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Q96QS1

- TSN32_HUMAN

UniProt

Q96QS1 - TSN32_HUMAN

Protein

Tetraspanin-32

Gene

TSPAN32

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cell-cell signaling Source: UniProtKB
    2. cytoskeleton organization Source: Ensembl
    3. defense response to protozoan Source: Ensembl
    4. integrin-mediated signaling pathway Source: Ensembl
    5. negative regulation of cell proliferation Source: Ensembl
    6. negative regulation of myeloid dendritic cell activation Source: Ensembl
    7. platelet aggregation Source: Ensembl
    8. regulation of defense response to virus Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-32
    Short name:
    Tspan-32
    Alternative name(s):
    Protein Phemx
    Gene namesi
    Name:TSPAN32
    Synonyms:PHEMX, TSSC6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13410. TSPAN32.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integrin alphaIIb-beta3 complex Source: Ensembl
    3. intracellular Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33257.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Tetraspanin-32PRO_0000219278Add
    BLAST

    Proteomic databases

    PaxDbiQ96QS1.
    PRIDEiQ96QS1.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously at low levels. High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus and spleen.1 Publication

    Developmental stagei

    Expressed from early embryogenesis through to adulthood.1 Publication

    Gene expression databases

    ArrayExpressiQ96QS1.
    BgeeiQ96QS1.
    CleanExiHS_TSPAN32.
    GenevestigatoriQ96QS1.

    Organism-specific databases

    HPAiHPA024135.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000182290.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41704.
    HOGENOMiHOG000081817.
    HOVERGENiHBG053580.
    InParanoidiQ96QS1.
    KOiK17359.
    OMAiAARQDCL.
    PhylomeDBiQ96QS1.
    TreeFamiTF336277.

    Family and domain databases

    Gene3Di1.10.1450.10. 1 hit.
    InterProiIPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    SUPFAMiSSF48652. SSF48652. 1 hit.

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q96QS1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPWSRVRVA KCQMLVTCFF ILLLGLSVAT MVTLTYFGAH FAVIRRASLE    50
    KNPYQAVHQW AFSAGLSLVG LLTLGAVLSA AATVREAQGL MAGGFLCFSL 100
    AFCAQVQVVF WRLHSPTQVE DAMLDTYDLV YEQAMKGTSH VRRQELAAIQ 150
    DVFLCCGKKS PFSRLGSTEA DLCQGEEAAR EDCLQGIRSF LRTHQQVASS 200
    LTSIGLALTV SALLFSSFLW FAIRCGCSLD RKGKYTLTPR ACGRQPQEPS 250
    LLRCSQGGPT HCLHSEAVAI GPRGCSGSLR WLQESDAAPL PLSCHLAAHR 300
    ALQGRSRGGL SGCPERGLSD 320
    Length:320
    Mass (Da):34,631
    Last modified:December 1, 2001 - v1
    Checksum:i534E4C29767B8E6D
    GO
    Isoform 2 (identifier: Q96QS1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-30: Missing.

    Show »
    Length:290
    Mass (Da):31,308
    Checksum:iB9E86C72A6C9B727
    GO
    Isoform 3 (identifier: Q96QS1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         241-253: ACGRQPQEPSLLR → SPGQKSRWAQWVP
         254-320: Missing.

    Show »
    Length:253
    Mass (Da):27,844
    Checksum:iA616383C45BE67E6
    GO
    Isoform 4 (identifier: Q96QS1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-30: Missing.
         137-154: GTSHVRRQELAAIQDVFL → VSVLWEEVSFQPSGEHRG
         155-320: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:124
    Mass (Da):13,643
    Checksum:i29B8FF48896D8BB8
    GO
    Isoform 5 (identifier: Q96QS1-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-258: VSALLFSSFL...PSLLRCSQGG → LGPQGQIHPD...SCYWSKRMLG
         259-320: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:258
    Mass (Da):28,211
    Checksum:i4564FAB7C7C2E9F4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3030Missing in isoform 2 and isoform 4. 2 PublicationsVSP_003932Add
    BLAST
    Alternative sequencei137 – 15418GTSHV…QDVFL → VSVLWEEVSFQPSGEHRG in isoform 4. 1 PublicationVSP_003933Add
    BLAST
    Alternative sequencei155 – 320166Missing in isoform 4. 1 PublicationVSP_003934Add
    BLAST
    Alternative sequencei210 – 25849VSALL…CSQGG → LGPQGQIHPDPTSMWPPAPG AQPLEMLPGWTHTLSPLRSS CYWSKRMLG in isoform 5. 1 PublicationVSP_003935Add
    BLAST
    Alternative sequencei241 – 25313ACGRQ…PSLLR → SPGQKSRWAQWVP in isoform 3. 1 PublicationVSP_003937Add
    BLAST
    Alternative sequencei254 – 32067Missing in isoform 3. 1 PublicationVSP_003938Add
    BLAST
    Alternative sequencei259 – 32062Missing in isoform 5. 1 PublicationVSP_003936Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125569 mRNA. Translation: AAD23580.1.
    AY039001 mRNA. Translation: AAK84431.1.
    BC016693 mRNA. Translation: AAH16693.1.
    AF176070 mRNA. Translation: AAG15840.1.
    AF176071 mRNA. Translation: AAG15841.1.
    CCDSiCCDS7733.1. [Q96QS1-1]
    RefSeqiNP_620591.3. NM_139022.2. [Q96QS1-1]
    UniGeneiHs.271954.

    Genome annotation databases

    EnsembliENST00000182290; ENSP00000182290; ENSG00000064201. [Q96QS1-1]
    ENST00000381121; ENSP00000370513; ENSG00000064201. [Q96QS1-3]
    ENST00000446063; ENSP00000395018; ENSG00000064201. [Q96QS1-5]
    GeneIDi10077.
    KEGGihsa:10077.
    UCSCiuc001lvx.1. human. [Q96QS1-3]
    uc001lvy.1. human. [Q96QS1-1]

    Polymorphism databases

    DMDMi20139069.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125569 mRNA. Translation: AAD23580.1 .
    AY039001 mRNA. Translation: AAK84431.1 .
    BC016693 mRNA. Translation: AAH16693.1 .
    AF176070 mRNA. Translation: AAG15840.1 .
    AF176071 mRNA. Translation: AAG15841.1 .
    CCDSi CCDS7733.1. [Q96QS1-1 ]
    RefSeqi NP_620591.3. NM_139022.2. [Q96QS1-1 ]
    UniGenei Hs.271954.

    3D structure databases

    ProteinModelPortali Q96QS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000182290.

    Polymorphism databases

    DMDMi 20139069.

    Proteomic databases

    PaxDbi Q96QS1.
    PRIDEi Q96QS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000182290 ; ENSP00000182290 ; ENSG00000064201 . [Q96QS1-1 ]
    ENST00000381121 ; ENSP00000370513 ; ENSG00000064201 . [Q96QS1-3 ]
    ENST00000446063 ; ENSP00000395018 ; ENSG00000064201 . [Q96QS1-5 ]
    GeneIDi 10077.
    KEGGi hsa:10077.
    UCSCi uc001lvx.1. human. [Q96QS1-3 ]
    uc001lvy.1. human. [Q96QS1-1 ]

    Organism-specific databases

    CTDi 10077.
    GeneCardsi GC11P002323.
    HGNCi HGNC:13410. TSPAN32.
    HPAi HPA024135.
    MIMi 603853. gene.
    neXtProti NX_Q96QS1.
    PharmGKBi PA33257.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41704.
    HOGENOMi HOG000081817.
    HOVERGENi HBG053580.
    InParanoidi Q96QS1.
    KOi K17359.
    OMAi AARQDCL.
    PhylomeDBi Q96QS1.
    TreeFami TF336277.

    Miscellaneous databases

    GeneWikii TSPAN32.
    GenomeRNAii 10077.
    NextBioi 38097.
    PROi Q96QS1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96QS1.
    Bgeei Q96QS1.
    CleanExi HS_TSPAN32.
    Genevestigatori Q96QS1.

    Family and domain databases

    Gene3Di 1.10.1450.10. 1 hit.
    InterProi IPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting."
      Lee M.P., Brandenburg S., Landes G.M., Adams M., Miller G., Feinberg A.P.
      Hum. Mol. Genet. 8:683-690(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs."
      Robb L., Tarrant J., Groom J., Ibrahim M., Li R., Borobakas B., Wright M.D.
      Biochim. Biophys. Acta 1522:31-41(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Lung.
    4. "Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7."
      Nicholson R.H., Pantano S., Eliason J.F., Galy A., Weiler S., Kaplan J., Hughes M.R., Ko M.S.H.
      Genomics 68:13-21(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-320 (ISOFORMS 3 AND 4), DEVELOPMENTAL STAGE.
    5. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

    Entry informationi

    Entry nameiTSN32_HUMAN
    AccessioniPrimary (citable) accession number: Q96QS1
    Secondary accession number(s): Q96KX4
    , Q9HC50, Q9HC51, Q9Y5U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3