Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase H2

Gene

PSKH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 77ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS07457-MONOMER.
SignaLinkiQ96QS6.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase H2 (EC:2.7.11.1)
Alternative name(s):
Protein serine kinase H2
Short name:
PSK-H2
Gene namesi
Name:PSKH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18997. PSKH2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147613.
PharmGKBiPA134961168.

Polymorphism and mutation databases

BioMutaiPSKH2.
DMDMi74762688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861711 – 385Serine/threonine-protein kinase H2Add BLAST385

Proteomic databases

PaxDbiQ96QS6.
PRIDEiQ96QS6.

PTM databases

iPTMnetiQ96QS6.
PhosphoSitePlusiQ96QS6.

Expressioni

Gene expression databases

BgeeiENSG00000147613.
CleanExiHS_PSKH2.
GenevisibleiQ96QS6. HS.

Organism-specific databases

HPAiHPA015095.

Interactioni

Protein-protein interaction databases

BioGridi124556. 12 interactors.
IntActiQ96QS6. 5 interactors.
STRINGi9606.ENSP00000276616.

Structurei

3D structure databases

ProteinModelPortaliQ96QS6.
SMRiQ96QS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 320Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118944.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ96QS6.
KOiK08808.
OMAiREACVSE.
OrthoDBiEOG091G0HK9.
PhylomeDBiQ96QS6.
TreeFamiTF314166.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCGASRKVV PGPPALAWAK HEGQNQAGVG GAGPGPEAAA QAAQRIQVAR
60 70 80 90 100
FRAKFDPRVL ARYDIKALIG TGSFSRVVRV EQKTTKKPFA IKVMETRERE
110 120 130 140 150
GREACVSELS VLRRVSHRYI VQLMEIFETE DQVYMVMELA TGGELFDRLI
160 170 180 190 200
AQGSFTERDA VRILQMVADG IRYLHALQIT HRNLKPENLL YYHPGEESKI
210 220 230 240 250
LITDFGLAYS GKKSGDWTMK TLCGTPEYIA PEVLLRKPYT SAVDMWALGV
260 270 280 290 300
ITYALLSGFL PFDDESQTRL YRKILKGKYN YTGEPWPSIS HLAKDFIDKL
310 320 330 340 350
LILEAGHRMS AGQALDHPWV ITMAAGSSMK NLQRAISRNL MQRASPHSQS
360 370 380
PGSAQSSKSH YSHKSRHMWS KRNLRIVESP LSALL
Length:385
Mass (Da):43,027
Last modified:December 1, 2001 - v1
Checksum:i6472D63BC7688334
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04061572G → D.1 PublicationCorresponds to variant rs56407605dbSNPEnsembl.1
Natural variantiVAR_04061679R → K.1 PublicationCorresponds to variant rs35315725dbSNPEnsembl.1
Natural variantiVAR_040617114R → Q.1 PublicationCorresponds to variant rs35915498dbSNPEnsembl.1
Natural variantiVAR_040618116S → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040619132Q → R.1 PublicationCorresponds to variant rs16879427dbSNPEnsembl.1
Natural variantiVAR_040620148R → Q.1 PublicationCorresponds to variant rs56356246dbSNPEnsembl.1
Natural variantiVAR_040621176A → S.1 PublicationCorresponds to variant rs6998760dbSNPEnsembl.1
Natural variantiVAR_040622211G → R.1 PublicationCorresponds to variant rs36074412dbSNPEnsembl.1
Natural variantiVAR_040623212K → I in a lung adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs778066815dbSNPEnsembl.1
Natural variantiVAR_040624225T → A.1 PublicationCorresponds to variant rs34457516dbSNPEnsembl.1
Natural variantiVAR_040625266S → R.1 PublicationCorresponds to variant rs34037815dbSNPEnsembl.1
Natural variantiVAR_040626336I → V.1 PublicationCorresponds to variant rs16876805dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037806 mRNA. Translation: AAK59985.1.
BC126180 mRNA. Translation: AAI26181.1.
BC126182 mRNA. Translation: AAI26183.1.
CCDSiCCDS6240.1.
RefSeqiNP_149117.1. NM_033126.2.
UniGeneiHs.680136.

Genome annotation databases

EnsembliENST00000276616; ENSP00000276616; ENSG00000147613.
GeneIDi85481.
KEGGihsa:85481.
UCSCiuc011lfy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037806 mRNA. Translation: AAK59985.1.
BC126180 mRNA. Translation: AAI26181.1.
BC126182 mRNA. Translation: AAI26183.1.
CCDSiCCDS6240.1.
RefSeqiNP_149117.1. NM_033126.2.
UniGeneiHs.680136.

3D structure databases

ProteinModelPortaliQ96QS6.
SMRiQ96QS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124556. 12 interactors.
IntActiQ96QS6. 5 interactors.
STRINGi9606.ENSP00000276616.

PTM databases

iPTMnetiQ96QS6.
PhosphoSitePlusiQ96QS6.

Polymorphism and mutation databases

BioMutaiPSKH2.
DMDMi74762688.

Proteomic databases

PaxDbiQ96QS6.
PRIDEiQ96QS6.

Protocols and materials databases

DNASUi85481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276616; ENSP00000276616; ENSG00000147613.
GeneIDi85481.
KEGGihsa:85481.
UCSCiuc011lfy.3. human.

Organism-specific databases

CTDi85481.
GeneCardsiPSKH2.
HGNCiHGNC:18997. PSKH2.
HPAiHPA015095.
neXtProtiNX_Q96QS6.
OpenTargetsiENSG00000147613.
PharmGKBiPA134961168.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118944.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ96QS6.
KOiK08808.
OMAiREACVSE.
OrthoDBiEOG091G0HK9.
PhylomeDBiQ96QS6.
TreeFamiTF314166.

Enzyme and pathway databases

BioCyciZFISH:HS07457-MONOMER.
SignaLinkiQ96QS6.

Miscellaneous databases

GenomeRNAii85481.
PROiQ96QS6.

Gene expression databases

BgeeiENSG00000147613.
CleanExiHS_PSKH2.
GenevisibleiQ96QS6. HS.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKPSH2_HUMAN
AccessioniPrimary (citable) accession number: Q96QS6
Secondary accession number(s): A0AV22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Asn-183 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.