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Q96QS1

- TSN32_HUMAN

UniProt

Q96QS1 - TSN32_HUMAN

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Protein
Tetraspanin-32
Gene
TSPAN32, PHEMX, TSSC6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cell-cell signaling Source: UniProtKB
  2. cytoskeleton organization Source: Ensembl
  3. defense response to protozoan Source: Ensembl
  4. integrin-mediated signaling pathway Source: Ensembl
  5. negative regulation of cell proliferation Source: Ensembl
  6. negative regulation of myeloid dendritic cell activation Source: Ensembl
  7. platelet aggregation Source: Ensembl
  8. regulation of defense response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-32
Short name:
Tspan-32
Alternative name(s):
Protein Phemx
Gene namesi
Name:TSPAN32
Synonyms:PHEMX, TSSC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13410. TSPAN32.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421Helical; Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST
Transmembranei203 – 22321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integrin alphaIIb-beta3 complex Source: Ensembl
  3. intracellular Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Tetraspanin-32
PRO_0000219278Add
BLAST

Proteomic databases

PaxDbiQ96QS1.
PRIDEiQ96QS1.

Expressioni

Tissue specificityi

Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus and spleen.1 Publication

Developmental stagei

Expressed from early embryogenesis through to adulthood.1 Publication

Gene expression databases

ArrayExpressiQ96QS1.
BgeeiQ96QS1.
CleanExiHS_TSPAN32.
GenevestigatoriQ96QS1.

Organism-specific databases

HPAiHPA024135.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000182290.

Structurei

3D structure databases

ProteinModelPortaliQ96QS1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41704.
HOGENOMiHOG000081817.
HOVERGENiHBG053580.
InParanoidiQ96QS1.
KOiK17359.
OMAiAARQDCL.
PhylomeDBiQ96QS1.
TreeFamiTF336277.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiIPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q96QS1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPWSRVRVA KCQMLVTCFF ILLLGLSVAT MVTLTYFGAH FAVIRRASLE    50
KNPYQAVHQW AFSAGLSLVG LLTLGAVLSA AATVREAQGL MAGGFLCFSL 100
AFCAQVQVVF WRLHSPTQVE DAMLDTYDLV YEQAMKGTSH VRRQELAAIQ 150
DVFLCCGKKS PFSRLGSTEA DLCQGEEAAR EDCLQGIRSF LRTHQQVASS 200
LTSIGLALTV SALLFSSFLW FAIRCGCSLD RKGKYTLTPR ACGRQPQEPS 250
LLRCSQGGPT HCLHSEAVAI GPRGCSGSLR WLQESDAAPL PLSCHLAAHR 300
ALQGRSRGGL SGCPERGLSD 320
Length:320
Mass (Da):34,631
Last modified:December 1, 2001 - v1
Checksum:i534E4C29767B8E6D
GO
Isoform 2 (identifier: Q96QS1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:290
Mass (Da):31,308
Checksum:iB9E86C72A6C9B727
GO
Isoform 3 (identifier: Q96QS1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-253: ACGRQPQEPSLLR → SPGQKSRWAQWVP
     254-320: Missing.

Show »
Length:253
Mass (Da):27,844
Checksum:iA616383C45BE67E6
GO
Isoform 4 (identifier: Q96QS1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.
     137-154: GTSHVRRQELAAIQDVFL → VSVLWEEVSFQPSGEHRG
     155-320: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:124
Mass (Da):13,643
Checksum:i29B8FF48896D8BB8
GO
Isoform 5 (identifier: Q96QS1-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-258: VSALLFSSFL...PSLLRCSQGG → LGPQGQIHPD...SCYWSKRMLG
     259-320: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:258
Mass (Da):28,211
Checksum:i4564FAB7C7C2E9F4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3030Missing in isoform 2 and isoform 4.
VSP_003932Add
BLAST
Alternative sequencei137 – 15418GTSHV…QDVFL → VSVLWEEVSFQPSGEHRG in isoform 4.
VSP_003933Add
BLAST
Alternative sequencei155 – 320166Missing in isoform 4.
VSP_003934Add
BLAST
Alternative sequencei210 – 25849VSALL…CSQGG → LGPQGQIHPDPTSMWPPAPG AQPLEMLPGWTHTLSPLRSS CYWSKRMLG in isoform 5.
VSP_003935Add
BLAST
Alternative sequencei241 – 25313ACGRQ…PSLLR → SPGQKSRWAQWVP in isoform 3.
VSP_003937Add
BLAST
Alternative sequencei254 – 32067Missing in isoform 3.
VSP_003938Add
BLAST
Alternative sequencei259 – 32062Missing in isoform 5.
VSP_003936Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF125569 mRNA. Translation: AAD23580.1.
AY039001 mRNA. Translation: AAK84431.1.
BC016693 mRNA. Translation: AAH16693.1.
AF176070 mRNA. Translation: AAG15840.1.
AF176071 mRNA. Translation: AAG15841.1.
CCDSiCCDS7733.1. [Q96QS1-1]
RefSeqiNP_620591.3. NM_139022.2. [Q96QS1-1]
UniGeneiHs.271954.

Genome annotation databases

EnsembliENST00000182290; ENSP00000182290; ENSG00000064201. [Q96QS1-1]
ENST00000381121; ENSP00000370513; ENSG00000064201. [Q96QS1-3]
ENST00000446063; ENSP00000395018; ENSG00000064201. [Q96QS1-5]
GeneIDi10077.
KEGGihsa:10077.
UCSCiuc001lvx.1. human. [Q96QS1-3]
uc001lvy.1. human. [Q96QS1-1]

Polymorphism databases

DMDMi20139069.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF125569 mRNA. Translation: AAD23580.1 .
AY039001 mRNA. Translation: AAK84431.1 .
BC016693 mRNA. Translation: AAH16693.1 .
AF176070 mRNA. Translation: AAG15840.1 .
AF176071 mRNA. Translation: AAG15841.1 .
CCDSi CCDS7733.1. [Q96QS1-1 ]
RefSeqi NP_620591.3. NM_139022.2. [Q96QS1-1 ]
UniGenei Hs.271954.

3D structure databases

ProteinModelPortali Q96QS1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000182290.

Polymorphism databases

DMDMi 20139069.

Proteomic databases

PaxDbi Q96QS1.
PRIDEi Q96QS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000182290 ; ENSP00000182290 ; ENSG00000064201 . [Q96QS1-1 ]
ENST00000381121 ; ENSP00000370513 ; ENSG00000064201 . [Q96QS1-3 ]
ENST00000446063 ; ENSP00000395018 ; ENSG00000064201 . [Q96QS1-5 ]
GeneIDi 10077.
KEGGi hsa:10077.
UCSCi uc001lvx.1. human. [Q96QS1-3 ]
uc001lvy.1. human. [Q96QS1-1 ]

Organism-specific databases

CTDi 10077.
GeneCardsi GC11P002323.
HGNCi HGNC:13410. TSPAN32.
HPAi HPA024135.
MIMi 603853. gene.
neXtProti NX_Q96QS1.
PharmGKBi PA33257.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41704.
HOGENOMi HOG000081817.
HOVERGENi HBG053580.
InParanoidi Q96QS1.
KOi K17359.
OMAi AARQDCL.
PhylomeDBi Q96QS1.
TreeFami TF336277.

Miscellaneous databases

GeneWikii TSPAN32.
GenomeRNAii 10077.
NextBioi 38097.
PROi Q96QS1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96QS1.
Bgeei Q96QS1.
CleanExi HS_TSPAN32.
Genevestigatori Q96QS1.

Family and domain databases

Gene3Di 1.10.1450.10. 1 hit.
InterProi IPR028977. CD81_LEL.
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
SUPFAMi SSF48652. SSF48652. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting."
    Lee M.P., Brandenburg S., Landes G.M., Adams M., Miller G., Feinberg A.P.
    Hum. Mol. Genet. 8:683-690(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs."
    Robb L., Tarrant J., Groom J., Ibrahim M., Li R., Borobakas B., Wright M.D.
    Biochim. Biophys. Acta 1522:31-41(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Lung.
  4. "Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7."
    Nicholson R.H., Pantano S., Eliason J.F., Galy A., Weiler S., Kaplan J., Hughes M.R., Ko M.S.H.
    Genomics 68:13-21(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-320 (ISOFORMS 3 AND 4), DEVELOPMENTAL STAGE.
  5. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

Entry informationi

Entry nameiTSN32_HUMAN
AccessioniPrimary (citable) accession number: Q96QS1
Secondary accession number(s): Q96KX4
, Q9HC50, Q9HC51, Q9Y5U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi