Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small integral membrane protein 14

Gene

SMIM14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 14
Gene namesi
Name:SMIM14
Synonyms:C4orf34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:27321. SMIM14.

Subcellular locationi

  • Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949LumenalSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Topological domaini71 – 9929CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi26 – 272LR → TN in N-gly,N; creates a N-glycosylation site. 1 Publication
Mutagenesisi76 – 772RG → TN in N-gly,C; does not creates a N-glycosylation site. 1 Publication

Organism-specific databases

PharmGKBiPA162379760.

Polymorphism and mutation databases

BioMutaiSMIM14.
DMDMi74732680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Small integral membrane protein 14PRO_0000268816Add
BLAST

Proteomic databases

PaxDbiQ96QK8.
PRIDEiQ96QK8.

PTM databases

iPTMnetiQ96QK8.
PhosphoSiteiQ96QK8.

Expressioni

Gene expression databases

BgeeiQ96QK8.
CleanExiHS_C4orf34.
ExpressionAtlasiQ96QK8. baseline and differential.
GenevisibleiQ96QK8. HS.

Organism-specific databases

HPAiHPA051299.

Interactioni

Protein-protein interaction databases

BioGridi128406. 3 interactions.
IntActiQ96QK8. 2 interactions.
STRINGi9606.ENSP00000295958.

Structurei

3D structure databases

ProteinModelPortaliQ96QK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J29M. Eukaryota.
ENOG41127PU. LUCA.
GeneTreeiENSGT00390000018294.
HOGENOMiHOG000037369.
HOVERGENiHBG057647.
InParanoidiQ96QK8.
OMAiSVTMILM.
OrthoDBiEOG7ZSHWG.
PhylomeDBiQ96QK8.
TreeFamiTF314023.

Family and domain databases

InterProiIPR020309. Uncharacterised_CD034/YQF4.
[Graphical view]
PfamiPF11027. DUF2615. 1 hit.
[Graphical view]
ProDomiPD288703. Uncharacterised_CD034/YQF4. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q96QK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGFDPCE CVCSHEHAMR RLINLLRQSQ SYCTDTECLQ ELPGPSGDNG
60 70 80 90
ISVTMILVAW MVIALILFLL RPPNLRGSSL PGKPTSPHNG QDPPAPPVD
Length:99
Mass (Da):10,710
Last modified:December 1, 2001 - v1
Checksum:iB0E90C424D2D34EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008502 mRNA. Translation: AAH08502.1.
CCDSiCCDS3456.1.
RefSeqiNP_001304825.1. NM_001317896.1.
NP_001304826.1. NM_001317897.1.
NP_777581.1. NM_174921.2.
UniGeneiHs.205952.
Hs.576320.

Genome annotation databases

EnsembliENST00000295958; ENSP00000295958; ENSG00000163683.
GeneIDi201895.
KEGGihsa:201895.
UCSCiuc003guo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC008502 mRNA. Translation: AAH08502.1.
CCDSiCCDS3456.1.
RefSeqiNP_001304825.1. NM_001317896.1.
NP_001304826.1. NM_001317897.1.
NP_777581.1. NM_174921.2.
UniGeneiHs.205952.
Hs.576320.

3D structure databases

ProteinModelPortaliQ96QK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128406. 3 interactions.
IntActiQ96QK8. 2 interactions.
STRINGi9606.ENSP00000295958.

PTM databases

iPTMnetiQ96QK8.
PhosphoSiteiQ96QK8.

Polymorphism and mutation databases

BioMutaiSMIM14.
DMDMi74732680.

Proteomic databases

PaxDbiQ96QK8.
PRIDEiQ96QK8.

Protocols and materials databases

DNASUi201895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295958; ENSP00000295958; ENSG00000163683.
GeneIDi201895.
KEGGihsa:201895.
UCSCiuc003guo.4. human.

Organism-specific databases

CTDi201895.
GeneCardsiSMIM14.
HGNCiHGNC:27321. SMIM14.
HPAiHPA051299.
neXtProtiNX_Q96QK8.
PharmGKBiPA162379760.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J29M. Eukaryota.
ENOG41127PU. LUCA.
GeneTreeiENSGT00390000018294.
HOGENOMiHOG000037369.
HOVERGENiHBG057647.
InParanoidiQ96QK8.
OMAiSVTMILM.
OrthoDBiEOG7ZSHWG.
PhylomeDBiQ96QK8.
TreeFamiTF314023.

Miscellaneous databases

GenomeRNAii201895.
NextBioi90210.
PROiQ96QK8.

Gene expression databases

BgeeiQ96QK8.
CleanExiHS_C4orf34.
ExpressionAtlasiQ96QK8. baseline and differential.
GenevisibleiQ96QK8. HS.

Family and domain databases

InterProiIPR020309. Uncharacterised_CD034/YQF4.
[Graphical view]
PfamiPF11027. DUF2615. 1 hit.
[Graphical view]
ProDomiPD288703. Uncharacterised_CD034/YQF4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein."
    Jun M.H., Jun Y.W., Kim K.H., Lee J.A., Jang D.J.
    BMB Rep. 47:563-568(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF 26-LEU-ARG-27 AND 76-ARG-GLY-77.

Entry informationi

Entry nameiSIM14_HUMAN
AccessioniPrimary (citable) accession number: Q96QK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: April 13, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.