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Protein

Small integral membrane protein 14

Gene

SMIM14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 14
Gene namesi
Name:SMIM14
Synonyms:C4orf34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163683.11
HGNCiHGNC:27321 SMIM14
neXtProtiNX_Q96QK8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49LumenalSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 99CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26 – 27LR → TN in N-gly,N; creates a N-glycosylation site. 1 Publication2
Mutagenesisi76 – 77RG → TN in N-gly,C; does not creates a N-glycosylation site. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000163683
PharmGKBiPA162379760

Polymorphism and mutation databases

BioMutaiSMIM14
DMDMi74732680

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002688161 – 99Small integral membrane protein 14Add BLAST99

Proteomic databases

PaxDbiQ96QK8
PeptideAtlasiQ96QK8
PRIDEiQ96QK8
ProteomicsDBi77885

PTM databases

iPTMnetiQ96QK8
PhosphoSitePlusiQ96QK8

Expressioni

Gene expression databases

BgeeiENSG00000163683
CleanExiHS_C4orf34
ExpressionAtlasiQ96QK8 baseline and differential
GenevisibleiQ96QK8 HS

Organism-specific databases

HPAiHPA051299

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-373430,EBI-743099

Protein-protein interaction databases

BioGridi128406, 3 interactors
IntActiQ96QK8, 4 interactors
MINTiQ96QK8
STRINGi9606.ENSP00000295958

Structurei

3D structure databases

ProteinModelPortaliQ96QK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J29M Eukaryota
ENOG41127PU LUCA
GeneTreeiENSGT00390000018294
HOGENOMiHOG000037369
HOVERGENiHBG057647
InParanoidiQ96QK8
OMAiYCTDNEC
OrthoDBiEOG091G10PJ
PhylomeDBiQ96QK8
TreeFamiTF314023

Family and domain databases

InterProiView protein in InterPro
IPR020309 Uncharacterised_CD034/YQF4
PANTHERiPTHR31019 PTHR31019, 1 hit
PfamiView protein in Pfam
PF11027 DUF2615, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD288703 Uncharacterised_CD034/YQF4, 1 hit

Sequencei

Sequence statusi: Complete.

Q96QK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGFDPCE CVCSHEHAMR RLINLLRQSQ SYCTDTECLQ ELPGPSGDNG
60 70 80 90
ISVTMILVAW MVIALILFLL RPPNLRGSSL PGKPTSPHNG QDPPAPPVD
Length:99
Mass (Da):10,710
Last modified:December 1, 2001 - v1
Checksum:iB0E90C424D2D34EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008502 mRNA Translation: AAH08502.1
CCDSiCCDS3456.1
RefSeqiNP_001304825.1, NM_001317896.1
NP_001304826.1, NM_001317897.1
NP_777581.1, NM_174921.2
XP_016863351.1, XM_017007862.1
XP_016863352.1, XM_017007863.1
UniGeneiHs.205952
Hs.576320

Genome annotation databases

EnsembliENST00000295958; ENSP00000295958; ENSG00000163683
GeneIDi201895
KEGGihsa:201895
UCSCiuc003guo.4 human

Similar proteinsi

Entry informationi

Entry nameiSIM14_HUMAN
AccessioniPrimary (citable) accession number: Q96QK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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