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Protein

Vacuolar protein sorting-associated protein 35

Gene

VPS35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R and SLC11A2. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15078903, PubMed:15247922, PubMed:20164305). Required for endosomal localization of FAM21C (PubMed:22070227). Mediates the association of the CSC with the WASH complex via FAM21 (PubMed:22070227, PubMed:24980502, PubMed:24819384). Required for the endosomal localization of TBC1D5 (PubMed:20923837).4 Publications8 Publications

GO - Molecular functioni

  • D1 dopamine receptor binding Source: ParkinsonsUK-UCL
  • protein transporter activity Source: GO_Central

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • mitochondrial fragmentation involved in apoptotic process Source: ParkinsonsUK-UCL
  • mitochondrion to lysosome transport Source: ParkinsonsUK-UCL
  • negative regulation of late endosome to lysosome transport Source: UniProtKB
  • neurotransmitter receptor transport, endosome to plasma membrane Source: ParkinsonsUK-UCL
  • positive regulation of canonical Wnt signaling pathway Source: Ensembl
  • positive regulation of dopamine receptor signaling pathway Source: ParkinsonsUK-UCL
  • positive regulation of gene expression Source: ParkinsonsUK-UCL
  • positive regulation of mitochondrial fission Source: ParkinsonsUK-UCL
  • positive regulation of Wnt protein secretion Source: Ensembl
  • regulation of cellular protein metabolic process Source: ParkinsonsUK-UCL
  • regulation of dendritic spine maintenance Source: ParkinsonsUK-UCL
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • regulation of mitochondrion organization Source: ParkinsonsUK-UCL
  • regulation of protein stability Source: ParkinsonsUK-UCL
  • regulation of terminal button organization Source: ParkinsonsUK-UCL
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • retrograde transport, endosome to plasma membrane Source: UniProtKB
  • transcytosis Source: UniProtKB
  • Wnt signaling pathway Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069329-MONOMER.
ReactomeiR-HSA-3238698. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 35
Short name:
hVPS35
Alternative name(s):
Maternal-embryonic 3
Vesicle protein sorting 35
Gene namesi
Name:VPS35
Synonyms:MEM3
ORF Names:TCCCTA00141
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13487. VPS35.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • early endosome Source: UniProtKB
  • endosome Source: UniProtKB
  • endosome membrane Source: ParkinsonsUK-UCL
  • extracellular exosome Source: UniProtKB
  • late endosome Source: GO_Central
  • lysosomal membrane Source: UniProtKB
  • mitochondrion-derived vesicle Source: ParkinsonsUK-UCL
  • postsynaptic density Source: Ensembl
  • retromer, cargo-selective complex Source: ParkinsonsUK-UCL
  • retromer complex Source: ParkinsonsUK-UCL
  • tubular endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Parkinson disease 17 (PARK17)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
See also OMIM:614203
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066659620D → N in PARK17; decreases interaction with FAM21C, FKBP15 and the WASH complex; impairs recruitment of the WASH complex to endosomes; shows reduced retrograde transport of selective cargo between lysosomes and the Golgi apparatus; shows a progressive reduction in neurite length and branching. 6 PublicationsCorresponds to variant rs188286943dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi108L → P: Disrupts interaction with VPS26; no effect on interaction with VPS29. 1 Publication1
Mutagenesisi675H → R: Disrupts interaction with VPS29. Does not effect interaction with VPS26. 1 Publication1

Keywords - Diseasei

Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNETi55737.
MalaCardsiVPS35.
MIMi614203. phenotype.
OpenTargetsiENSG00000069329.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA37783.

Chemistry databases

ChEMBLiCHEMBL2216744.

Polymorphism and mutation databases

BioMutaiVPS35.
DMDMi25453321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658961 – 796Vacuolar protein sorting-associated protein 35Add BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei783PhosphoserineBy similarity1
Modified residuei791PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96QK1.
MaxQBiQ96QK1.
PaxDbiQ96QK1.
PeptideAtlasiQ96QK1.
PRIDEiQ96QK1.

PTM databases

iPTMnetiQ96QK1.
PhosphoSitePlusiQ96QK1.
SwissPalmiQ96QK1.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.

Gene expression databases

BgeeiENSG00000069329.
ExpressionAtlasiQ96QK1. baseline and differential.
GenevisibleiQ96QK1. HS.

Organism-specific databases

HPAiHPA040802.

Interactioni

Subunit structurei

Component of the heterotrimeric retromer cargo-selective complex (CSC), also decribed as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35 (PubMed:11102511). The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform (By similarity). The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex (Probable). Interacts with VPS26A, VPS26B, VPS29, SNX1, SNX2, IGF2R, SNX3, GOLPH3, LRRK2, SLC11A2, FAM21A, FAM21C, FKBP15, WASH1, RAB7A, SNX27, KIAA0196, EHD1 (PubMed:11102511, PubMed:15078903, PubMed:17868075PubMed:22070227, PubMed:19553991, PubMed:21725319, PubMed:22070227, PubMed:22513087, PubMed:23331060, PubMed:23563491, PubMed:23395371, PubMed:24344282, PubMed:24980502, PubMed:17891154, PubMed:19531583). Interacts with MAGEL2; leading to recruitment of the TRIM27:MAGEL2 E3 ubiquitin ligase complex retromer-containing endosomes (PubMed:23452853).2 PublicationsBy similarity14 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SNX1Q135962EBI-1054634,EBI-2822329
VPS26AO754367EBI-1054634,EBI-1043891
VPS29Q9UBQ05EBI-1054634,EBI-718596

GO - Molecular functioni

  • D1 dopamine receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi120855. 73 interactors.
DIPiDIP-29076N.
IntActiQ96QK1. 29 interactors.
MINTiMINT-5001902.
STRINGi9606.ENSP00000299138.

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni484 – 487Combined sources4
Helixi488 – 498Combined sources11
Helixi503 – 518Combined sources16
Beta strandi522 – 524Combined sources3
Helixi525 – 544Combined sources20
Turni545 – 549Combined sources5
Helixi553 – 573Combined sources21
Helixi578 – 594Combined sources17
Helixi599 – 617Combined sources19
Helixi621 – 635Combined sources15
Helixi643 – 658Combined sources16
Helixi663 – 672Combined sources10
Helixi674 – 678Combined sources5
Turni683 – 687Combined sources5
Helixi693 – 709Combined sources17
Helixi713 – 731Combined sources19
Turni732 – 734Combined sources3
Helixi740 – 751Combined sources12
Turni752 – 755Combined sources4
Helixi761 – 776Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R17X-ray2.80C/D483-780[»]
ProteinModelPortaliQ96QK1.
SMRiQ96QK1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96QK1.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 44Interaction with SNX31 PublicationAdd BLAST20
Regioni205 – 215Interaction with SNX31 PublicationAdd BLAST11
Regioni438 – 796Interaction with SLC11A21 PublicationAdd BLAST359
Regioni500 – 693Interaction with IGF2R cytoplasmic domain1 PublicationAdd BLAST194

Sequence similaritiesi

Belongs to the VPS35 family.Curated

Phylogenomic databases

eggNOGiKOG1107. Eukaryota.
ENOG410XNXC. LUCA.
GeneTreeiENSGT00390000007315.
HOVERGENiHBG054277.
InParanoidiQ96QK1.
KOiK18468.
OMAiLWIRMEA.
OrthoDBiEOG091G0OHF.
PhylomeDBiQ96QK1.
TreeFamiTF105659.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005378. Vps35.
[Graphical view]
PANTHERiPTHR11099. PTHR11099. 1 hit.
PfamiPF03635. Vps35. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q96QK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTTQQSPQD EQEKLLDEAI QAVKVQSFQM KRCLDKNKLM DALKHASNML
60 70 80 90 100
GELRTSMLSP KSYYELYMAI SDELHYLEVY LTDEFAKGRK VADLYELVQY
110 120 130 140 150
AGNIIPRLYL LITVGVVYVK SFPQSRKDIL KDLVEMCRGV QHPLRGLFLR
160 170 180 190 200
NYLLQCTRNI LPDEGEPTDE ETTGDISDSM DFVLLNFAEM NKLWVRMQHQ
210 220 230 240 250
GHSRDREKRE RERQELRILV GTNLVRLSQL EGVNVERYKQ IVLTGILEQV
260 270 280 290 300
VNCRDALAQE YLMECIIQVF PDEFHLQTLN PFLRACAELH QNVNVKNIII
310 320 330 340 350
ALIDRLALFA HREDGPGIPA DIKLFDIFSQ QVATVIQSRQ DMPSEDVVSL
360 370 380 390 400
QVSLINLAMK CYPDRVDYVD KVLETTVEIF NKLNLEHIAT SSAVSKELTR
410 420 430 440 450
LLKIPVDTYN NILTVLKLKH FHPLFEYFDY ESRKSMSCYV LSNVLDYNTE
460 470 480 490 500
IVSQDQVDSI MNLVSTLIQD QPDQPVEDPD PEDFADEQSL VGRFIHLLRS
510 520 530 540 550
EDPDQQYLIL NTARKHFGAG GNQRIRFTLP PLVFAAYQLA FRYKENSKVD
560 570 580 590 600
DKWEKKCQKI FSFAHQTISA LIKAELAELP LRLFLQGALA AGEIGFENHE
610 620 630 640 650
TVAYEFMSQA FSLYEDEISD SKAQLAAITL IIGTFERMKC FSEENHEPLR
660 670 680 690 700
TQCALAASKL LKKPDQGRAV STCAHLFWSG RNTDKNGEEL HGGKRVMECL
710 720 730 740 750
KKALKIANQC MDPSLQVQLF IEILNRYIYF YEKENDAVTI QVLNQLIQKI
760 770 780 790
REDLPNLESS EETEQINKHF HNTLEHLRLR RESPESEGPI YEGLIL
Length:796
Mass (Da):91,707
Last modified:November 25, 2002 - v2
Checksum:i28D2DD1C6B920A0A
GO

Sequence cautioni

The sequence AAG01989 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91137 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14626 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42A → S in CAB66822 (PubMed:11230166).Curated1
Sequence conflicti160I → T in BAB14626 (PubMed:14702039).Curated1
Sequence conflicti168T → P in AAF89953 (PubMed:11102511).Curated1
Sequence conflicti453S → F in AAH10362 (PubMed:15489334).Curated1
Sequence conflicti526R → G in BAA91790 (PubMed:14702039).Curated1
Sequence conflicti694K → E in BAA91790 (PubMed:14702039).Curated1
Sequence conflicti796L → H in BAA91137 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06665351G → S.1 PublicationCorresponds to variant rs193077277dbSNPEnsembl.1
Natural variantiVAR_06665457M → I.1 PublicationCorresponds to variant rs183554824dbSNPEnsembl.1
Natural variantiVAR_06665582T → R.1 PublicationCorresponds to variant rs188245364dbSNPEnsembl.1
Natural variantiVAR_066656241I → M Found in a patient with Parkinson disease. 1 PublicationCorresponds to variant rs192783364dbSNPEnsembl.1
Natural variantiVAR_066657316P → S Found in a patient with Parkinson disease. 1 PublicationCorresponds to variant rs770029606dbSNPEnsembl.1
Natural variantiVAR_066658524R → W Found in a patient with Parkinson disease. 1 PublicationCorresponds to variant rs184277092dbSNPEnsembl.1
Natural variantiVAR_054046602V → D.Corresponds to variant rs34687100dbSNPEnsembl.1
Natural variantiVAR_066659620D → N in PARK17; decreases interaction with FAM21C, FKBP15 and the WASH complex; impairs recruitment of the WASH complex to endosomes; shows reduced retrograde transport of selective cargo between lysosomes and the Golgi apparatus; shows a progressive reduction in neurite length and branching. 6 PublicationsCorresponds to variant rs188286943dbSNPEnsembl.1
Natural variantiVAR_066660737A → V.1 PublicationCorresponds to variant rs749516404dbSNPEnsembl.1
Natural variantiVAR_066661774L → M.1 PublicationCorresponds to variant rs192419029dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191298 mRNA. Translation: AAF02778.2.
AF186382 mRNA. Translation: AAG40619.1.
AF175265 mRNA. Translation: AAF89953.1.
AF183418 mRNA. Translation: AAG09687.1.
AK001614 mRNA. Translation: BAA91790.1.
AK023650 mRNA. Translation: BAB14626.1. Different initiation.
AK000395 mRNA. Translation: BAA91137.1. Different initiation.
AL136888 mRNA. Translation: CAB66822.1.
AL512769 mRNA. Translation: CAC21686.1.
BC002414 mRNA. Translation: AAH02414.1.
BC010362 mRNA. Translation: AAH10362.1.
BC093036 mRNA. Translation: AAH93036.1.
AY007112 mRNA. Translation: AAG01989.1. Different initiation.
CCDSiCCDS10721.1.
PIRiJC7516.
RefSeqiNP_060676.2. NM_018206.5.
UniGeneiHs.454528.
Hs.595143.

Genome annotation databases

EnsembliENST00000299138; ENSP00000299138; ENSG00000069329.
GeneIDi55737.
KEGGihsa:55737.
UCSCiuc002eef.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191298 mRNA. Translation: AAF02778.2.
AF186382 mRNA. Translation: AAG40619.1.
AF175265 mRNA. Translation: AAF89953.1.
AF183418 mRNA. Translation: AAG09687.1.
AK001614 mRNA. Translation: BAA91790.1.
AK023650 mRNA. Translation: BAB14626.1. Different initiation.
AK000395 mRNA. Translation: BAA91137.1. Different initiation.
AL136888 mRNA. Translation: CAB66822.1.
AL512769 mRNA. Translation: CAC21686.1.
BC002414 mRNA. Translation: AAH02414.1.
BC010362 mRNA. Translation: AAH10362.1.
BC093036 mRNA. Translation: AAH93036.1.
AY007112 mRNA. Translation: AAG01989.1. Different initiation.
CCDSiCCDS10721.1.
PIRiJC7516.
RefSeqiNP_060676.2. NM_018206.5.
UniGeneiHs.454528.
Hs.595143.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R17X-ray2.80C/D483-780[»]
ProteinModelPortaliQ96QK1.
SMRiQ96QK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120855. 73 interactors.
DIPiDIP-29076N.
IntActiQ96QK1. 29 interactors.
MINTiMINT-5001902.
STRINGi9606.ENSP00000299138.

Chemistry databases

ChEMBLiCHEMBL2216744.

PTM databases

iPTMnetiQ96QK1.
PhosphoSitePlusiQ96QK1.
SwissPalmiQ96QK1.

Polymorphism and mutation databases

BioMutaiVPS35.
DMDMi25453321.

Proteomic databases

EPDiQ96QK1.
MaxQBiQ96QK1.
PaxDbiQ96QK1.
PeptideAtlasiQ96QK1.
PRIDEiQ96QK1.

Protocols and materials databases

DNASUi55737.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299138; ENSP00000299138; ENSG00000069329.
GeneIDi55737.
KEGGihsa:55737.
UCSCiuc002eef.5. human.

Organism-specific databases

CTDi55737.
DisGeNETi55737.
GeneCardsiVPS35.
GeneReviewsiVPS35.
HGNCiHGNC:13487. VPS35.
HPAiHPA040802.
MalaCardsiVPS35.
MIMi601501. gene.
614203. phenotype.
neXtProtiNX_Q96QK1.
OpenTargetsiENSG00000069329.
Orphaneti2828. Young adult-onset Parkinsonism.
PharmGKBiPA37783.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1107. Eukaryota.
ENOG410XNXC. LUCA.
GeneTreeiENSGT00390000007315.
HOVERGENiHBG054277.
InParanoidiQ96QK1.
KOiK18468.
OMAiLWIRMEA.
OrthoDBiEOG091G0OHF.
PhylomeDBiQ96QK1.
TreeFamiTF105659.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069329-MONOMER.
ReactomeiR-HSA-3238698. WNT ligand biogenesis and trafficking.

Miscellaneous databases

ChiTaRSiVPS35. human.
EvolutionaryTraceiQ96QK1.
GeneWikiiVPS35.
GenomeRNAii55737.
PROiQ96QK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000069329.
ExpressionAtlasiQ96QK1. baseline and differential.
GenevisibleiQ96QK1. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005378. Vps35.
[Graphical view]
PANTHERiPTHR11099. PTHR11099. 1 hit.
PfamiPF03635. Vps35. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiVPS35_HUMAN
AccessioniPrimary (citable) accession number: Q96QK1
Secondary accession number(s): Q561W2
, Q9H016, Q9H096, Q9H4P3, Q9H8J0, Q9NRS7, Q9NVG2, Q9NX80, Q9NZK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.