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Q96QP1

- ALPK1_HUMAN

UniProt

Q96QP1 - ALPK1_HUMAN

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Protein

Alpha-protein kinase 1

Gene
ALPK1, KIAA1527, LAK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 1 (EC:2.7.11.-)
Alternative name(s):
Chromosome 4 kinase
Lymphocyte alpha-protein kinase
Gene namesi
Name:ALPK1
Synonyms:KIAA1527, LAK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:20917. ALPK1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12441244Alpha-protein kinase 1PRO_0000260028Add
BLAST

Proteomic databases

PaxDbiQ96QP1.
PRIDEiQ96QP1.

PTM databases

PhosphoSiteiQ96QP1.

Expressioni

Tissue specificityi

Highly expressed in liver.1 Publication

Gene expression databases

ArrayExpressiQ96QP1.
BgeeiQ96QP1.
CleanExiHS_ALPK1.
GenevestigatoriQ96QP1.

Organism-specific databases

HPAiHPA027435.
HPA027443.

Interactioni

Protein-protein interaction databases

BioGridi123183. 2 interactions.
IntActiQ96QP1. 1 interaction.
STRINGi9606.ENSP00000177648.

Structurei

3D structure databases

ProteinModelPortaliQ96QP1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1017 – 1237221Alpha-type protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi105 – 1095Poly-Ala
Compositional biasi921 – 96040Ser-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG73232.
HOGENOMiHOG000169279.
HOVERGENiHBG079770.
InParanoidiQ96QP1.
KOiK08868.
OMAiNIRGTCL.
OrthoDBiEOG76QFGG.
PhylomeDBiQ96QP1.
TreeFamiTF316085.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96QP1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ALLPSELRTL     50
IQEAKEMKWP FVPEKWQYKQ AVGPEDKTNL KDVIGAGLQQ LLASLRASIL 100
ARDCAAAAAI VFLVDRFLYG LDVSGKLLQV AKGLHKLQPA TPIAPQVVIR 150
QARISVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR 200
GQILQKLGMW YEAAELIWAS IVGYLALPQP DKKGLSTSLG ILADIFVSMS 250
KNDYEKFKNN PQINLSLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV 300
NIRGTCLLSY SSSNDCPPEL KNLHLCEAKE AFEIGLLTKR DDEPVTGKQE 350
LHSFVKAAFG LTTVHRRLHG ETGTVHAASQ LCKEAMGKLY NFSTSSRSQD 400
REALSQEVMS VIAQVKEHLQ VQSFSNVDDR SYVPESFECR LDKLILHGQG 450
DFQKILDTYS QHHTSVCEVF ESDCGNNKNE QKDAKTGVCI TALKTEIKNI 500
DTVSTTQEKP HCQRDTGISS SLMGKNVQRE LRRGGRRNWT HSDAFRVSLD 550
QDVETETEPS DYSNGEGAVF NKSLSGSQTS SAWSNLSGFS SSASWEEVNY 600
HVDDRSARKE PGKEHLVDTQ CSTALSEELE NDREGRAMHS LHSQLHDLSL 650
QEPNNDNLEP SQNQPQQQMP LTPFSPHNTP GIFLAPGAGL LEGAPEGIQE 700
VRNMGPRNTS AHSRPSYRSA SWSSDSGRPK NMGTHPSVQK EEAFEIIVEF 750
PETNCDVKDR QGKEQGEEIS ERGAGPTFKA SPSWVDPEGE TAESTEDAPL 800
DFHRVLHNSL GNISMLPCSS FTPNWPVQNP DSRKSGGPVA EQGIDPDAST 850
VDEEGQLLDS MDVPCTNGHG SHRLCILRQP PGQRAETPNS SVSGNILFPV 900
LSEDCTTTEE GNQPGNMLNC SQNSSSSSVW WLKSPAFSSG SSEGDSPWSY 950
LNSSGSSWVS LPGKMRKEIL EARTLQPDDF EKLLAGVRHD WLFQRLENTG 1000
VFKPSQLHRA HSALLLKYSK KSELWTAQET IVYLGDYLTV KKKGRQRNAF 1050
WVHHLHQEEI LGRYVGKDYK EQKGLWHHFT DVERQMTAQH YVTEFNKRLY 1100
EQNIPTQIFY IPSTILLILE DKTIKGCISV EPYILGEFVK LSNNTKVVKT 1150
EYKATEYGLA YGHFSYEFSN HRDVVVDLQG WVTGNGKGLI YLTDPQIHSV 1200
DQKVFTTNFG KRGIFYFFNN QHVECNEICH RLSLTRPSME KPCT 1244
Length:1,244
Mass (Da):138,861
Last modified:October 5, 2010 - v3
Checksum:i857D353D159A1630
GO
Isoform 2 (identifier: Q96QP1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MNNQKVVAVL...VIGAGLQQLL → MCRKRTRARTSAAE

Note: No experimental confirmation available.

Show »
Length:1,166
Mass (Da):129,951
Checksum:i1996AB197A4DDEEC
GO

Sequence cautioni

The sequence BAC85140.1 differs from that shown. Reason: Intron retention.
The sequence BAC85140.1 differs from that shown. Reason: Frameshift at positions 208 and 1022.
The sequence BC060780 differs from that shown. Reason: Frameshift at position 1044.
The sequence BAC85140.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671Q → R.1 Publication
Corresponds to variant rs33943680 [ dbSNP | Ensembl ].
VAR_041511
Natural varianti175 – 1751N → D.1 Publication
Corresponds to variant rs6533616 [ dbSNP | Ensembl ].
VAR_028982
Natural varianti292 – 2921T → M.1 Publication
Corresponds to variant rs34120296 [ dbSNP | Ensembl ].
VAR_041512
Natural varianti320 – 3201L → M.1 Publication
VAR_041513
Natural varianti339 – 3391K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
VAR_041514
Natural varianti383 – 3831K → E.1 Publication
Corresponds to variant rs147641444 [ dbSNP | Ensembl ].
VAR_041515
Natural varianti565 – 5651G → D.5 Publications
Corresponds to variant rs2074388 [ dbSNP | Ensembl ].
VAR_028983
Natural varianti642 – 6421H → R.5 Publications
Corresponds to variant rs13148353 [ dbSNP | Ensembl ].
VAR_028984
Natural varianti660 – 6601P → L.1 Publication
Corresponds to variant rs35389530 [ dbSNP | Ensembl ].
VAR_041516
Natural varianti681 – 6811G → D.2 Publications
Corresponds to variant rs35519493 [ dbSNP | Ensembl ].
VAR_041517
Natural varianti732 – 7321M → I.5 Publications
Corresponds to variant rs2074379 [ dbSNP | Ensembl ].
VAR_028985
Natural varianti861 – 8611M → T.5 Publications
Corresponds to variant rs11726117 [ dbSNP | Ensembl ].
VAR_028986
Natural varianti870 – 8701G → S.1 Publication
Corresponds to variant rs2074380 [ dbSNP | Ensembl ].
VAR_028987
Natural varianti873 – 8731R → I.1 Publication
Corresponds to variant rs34946272 [ dbSNP | Ensembl ].
VAR_041518
Natural varianti910 – 9101E → D.1 Publication
Corresponds to variant rs35308602 [ dbSNP | Ensembl ].
VAR_041519
Natural varianti916 – 9161N → D.1 Publication
Corresponds to variant rs2074381 [ dbSNP | Ensembl ].
VAR_028988
Natural varianti935 – 9351P → L.1 Publication
Corresponds to variant rs34780600 [ dbSNP | Ensembl ].
VAR_041520
Natural varianti1008 – 10081H → P.
Corresponds to variant rs34079946 [ dbSNP | Ensembl ].
VAR_057741
Natural varianti1084 – 10841R → Q.1 Publication
Corresponds to variant rs34677416 [ dbSNP | Ensembl ].
VAR_041521
Natural varianti1117 – 11171L → P.1 Publication
Corresponds to variant rs35756863 [ dbSNP | Ensembl ].
VAR_041522
Natural varianti1160 – 11601A → G.1 Publication
Corresponds to variant rs55696324 [ dbSNP | Ensembl ].
VAR_041523

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292MNNQK…LQQLL → MCRKRTRARTSAAE in isoform 2. VSP_044735Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831V → L in BAC85140. 1 Publication
Sequence conflicti577 – 5771S → G in BAG65473. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044164 mRNA. Translation: AAK94675.1.
AK304708 mRNA. Translation: BAG65473.1.
AC004049 Genomic DNA. No translation available.
AC109347 Genomic DNA. No translation available.
BC060780 mRNA. No translation available.
AK131090 mRNA. Translation: BAC85140.1. Sequence problems.
AB040960 mRNA. Translation: BAA96051.1.
AB075877 mRNA. Translation: BAD38659.1.
CCDSiCCDS3697.1. [Q96QP1-1]
CCDS58923.1. [Q96QP1-2]
RefSeqiNP_001095876.1. NM_001102406.1. [Q96QP1-1]
NP_001240813.1. NM_001253884.1. [Q96QP1-2]
NP_079420.3. NM_025144.3. [Q96QP1-1]
UniGeneiHs.652825.

Genome annotation databases

EnsembliENST00000177648; ENSP00000177648; ENSG00000073331. [Q96QP1-1]
ENST00000458497; ENSP00000398048; ENSG00000073331. [Q96QP1-1]
ENST00000504176; ENSP00000426044; ENSG00000073331. [Q96QP1-2]
GeneIDi80216.
KEGGihsa:80216.
UCSCiuc003ian.4. human. [Q96QP1-1]

Polymorphism databases

DMDMi308153632.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044164 mRNA. Translation: AAK94675.1 .
AK304708 mRNA. Translation: BAG65473.1 .
AC004049 Genomic DNA. No translation available.
AC109347 Genomic DNA. No translation available.
BC060780 mRNA. No translation available.
AK131090 mRNA. Translation: BAC85140.1 . Sequence problems.
AB040960 mRNA. Translation: BAA96051.1 .
AB075877 mRNA. Translation: BAD38659.1 .
CCDSi CCDS3697.1. [Q96QP1-1 ]
CCDS58923.1. [Q96QP1-2 ]
RefSeqi NP_001095876.1. NM_001102406.1. [Q96QP1-1 ]
NP_001240813.1. NM_001253884.1. [Q96QP1-2 ]
NP_079420.3. NM_025144.3. [Q96QP1-1 ]
UniGenei Hs.652825.

3D structure databases

ProteinModelPortali Q96QP1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123183. 2 interactions.
IntActi Q96QP1. 1 interaction.
STRINGi 9606.ENSP00000177648.

PTM databases

PhosphoSitei Q96QP1.

Polymorphism databases

DMDMi 308153632.

Proteomic databases

PaxDbi Q96QP1.
PRIDEi Q96QP1.

Protocols and materials databases

DNASUi 80216.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000177648 ; ENSP00000177648 ; ENSG00000073331 . [Q96QP1-1 ]
ENST00000458497 ; ENSP00000398048 ; ENSG00000073331 . [Q96QP1-1 ]
ENST00000504176 ; ENSP00000426044 ; ENSG00000073331 . [Q96QP1-2 ]
GeneIDi 80216.
KEGGi hsa:80216.
UCSCi uc003ian.4. human. [Q96QP1-1 ]

Organism-specific databases

CTDi 80216.
GeneCardsi GC04P113218.
H-InvDB HIX0004446.
HGNCi HGNC:20917. ALPK1.
HPAi HPA027435.
HPA027443.
MIMi 607347. gene.
neXtProti NX_Q96QP1.
PharmGKBi PA134891785.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73232.
HOGENOMi HOG000169279.
HOVERGENi HBG079770.
InParanoidi Q96QP1.
KOi K08868.
OMAi NIRGTCL.
OrthoDBi EOG76QFGG.
PhylomeDBi Q96QP1.
TreeFami TF316085.

Miscellaneous databases

GeneWikii ALPK1.
GenomeRNAii 80216.
NextBioi 70616.
PROi Q96QP1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96QP1.
Bgeei Q96QP1.
CleanExi HS_ALPK1.
Genevestigatori Q96QP1.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view ]
Pfami PF02816. Alpha_kinase. 1 hit.
[Graphical view ]
SMARTi SM00811. Alpha_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51158. ALPHA_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alpha-kinases: a new class of protein kinases with a novel catalytic domain."
    Ryazanov A.G., Pavur K.S., Dorovkov M.V.
    Curr. Biol. 9:R43-R45(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ASP-565; ARG-642; ILE-732 AND THR-861.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ASP-565; ARG-642; ASP-681; ILE-732 AND THR-861.
    Tissue: Uterus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-1244 (ISOFORM 1), VARIANTS ASP-565; ARG-642; ILE-732 AND THR-861.
    Tissue: Spleen.
  6. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 444-1244 (ISOFORM 1), VARIANTS ASP-565; ARG-642; ILE-732 AND THR-861, TISSUE SPECIFICITY.
    Tissue: Brain.
  7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  8. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1018-1244 (ISOFORM 1).
  9. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-67; ASP-175; MET-292; MET-320; GLU-339; GLU-383; ASP-565; ARG-642; LEU-660; ASP-681; ILE-732; THR-861; SER-870; ILE-873; ASP-910; ASP-916; LEU-935; GLN-1084; PRO-1117 AND GLY-1160.

Entry informationi

Entry nameiALPK1_HUMAN
AccessioniPrimary (citable) accession number: Q96QP1
Secondary accession number(s): B4E3G1
, F5H138, Q68CI9, Q6P9F9, Q6ZNK4, Q9P201
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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