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Protein

Secretoglobin family 3A member 1

Gene

SCGB3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Secreted cytokine-like protein. Inhibits cell growth in vitro.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

  • negative regulation of cell growth Source: UniProtKB
  • positive regulation of myoblast fusion Source: Ensembl
  • regulation of cell proliferation Source: UniProtKB

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 3A member 1
Alternative name(s):
Cytokine HIN-1
High in normal 1
Pneumo secretory protein 2
Short name:
PnSP-2
Uteroglobin-related protein 2
Gene namesi
Name:SCGB3A1
Synonyms:HIN1, PNSP2, UGRP2
ORF Names:UNQ629/PRO1245
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000161055.3.
HGNCiHGNC:18384. SCGB3A1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi92304.
OpenTargetsiENSG00000161055.
PharmGKBiPA34994.

Polymorphism and mutation databases

BioMutaiSCGB3A1.
DMDMi46397901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003638321 – 104Secretoglobin family 3A member 1Add BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96QR1.
PeptideAtlasiQ96QR1.
PRIDEiQ96QR1.

Expressioni

Tissue specificityi

Highly expressed in lung and prostate (PubMed:11481438). Also found in mammary gland, spleen, pancreas, testis and liver (PubMed:11481438). Detected throughout the airway epithelium in lung, with highest expression in large airways (PubMed:12406855). Found in lung submucosal glands where it localizes to acinar and ductile cells (PubMed:12406855). Not detected in respiratory bronchioles, alveolar ducts or alveolar epithelium (PubMed:12406855). In mammary gland, specifically localizes to luminal epithelial cells (PubMed:11481438).2 Publications

Gene expression databases

BgeeiENSG00000161055.
CleanExiHS_SCGB3A1.
GenevisibleiQ96QR1. HS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi124931. 14 interactors.
IntActiQ96QR1. 7 interactors.
STRINGi9606.ENSP00000292641.

Structurei

3D structure databases

ProteinModelPortaliQ96QR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family. UGRP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J536. Eukaryota.
ENOG4111BGJ. LUCA.
GeneTreeiENSGT00420000029848.
HOGENOMiHOG000128185.
HOVERGENiHBG079305.
InParanoidiQ96QR1.
OMAiQKCVAEL.
PhylomeDBiQ96QR1.
TreeFamiTF336928.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96QR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAALLGLC VALSCSSAAA FLVGSAKPVA QPVAALESAA EAGAGTLANP
60 70 80 90 100
LGTLNPLKLL LSSLGIPVNH LIEGSQKCVA ELGPQAVGAV KALKALLGAL

TVFG
Length:104
Mass (Da):10,100
Last modified:April 13, 2004 - v2
Checksum:iC1A0951F8FB1455F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → R in AAK82942 (PubMed:11481438).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040564 mRNA. Translation: AAK82942.1.
AF313458 mRNA. Translation: AAL26217.1.
AF436839 mRNA. Translation: AAQ04481.1.
AY359064 mRNA. Translation: AAQ89423.1.
BC029176 mRNA. Translation: AAH29176.1.
BC072673 mRNA. Translation: AAH72673.1.
CCDSiCCDS4456.1.
RefSeqiNP_443095.2. NM_052863.2.
UniGeneiHs.62492.

Genome annotation databases

EnsembliENST00000292641; ENSP00000292641; ENSG00000161055.
GeneIDi92304.
KEGGihsa:92304.
UCSCiuc003mly.4. human.

Similar proteinsi

Entry informationi

Entry nameiSG3A1_HUMAN
AccessioniPrimary (citable) accession number: Q96QR1
Secondary accession number(s): Q96PL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: April 13, 2004
Last modified: October 25, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families