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Protein

Transcriptional activator protein Pur-beta

Gene

PURB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 254By similarityAdd BLAST227

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein Pur-beta
Alternative name(s):
Purine-rich element-binding protein B
Gene namesi
Name:PURB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9702. PURB.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5814.
OpenTargetsiENSG00000146676.
PharmGKBiPA34046.

Polymorphism and mutation databases

DMDMi74732688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002256152 – 312Transcriptional activator protein Pur-betaAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei24Omega-N-methylarginineBy similarity1
Modified residuei31PhosphothreonineBy similarity1
Modified residuei101PhosphoserineCombined sources1
Modified residuei152Omega-N-methylarginineBy similarity1
Modified residuei267N6-acetyllysineBy similarity1
Modified residuei294Omega-N-methylarginineBy similarity1
Modified residuei298PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ96QR8.
MaxQBiQ96QR8.
PaxDbiQ96QR8.
PeptideAtlasiQ96QR8.
PRIDEiQ96QR8.

PTM databases

iPTMnetiQ96QR8.
PhosphoSitePlusiQ96QR8.

Expressioni

Tissue specificityi

Expressed in myocardium of heart failure patients.1 Publication

Gene expression databases

BgeeiENSG00000146676.
CleanExiHS_PURB.
GenevisibleiQ96QR8. HS.

Organism-specific databases

HPAiHPA048766.

Interactioni

Subunit structurei

Homodimer, heterodimer with PURA and heterotrimer with PURA and YBX1/Y-box protein 1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111773. 25 interactors.
IntActiQ96QR8. 11 interactors.
STRINGi9606.ENSP00000379051.

Structurei

3D structure databases

ProteinModelPortaliQ96QR8.
SMRiQ96QR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi153 – 222Gly-richAdd BLAST70

Sequence similaritiesi

Belongs to the PUR DNA-binding protein family.Curated

Phylogenomic databases

eggNOGiKOG3074. Eukaryota.
ENOG410ZKKR. LUCA.
GeneTreeiENSGT00390000015406.
HOGENOMiHOG000232132.
HOVERGENiHBG006888.
InParanoidiQ96QR8.
OMAiENQRGRY.
OrthoDBiEOG091G0JS7.
PhylomeDBiQ96QR8.
TreeFamiTF313701.

Family and domain databases

InterProiIPR006628. PUR-bd_fam.
IPR030499. PURbeta.
[Graphical view]
PANTHERiPTHR12611. PTHR12611. 1 hit.
PTHR12611:SF4. PTHR12611:SF4. 1 hit.
PfamiPF04845. PurA. 1 hit.
[Graphical view]
SMARTiSM00712. PUR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96QR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGDSGSER GGGGGPCGFQ PASRGGGEQE TQELASKRLD IQNKRFYLDV
60 70 80 90 100
KQNAKGRFLK IAEVGAGGSK SRLTLSMAVA AEFRDSLGDF IEHYAQLGPS
110 120 130 140 150
SPEQLAAGAE EGGGPRRALK SEFLVRENRK YYLDLKENQR GRFLRIRQTV
160 170 180 190 200
NRGGGGFGAG PGPGGLQSGQ TIALPAQGLI EFRDALAKLI DDYGGEDDEL
210 220 230 240 250
AGGPGGGAGG PGGGLYGELP EGTSITVDSK RFFFDVGCNK YGVFLRVSEV
260 270 280 290 300
KPSYRNAITV PFKAWGKFGG AFCRYADEMK EIQERQRDKL YERRGGGSGG
310
GEESEGEEVD ED
Length:312
Mass (Da):33,241
Last modified:January 23, 2007 - v3
Checksum:iE39E84E8D2957A18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039216 mRNA. Translation: AAK72462.1.
AC004854 Genomic DNA. Translation: AAS00366.1.
CH236960 Genomic DNA. Translation: EAL23749.1.
CH471128 Genomic DNA. Translation: EAW61073.1.
BC101735 mRNA. Translation: AAI01736.1.
BC101737 mRNA. Translation: AAI01738.1.
CCDSiCCDS5499.1.
PIRiB45036.
RefSeqiNP_150093.1. NM_033224.4.
UniGeneiHs.349150.
Hs.596321.

Genome annotation databases

EnsembliENST00000395699; ENSP00000379051; ENSG00000146676.
GeneIDi5814.
KEGGihsa:5814.
UCSCiuc003tme.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY039216 mRNA. Translation: AAK72462.1.
AC004854 Genomic DNA. Translation: AAS00366.1.
CH236960 Genomic DNA. Translation: EAL23749.1.
CH471128 Genomic DNA. Translation: EAW61073.1.
BC101735 mRNA. Translation: AAI01736.1.
BC101737 mRNA. Translation: AAI01738.1.
CCDSiCCDS5499.1.
PIRiB45036.
RefSeqiNP_150093.1. NM_033224.4.
UniGeneiHs.349150.
Hs.596321.

3D structure databases

ProteinModelPortaliQ96QR8.
SMRiQ96QR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111773. 25 interactors.
IntActiQ96QR8. 11 interactors.
STRINGi9606.ENSP00000379051.

PTM databases

iPTMnetiQ96QR8.
PhosphoSitePlusiQ96QR8.

Polymorphism and mutation databases

DMDMi74732688.

Proteomic databases

EPDiQ96QR8.
MaxQBiQ96QR8.
PaxDbiQ96QR8.
PeptideAtlasiQ96QR8.
PRIDEiQ96QR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395699; ENSP00000379051; ENSG00000146676.
GeneIDi5814.
KEGGihsa:5814.
UCSCiuc003tme.5. human.

Organism-specific databases

CTDi5814.
DisGeNETi5814.
GeneCardsiPURB.
H-InvDBHIX0034001.
HGNCiHGNC:9702. PURB.
HPAiHPA048766.
MIMi608887. gene.
neXtProtiNX_Q96QR8.
OpenTargetsiENSG00000146676.
PharmGKBiPA34046.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3074. Eukaryota.
ENOG410ZKKR. LUCA.
GeneTreeiENSGT00390000015406.
HOGENOMiHOG000232132.
HOVERGENiHBG006888.
InParanoidiQ96QR8.
OMAiENQRGRY.
OrthoDBiEOG091G0JS7.
PhylomeDBiQ96QR8.
TreeFamiTF313701.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146676-MONOMER.

Miscellaneous databases

ChiTaRSiPURB. human.
GeneWikiiPURB.
GenomeRNAii5814.
PROiQ96QR8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146676.
CleanExiHS_PURB.
GenevisibleiQ96QR8. HS.

Family and domain databases

InterProiIPR006628. PUR-bd_fam.
IPR030499. PURbeta.
[Graphical view]
PANTHERiPTHR12611. PTHR12611. 1 hit.
PTHR12611:SF4. PTHR12611:SF4. 1 hit.
PfamiPF04845. PurA. 1 hit.
[Graphical view]
SMARTiSM00712. PUR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPURB_HUMAN
AccessioniPrimary (citable) accession number: Q96QR8
Secondary accession number(s): A4D2L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Defects in PURB may be a cause of progression of myelodysplastic syndrome (MDS) towards acute myelogenous leukemia (AML). MDS refers to a heterogeneous group of closely related hematopoietic disorders. All are characterized by a cellular marrow with impaired morphology and maturation (dysmyelopoiesis) and peripheral blood cytopenias, resulting from ineffective blood cell production. Some patients with MDS develop acute myelogenous leukemia (AML), a malignant disease in which hematopoietic precursors are arrested in an early stage of development.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.