Alpha-protein kinase 1 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q96QP1 (ALPK1_HUMAN)

Last modified November 24, 2009. Version 60. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Alpha-protein kinase 1
    EC=2.7.11.-
Alternative name(s):
    Lymphocyte alpha-protein kinase
    Chromosome 4 kinase

Gene names

Name:	ALPK1
Synonyms:	KIAA1527, LAK

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.
Tissue specificity	Highly expressed in liver. Ref.4
Sequence similarities	Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. Contains 1 alpha-type protein kinase domain.
Sequence caution	The sequence BAC85140.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC85140.1 differs from that shown. Reason: Frameshift at positions 208 and 1022. The sequence BAC85140.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention. The sequence BC060780 differs from that shown. Reason: Frameshift at position 1044.

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Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1244

1244

Alpha-protein kinase 1

PRO_0000260028

Regions

Domain

1017 – 1237

221

Alpha-type protein kinase

Compositional bias

105 – 109

Poly-Ala

Compositional bias

921 – 960

Ser-rich

Natural variations

Natural variant

Q → R: dbSNP rs33943680. Ref.7

VAR_041511

Natural variant

175

N → D: dbSNP rs6533616. Ref.7

VAR_028982

Natural variant

292

T → M: dbSNP rs34120296.

VAR_041512

Natural variant

320

L → M

VAR_041513

Natural variant

339

K → E in an ovarian mucinous carcinoma sample; somatic mutation. Ref.7

VAR_041514

Natural variant

383

K → E

VAR_041515

Natural variant

565

D → G: dbSNP rs2074388. Ref.7 Ref.2

VAR_028983

Natural variant

642

H → R: dbSNP rs13148353. Ref.4 Ref.7 Ref.1 Ref.3

VAR_028984

Natural variant

660

P → L: dbSNP rs35389530. Ref.7

VAR_041516

Natural variant

681

G → D: dbSNP rs35519493. Ref.7

VAR_041517

Natural variant

732

I → M: dbSNP rs2074379. Ref.7 Ref.2

VAR_028985

Natural variant

861

T → M: dbSNP rs11726117. Ref.7 Ref.2

VAR_028986

Natural variant

870

G → S: dbSNP rs2074380. Ref.7

VAR_028987

Natural variant

873

R → I: dbSNP rs34946272. Ref.7

VAR_041518

Natural variant

910

E → D: dbSNP rs35308602. Ref.7

VAR_041519

Natural variant

916

N → D: dbSNP rs2074381. Ref.7

VAR_028988

Natural variant

935

P → L: dbSNP rs34780600.

VAR_041520

Natural variant

1008

H → P: dbSNP rs34079946.

VAR_057741

Natural variant

1084

R → Q: dbSNP rs34677416.

VAR_041521

Natural variant

1117

L → P: dbSNP rs35756863. Ref.7

VAR_041522

Natural variant

1160

A → G: dbSNP rs55696324.

VAR_041523

Experimental info

Sequence conflict

V → L in BAC85140. Ref.3

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Sequences

Sequence

Length

Mass (Da)

Tools

Q96QP1-1 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: E4E62E6B3579257E
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FASTA

1,244

138,871

        10         20         30         40         50         60 
MNNQKVVAVL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ALLPSELRTL IQEAKEMKWP 

        70         80         90        100        110        120 
FVPEKWQYKQ AVGPEDKTNL KDVIGAGLQQ LLASLRASIL ARDCAAAAAI VFLVDRFLYG 

       130        140        150        160        170        180 
LDVSGKLLQV AKGLHKLQPA TPIAPQVVIR QARISVNSGK LLKAEYILSS LISNNGATGT 

       190        200        210        220        230        240 
WLYRNESDKV LVQSVCIQIR GQILQKLGMW YEAAELIWAS IVGYLALPQP DKKGLSTSLG 

       250        260        270        280        290        300 
ILADIFVSMS KNDYEKFKNN PQINLSLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV 

       310        320        330        340        350        360 
NIRGTCLLSY SSSNDCPPEL KNLHLCEAKE AFEIGLLTKR DDEPVTGKQE LHSFVKAAFG 

       370        380        390        400        410        420 
LTTVHRRLHG ETGTVHAASQ LCKEAMGKLY NFSTSSRSQD REALSQEVMS VIAQVKEHLQ 

       430        440        450        460        470        480 
VQSFSNVDDR SYVPESFECR LDKLILHGQG DFQKILDTYS QHHTSVCEVF ESDCGNNKNE 

       490        500        510        520        530        540 
QKDAKTGVCI TALKTEIKNI DTVSTTQEKP HCQRDTGISS SLMGKNVQRE LRRGGRRNWT 

       550        560        570        580        590        600 
HSDAFRVSLD QDVETETEPS DYSNDEGAVF NKSLSGSQTS SAWSNLSGFS SSASWEEVNY 

       610        620        630        640        650        660 
HVDDRSARKE PGKEHLVDTQ CSTALSEELE NDREGRAMHS LHSQLHDLSL QEPNNDNLEP 

       670        680        690        700        710        720 
SQNQPQQQMP LTPFSPHNTP GIFLAPGAGL LEGAPEGIQE VRNMGPRNTS AHSRPSYRSA 

       730        740        750        760        770        780 
SWSSDSGRPK NIGTHPSVQK EEAFEIIVEF PETNCDVKDR QGKEQGEEIS ERGAGPTFKA 

       790        800        810        820        830        840 
SPSWVDPEGE TAESTEDAPL DFHRVLHNSL GNISMLPCSS FTPNWPVQNP DSRKSGGPVA 

       850        860        870        880        890        900 
EQGIDPDAST VDEEGQLLDS TDVPCTNGHG SHRLCILRQP PGQRAETPNS SVSGNILFPV 

       910        920        930        940        950        960 
LSEDCTTTEE GNQPGNMLNC SQNSSSSSVW WLKSPAFSSG SSEGDSPWSY LNSSGSSWVS 

       970        980        990       1000       1010       1020 
LPGKMRKEIL EARTLQPDDF EKLLAGVRHD WLFQRLENTG VFKPSQLHRA HSALLLKYSK 

      1030       1040       1050       1060       1070       1080 
KSELWTAQET IVYLGDYLTV KKKGRQRNAF WVHHLHQEEI LGRYVGKDYK EQKGLWHHFT 

      1090       1100       1110       1120       1130       1140 
DVERQMTAQH YVTEFNKRLY EQNIPTQIFY IPSTILLILE DKTIKGCISV EPYILGEFVK 

      1150       1160       1170       1180       1190       1200 
LSNNTKVVKT EYKATEYGLA YGHFSYEFSN HRDVVVDLQG WVTGNGKGLI YLTDPQIHSV 

      1210       1220       1230       1240 
DQKVFTTNFG KRGIFYFFNN QHVECNEICH RLSLTRPSME KPCT

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Alpha-kinases: a new class of protein kinases with a novel catalytic domain." Ryazanov A.G., Pavur K.S., Dorovkov M.V. Curr. Biol. 9:R43-R45(1999) [PubMed: 10021370] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-642.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-565; MET-732 AND MET-861. Tissue: Placenta.
[3]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 77-1244, VARIANT ARG-642. Tissue: Spleen.
[4]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 444-1244, VARIANT ARG-642, TISSUE SPECIFICITY. Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas." Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A. Oncogene 23:5901-5911(2004) [PubMed: 15221005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1018-1244.
[7]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-67; ASP-175; MET-292; MET-320; GLU-339; GLU-383; GLY-565; ARG-642; LEU-660; ASP-681; MET-732; MET-861; SER-870; ILE-873; ASP-910; ASP-916; LEU-935; GLN-1084; PRO-1117 AND GLY-1160.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	AY044164 mRNA. Translation: AAK94675.1. BC060780 mRNA. No translation available. AK131090 mRNA. Translation: BAC85140.1. Sequence problems. AB040960 mRNA. Translation: BAA96051.1. AB075877 mRNA. Translation: BAD38659.1.
IPI	IPI00304706.
RefSeq	NP_001095876.1. NP_079420.3.
UniGene	Hs.652825
3D structure databases
HSSP	HSSP built from PDB template 1IA9 based on UniProtKB Q923J1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96QP1.
PTM databases
PhosphoSite	Q96QP1.
Proteomic databases
PRIDE	Q96QP1.
Genome annotation databases
Ensembl	ENST00000177648; ENSP00000177648; ENSG00000073331; Homo sapiens. [Genome view] ENST00000458497; ENSP00000398048; ENSG00000073331; Homo sapiens. [Genome view]
GeneID	80216.
KEGG	hsa:80216.
UCSC	uc003ian.2. human.
Organism-specific databases
CTD	80216.
GeneCards	GC04P113438.
HGNC	HGNC:20917. ALPK1.
MIM	607347. gene.
PharmGKB	PA134891785.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96QP1.
Gene expression databases
ArrayExpress	Q96QP1.
Bgee	Q96QP1.
CleanEx	HS_ALPK1.
Genevestigator	Q96QP1.
GermOnline	ENSG00000073331. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR004166. MHCK_EF2_kinase. [Graphical view]
Pfam	PF02816. Alpha_kinase. 1 hit. [Graphical view]
SMART	SM00811. Alpha_kinase. 1 hit. [Graphical view]
PROSITE	PS51158. ALPHA_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	70616.
SOURCE	Search...

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Entry information

Entry name

ALPK1_HUMAN

Accession

Primary (citable) accession number: Q96QP1
Secondary accession number(s): Q68CI9

Q9P201

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	November 24, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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