Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96QT4

- TRPM7_HUMAN

UniProt

Q96QT4 - TRPM7_HUMAN

Protein

Transient receptor potential cation channel subfamily M member 7

Gene

TRPM7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).3 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1624 – 16241ATPBy similarity
    Binding sitei1648 – 16481ATPBy similarity
    Binding sitei1720 – 17201ATPBy similarity
    Metal bindingi1753 – 17531ZincBy similarity
    Active sitei1767 – 17671Proton acceptorBy similarity
    Binding sitei1769 – 17691ATPBy similarity
    Binding sitei1777 – 17771ATPBy similarity
    Metal bindingi1810 – 18101ZincBy similarity
    Metal bindingi1812 – 18121ZincBy similarity
    Metal bindingi1816 – 18161ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1794 – 18007ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium channel activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. actomyosin structure organization Source: Ensembl
    2. calcium-dependent cell-matrix adhesion Source: Ensembl
    3. calcium ion transmembrane transport Source: Reactome
    4. ion transmembrane transport Source: Reactome
    5. necroptotic process Source: UniProtKB
    6. protein autophosphorylation Source: Ensembl
    7. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Calcium transport, Ion transport, Necrosis, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_169333. TRP channels.

    Protein family/group databases

    TCDBi1.A.4.5.1. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily M member 7 (EC:2.7.11.1)
    Alternative name(s):
    Channel-kinase 1
    Long transient receptor potential channel 7
    Short name:
    LTrpC-7
    Short name:
    LTrpC7
    Gene namesi
    Name:TRPM7
    Synonyms:CHAK1, LTRPC7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:17994. TRPM7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    3. ruffle Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1) [MIM:105500]: A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1648 – 16481K → R: Loss of kinase activity. 1 Publication
    Mutagenesisi1799 – 17991G → D: Loss of kinase activity. 1 Publication

    Keywords - Diseasei

    Amyotrophic lateral sclerosis, Neurodegeneration, Parkinsonism

    Organism-specific databases

    MIMi105500. phenotype.
    Orphaneti90020. Amyotrophic lateral sclerosis-parkinsonism-dementia complex.
    PharmGKBiPA38273.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18651865Transient receptor potential cation channel subfamily M member 7PRO_0000215331Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei1224 – 12241PhosphoserineBy similarity
    Modified residuei1301 – 13011PhosphoserineBy similarity
    Modified residuei1386 – 13861PhosphoserineBy similarity
    Modified residuei1387 – 13871PhosphoserineBy similarity
    Modified residuei1405 – 14051PhosphothreonineBy similarity
    Modified residuei1467 – 14671PhosphothreonineBy similarity
    Modified residuei1477 – 14771Phosphoserine1 Publication
    Modified residuei1500 – 15001PhosphoserineBy similarity
    Modified residuei1504 – 15041PhosphoserineBy similarity
    Modified residuei1569 – 15691PhosphoserineBy similarity
    Modified residuei1851 – 18511PhosphoserineBy similarity

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96QT4.
    PaxDbiQ96QT4.
    PRIDEiQ96QT4.

    PTM databases

    PhosphoSiteiQ96QT4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96QT4.
    BgeeiQ96QT4.
    CleanExiHS_TRPM7.
    GenevestigatoriQ96QT4.

    Organism-specific databases

    HPAiHPA035523.
    HPA052173.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with PLCB1 By similarity. Forms heterodimers with TRPM6.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi120177. 9 interactions.
    IntActiQ96QT4. 3 interactions.
    MINTiMINT-2815126.
    STRINGi9606.ENSP00000320239.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QT4.
    SMRiQ96QT4. Positions 1198-1249, 1551-1830.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 755755CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini777 – 85579ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini877 – 91842CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini940 – 96223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini984 – 99512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1017 – 103519ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1057 – 107418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1096 – 1865770CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei1036 – 105621Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei756 – 77621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei856 – 87621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei919 – 93921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei963 – 98321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei996 – 101621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1075 – 109521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1594 – 1824231Alpha-type protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1198 – 125053By similarityAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated
    Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253824.
    HOGENOMiHOG000230920.
    HOVERGENiHBG055663.
    InParanoidiQ96QT4.
    KOiK04982.
    OMAiKQGPTNP.
    PhylomeDBiQ96QT4.
    TreeFamiTF314204.

    Family and domain databases

    InterProiIPR005821. Ion_trans_dom.
    IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    IPR029601. TRPM7.
    [Graphical view]
    PANTHERiPTHR13800:SF8. PTHR13800:SF8. 1 hit.
    PfamiPF02816. Alpha_kinase. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    SMARTiSM00811. Alpha_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51158. ALPHA_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96QT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ     50
    HACFTASLAM KYSDVKLGDH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG 100
    SHSYRAKYVR LSYDTKPEVI LQLLLKEWQM ELPKLVISVH GGMQKFELHP 150
    RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV AKHVGDALKE HASRSSRKIC 200
    TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN LHSHFILVDD 250
    GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV 300
    LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI 350
    KKTFNFGQNE ALHLFQTLME CMKRKELITV FHIGSDEHQD IDVAILTALL 400
    KGTNASAFDQ LILTLAWDRV DIAKNHVFVY GQQWLVGSLE QAMLDALVMD 450
    RVAFVKLLIE NGVSMHKFLT IPRLEELYNT KQGPTNPMLF HLVRDVKQGN 500
    LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL GGNNRRSGRN 550
    TSSSTPQLRK SHESFGNRAD KKEKMRHNHF IKTAQPYRPK IDTVMEEGKK 600
    KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA 650
    KALVACKIYR SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ 700
    DETMAMKLLT YELKNWSNST CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR 750
    LNMRKNSWYK VILSILVPPA ILLLEYKTKA EMSHIPQSQD AHQMTMDDSE 800
    NNFQNITEEI PMEVFKEVRI LDSNEGKNEM EIQMKSKKLP ITRKFYAFYH 850
    APIVKFWFNT LAYLGFLMLY TFVVLVQMEQ LPSVQEWIVI AYIFTYAIEK 900
    VREIFMSEAG KVNQKIKVWF SDYFNISDTI AIISFFIGFG LRFGAKWNFA 950
    NAYDNHVFVA GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM 1000
    FYIVVIMALV LLSFGVPRKA ILYPHEAPSW TLAKDIVFHP YWMIFGEVYA 1050
    YEIDVCANDS VIPQICGPGT WLTPFLQAVY LFVQYIIMVN LLIAFFNNVY 1100
    LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS LFCCICKRRK 1150
    KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFNEKDDKFH SGSEERIRVT 1200
    FERVEQMCIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT 1250
    AQKASEASKV HNEITRELSI SKHLAQNLID DGPVRPSVWK KHGVVNTLSS 1300
    SLPQGDLESN NPFHCNILMK DDKDPQCNIF GQDLPAVPQR KEFNFPEAGS 1350
    SSGALFPSAV SPPELRQRLH GVELLKIFNK NQKLGSSSTS IPHLSSPPTK 1400
    FFVSTPSQPS CKSHLETGTK DQETVCSKAT EGDNTEFGAF VGHRDSMDLQ 1450
    RFKETSNKIK ILSNNNTSEN TLKRVSSLAG FTDCHRTSIP VHSKQAEKIS 1500
    RRPSTEDTHE VDSKAALIPD WLQDRPSNRE MPSEEGTLNG LTSPFKPAMD 1550
    TNYYYSAVER NNLMRLSQSI PFTPVPPRGE PVTVYRLEES SPNILNNSMS 1600
    SWSQLGLCAK IEFLSKEEMG GGLRRAVKVQ CTWSEHDILK SGHLYIIKSF 1650
    LPEVVNTWSS IYKEDTVLHL CLREIQQQRA AQKLTFAFNQ MKPKSIPYSP 1700
    RFLEVFLLYC HSAGQWFAVE ECMTGEFRKY NNNNGDEIIP TNTLEEIMLA 1750
    FSHWTYEYTR GELLVLDLQG VGENLTDPSV IKAEEKRSCD MVFGPANLGE 1800
    DAIKNFRAKH HCNSCCRKLK LPDLKRNDYT PDKIIFPQDE PSDLNLQPGN 1850
    STKESESTNS VRLML 1865
    Length:1,865
    Mass (Da):212,697
    Last modified:December 1, 2001 - v1
    Checksum:iBE732674D52D7485
    GO

    Sequence cautioni

    The sequence BAC11462.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD18773.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti573 – 5753EKM → KKK in BAD18773. (PubMed:14702039)Curated
    Sequence conflicti998 – 9981A → S(PubMed:15489334)Curated
    Sequence conflicti1496 – 14961Missing in AAK19738. (PubMed:14594813)Curated
    Sequence conflicti1520 – 15201D → V in AAK19738. (PubMed:14594813)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681G → V.1 Publication
    Corresponds to variant rs56064201 [ dbSNP | Ensembl ].
    VAR_042395
    Natural varianti406 – 4061S → C in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
    VAR_042396
    Natural varianti459 – 4591I → T.1 Publication
    Corresponds to variant rs55924090 [ dbSNP | Ensembl ].
    VAR_042397
    Natural varianti574 – 5741K → N.1 Publication
    Corresponds to variant rs56040619 [ dbSNP | Ensembl ].
    VAR_042398
    Natural varianti720 – 7201T → S in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication
    VAR_042399
    Natural varianti830 – 8301M → V in a gastric adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_042400
    Natural varianti949 – 9491F → Y.1 Publication
    Corresponds to variant rs55681028 [ dbSNP | Ensembl ].
    VAR_042401
    Natural varianti1033 – 10331A → G.
    Corresponds to variant rs34530969 [ dbSNP | Ensembl ].
    VAR_052381
    Natural varianti1064 – 10641Q → R.1 Publication
    Corresponds to variant rs56298128 [ dbSNP | Ensembl ].
    VAR_042402
    Natural varianti1145 – 11451I → V.
    Corresponds to variant rs34711809 [ dbSNP | Ensembl ].
    VAR_052382
    Natural varianti1211 – 12111I → T.1 Publication
    Corresponds to variant rs56090496 [ dbSNP | Ensembl ].
    VAR_042403
    Natural varianti1254 – 12541A → V.1 Publication
    Corresponds to variant rs56288221 [ dbSNP | Ensembl ].
    VAR_042404
    Natural varianti1306 – 13061D → E.1 Publication
    Corresponds to variant rs55970334 [ dbSNP | Ensembl ].
    VAR_042405
    Natural varianti1444 – 14441R → K.1 Publication
    Corresponds to variant rs55840070 [ dbSNP | Ensembl ].
    VAR_042406
    Natural varianti1482 – 14821T → I Mutant channels are functional but show increased susceptibility to inhibition by intracellular magnesium concentrations compared to wild-type channels. 3 Publications
    Corresponds to variant rs8042919 [ dbSNP | Ensembl ].
    VAR_019967

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032950 mRNA. Translation: AAK44211.1.
    AF346629 mRNA. Translation: AAK19738.2.
    AK000124 mRNA. Translation: BAA90958.1.
    AK172800 mRNA. Translation: BAD18773.1. Different initiation.
    AK075193 mRNA. Translation: BAC11462.1. Different initiation.
    BC051024 mRNA. Translation: AAH51024.1.
    CCDSiCCDS42035.1.
    RefSeqiNP_060142.3. NM_017672.4.
    UniGeneiHs.512894.

    Genome annotation databases

    EnsembliENST00000313478; ENSP00000320239; ENSG00000092439.
    ENST00000560638; ENSP00000452873; ENSG00000092439.
    GeneIDi54822.
    KEGGihsa:54822.
    UCSCiuc001zyt.4. human.

    Polymorphism databases

    DMDMi56404941.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032950 mRNA. Translation: AAK44211.1 .
    AF346629 mRNA. Translation: AAK19738.2 .
    AK000124 mRNA. Translation: BAA90958.1 .
    AK172800 mRNA. Translation: BAD18773.1 . Different initiation.
    AK075193 mRNA. Translation: BAC11462.1 . Different initiation.
    BC051024 mRNA. Translation: AAH51024.1 .
    CCDSi CCDS42035.1.
    RefSeqi NP_060142.3. NM_017672.4.
    UniGenei Hs.512894.

    3D structure databases

    ProteinModelPortali Q96QT4.
    SMRi Q96QT4. Positions 1198-1249, 1551-1830.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120177. 9 interactions.
    IntActi Q96QT4. 3 interactions.
    MINTi MINT-2815126.
    STRINGi 9606.ENSP00000320239.

    Chemistry

    ChEMBLi CHEMBL1250412.
    GuidetoPHARMACOLOGYi 499.

    Protein family/group databases

    TCDBi 1.A.4.5.1. the transient receptor potential ca(2+) channel (trp-cc) family.

    PTM databases

    PhosphoSitei Q96QT4.

    Polymorphism databases

    DMDMi 56404941.

    Proteomic databases

    MaxQBi Q96QT4.
    PaxDbi Q96QT4.
    PRIDEi Q96QT4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313478 ; ENSP00000320239 ; ENSG00000092439 .
    ENST00000560638 ; ENSP00000452873 ; ENSG00000092439 .
    GeneIDi 54822.
    KEGGi hsa:54822.
    UCSCi uc001zyt.4. human.

    Organism-specific databases

    CTDi 54822.
    GeneCardsi GC15M050852.
    HGNCi HGNC:17994. TRPM7.
    HPAi HPA035523.
    HPA052173.
    MIMi 105500. phenotype.
    605692. gene.
    neXtProti NX_Q96QT4.
    Orphaneti 90020. Amyotrophic lateral sclerosis-parkinsonism-dementia complex.
    PharmGKBi PA38273.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253824.
    HOGENOMi HOG000230920.
    HOVERGENi HBG055663.
    InParanoidi Q96QT4.
    KOi K04982.
    OMAi KQGPTNP.
    PhylomeDBi Q96QT4.
    TreeFami TF314204.

    Enzyme and pathway databases

    Reactomei REACT_169333. TRP channels.

    Miscellaneous databases

    ChiTaRSi TRPM7. human.
    GeneWikii TRPM7.
    GenomeRNAii 54822.
    NextBioi 57577.
    PROi Q96QT4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96QT4.
    Bgeei Q96QT4.
    CleanExi HS_TRPM7.
    Genevestigatori Q96QT4.

    Family and domain databases

    InterProi IPR005821. Ion_trans_dom.
    IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    IPR029601. TRPM7.
    [Graphical view ]
    PANTHERi PTHR13800:SF8. PTHR13800:SF8. 1 hit.
    Pfami PF02816. Alpha_kinase. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    SMARTi SM00811. Alpha_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51158. ALPHA_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability."
      Nadler M.J.S., Hermosura M.C., Inabe K., Perraud A.-L., Zhu Q., Stokes A.J., Kurosaki T., Kinet J.-P., Penner R., Scharenberg A.M., Fleig A.
      Nature 411:590-595(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    2. "Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel."
      Ryazanova L.V., Dorovkov M.V., Ansari A., Ryazanov A.G.
      J. Biol. Chem. 279:3708-3716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-575 AND 1096-1865, VARIANT ILE-1482.
      Tissue: Colon and Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-998.
      Tissue: Liver.
    5. Cited for: FUNCTION, MUTAGENESIS OF LYS-1648 AND GLY-1799.
    6. "Phosphorylation of annexin I by TRPM7 channel-kinase."
      Dorovkov M.V., Ryazanov A.G.
      J. Biol. Chem. 279:50643-50646(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia."
      Chubanov V., Waldegger S., Mederos y Schnitzler M., Vitzthum H., Sassen M.C., Seyberth H.W., Konrad M., Gudermann T.
      Proc. Natl. Acad. Sci. U.S.A. 101:2894-2899(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRPM6.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1477, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis."
      Cai Z., Jitkaew S., Zhao J., Chiang H.C., Choksi S., Liu J., Ward Y., Wu L.G., Liu Z.G.
      Nat. Cell Biol. 16:55-65(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders."
      Hermosura M.C., Nayakanti H., Dorovkov M.V., Calderon F.R., Ryazanov A.G., Haymer D.S., Garruto R.M.
      Proc. Natl. Acad. Sci. U.S.A. 102:11510-11515(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ILE-1482, CHARACTERIZATION OF VARIANT ILE-1482.
    13. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-68; CYS-406; THR-459; ASN-574; SER-720; VAL-830; TYR-949; ARG-1064; THR-1211; VAL-1254; GLU-1306; LYS-1444 AND ILE-1482.

    Entry informationi

    Entry nameiTRPM7_HUMAN
    AccessioniPrimary (citable) accession number: Q96QT4
    Secondary accession number(s): Q6ZMF5
    , Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3