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Protein

Alpha-protein kinase 1

Gene

ALPK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 1 (EC:2.7.11.-)
Alternative name(s):
Chromosome 4 kinase
Lymphocyte alpha-protein kinase
Gene namesi
Name:ALPK1
Synonyms:KIAA1527, LAK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000073331.17.
HGNCiHGNC:20917. ALPK1.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi80216.
OpenTargetsiENSG00000073331.
PharmGKBiPA134891785.

Polymorphism and mutation databases

BioMutaiALPK1.
DMDMi308153632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600281 – 1244Alpha-protein kinase 1Add BLAST1244

Proteomic databases

EPDiQ96QP1.
MaxQBiQ96QP1.
PaxDbiQ96QP1.
PeptideAtlasiQ96QP1.
PRIDEiQ96QP1.

PTM databases

iPTMnetiQ96QP1.
PhosphoSitePlusiQ96QP1.

Expressioni

Tissue specificityi

Highly expressed in liver.1 Publication

Gene expression databases

BgeeiENSG00000073331.
CleanExiHS_ALPK1.
ExpressionAtlasiQ96QP1. baseline and differential.
GenevisibleiQ96QP1. HS.

Organism-specific databases

HPAiHPA027435.
HPA027443.

Interactioni

Protein-protein interaction databases

BioGridi123183. 6 interactors.
IntActiQ96QP1. 2 interactors.
STRINGi9606.ENSP00000177648.

Structurei

3D structure databases

ProteinModelPortaliQ96QP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1017 – 1237Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST221

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 109Poly-Ala5
Compositional biasi921 – 960Ser-richAdd BLAST40

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFN0. Eukaryota.
ENOG4110KQR. LUCA.
GeneTreeiENSGT00800000124135.
HOGENOMiHOG000169279.
HOVERGENiHBG079770.
InParanoidiQ96QP1.
KOiK08868.
OMAiNIRGTCL.
OrthoDBiEOG091G00VW.
PhylomeDBiQ96QP1.
TreeFamiTF316085.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR004166. MHCK_EF2_kinase.
PfamiView protein in Pfam
PF02816. Alpha_kinase. 1 hit.
SMARTiView protein in SMART
SM00811. Alpha_kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51158. ALPHA_KINASE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96QP1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ALLPSELRTL
60 70 80 90 100
IQEAKEMKWP FVPEKWQYKQ AVGPEDKTNL KDVIGAGLQQ LLASLRASIL
110 120 130 140 150
ARDCAAAAAI VFLVDRFLYG LDVSGKLLQV AKGLHKLQPA TPIAPQVVIR
160 170 180 190 200
QARISVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR
210 220 230 240 250
GQILQKLGMW YEAAELIWAS IVGYLALPQP DKKGLSTSLG ILADIFVSMS
260 270 280 290 300
KNDYEKFKNN PQINLSLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV
310 320 330 340 350
NIRGTCLLSY SSSNDCPPEL KNLHLCEAKE AFEIGLLTKR DDEPVTGKQE
360 370 380 390 400
LHSFVKAAFG LTTVHRRLHG ETGTVHAASQ LCKEAMGKLY NFSTSSRSQD
410 420 430 440 450
REALSQEVMS VIAQVKEHLQ VQSFSNVDDR SYVPESFECR LDKLILHGQG
460 470 480 490 500
DFQKILDTYS QHHTSVCEVF ESDCGNNKNE QKDAKTGVCI TALKTEIKNI
510 520 530 540 550
DTVSTTQEKP HCQRDTGISS SLMGKNVQRE LRRGGRRNWT HSDAFRVSLD
560 570 580 590 600
QDVETETEPS DYSNGEGAVF NKSLSGSQTS SAWSNLSGFS SSASWEEVNY
610 620 630 640 650
HVDDRSARKE PGKEHLVDTQ CSTALSEELE NDREGRAMHS LHSQLHDLSL
660 670 680 690 700
QEPNNDNLEP SQNQPQQQMP LTPFSPHNTP GIFLAPGAGL LEGAPEGIQE
710 720 730 740 750
VRNMGPRNTS AHSRPSYRSA SWSSDSGRPK NMGTHPSVQK EEAFEIIVEF
760 770 780 790 800
PETNCDVKDR QGKEQGEEIS ERGAGPTFKA SPSWVDPEGE TAESTEDAPL
810 820 830 840 850
DFHRVLHNSL GNISMLPCSS FTPNWPVQNP DSRKSGGPVA EQGIDPDAST
860 870 880 890 900
VDEEGQLLDS MDVPCTNGHG SHRLCILRQP PGQRAETPNS SVSGNILFPV
910 920 930 940 950
LSEDCTTTEE GNQPGNMLNC SQNSSSSSVW WLKSPAFSSG SSEGDSPWSY
960 970 980 990 1000
LNSSGSSWVS LPGKMRKEIL EARTLQPDDF EKLLAGVRHD WLFQRLENTG
1010 1020 1030 1040 1050
VFKPSQLHRA HSALLLKYSK KSELWTAQET IVYLGDYLTV KKKGRQRNAF
1060 1070 1080 1090 1100
WVHHLHQEEI LGRYVGKDYK EQKGLWHHFT DVERQMTAQH YVTEFNKRLY
1110 1120 1130 1140 1150
EQNIPTQIFY IPSTILLILE DKTIKGCISV EPYILGEFVK LSNNTKVVKT
1160 1170 1180 1190 1200
EYKATEYGLA YGHFSYEFSN HRDVVVDLQG WVTGNGKGLI YLTDPQIHSV
1210 1220 1230 1240
DQKVFTTNFG KRGIFYFFNN QHVECNEICH RLSLTRPSME KPCT
Length:1,244
Mass (Da):138,861
Last modified:October 5, 2010 - v3
Checksum:i857D353D159A1630
GO
Isoform 2 (identifier: Q96QP1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MNNQKVVAVL...VIGAGLQQLL → MCRKRTRARTSAAE

Note: No experimental confirmation available.
Show »
Length:1,166
Mass (Da):129,951
Checksum:i1996AB197A4DDEEC
GO

Sequence cautioni

The sequence BAC85140 differs from that shown. Intron retention.Curated
The sequence BAC85140 differs from that shown. Reason: Frameshift at positions 208 and 1022.Curated
The sequence BAC85140 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BC060780 differs from that shown. Reason: Frameshift at position 1044.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83V → L in BAC85140 (Ref. 5) Curated1
Sequence conflicti577S → G in BAG65473 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04151167Q → R1 PublicationCorresponds to variant dbSNP:rs33943680Ensembl.1
Natural variantiVAR_028982175N → D1 PublicationCorresponds to variant dbSNP:rs6533616Ensembl.1
Natural variantiVAR_041512292T → M1 PublicationCorresponds to variant dbSNP:rs34120296Ensembl.1
Natural variantiVAR_041513320L → M1 Publication1
Natural variantiVAR_041514339K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041515383K → E1 PublicationCorresponds to variant dbSNP:rs147641444Ensembl.1
Natural variantiVAR_028983565G → D5 PublicationsCorresponds to variant dbSNP:rs2074388Ensembl.1
Natural variantiVAR_028984642H → R5 PublicationsCorresponds to variant dbSNP:rs13148353Ensembl.1
Natural variantiVAR_041516660P → L1 PublicationCorresponds to variant dbSNP:rs35389530Ensembl.1
Natural variantiVAR_041517681G → D2 PublicationsCorresponds to variant dbSNP:rs35519493Ensembl.1
Natural variantiVAR_028985732M → I5 PublicationsCorresponds to variant dbSNP:rs2074379Ensembl.1
Natural variantiVAR_028986861M → T5 PublicationsCorresponds to variant dbSNP:rs11726117Ensembl.1
Natural variantiVAR_028987870G → S1 PublicationCorresponds to variant dbSNP:rs2074380Ensembl.1
Natural variantiVAR_041518873R → I1 PublicationCorresponds to variant dbSNP:rs34946272Ensembl.1
Natural variantiVAR_041519910E → D1 PublicationCorresponds to variant dbSNP:rs35308602Ensembl.1
Natural variantiVAR_028988916N → D1 PublicationCorresponds to variant dbSNP:rs2074381Ensembl.1
Natural variantiVAR_041520935P → L1 PublicationCorresponds to variant dbSNP:rs34780600Ensembl.1
Natural variantiVAR_0577411008H → P. Corresponds to variant dbSNP:rs34079946Ensembl.1
Natural variantiVAR_0415211084R → Q1 PublicationCorresponds to variant dbSNP:rs34677416Ensembl.1
Natural variantiVAR_0415221117L → P1 PublicationCorresponds to variant dbSNP:rs35756863Ensembl.1
Natural variantiVAR_0415231160A → G1 PublicationCorresponds to variant dbSNP:rs55696324Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0447351 – 92MNNQK…LQQLL → MCRKRTRARTSAAE in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044164 mRNA. Translation: AAK94675.1.
AK304708 mRNA. Translation: BAG65473.1.
AC004049 Genomic DNA. No translation available.
AC109347 Genomic DNA. No translation available.
BC060780 mRNA. No translation available.
AK131090 mRNA. Translation: BAC85140.1. Sequence problems.
AB040960 mRNA. Translation: BAA96051.1.
AB075877 mRNA. Translation: BAD38659.1.
CCDSiCCDS3697.1. [Q96QP1-1]
CCDS58923.1. [Q96QP1-2]
RefSeqiNP_001095876.1. NM_001102406.1. [Q96QP1-1]
NP_001240813.1. NM_001253884.1. [Q96QP1-2]
NP_079420.3. NM_025144.3. [Q96QP1-1]
UniGeneiHs.652825.

Genome annotation databases

EnsembliENST00000177648; ENSP00000177648; ENSG00000073331. [Q96QP1-1]
ENST00000458497; ENSP00000398048; ENSG00000073331. [Q96QP1-1]
ENST00000504176; ENSP00000426044; ENSG00000073331. [Q96QP1-2]
GeneIDi80216.
KEGGihsa:80216.
UCSCiuc003ian.5. human. [Q96QP1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiALPK1_HUMAN
AccessioniPrimary (citable) accession number: Q96QP1
Secondary accession number(s): B4E3G1
, F5H138, Q68CI9, Q6P9F9, Q6ZNK4, Q9P201
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 5, 2010
Last modified: November 22, 2017
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families