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Q96QK1

- VPS35_HUMAN

UniProt

Q96QK1 - VPS35_HUMAN

Protein

Vacuolar protein sorting-associated protein 35

Gene

VPS35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (25 Nov 2002)
      Previous versions | rss
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    Functioni

    Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell death Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW
    3. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 35
    Short name:
    hVPS35
    Alternative name(s):
    Maternal-embryonic 3
    Vesicle protein sorting 35
    Gene namesi
    Name:VPS35
    Synonyms:MEM3
    ORF Names:TCCCTA00141
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:13487. VPS35.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endosome Source: LIFEdb
    3. extracellular vesicular exosome Source: UniProt
    4. lysosomal membrane Source: UniProtKB
    5. retromer complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Parkinson disease 17 (PARK17) [MIM:614203]: An autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti620 – 6201D → N in PARK17; shows reduce retrograde transport of selective cargo between lysosomes and the Golgi apparatus; shows a progressive reduction in neurite length and branching. 3 Publications
    VAR_066659

    Keywords - Diseasei

    Neurodegeneration, Parkinson disease, Parkinsonism

    Organism-specific databases

    MIMi614203. phenotype.
    Orphaneti2828. Young adult-onset Parkinsonism.
    PharmGKBiPA37783.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 796796Vacuolar protein sorting-associated protein 35PRO_0000065896Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71Phosphoserine1 Publication
    Modified residuei791 – 7911PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96QK1.
    PaxDbiQ96QK1.
    PeptideAtlasiQ96QK1.
    PRIDEiQ96QK1.

    PTM databases

    PhosphoSiteiQ96QK1.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.

    Gene expression databases

    BgeeiQ96QK1.
    GenevestigatoriQ96QK1.

    Organism-specific databases

    HPAiHPA040802.

    Interactioni

    Subunit structurei

    Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS26A and VPS26B. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GOLPH3. Interacts with MAGEL2; leading to recruitment of the TRIM27:MAGEL2 E3 ubiquitin ligase complex retromer-containing endosomes. Interacts with LRRK2.6 Publications

    Protein-protein interaction databases

    BioGridi120855. 63 interactions.
    DIPiDIP-29076N.
    IntActiQ96QK1. 18 interactions.
    MINTiMINT-5001902.

    Structurei

    Secondary structure

    1
    796
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni484 – 4874
    Helixi488 – 49811
    Helixi503 – 51816
    Beta strandi522 – 5243
    Helixi525 – 54420
    Turni545 – 5495
    Helixi553 – 57321
    Helixi578 – 59417
    Helixi599 – 61719
    Helixi621 – 63515
    Helixi643 – 65816
    Helixi663 – 67210
    Helixi674 – 6785
    Turni683 – 6875
    Helixi693 – 70917
    Helixi713 – 73119
    Turni732 – 7343
    Helixi740 – 75112
    Turni752 – 7554
    Helixi761 – 77616

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2R17X-ray2.80C/D483-780[»]
    ProteinModelPortaliQ96QK1.
    SMRiQ96QK1. Positions 483-780.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96QK1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the VPS35 family.Curated

    Phylogenomic databases

    eggNOGiNOG252873.
    HOVERGENiHBG054277.
    InParanoidiQ96QK1.
    OMAiHELQCLE.
    OrthoDBiEOG7TMZR5.
    PhylomeDBiQ96QK1.
    TreeFamiTF105659.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR005378. Vps35.
    [Graphical view]
    PANTHERiPTHR11099. PTHR11099. 1 hit.
    PfamiPF03635. Vps35. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009375. Retromer_Vps35. 1 hit.
    SUPFAMiSSF48371. SSF48371. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q96QK1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTTQQSPQD EQEKLLDEAI QAVKVQSFQM KRCLDKNKLM DALKHASNML    50
    GELRTSMLSP KSYYELYMAI SDELHYLEVY LTDEFAKGRK VADLYELVQY 100
    AGNIIPRLYL LITVGVVYVK SFPQSRKDIL KDLVEMCRGV QHPLRGLFLR 150
    NYLLQCTRNI LPDEGEPTDE ETTGDISDSM DFVLLNFAEM NKLWVRMQHQ 200
    GHSRDREKRE RERQELRILV GTNLVRLSQL EGVNVERYKQ IVLTGILEQV 250
    VNCRDALAQE YLMECIIQVF PDEFHLQTLN PFLRACAELH QNVNVKNIII 300
    ALIDRLALFA HREDGPGIPA DIKLFDIFSQ QVATVIQSRQ DMPSEDVVSL 350
    QVSLINLAMK CYPDRVDYVD KVLETTVEIF NKLNLEHIAT SSAVSKELTR 400
    LLKIPVDTYN NILTVLKLKH FHPLFEYFDY ESRKSMSCYV LSNVLDYNTE 450
    IVSQDQVDSI MNLVSTLIQD QPDQPVEDPD PEDFADEQSL VGRFIHLLRS 500
    EDPDQQYLIL NTARKHFGAG GNQRIRFTLP PLVFAAYQLA FRYKENSKVD 550
    DKWEKKCQKI FSFAHQTISA LIKAELAELP LRLFLQGALA AGEIGFENHE 600
    TVAYEFMSQA FSLYEDEISD SKAQLAAITL IIGTFERMKC FSEENHEPLR 650
    TQCALAASKL LKKPDQGRAV STCAHLFWSG RNTDKNGEEL HGGKRVMECL 700
    KKALKIANQC MDPSLQVQLF IEILNRYIYF YEKENDAVTI QVLNQLIQKI 750
    REDLPNLESS EETEQINKHF HNTLEHLRLR RESPESEGPI YEGLIL 796
    Length:796
    Mass (Da):91,707
    Last modified:November 25, 2002 - v2
    Checksum:i28D2DD1C6B920A0A
    GO

    Sequence cautioni

    The sequence AAG01989.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA91137.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14626.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421A → S in CAB66822. (PubMed:11230166)Curated
    Sequence conflicti160 – 1601I → T in BAB14626. (PubMed:14702039)Curated
    Sequence conflicti168 – 1681T → P in AAF89953. (PubMed:11102511)Curated
    Sequence conflicti453 – 4531S → F in AAH10362. (PubMed:15489334)Curated
    Sequence conflicti526 – 5261R → G in BAA91790. (PubMed:14702039)Curated
    Sequence conflicti694 – 6941K → E in BAA91790. (PubMed:14702039)Curated
    Sequence conflicti796 – 7961L → H in BAA91137. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511G → S.1 Publication
    VAR_066653
    Natural varianti57 – 571M → I.1 Publication
    VAR_066654
    Natural varianti82 – 821T → R.1 Publication
    VAR_066655
    Natural varianti241 – 2411I → M Found in a patient with Parkinson disease. 1 Publication
    VAR_066656
    Natural varianti316 – 3161P → S Found in a patient with Parkinson disease. 1 Publication
    VAR_066657
    Natural varianti524 – 5241R → W Found in a patient with Parkinson disease. 1 Publication
    VAR_066658
    Natural varianti602 – 6021V → D.
    Corresponds to variant rs34687100 [ dbSNP | Ensembl ].
    VAR_054046
    Natural varianti620 – 6201D → N in PARK17; shows reduce retrograde transport of selective cargo between lysosomes and the Golgi apparatus; shows a progressive reduction in neurite length and branching. 3 Publications
    VAR_066659
    Natural varianti737 – 7371A → V.1 Publication
    VAR_066660
    Natural varianti774 – 7741L → M.1 Publication
    VAR_066661

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191298 mRNA. Translation: AAF02778.2.
    AF186382 mRNA. Translation: AAG40619.1.
    AF175265 mRNA. Translation: AAF89953.1.
    AF183418 mRNA. Translation: AAG09687.1.
    AK001614 mRNA. Translation: BAA91790.1.
    AK023650 mRNA. Translation: BAB14626.1. Different initiation.
    AK000395 mRNA. Translation: BAA91137.1. Different initiation.
    AL136888 mRNA. Translation: CAB66822.1.
    AL512769 mRNA. Translation: CAC21686.1.
    BC002414 mRNA. Translation: AAH02414.1.
    BC010362 mRNA. Translation: AAH10362.1.
    BC093036 mRNA. Translation: AAH93036.1.
    AY007112 mRNA. Translation: AAG01989.1. Different initiation.
    CCDSiCCDS10721.1.
    PIRiJC7516.
    RefSeqiNP_060676.2. NM_018206.4.
    UniGeneiHs.454528.

    Genome annotation databases

    EnsembliENST00000299138; ENSP00000299138; ENSG00000069329.
    GeneIDi55737.
    KEGGihsa:55737.
    UCSCiuc002eed.3. human.

    Polymorphism databases

    DMDMi25453321.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191298 mRNA. Translation: AAF02778.2 .
    AF186382 mRNA. Translation: AAG40619.1 .
    AF175265 mRNA. Translation: AAF89953.1 .
    AF183418 mRNA. Translation: AAG09687.1 .
    AK001614 mRNA. Translation: BAA91790.1 .
    AK023650 mRNA. Translation: BAB14626.1 . Different initiation.
    AK000395 mRNA. Translation: BAA91137.1 . Different initiation.
    AL136888 mRNA. Translation: CAB66822.1 .
    AL512769 mRNA. Translation: CAC21686.1 .
    BC002414 mRNA. Translation: AAH02414.1 .
    BC010362 mRNA. Translation: AAH10362.1 .
    BC093036 mRNA. Translation: AAH93036.1 .
    AY007112 mRNA. Translation: AAG01989.1 . Different initiation.
    CCDSi CCDS10721.1.
    PIRi JC7516.
    RefSeqi NP_060676.2. NM_018206.4.
    UniGenei Hs.454528.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2R17 X-ray 2.80 C/D 483-780 [» ]
    ProteinModelPortali Q96QK1.
    SMRi Q96QK1. Positions 483-780.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120855. 63 interactions.
    DIPi DIP-29076N.
    IntActi Q96QK1. 18 interactions.
    MINTi MINT-5001902.

    Chemistry

    ChEMBLi CHEMBL2216744.

    PTM databases

    PhosphoSitei Q96QK1.

    Polymorphism databases

    DMDMi 25453321.

    Proteomic databases

    MaxQBi Q96QK1.
    PaxDbi Q96QK1.
    PeptideAtlasi Q96QK1.
    PRIDEi Q96QK1.

    Protocols and materials databases

    DNASUi 55737.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299138 ; ENSP00000299138 ; ENSG00000069329 .
    GeneIDi 55737.
    KEGGi hsa:55737.
    UCSCi uc002eed.3. human.

    Organism-specific databases

    CTDi 55737.
    GeneCardsi GC16M046691.
    GeneReviewsi VPS35.
    HGNCi HGNC:13487. VPS35.
    HPAi HPA040802.
    MIMi 601501. gene.
    614203. phenotype.
    neXtProti NX_Q96QK1.
    Orphaneti 2828. Young adult-onset Parkinsonism.
    PharmGKBi PA37783.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252873.
    HOVERGENi HBG054277.
    InParanoidi Q96QK1.
    OMAi HELQCLE.
    OrthoDBi EOG7TMZR5.
    PhylomeDBi Q96QK1.
    TreeFami TF105659.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    ChiTaRSi VPS35. human.
    EvolutionaryTracei Q96QK1.
    GeneWikii VPS35.
    GenomeRNAii 55737.
    NextBioi 60680.
    PROi Q96QK1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96QK1.
    Genevestigatori Q96QK1.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR005378. Vps35.
    [Graphical view ]
    PANTHERi PTHR11099. PTHR11099. 1 hit.
    Pfami PF03635. Vps35. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009375. Retromer_Vps35. 1 hit.
    SUPFAMi SSF48371. SSF48371. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Human homologues of yeast vacuolar protein sorting 29 and 35."
      Edgar A.J., Polak J.M.
      Biochem. Biophys. Res. Commun. 277:622-630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21."
      Zhang P., Yu L., Gao J., Fu Q., Dai F., Zhao Y., Zheng L., Zhao S.
      Genomics 70:253-257(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."
      Renfrew Haft C., de la Luz Sierra M., Bafford R., Lesniak M.A., Barr V.A., Taylor S.I.
      Mol. Biol. Cell 11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH VPS29; VPS26A; SNX1 AND SNX2.
      Tissue: Colon.
    4. "A novel gene expressed in human pheochromocytoma."
      Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pheochromocytoma.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ileal mucosa, Placenta and Teratocarcinoma.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Placenta and Prostate.
    8. "Pediatric leukemia cDNA sequencing project."
      Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-796.
      Tissue: Leukemia.
    9. "Exportin 7 defines a novel general nuclear export pathway."
      Mingot J.-M., Bohnsack M.T., Jaekle U., Goerlich D.
      EMBO J. 23:3227-3236(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH XPO7; ARHGAP1; EIF4A1; VPS26A; VPS29 AND SFN.
    10. "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor."
      Verges M., Luton F., Gruber C., Tiemann F., Reinders L.G., Huang L., Burlingame A.L., Haft C.R., Mostov K.E.
      Nat. Cell Biol. 6:763-769(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. Cited for: INTERACTION WITH GOLPH3.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination."
      Hao Y.H., Doyle J.M., Ramanathan S., Gomez T.S., Jia D., Xu M., Chen Z.J., Billadeau D.D., Rosen M.K., Potts P.R.
      Cell 152:1051-1064(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAGEL2.
    15. "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
      MacLeod D.A., Rhinn H., Kuwahara T., Zolin A., Di Paolo G., McCabe B.D., MacCabe B.D., Marder K.S., Honig L.S., Clark L.N., Small S.A., Abeliovich A.
      Neuron 77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN RETROGRADE TRANSPORT, INTERACTION WITH LRRK2, CHARACTERIZATION OF VARIANT PARK17 ASN-620.
    16. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 483-780 IN COMPLEX WITH VPS29, ELECTRON MICROSCOPY OF THE RETROMER COMPLEX CONTAINING VPS29; VPS35 AND VPS26.
    17. Cited for: VARIANT PARK17 ASN-620, VARIANTS SER-316 AND VAL-737.
    18. Cited for: VARIANT PARK17 ASN-620, VARIANTS SER-51; ILE-57; ARG-82; MET-241; TRP-524 AND MET-774.
    19. "Identification of VPS35 mutations replicated in French families with Parkinson disease."
      Lesage S., Condroyer C., Klebe S., Honore A., Tison F., Brefel-Courbon C., Durr A., Brice A.
      Neurology 78:1449-1450(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PARK17 ASN-620.

    Entry informationi

    Entry nameiVPS35_HUMAN
    AccessioniPrimary (citable) accession number: Q96QK1
    Secondary accession number(s): Q561W2
    , Q9H016, Q9H096, Q9H4P3, Q9H8J0, Q9NRS7, Q9NVG2, Q9NX80, Q9NZK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: November 25, 2002
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3