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Protein

Secretoglobin family 3A member 1

Gene

SCGB3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential growth inhibitory cytokine.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

  • negative regulation of cell growth Source: UniProtKB
  • positive regulation of myoblast fusion Source: Ensembl
  • regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 3A member 1
Alternative name(s):
Cytokine HIN-1
High in normal 1
Pneumo secretory protein 2
Short name:
PnSP-2
Uteroglobin-related protein 2
Gene namesi
Name:SCGB3A1
Synonyms:HIN1, PNSP2, UGRP2
ORF Names:UNQ629/PRO1245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18384. SCGB3A1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34994.

Polymorphism and mutation databases

BioMutaiSCGB3A1.
DMDMi46397901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 10484Secretoglobin family 3A member 1PRO_0000036383Add
BLAST

Proteomic databases

PaxDbiQ96QR1.
PeptideAtlasiQ96QR1.
PRIDEiQ96QR1.

PTM databases

PhosphoSiteiQ96QR1.

Expressioni

Tissue specificityi

Highly expressed in breast tissues. Absent in breast cancer cell lines.

Gene expression databases

BgeeiQ96QR1.
CleanExiHS_SCGB3A1.
GenevisibleiQ96QR1. HS.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi124931. 9 interactions.
IntActiQ96QR1. 7 interactions.
STRINGi9606.ENSP00000292641.

Structurei

3D structure databases

ProteinModelPortaliQ96QR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family. UGRP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J536. Eukaryota.
ENOG4111BGJ. LUCA.
GeneTreeiENSGT00420000029848.
HOGENOMiHOG000128185.
HOVERGENiHBG079305.
InParanoidiQ96QR1.
OMAiQKCVAEL.
OrthoDBiEOG7CVQ1R.
PhylomeDBiQ96QR1.
TreeFamiTF336928.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96QR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAALLGLC VALSCSSAAA FLVGSAKPVA QPVAALESAA EAGAGTLANP
60 70 80 90 100
LGTLNPLKLL LSSLGIPVNH LIEGSQKCVA ELGPQAVGAV KALKALLGAL

TVFG
Length:104
Mass (Da):10,100
Last modified:April 13, 2004 - v2
Checksum:iC1A0951F8FB1455F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191A → R in AAK82942 (PubMed:11481438).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040564 mRNA. Translation: AAK82942.1.
AF313458 mRNA. Translation: AAL26217.1.
AF436839 mRNA. Translation: AAQ04481.1.
AY359064 mRNA. Translation: AAQ89423.1.
BC029176 mRNA. Translation: AAH29176.1.
BC072673 mRNA. Translation: AAH72673.1.
CCDSiCCDS4456.1.
RefSeqiNP_443095.2. NM_052863.2.
UniGeneiHs.62492.

Genome annotation databases

EnsembliENST00000292641; ENSP00000292641; ENSG00000161055.
GeneIDi92304.
KEGGihsa:92304.
UCSCiuc003mly.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040564 mRNA. Translation: AAK82942.1.
AF313458 mRNA. Translation: AAL26217.1.
AF436839 mRNA. Translation: AAQ04481.1.
AY359064 mRNA. Translation: AAQ89423.1.
BC029176 mRNA. Translation: AAH29176.1.
BC072673 mRNA. Translation: AAH72673.1.
CCDSiCCDS4456.1.
RefSeqiNP_443095.2. NM_052863.2.
UniGeneiHs.62492.

3D structure databases

ProteinModelPortaliQ96QR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124931. 9 interactions.
IntActiQ96QR1. 7 interactions.
STRINGi9606.ENSP00000292641.

PTM databases

PhosphoSiteiQ96QR1.

Polymorphism and mutation databases

BioMutaiSCGB3A1.
DMDMi46397901.

Proteomic databases

PaxDbiQ96QR1.
PeptideAtlasiQ96QR1.
PRIDEiQ96QR1.

Protocols and materials databases

DNASUi92304.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292641; ENSP00000292641; ENSG00000161055.
GeneIDi92304.
KEGGihsa:92304.
UCSCiuc003mly.4. human.

Organism-specific databases

CTDi92304.
GeneCardsiSCGB3A1.
HGNCiHGNC:18384. SCGB3A1.
MIMi606500. gene.
neXtProtiNX_Q96QR1.
PharmGKBiPA34994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J536. Eukaryota.
ENOG4111BGJ. LUCA.
GeneTreeiENSGT00420000029848.
HOGENOMiHOG000128185.
HOVERGENiHBG079305.
InParanoidiQ96QR1.
OMAiQKCVAEL.
OrthoDBiEOG7CVQ1R.
PhylomeDBiQ96QR1.
TreeFamiTF336928.

Miscellaneous databases

ChiTaRSiSCGB3A1. human.
GeneWikiiSCGB3A1.
GenomeRNAii92304.
PROiQ96QR1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96QR1.
CleanExiHS_SCGB3A1.
GenevisibleiQ96QR1. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor."
    Niimi T., Keck-Waggoner C.L., Popescu N.C., Zhou Y., Levitt R.C., Kimura S.
    Mol. Endocrinol. 15:2021-2036(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning of PnSP-1, a protein of the respiratory tract with potential association to atopy."
    Clippe A., Laing I.A., LeSouef P.N., Bernard A., Knoops B.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.

Entry informationi

Entry nameiSG3A1_HUMAN
AccessioniPrimary (citable) accession number: Q96QR1
Secondary accession number(s): Q96PL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: April 13, 2004
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.