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Protein

Protein FRG2-like-1

Gene

FRG2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FRG2-like-1
Alternative name(s):
FSHD region gene 2 protein family member B
HSA10-FRG2
Gene namesi
Name:FRG2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000225899.7.
HGNCiHGNC:33518. FRG2B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388920.

Polymorphism and mutation databases

BioMutaiFRG2B.
DMDMi74717197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003006911 – 278Protein FRG2-like-1Add BLAST278

Proteomic databases

PaxDbiQ96QU4.
PRIDEiQ96QU4.

PTM databases

iPTMnetiQ96QU4.
PhosphoSitePlusiQ96QU4.

Expressioni

Gene expression databases

BgeeiENSG00000225899.
CleanExiHS_FRG2B.
ExpressionAtlasiQ96QU4. baseline and differential.

Organism-specific databases

HPAiHPA039264.
HPA047769.

Structurei

3D structure databases

ProteinModelPortaliQ96QU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FRG2 family.Curated

Phylogenomic databases

eggNOGiENOG410JDY8. Eukaryota.
ENOG4111DM4. LUCA.
GeneTreeiENSGT00530000064266.
HOGENOMiHOG000112644.
HOVERGENiHBG106627.
InParanoidiQ96QU4.
PhylomeDBiQ96QU4.
TreeFamiTF342559.

Family and domain databases

InterProiView protein in InterPro
IPR026245. FRG2.
PANTHERiPTHR31883. PTHR31883. 1 hit.
PfamiView protein in Pfam
PF15315. FRG2. 1 hit.
PRINTSiPR02074. PROTEINFRG2.

Sequencei

Sequence statusi: Complete.

Q96QU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGNEDPDL HCSSIQCSTD QPPFQQISFT EKGSDEKKPF KEKGKTAFSH
60 70 80 90 100
SSEKHIQRQG SEPNPNKENS EETKLKAGNS TAGSEPESSS YRENCRKRKM
110 120 130 140 150
SSKDSCQDTA GNCPEKECSL SLNKKSRSST PVHNSEIQET CDAHHRGRSR
160 170 180 190 200
ACTGRSKRHR SRALGVQTPS IRKSLVTSVR AMSEAVYQDL AQVWAQQIHS
210 220 230 240 250
PLTCEQLTLL TRLRGPLCAQ VQTLYSMATQ AAYVFPAESW LVPATLPGPG
260 270
ESALDREAHP FPGQEITETV SGSDEAKL
Length:278
Mass (Da):30,564
Last modified:December 1, 2001 - v1
Checksum:i38E4BDA1AEBED435
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59Q → QA in CAH69901 (PubMed:15164054).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028079 Genomic DNA. Translation: AAK21977.1.
AY744466 mRNA. Translation: AAV30885.1.
AL731696 Genomic DNA. Translation: CAH69901.1.
CCDSiCCDS44502.1.
RefSeqiNP_001074467.1. NM_001080998.1.
UniGeneiHs.690471.

Genome annotation databases

EnsembliENST00000425520; ENSP00000401310; ENSG00000225899.
GeneIDi441581.
KEGGihsa:441581.
UCSCiuc010qvg.2. human.

Similar proteinsi

Entry informationi

Entry nameiFRG2B_HUMAN
AccessioniPrimary (citable) accession number: Q96QU4
Secondary accession number(s): Q5VSQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families