianti393 – 3931S → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_038686
Natural varianti421 – 4211P → L.1 Publication
Corresponds to variant rs3107275 [ dbSNP | Ensembl ].
VAR_038687

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 15842LSQRD…KSPVP → PPGGSGQVPVFLLQEPSTPQ TRECGCPEWWCLALLCSGHG AV in isoform 2. 1 PublicationVSP_055800Add
BLAST
Alternative sequencei159 – 501343Missing in isoform 2. 1 PublicationVSP_055801Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026508 mRNA. Translation: AAK11482.1.
AK057649 mRNA. Translation: BAB71541.1.
AK304074 mRNA. Translation: BAG64981.1.
AC134775 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68072.1.
BC020197 mRNA. Translation: AAH20197.1.
CCDSiCCDS7907.1. [Q96QU6-1]
RefSeqiNP_001120691.1. NM_001127219.1. [Q96QU6-1]
NP_115981.1. NM_032592.3. [Q96QU6-1]
UniGeneiHs.126706.

Genome annotation databases

EnsembliENST00000263776; ENSP00000263776; ENSG00000110455. [Q96QU6-1]
GeneIDi84680.
KEGGihsa:84680.
UCSCiuc001mxx.3. human. [Q96QU6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026508 mRNA. Translation: AAK11482.1.
AK057649 mRNA. Translation: BAB71541.1.
AK304074 mRNA. Translation: BAG64981.1.
AC134775 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68072.1.
BC020197 mRNA. Translation: AAH20197.1.
CCDSiCCDS7907.1. [Q96QU6-1]
RefSeqiNP_001120691.1. NM_001127219.1. [Q96QU6-1]
NP_115981.1. NM_032592.3. [Q96QU6-1]
UniGeneiHs.126706.

3D structure databases

ProteinModelPortaliQ96QU6.
SMRiQ96QU6. Positions 80-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124199. 4 interactions.
IntActiQ96QU6. 1 interaction.
MINTiMINT-1470212.
STRINGi9606.ENSP00000263776.

PTM databases

iPTMnetiQ96QU6.
PhosphoSiteiQ96QU6.

Polymorphism and mutation databases

BioMutaiACCS.
DMDMi74717198.

Proteomic databases

EPDiQ96QU6.
MaxQBiQ96QU6.
PaxDbiQ96QU6.
PeptideAtlasiQ96QU6.
PRIDEiQ96QU6.

Protocols and materials databases

DNASUi84680.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263776; ENSP00000263776; ENSG00000110455. [Q96QU6-1]
GeneIDi84680.
KEGGihsa:84680.
UCSCiuc001mxx.3. human. [Q96QU6-1]

Organism-specific databases

CTDi84680.
GeneCardsiACCS.
HGNCiHGNC:23989. ACCS.
HPAiHPA018873.
HPA021654.
MIMi608405. gene.
neXtProtiNX_Q96QU6.
PharmGKBiPA162375284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0256. Eukaryota.
COG0436. LUCA.
GeneTreeiENSGT00390000005703.
HOGENOMiHOG000033689.
HOVERGENiHBG055243.
InParanoidiQ96QU6.
OMAiRIIPVEC.
PhylomeDBiQ96QU6.
TreeFamiTF354218.

Miscellaneous databases

GenomeRNAii84680.
PROiQ96QU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96QU6.
CleanExiHS_ACCS.
ExpressionAtlasiQ96QU6. baseline and differential.
GenevisibleiQ96QU6. HS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human cDNA for a homologue of the plant enzyme 1-aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity."
    Koch K.A., Capitani G., Gruetter M.G., Kirsch J.F.
    Gene 272:75-84(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: TracheaImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-421.
    Tissue: UterusImported.
  6. Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-221 AND LEU-393.

Entry informationi

Entry namei1A1L1_HUMAN
AccessioniPrimary (citable) accession number: Q96QU6
Secondary accession number(s): B4E219, Q8WUL4, Q96LX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are necessary for activity.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.