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Protein

Serine/threonine-protein kinase H2

Gene

PSKH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 779ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96QS6.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase H2 (EC:2.7.11.1)
Alternative name(s):
Protein serine kinase H2
Short name:
PSK-H2
Gene namesi
Name:PSKH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18997. PSKH2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961168.

Polymorphism and mutation databases

BioMutaiPSKH2.
DMDMi74762688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Serine/threonine-protein kinase H2PRO_0000086171Add
BLAST

Proteomic databases

PaxDbiQ96QS6.
PRIDEiQ96QS6.

PTM databases

iPTMnetiQ96QS6.
PhosphoSiteiQ96QS6.

Expressioni

Gene expression databases

BgeeiQ96QS6.
CleanExiHS_PSKH2.
GenevisibleiQ96QS6. HS.

Organism-specific databases

HPAiHPA015095.

Interactioni

Protein-protein interaction databases

BioGridi124556. 12 interactions.
IntActiQ96QS6. 5 interactions.
STRINGi9606.ENSP00000276616.

Structurei

3D structure databases

ProteinModelPortaliQ96QS6.
SMRiQ96QS6. Positions 38-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 320258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118944.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ96QS6.
KOiK08808.
OMAiGLAHSGN.
OrthoDBiEOG7WHH9K.
PhylomeDBiQ96QS6.
TreeFamiTF314166.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGASRKVV PGPPALAWAK HEGQNQAGVG GAGPGPEAAA QAAQRIQVAR
60 70 80 90 100
FRAKFDPRVL ARYDIKALIG TGSFSRVVRV EQKTTKKPFA IKVMETRERE
110 120 130 140 150
GREACVSELS VLRRVSHRYI VQLMEIFETE DQVYMVMELA TGGELFDRLI
160 170 180 190 200
AQGSFTERDA VRILQMVADG IRYLHALQIT HRNLKPENLL YYHPGEESKI
210 220 230 240 250
LITDFGLAYS GKKSGDWTMK TLCGTPEYIA PEVLLRKPYT SAVDMWALGV
260 270 280 290 300
ITYALLSGFL PFDDESQTRL YRKILKGKYN YTGEPWPSIS HLAKDFIDKL
310 320 330 340 350
LILEAGHRMS AGQALDHPWV ITMAAGSSMK NLQRAISRNL MQRASPHSQS
360 370 380
PGSAQSSKSH YSHKSRHMWS KRNLRIVESP LSALL
Length:385
Mass (Da):43,027
Last modified:December 1, 2001 - v1
Checksum:i6472D63BC7688334
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721G → D.1 Publication
Corresponds to variant rs56407605 [ dbSNP | Ensembl ].
VAR_040615
Natural varianti79 – 791R → K.1 Publication
Corresponds to variant rs35315725 [ dbSNP | Ensembl ].
VAR_040616
Natural varianti114 – 1141R → Q.1 Publication
Corresponds to variant rs35915498 [ dbSNP | Ensembl ].
VAR_040617
Natural varianti116 – 1161S → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040618
Natural varianti132 – 1321Q → R.1 Publication
Corresponds to variant rs16879427 [ dbSNP | Ensembl ].
VAR_040619
Natural varianti148 – 1481R → Q.1 Publication
Corresponds to variant rs56356246 [ dbSNP | Ensembl ].
VAR_040620
Natural varianti176 – 1761A → S.1 Publication
Corresponds to variant rs6998760 [ dbSNP | Ensembl ].
VAR_040621
Natural varianti211 – 2111G → R.1 Publication
Corresponds to variant rs36074412 [ dbSNP | Ensembl ].
VAR_040622
Natural varianti212 – 2121K → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040623
Natural varianti225 – 2251T → A.1 Publication
Corresponds to variant rs34457516 [ dbSNP | Ensembl ].
VAR_040624
Natural varianti266 – 2661S → R.1 Publication
Corresponds to variant rs34037815 [ dbSNP | Ensembl ].
VAR_040625
Natural varianti336 – 3361I → V.1 Publication
Corresponds to variant rs16876805 [ dbSNP | Ensembl ].
VAR_040626

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037806 mRNA. Translation: AAK59985.1.
BC126180 mRNA. Translation: AAI26181.1.
BC126182 mRNA. Translation: AAI26183.1.
CCDSiCCDS6240.1.
RefSeqiNP_149117.1. NM_033126.1.
UniGeneiHs.680136.

Genome annotation databases

EnsembliENST00000276616; ENSP00000276616; ENSG00000147613.
GeneIDi85481.
KEGGihsa:85481.
UCSCiuc011lfy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037806 mRNA. Translation: AAK59985.1.
BC126180 mRNA. Translation: AAI26181.1.
BC126182 mRNA. Translation: AAI26183.1.
CCDSiCCDS6240.1.
RefSeqiNP_149117.1. NM_033126.1.
UniGeneiHs.680136.

3D structure databases

ProteinModelPortaliQ96QS6.
SMRiQ96QS6. Positions 38-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124556. 12 interactions.
IntActiQ96QS6. 5 interactions.
STRINGi9606.ENSP00000276616.

PTM databases

iPTMnetiQ96QS6.
PhosphoSiteiQ96QS6.

Polymorphism and mutation databases

BioMutaiPSKH2.
DMDMi74762688.

Proteomic databases

PaxDbiQ96QS6.
PRIDEiQ96QS6.

Protocols and materials databases

DNASUi85481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276616; ENSP00000276616; ENSG00000147613.
GeneIDi85481.
KEGGihsa:85481.
UCSCiuc011lfy.3. human.

Organism-specific databases

CTDi85481.
GeneCardsiPSKH2.
HGNCiHGNC:18997. PSKH2.
HPAiHPA015095.
neXtProtiNX_Q96QS6.
PharmGKBiPA134961168.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118944.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ96QS6.
KOiK08808.
OMAiGLAHSGN.
OrthoDBiEOG7WHH9K.
PhylomeDBiQ96QS6.
TreeFamiTF314166.

Enzyme and pathway databases

SignaLinkiQ96QS6.

Miscellaneous databases

GenomeRNAii85481.
PROiQ96QS6.

Gene expression databases

BgeeiQ96QS6.
CleanExiHS_PSKH2.
GenevisibleiQ96QS6. HS.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Scharm B.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-72; LYS-79; GLN-114; ILE-116; ARG-132; GLN-148; SER-176; ARG-211; ILE-212; ALA-225; ARG-266 AND VAL-336.

Entry informationi

Entry nameiKPSH2_HUMAN
AccessioniPrimary (citable) accession number: Q96QS6
Secondary accession number(s): A0AV22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Asn-183 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.