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Q96QP1

- ALPK1_HUMAN

UniProt

Q96QP1 - ALPK1_HUMAN

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Protein
Alpha-protein kinase 1
Gene
ALPK1, KIAA1527, LAK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-protein kinase 1 (EC:2.7.11.-)
    Alternative name(s):
    Chromosome 4 kinase
    Lymphocyte alpha-protein kinase
    Gene namesi
    Name:ALPK1
    Synonyms:KIAA1527, LAK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:20917. ALPK1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891785.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12441244Alpha-protein kinase 1
    PRO_0000260028Add
    BLAST

    Proteomic databases

    PaxDbiQ96QP1.
    PRIDEiQ96QP1.

    PTM databases

    PhosphoSiteiQ96QP1.

    Expressioni

    Tissue specificityi

    Highly expressed in liver.1 Publication

    Gene expression databases

    ArrayExpressiQ96QP1.
    BgeeiQ96QP1.
    CleanExiHS_ALPK1.
    GenevestigatoriQ96QP1.

    Organism-specific databases

    HPAiHPA027435.
    HPA027443.

    Interactioni

    Protein-protein interaction databases

    BioGridi123183. 2 interactions.
    IntActiQ96QP1. 1 interaction.
    STRINGi9606.ENSP00000177648.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QP1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1017 – 1237221Alpha-type protein kinase
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi105 – 1095Poly-Ala
    Compositional biasi921 – 96040Ser-rich
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG73232.
    HOGENOMiHOG000169279.
    HOVERGENiHBG079770.
    InParanoidiQ96QP1.
    KOiK08868.
    OMAiNIRGTCL.
    OrthoDBiEOG76QFGG.
    PhylomeDBiQ96QP1.
    TreeFamiTF316085.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    [Graphical view]
    PfamiPF02816. Alpha_kinase. 1 hit.
    [Graphical view]
    SMARTiSM00811. Alpha_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51158. ALPHA_KINASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96QP1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ALLPSELRTL     50
    IQEAKEMKWP FVPEKWQYKQ AVGPEDKTNL KDVIGAGLQQ LLASLRASIL 100
    ARDCAAAAAI VFLVDRFLYG LDVSGKLLQV AKGLHKLQPA TPIAPQVVIR 150
    QARISVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR 200
    GQILQKLGMW YEAAELIWAS IVGYLALPQP DKKGLSTSLG ILADIFVSMS 250
    KNDYEKFKNN PQINLSLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV 300
    NIRGTCLLSY SSSNDCPPEL KNLHLCEAKE AFEIGLLTKR DDEPVTGKQE 350
    LHSFVKAAFG LTTVHRRLHG ETGTVHAASQ LCKEAMGKLY NFSTSSRSQD 400
    REALSQEVMS VIAQVKEHLQ VQSFSNVDDR SYVPESFECR LDKLILHGQG 450
    DFQKILDTYS QHHTSVCEVF ESDCGNNKNE QKDAKTGVCI TALKTEIKNI 500
    DTVSTTQEKP HCQRDTGISS SLMGKNVQRE LRRGGRRNWT HSDAFRVSLD 550
    QDVETETEPS DYSNGEGAVF NKSLSGSQTS SAWSNLSGFS SSASWEEVNY 600
    HVDDRSARKE PGKEHLVDTQ CSTALSEELE NDREGRAMHS LHSQLHDLSL 650
    QEPNNDNLEP SQNQPQQQMP LTPFSPHNTP GIFLAPGAGL LEGAPEGIQE 700
    VRNMGPRNTS AHSRPSYRSA SWSSDSGRPK NMGTHPSVQK EEAFEIIVEF 750
    PETNCDVKDR QGKEQGEEIS ERGAGPTFKA SPSWVDPEGE TAESTEDAPL 800
    DFHRVLHNSL GNISMLPCSS FTPNWPVQNP DSRKSGGPVA EQGIDPDAST 850
    VDEEGQLLDS MDVPCTNGHG SHRLCILRQP PGQRAETPNS SVSGNILFPV 900
    LSEDCTTTEE GNQPGNMLNC SQNSSSSSVW WLKSPAFSSG SSEGDSPWSY 950
    LNSSGSSWVS LPGKMRKEIL EARTLQPDDF EKLLAGVRHD WLFQRLENTG 1000
    VFKPSQLHRA HSALLLKYSK KSELWTAQET IVYLGDYLTV KKKGRQRNAF 1050
    WVHHLHQEEI LGRYVGKDYK EQKGLWHHFT DVERQMTAQH YVTEFNKRLY 1100
    EQNIPTQIFY IPSTILLILE DKTIKGCISV EPYILGEFVK LSNNTKVVKT 1150
    EYKATEYGLA YGHFSYEFSN HRDVVVDLQG WVTGNGKGLI YLTDPQIHSV 1200
    DQKVFTTNFG KRGIFYFFNN QHVECNEICH RLSLTRPSME KPCT 1244
    Length:1,244
    Mass (Da):138,861
    Last modified:October 5, 2010 - v3
    Checksum:i857D353D159A1630
    GO
    Isoform 2 (identifier: Q96QP1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-92: MNNQKVVAVL...VIGAGLQQLL → MCRKRTRARTSAAE

    Note: No experimental confirmation available.

    Show »
    Length:1,166
    Mass (Da):129,951
    Checksum:i1996AB197A4DDEEC
    GO

    Sequence cautioni

    The sequence BAC85140.1 differs from that shown. Reason: Intron retention.
    The sequence BAC85140.1 differs from that shown. Reason: Frameshift at positions 208 and 1022.
    The sequence BC060780 differs from that shown. Reason: Frameshift at position 1044.
    The sequence BAC85140.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671Q → R.1 Publication
    Corresponds to variant rs33943680 [ dbSNP | Ensembl ].
    VAR_041511
    Natural varianti175 – 1751N → D.1 Publication
    Corresponds to variant rs6533616 [ dbSNP | Ensembl ].
    VAR_028982
    Natural varianti292 – 2921T → M.1 Publication
    Corresponds to variant rs34120296 [ dbSNP | Ensembl ].
    VAR_041512
    Natural varianti320 – 3201L → M.1 Publication
    VAR_041513
    Natural varianti339 – 3391K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
    VAR_041514
    Natural varianti383 – 3831K → E.1 Publication
    Corresponds to variant rs147641444 [ dbSNP | Ensembl ].
    VAR_041515
    Natural varianti565 – 5651G → D.5 Publications
    Corresponds to variant rs2074388 [ dbSNP | Ensembl ].
    VAR_028983
    Natural varianti642 – 6421H → R.5 Publications
    Corresponds to variant rs13148353 [ dbSNP | Ensembl ].
    VAR_028984
    Natural varianti660 – 6601P → L.1 Publication
    Corresponds to variant rs35389530 [ dbSNP | Ensembl ].
    VAR_041516
    Natural varianti681 – 6811G → D.2 Publications
    Corresponds to variant rs35519493 [ dbSNP | Ensembl ].
    VAR_041517
    Natural varianti732 – 7321M → I.5 Publications
    Corresponds to variant rs2074379 [ dbSNP | Ensembl ].
    VAR_028985
    Natural varianti861 – 8611M → T.5 Publications
    Corresponds to variant rs11726117 [ dbSNP | Ensembl ].
    VAR_028986
    Natural varianti870 – 8701G → S.1 Publication
    Corresponds to variant rs2074380 [ dbSNP | Ensembl ].
    VAR_028987
    Natural varianti873 – 8731R → I.1 Publication
    Corresponds to variant rs34946272 [ dbSNP | Ensembl ].
    VAR_041518
    Natural varianti910 – 9101E → D.1 Publication
    Corresponds to variant rs35308602 [ dbSNP | Ensembl ].
    VAR_041519
    Natural varianti916 – 9161N → D.1 Publication
    Corresponds to variant rs2074381 [ dbSNP | Ensembl ].
    VAR_028988
    Natural varianti935 – 9351P → L.1 Publication
    Corresponds to variant rs34780600 [ dbSNP | Ensembl ].
    VAR_041520
    Natural varianti1008 – 10081H → P.
    Corresponds to variant rs34079946 [ dbSNP | Ensembl ].
    VAR_057741
    Natural varianti1084 – 10841R → Q.1 Publication
    Corresponds to variant rs34677416 [ dbSNP | Ensembl ].
    VAR_041521
    Natural varianti1117 – 11171L → P.1 Publication
    Corresponds to variant rs35756863 [ dbSNP | Ensembl ].
    VAR_041522
    Natural varianti1160 – 11601A → G.1 Publication
    Corresponds to variant rs55696324 [ dbSNP | Ensembl ].
    VAR_041523

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9292MNNQK…LQQLL → MCRKRTRARTSAAE in isoform 2.
    VSP_044735Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831V → L in BAC85140. 1 Publication
    Sequence conflicti577 – 5771S → G in BAG65473. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY044164 mRNA. Translation: AAK94675.1.
    AK304708 mRNA. Translation: BAG65473.1.
    AC004049 Genomic DNA. No translation available.
    AC109347 Genomic DNA. No translation available.
    BC060780 mRNA. No translation available.
    AK131090 mRNA. Translation: BAC85140.1. Sequence problems.
    AB040960 mRNA. Translation: BAA96051.1.
    AB075877 mRNA. Translation: BAD38659.1.
    CCDSiCCDS3697.1. [Q96QP1-1]
    CCDS58923.1. [Q96QP1-2]
    RefSeqiNP_001095876.1. NM_001102406.1. [Q96QP1-1]
    NP_001240813.1. NM_001253884.1. [Q96QP1-2]
    NP_079420.3. NM_025144.3. [Q96QP1-1]
    UniGeneiHs.652825.

    Genome annotation databases

    EnsembliENST00000177648; ENSP00000177648; ENSG00000073331. [Q96QP1-1]
    ENST00000458497; ENSP00000398048; ENSG00000073331. [Q96QP1-1]
    ENST00000504176; ENSP00000426044; ENSG00000073331. [Q96QP1-2]
    GeneIDi80216.
    KEGGihsa:80216.
    UCSCiuc003ian.4. human. [Q96QP1-1]

    Polymorphism databases

    DMDMi308153632.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY044164 mRNA. Translation: AAK94675.1 .
    AK304708 mRNA. Translation: BAG65473.1 .
    AC004049 Genomic DNA. No translation available.
    AC109347 Genomic DNA. No translation available.
    BC060780 mRNA. No translation available.
    AK131090 mRNA. Translation: BAC85140.1 . Sequence problems.
    AB040960 mRNA. Translation: BAA96051.1 .
    AB075877 mRNA. Translation: BAD38659.1 .
    CCDSi CCDS3697.1. [Q96QP1-1 ]
    CCDS58923.1. [Q96QP1-2 ]
    RefSeqi NP_001095876.1. NM_001102406.1. [Q96QP1-1 ]
    NP_001240813.1. NM_001253884.1. [Q96QP1-2 ]
    NP_079420.3. NM_025144.3. [Q96QP1-1 ]
    UniGenei Hs.652825.

    3D structure databases

    ProteinModelPortali Q96QP1.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 123183. 2 interactions.
    IntActi Q96QP1. 1 interaction.
    STRINGi 9606.ENSP00000177648.

    PTM databases

    PhosphoSitei Q96QP1.

    Polymorphism databases

    DMDMi 308153632.

    Proteomic databases

    PaxDbi Q96QP1.
    PRIDEi Q96QP1.

    Protocols and materials databases

    DNASUi 80216.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000177648 ; ENSP00000177648 ; ENSG00000073331 . [Q96QP1-1 ]
    ENST00000458497 ; ENSP00000398048 ; ENSG00000073331 . [Q96QP1-1 ]
    ENST00000504176 ; ENSP00000426044 ; ENSG00000073331 . [Q96QP1-2 ]
    GeneIDi 80216.
    KEGGi hsa:80216.
    UCSCi uc003ian.4. human. [Q96QP1-1 ]

    Organism-specific databases

    CTDi 80216.
    GeneCardsi GC04P113218.
    H-InvDB HIX0004446.
    HGNCi HGNC:20917. ALPK1.
    HPAi HPA027435.
    HPA027443.
    MIMi 607347. gene.
    neXtProti NX_Q96QP1.
    PharmGKBi PA134891785.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73232.
    HOGENOMi HOG000169279.
    HOVERGENi HBG079770.
    InParanoidi Q96QP1.
    KOi K08868.
    OMAi NIRGTCL.
    OrthoDBi EOG76QFGG.
    PhylomeDBi Q96QP1.
    TreeFami TF316085.

    Miscellaneous databases

    GeneWikii ALPK1.
    GenomeRNAii 80216.
    NextBioi 70616.
    PROi Q96QP1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96QP1.
    Bgeei Q96QP1.
    CleanExi HS_ALPK1.
    Genevestigatori Q96QP1.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    [Graphical view ]
    Pfami PF02816. Alpha_kinase. 1 hit.
    [Graphical view ]
    SMARTi SM00811. Alpha_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51158. ALPHA_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Alpha-kinases: a new class of protein kinases with a novel catalytic domain."
      Ryazanov A.G., Pavur K.S., Dorovkov M.V.
      Curr. Biol. 9:R43-R45(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASP-565; ARG-642; ILE-732 AND THR-861.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ASP-565; ARG-642; ASP-681; ILE-732 AND THR-861.
      Tissue: Uterus.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    5. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-1244 (ISOFORM 1), VARIANTS ASP-565; ARG-642; ILE-732 AND THR-861.
      Tissue: Spleen.
    6. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 444-1244 (ISOFORM 1), VARIANTS ASP-565; ARG-642; ILE-732 AND THR-861, TISSUE SPECIFICITY.
      Tissue: Brain.
    7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    8. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
      Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1018-1244 (ISOFORM 1).
    9. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-67; ASP-175; MET-292; MET-320; GLU-339; GLU-383; ASP-565; ARG-642; LEU-660; ASP-681; ILE-732; THR-861; SER-870; ILE-873; ASP-910; ASP-916; LEU-935; GLN-1084; PRO-1117 AND GLY-1160.

    Entry informationi

    Entry nameiALPK1_HUMAN
    AccessioniPrimary (citable) accession number: Q96QP1
    Secondary accession number(s): B4E3G1
    , F5H138, Q68CI9, Q6P9F9, Q6ZNK4, Q9P201
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: October 5, 2010
    Last modified: July 9, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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