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Q96QK1

- VPS35_HUMAN

UniProt

Q96QK1 - VPS35_HUMAN

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Protein
Vacuolar protein sorting-associated protein 35
Gene
VPS35, MEM3, TCCCTA00141
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. cell death Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
  3. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 35
Short name:
hVPS35
Alternative name(s):
Maternal-embryonic 3
Vesicle protein sorting 35
Gene namesi
Name:VPS35
Synonyms:MEM3
ORF Names:TCCCTA00141
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:13487. VPS35.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endosome Source: LIFEdb
  3. extracellular vesicular exosome Source: UniProt
  4. lysosomal membrane Source: UniProtKB
  5. retromer complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Parkinson disease 17 (PARK17) [MIM:614203]: An autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
Note: The disease is caused by mutations affecting the gene represented in this entry.3 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti620 – 6201D → N in PARK17; shows reduce retrograde transport of selective cargo between lysosomes and the Golgi apparatus; shows a progressive reduction in neurite length and branching.
VAR_066659

Keywords - Diseasei

Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

MIMi614203. phenotype.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA37783.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796Vacuolar protein sorting-associated protein 35
PRO_0000065896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphoserine1 Publication
Modified residuei791 – 7911Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96QK1.
PaxDbiQ96QK1.
PeptideAtlasiQ96QK1.
PRIDEiQ96QK1.

PTM databases

PhosphoSiteiQ96QK1.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.

Gene expression databases

BgeeiQ96QK1.
GenevestigatoriQ96QK1.

Organism-specific databases

HPAiHPA040802.

Interactioni

Subunit structurei

Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS26A and VPS26B. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GOLPH3. Interacts with MAGEL2; leading to recruitment of the TRIM27:MAGEL2 E3 ubiquitin ligase complex retromer-containing endosomes. Interacts with LRRK2.4 Publications

Protein-protein interaction databases

BioGridi120855. 63 interactions.
DIPiDIP-29076N.
IntActiQ96QK1. 18 interactions.
MINTiMINT-5001902.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni484 – 4874
Helixi488 – 49811
Helixi503 – 51816
Beta strandi522 – 5243
Helixi525 – 54420
Turni545 – 5495
Helixi553 – 57321
Helixi578 – 59417
Helixi599 – 61719
Helixi621 – 63515
Helixi643 – 65816
Helixi663 – 67210
Helixi674 – 6785
Turni683 – 6875
Helixi693 – 70917
Helixi713 – 73119
Turni732 – 7343
Helixi740 – 75112
Turni752 – 7554
Helixi761 – 77616

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R17X-ray2.80C/D483-780[»]
ProteinModelPortaliQ96QK1.
SMRiQ96QK1. Positions 483-780.

Miscellaneous databases

EvolutionaryTraceiQ96QK1.

Family & Domainsi

Sequence similaritiesi

Belongs to the VPS35 family.

Phylogenomic databases

eggNOGiNOG252873.
HOVERGENiHBG054277.
InParanoidiQ96QK1.
OMAiHELQCLE.
OrthoDBiEOG7TMZR5.
PhylomeDBiQ96QK1.
TreeFamiTF105659.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005378. Vps35.
[Graphical view]
PANTHERiPTHR11099. PTHR11099. 1 hit.
PfamiPF03635. Vps35. 1 hit.
[Graphical view]
PIRSFiPIRSF009375. Retromer_Vps35. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q96QK1-1 [UniParc]FASTAAdd to Basket

« Hide

MPTTQQSPQD EQEKLLDEAI QAVKVQSFQM KRCLDKNKLM DALKHASNML    50
GELRTSMLSP KSYYELYMAI SDELHYLEVY LTDEFAKGRK VADLYELVQY 100
AGNIIPRLYL LITVGVVYVK SFPQSRKDIL KDLVEMCRGV QHPLRGLFLR 150
NYLLQCTRNI LPDEGEPTDE ETTGDISDSM DFVLLNFAEM NKLWVRMQHQ 200
GHSRDREKRE RERQELRILV GTNLVRLSQL EGVNVERYKQ IVLTGILEQV 250
VNCRDALAQE YLMECIIQVF PDEFHLQTLN PFLRACAELH QNVNVKNIII 300
ALIDRLALFA HREDGPGIPA DIKLFDIFSQ QVATVIQSRQ DMPSEDVVSL 350
QVSLINLAMK CYPDRVDYVD KVLETTVEIF NKLNLEHIAT SSAVSKELTR 400
LLKIPVDTYN NILTVLKLKH FHPLFEYFDY ESRKSMSCYV LSNVLDYNTE 450
IVSQDQVDSI MNLVSTLIQD QPDQPVEDPD PEDFADEQSL VGRFIHLLRS 500
EDPDQQYLIL NTARKHFGAG GNQRIRFTLP PLVFAAYQLA FRYKENSKVD 550
DKWEKKCQKI FSFAHQTISA LIKAELAELP LRLFLQGALA AGEIGFENHE 600
TVAYEFMSQA FSLYEDEISD SKAQLAAITL IIGTFERMKC FSEENHEPLR 650
TQCALAASKL LKKPDQGRAV STCAHLFWSG RNTDKNGEEL HGGKRVMECL 700
KKALKIANQC MDPSLQVQLF IEILNRYIYF YEKENDAVTI QVLNQLIQKI 750
REDLPNLESS EETEQINKHF HNTLEHLRLR RESPESEGPI YEGLIL 796
Length:796
Mass (Da):91,707
Last modified:November 25, 2002 - v2
Checksum:i28D2DD1C6B920A0A
GO

Sequence cautioni

The sequence AAG01989.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA91137.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14626.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511G → S.1 Publication
VAR_066653
Natural varianti57 – 571M → I.1 Publication
VAR_066654
Natural varianti82 – 821T → R.1 Publication
VAR_066655
Natural varianti241 – 2411I → M Found in a patient with Parkinson disease. 1 Publication
VAR_066656
Natural varianti316 – 3161P → S Found in a patient with Parkinson disease. 1 Publication
VAR_066657
Natural varianti524 – 5241R → W Found in a patient with Parkinson disease. 1 Publication
VAR_066658
Natural varianti602 – 6021V → D.
Corresponds to variant rs34687100 [ dbSNP | Ensembl ].
VAR_054046
Natural varianti620 – 6201D → N in PARK17; shows reduce retrograde transport of selective cargo between lysosomes and the Golgi apparatus; shows a progressive reduction in neurite length and branching.
VAR_066659
Natural varianti737 – 7371A → V.1 Publication
VAR_066660
Natural varianti774 – 7741L → M.1 Publication
VAR_066661

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421A → S in CAB66822. 1 Publication
Sequence conflicti160 – 1601I → T in BAB14626. 1 Publication
Sequence conflicti168 – 1681T → P in AAF89953. 1 Publication
Sequence conflicti453 – 4531S → F in AAH10362. 1 Publication
Sequence conflicti526 – 5261R → G in BAA91790. 1 Publication
Sequence conflicti694 – 6941K → E in BAA91790. 1 Publication
Sequence conflicti796 – 7961L → H in BAA91137. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF191298 mRNA. Translation: AAF02778.2.
AF186382 mRNA. Translation: AAG40619.1.
AF175265 mRNA. Translation: AAF89953.1.
AF183418 mRNA. Translation: AAG09687.1.
AK001614 mRNA. Translation: BAA91790.1.
AK023650 mRNA. Translation: BAB14626.1. Different initiation.
AK000395 mRNA. Translation: BAA91137.1. Different initiation.
AL136888 mRNA. Translation: CAB66822.1.
AL512769 mRNA. Translation: CAC21686.1.
BC002414 mRNA. Translation: AAH02414.1.
BC010362 mRNA. Translation: AAH10362.1.
BC093036 mRNA. Translation: AAH93036.1.
AY007112 mRNA. Translation: AAG01989.1. Different initiation.
CCDSiCCDS10721.1.
PIRiJC7516.
RefSeqiNP_060676.2. NM_018206.4.
UniGeneiHs.454528.

Genome annotation databases

EnsembliENST00000299138; ENSP00000299138; ENSG00000069329.
GeneIDi55737.
KEGGihsa:55737.
UCSCiuc002eed.3. human.

Polymorphism databases

DMDMi25453321.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF191298 mRNA. Translation: AAF02778.2 .
AF186382 mRNA. Translation: AAG40619.1 .
AF175265 mRNA. Translation: AAF89953.1 .
AF183418 mRNA. Translation: AAG09687.1 .
AK001614 mRNA. Translation: BAA91790.1 .
AK023650 mRNA. Translation: BAB14626.1 . Different initiation.
AK000395 mRNA. Translation: BAA91137.1 . Different initiation.
AL136888 mRNA. Translation: CAB66822.1 .
AL512769 mRNA. Translation: CAC21686.1 .
BC002414 mRNA. Translation: AAH02414.1 .
BC010362 mRNA. Translation: AAH10362.1 .
BC093036 mRNA. Translation: AAH93036.1 .
AY007112 mRNA. Translation: AAG01989.1 . Different initiation.
CCDSi CCDS10721.1.
PIRi JC7516.
RefSeqi NP_060676.2. NM_018206.4.
UniGenei Hs.454528.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2R17 X-ray 2.80 C/D 483-780 [» ]
ProteinModelPortali Q96QK1.
SMRi Q96QK1. Positions 483-780.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120855. 63 interactions.
DIPi DIP-29076N.
IntActi Q96QK1. 18 interactions.
MINTi MINT-5001902.

Chemistry

ChEMBLi CHEMBL2216744.

PTM databases

PhosphoSitei Q96QK1.

Polymorphism databases

DMDMi 25453321.

Proteomic databases

MaxQBi Q96QK1.
PaxDbi Q96QK1.
PeptideAtlasi Q96QK1.
PRIDEi Q96QK1.

Protocols and materials databases

DNASUi 55737.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299138 ; ENSP00000299138 ; ENSG00000069329 .
GeneIDi 55737.
KEGGi hsa:55737.
UCSCi uc002eed.3. human.

Organism-specific databases

CTDi 55737.
GeneCardsi GC16M046691.
GeneReviewsi VPS35.
HGNCi HGNC:13487. VPS35.
HPAi HPA040802.
MIMi 601501. gene.
614203. phenotype.
neXtProti NX_Q96QK1.
Orphaneti 2828. Young adult-onset Parkinsonism.
PharmGKBi PA37783.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252873.
HOVERGENi HBG054277.
InParanoidi Q96QK1.
OMAi HELQCLE.
OrthoDBi EOG7TMZR5.
PhylomeDBi Q96QK1.
TreeFami TF105659.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.

Miscellaneous databases

ChiTaRSi VPS35. human.
EvolutionaryTracei Q96QK1.
GeneWikii VPS35.
GenomeRNAii 55737.
NextBioi 60680.
PROi Q96QK1.
SOURCEi Search...

Gene expression databases

Bgeei Q96QK1.
Genevestigatori Q96QK1.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR005378. Vps35.
[Graphical view ]
PANTHERi PTHR11099. PTHR11099. 1 hit.
Pfami PF03635. Vps35. 1 hit.
[Graphical view ]
PIRSFi PIRSF009375. Retromer_Vps35. 1 hit.
SUPFAMi SSF48371. SSF48371. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human homologues of yeast vacuolar protein sorting 29 and 35."
    Edgar A.J., Polak J.M.
    Biochem. Biophys. Res. Commun. 277:622-630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21."
    Zhang P., Yu L., Gao J., Fu Q., Dai F., Zhao Y., Zheng L., Zhao S.
    Genomics 70:253-257(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."
    Renfrew Haft C., de la Luz Sierra M., Bafford R., Lesniak M.A., Barr V.A., Taylor S.I.
    Mol. Biol. Cell 11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH VPS29; VPS26A; SNX1 AND SNX2.
    Tissue: Colon.
  4. "A novel gene expressed in human pheochromocytoma."
    Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pheochromocytoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ileal mucosa, Placenta and Teratocarcinoma.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Placenta and Prostate.
  8. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-796.
    Tissue: Leukemia.
  9. "Exportin 7 defines a novel general nuclear export pathway."
    Mingot J.-M., Bohnsack M.T., Jaekle U., Goerlich D.
    EMBO J. 23:3227-3236(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH XPO7; ARHGAP1; EIF4A1; VPS26A; VPS29 AND SFN.
  10. "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor."
    Verges M., Luton F., Gruber C., Tiemann F., Reinders L.G., Huang L., Burlingame A.L., Haft C.R., Mostov K.E.
    Nat. Cell Biol. 6:763-769(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. Cited for: INTERACTION WITH GOLPH3.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination."
    Hao Y.H., Doyle J.M., Ramanathan S., Gomez T.S., Jia D., Xu M., Chen Z.J., Billadeau D.D., Rosen M.K., Potts P.R.
    Cell 152:1051-1064(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAGEL2.
  15. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
    MacLeod D.A., Rhinn H., Kuwahara T., Zolin A., Di Paolo G., McCabe B.D., MacCabe B.D., Marder K.S., Honig L.S., Clark L.N., Small S.A., Abeliovich A.
    Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN RETROGRADE TRANSPORT, INTERACTION WITH LRRK2, CHARACTERIZATION OF VARIANT PARK17 ASN-620.
  16. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 483-780 IN COMPLEX WITH VPS29, ELECTRON MICROSCOPY OF THE RETROMER COMPLEX CONTAINING VPS29; VPS35 AND VPS26.
  17. Cited for: VARIANT PARK17 ASN-620, VARIANTS SER-316 AND VAL-737.
  18. Cited for: VARIANT PARK17 ASN-620, VARIANTS SER-51; ILE-57; ARG-82; MET-241; TRP-524 AND MET-774.
  19. "Identification of VPS35 mutations replicated in French families with Parkinson disease."
    Lesage S., Condroyer C., Klebe S., Honore A., Tison F., Brefel-Courbon C., Durr A., Brice A.
    Neurology 78:1449-1450(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PARK17 ASN-620.

Entry informationi

Entry nameiVPS35_HUMAN
AccessioniPrimary (citable) accession number: Q96QK1
Secondary accession number(s): Q561W2
, Q9H016, Q9H096, Q9H4P3, Q9H8J0, Q9NRS7, Q9NVG2, Q9NX80, Q9NZK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: September 3, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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