##gff-version 3 Q96QP1 UniProtKB Chain 1 1244 . . . ID=PRO_0000260028;Note=Alpha-protein kinase 1 Q96QP1 UniProtKB Domain 1017 1237 . . . Note=Alpha-type protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00501 Q96QP1 UniProtKB Region 650 675 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QP1 UniProtKB Region 701 737 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QP1 UniProtKB Region 757 798 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QP1 UniProtKB Region 824 848 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QP1 UniProtKB Compositional bias 703 733 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q96QP1 UniProtKB Binding site 61 61 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Binding site 67 67 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Binding site 116 116 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Binding site 150 153 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Binding site 231 231 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Binding site 233 233 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Binding site 236 237 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Binding site 295 295 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Alternative sequence 1 92 . . . ID=VSP_044735;Note=In isoform 2. MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLL->MCRKRTRARTSAAE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q96QP1 UniProtKB Natural variant 67 67 . . . ID=VAR_041511;Note=Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs33943680,PMID:17344846 Q96QP1 UniProtKB Natural variant 175 175 . . . ID=VAR_028982;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs6533616,PMID:17344846 Q96QP1 UniProtKB Natural variant 237 237 . . . ID=VAR_084993;Note=In ROSAH. T->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:30967659,ECO:0000269|PubMed:31939038;Dbxref=PMID:30967659,PMID:31939038 Q96QP1 UniProtKB Natural variant 292 292 . . . ID=VAR_041512;Note=T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34120296,PMID:17344846 Q96QP1 UniProtKB Natural variant 320 320 . . . ID=VAR_041513;Note=L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs757602009,PMID:17344846 Q96QP1 UniProtKB Natural variant 339 339 . . . ID=VAR_041514;Note=In an ovarian mucinous carcinoma sample%3B somatic mutation. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Q96QP1 UniProtKB Natural variant 383 383 . . . ID=VAR_041515;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs147641444,PMID:17344846 Q96QP1 UniProtKB Natural variant 565 565 . . . ID=VAR_028983;Note=G->D;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10021370,ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.5;Dbxref=dbSNP:rs2074388,PMID:10021370,PMID:10819331,PMID:14702039,PMID:17344846 Q96QP1 UniProtKB Natural variant 642 642 . . . ID=VAR_028984;Note=H->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10021370,ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.5;Dbxref=dbSNP:rs13148353,PMID:10021370,PMID:10819331,PMID:14702039,PMID:17344846 Q96QP1 UniProtKB Natural variant 660 660 . . . ID=VAR_041516;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35389530,PMID:17344846 Q96QP1 UniProtKB Natural variant 681 681 . . . ID=VAR_041517;Note=G->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35519493,PMID:14702039,PMID:17344846 Q96QP1 UniProtKB Natural variant 732 732 . . . ID=VAR_028985;Note=M->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10021370,ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.5;Dbxref=dbSNP:rs2074379,PMID:10021370,PMID:10819331,PMID:14702039,PMID:17344846 Q96QP1 UniProtKB Natural variant 861 861 . . . ID=VAR_028986;Note=M->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10021370,ECO:0000269|PubMed:10819331,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.5;Dbxref=dbSNP:rs11726117,PMID:10021370,PMID:10819331,PMID:14702039,PMID:17344846 Q96QP1 UniProtKB Natural variant 870 870 . . . ID=VAR_028987;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs2074380,PMID:17344846 Q96QP1 UniProtKB Natural variant 873 873 . . . ID=VAR_041518;Note=R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34946272,PMID:17344846 Q96QP1 UniProtKB Natural variant 910 910 . . . ID=VAR_041519;Note=E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35308602,PMID:17344846 Q96QP1 UniProtKB Natural variant 916 916 . . . ID=VAR_028988;Note=N->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs2074381,PMID:17344846 Q96QP1 UniProtKB Natural variant 935 935 . . . ID=VAR_041520;Note=P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34780600,PMID:17344846 Q96QP1 UniProtKB Natural variant 1008 1008 . . . ID=VAR_057741;Note=H->P;Dbxref=dbSNP:rs34079946 Q96QP1 UniProtKB Natural variant 1084 1084 . . . ID=VAR_041521;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34677416,PMID:17344846 Q96QP1 UniProtKB Natural variant 1117 1117 . . . ID=VAR_041522;Note=L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs35756863,PMID:17344846 Q96QP1 UniProtKB Natural variant 1160 1160 . . . ID=VAR_041523;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55696324,PMID:17344846 Q96QP1 UniProtKB Mutagenesis 67 67 . . . Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity%3B when associated with A-231. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Mutagenesis 116 116 . . . Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Mutagenesis 150 150 . . . Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Mutagenesis 153 153 . . . Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Mutagenesis 231 231 . . . Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity%3B when associated with A-67. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Mutagenesis 233 233 . . . Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Mutagenesis 237 237 . . . Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity%3B when associated with K-295. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Mutagenesis 295 295 . . . Note=Impaired ADP-D-glycero-beta-D-manno-heptose-binding and ability to activate the serine/threonine-protein kinase activity%3B when associated with E-237. F->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Mutagenesis 1067 1067 . . . Note=Abolishes the serine/threonine-protein kinase and ability to initiate the innate immune response. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30111836;Dbxref=PMID:30111836 Q96QP1 UniProtKB Sequence conflict 83 83 . . . Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96QP1 UniProtKB Sequence conflict 577 577 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96QP1 UniProtKB Helix 4 23 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 30 41 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 45 55 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Turn 65 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 74 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 80 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 88 100 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 104 120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 124 137 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 145 157 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 161 173 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Turn 174 176 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Beta strand 184 186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 187 206 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 210 225 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Beta strand 227 229 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 232 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 251 258 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 266 270 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 274 288 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Turn 289 291 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 293 311 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 318 337 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 348 369 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 373 394 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 398 418 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C Q96QP1 UniProtKB Helix 442 444 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5Z2C