##gff-version 3 Q96QT4 UniProtKB Chain 1 1865 . . . ID=PRO_0000215331;Note=Transient receptor potential cation channel subfamily M member 7 Q96QT4 UniProtKB Topological domain 1 755 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Transmembrane 756 776 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Topological domain 777 855 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Transmembrane 856 876 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Topological domain 877 918 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Transmembrane 919 939 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Topological domain 940 962 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Transmembrane 963 983 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Topological domain 984 995 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Transmembrane 996 1016 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Topological domain 1017 1035 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Intramembrane 1036 1056 . . . Note=Pore-forming;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Topological domain 1057 1074 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Transmembrane 1075 1095 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Topological domain 1096 1865 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96QT4 UniProtKB Domain 1594 1824 . . . Note=Alpha-type protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00501 Q96QT4 UniProtKB Region 544 575 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QT4 UniProtKB Region 1386 1407 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QT4 UniProtKB Region 1492 1511 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QT4 UniProtKB Region 1524 1543 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QT4 UniProtKB Region 1836 1865 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QT4 UniProtKB Coiled coil 1198 1250 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Compositional bias 544 562 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QT4 UniProtKB Compositional bias 1843 1865 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QT4 UniProtKB Active site 1767 1767 . . . Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1624 1624 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1648 1648 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1720 1720 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1753 1753 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1769 1769 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1777 1777 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1794 1800 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1810 1810 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1812 1812 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Binding site 1816 1816 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96QT4 UniProtKB Modified residue 1 1 . . . Note=N-acetylmethionine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q96QT4 UniProtKB Modified residue 101 101 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96QT4 UniProtKB Modified residue 1224 1224 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1255 1255 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1301 1301 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1386 1386 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1387 1387 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96QT4 UniProtKB Modified residue 1390 1390 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96QT4 UniProtKB Modified residue 1395 1395 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96QT4 UniProtKB Modified residue 1404 1404 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96QT4 UniProtKB Modified residue 1405 1405 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1446 1446 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1467 1467 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1477 1477 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q96QT4 UniProtKB Modified residue 1500 1500 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1504 1504 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Modified residue 1527 1527 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96QT4 UniProtKB Modified residue 1569 1569 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q96QT4 UniProtKB Modified residue 1851 1851 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q923J1 Q96QT4 UniProtKB Natural variant 68 68 . . . ID=VAR_042395;Note=G->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56064201,PMID:17344846 Q96QT4 UniProtKB Natural variant 406 406 . . . ID=VAR_042396;Note=In an ovarian serous carcinoma sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Q96QT4 UniProtKB Natural variant 459 459 . . . ID=VAR_042397;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55924090,PMID:17344846 Q96QT4 UniProtKB Natural variant 574 574 . . . ID=VAR_042398;Note=K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56040619,PMID:17344846 Q96QT4 UniProtKB Natural variant 720 720 . . . ID=VAR_042399;Note=In a breast infiltrating ductal carcinoma sample%3B somatic mutation. T->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1040254222,PMID:17344846 Q96QT4 UniProtKB Natural variant 830 830 . . . ID=VAR_042400;Note=In a gastric adenocarcinoma sample%3B somatic mutation. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Q96QT4 UniProtKB Natural variant 949 949 . . . ID=VAR_042401;Note=F->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55681028,PMID:17344846 Q96QT4 UniProtKB Natural variant 1033 1033 . . . ID=VAR_052381;Note=A->G;Dbxref=dbSNP:rs34530969 Q96QT4 UniProtKB Natural variant 1046 1046 . . . ID=VAR_086707;Note=Found in a patient with hypomagnesemia and secondary hypocalcemia%3B likely pathogenic%3B de novo variant%3B causes severely reduced Mg(2+) uptake in transfected cells. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35561741;Dbxref=dbSNP:rs2059709974,PMID:35561741 Q96QT4 UniProtKB Natural variant 1064 1064 . . . ID=VAR_042402;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56298128,PMID:17344846 Q96QT4 UniProtKB Natural variant 1145 1145 . . . ID=VAR_052382;Note=I->V;Dbxref=dbSNP:rs34711809 Q96QT4 UniProtKB Natural variant 1211 1211 . . . ID=VAR_042403;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56090496,PMID:17344846 Q96QT4 UniProtKB Natural variant 1254 1254 . . . ID=VAR_042404;Note=A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56288221,PMID:17344846 Q96QT4 UniProtKB Natural variant 1306 1306 . . . ID=VAR_042405;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55970334,PMID:17344846 Q96QT4 UniProtKB Natural variant 1444 1444 . . . ID=VAR_042406;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55840070,PMID:17344846 Q96QT4 UniProtKB Natural variant 1482 1482 . . . ID=VAR_019967;Note=Mutant channels are functional but show increased susceptibility to inhibition by intracellular magnesium concentrations compared to wild-type channels. T->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16051700,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs8042919,PMID:14702039,PMID:16051700,PMID:17344846 Q96QT4 UniProtKB Mutagenesis 1648 1648 . . . Note=Loss of kinase activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12887921;Dbxref=PMID:12887921 Q96QT4 UniProtKB Mutagenesis 1799 1799 . . . Note=Loss of kinase activity. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12887921;Dbxref=PMID:12887921 Q96QT4 UniProtKB Sequence conflict 573 575 . . . Note=EKM->KKK;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96QT4 UniProtKB Sequence conflict 998 998 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96QT4 UniProtKB Sequence conflict 1496 1496 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96QT4 UniProtKB Sequence conflict 1520 1520 . . . Note=D->V;Ontology_term=ECO:0000305;evidence=ECO:0000305