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Q96QH8

- LYZL5_HUMAN

UniProt

Q96QH8 - LYZL5_HUMAN

Protein

Sperm acrosome-associated protein 5

Gene

SPACA5

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm acrosome-associated protein 5 (EC:3.2.1.17)
    Alternative name(s):
    Lysozyme-like protein 5
    Sperm-specific lysozyme-like protein X
    Short name:
    SLLP-X
    Gene namesi
    Name:SPACA5
    Synonyms:LYZL5, SPACA5A
    ORF Names:UNQ6288/PRO20753
    AND
    Name:SPACA5B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:31353. SPACA5.
    HGNC:19142. SPACA5B.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162404365.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 159138Sperm acrosome-associated protein 5PRO_0000284470Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 147PROSITE-ProRule annotation
    Disulfide bondi51 ↔ 135PROSITE-ProRule annotation
    Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
    Disulfide bondi96 ↔ 114PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ96QH8.

    Expressioni

    Gene expression databases

    BgeeiQ96QH8.
    CleanExiHS_SPACA5.
    HS_SPACA5B.
    GenevestigatoriQ96QH8.

    Interactioni

    Protein-protein interaction databases

    BioGridi133301. 1 interaction.
    STRINGi9606.ENSP00000304762.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QH8.
    SMRiQ96QH8. Positions 21-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74463.
    HOGENOMiHOG000037357.
    HOVERGENiHBG052297.
    InParanoidiQ96QH8.
    KOiK01185.
    OMAiMTITKEM.
    OrthoDBiEOG7BW0M5.
    PhylomeDBiQ96QH8.
    TreeFamiTF324882.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96QH8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAWGTVVVT LATLMVVTVD AKIYERCELA ARLERAGLNG YKGYGVGDWL    50
    CMAHYESGFD TAFVDHNPDG SSEYGIFQLN SAWWCDNGIT PTKNLCHMDC 100
    HDLLNRHILD DIRCAKQIVS SQNGLSAWTS WRLHCSGHDL SEWLKGCDMH 150
    VKIDPKIHP 159
    Length:159
    Mass (Da):17,896
    Last modified:December 1, 2001 - v1
    Checksum:iDD081C9CB5946277
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261R → L in AAQ89203. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217622 mRNA. Translation: AAQ13890.1.
    AY358844 mRNA. Translation: AAQ89203.1.
    Z98304 Genomic DNA. Translation: CAC41950.1.
    AL356464 Genomic DNA. Translation: CAI40526.1.
    CCDSiCCDS14286.1.
    CCDS35238.1.
    RefSeqiNP_001073369.1. NM_001079900.1.
    NP_995328.2. NM_205856.3.
    XP_006724593.1. XM_006724530.1.
    XP_006724594.1. XM_006724531.1.
    UniGeneiHs.319319.
    Hs.712503.

    Genome annotation databases

    EnsembliENST00000304270; ENSP00000304762; ENSG00000171478.
    ENST00000304355; ENSP00000305847; ENSG00000171489.
    ENST00000376940; ENSP00000366139; ENSG00000171489.
    GeneIDi389852.
    729201.
    KEGGihsa:389852.
    hsa:729201.
    UCSCiuc004diu.3. human.

    Polymorphism databases

    DMDMi74761053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217622 mRNA. Translation: AAQ13890.1 .
    AY358844 mRNA. Translation: AAQ89203.1 .
    Z98304 Genomic DNA. Translation: CAC41950.1 .
    AL356464 Genomic DNA. Translation: CAI40526.1 .
    CCDSi CCDS14286.1.
    CCDS35238.1.
    RefSeqi NP_001073369.1. NM_001079900.1.
    NP_995328.2. NM_205856.3.
    XP_006724593.1. XM_006724530.1.
    XP_006724594.1. XM_006724531.1.
    UniGenei Hs.319319.
    Hs.712503.

    3D structure databases

    ProteinModelPortali Q96QH8.
    SMRi Q96QH8. Positions 21-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 133301. 1 interaction.
    STRINGi 9606.ENSP00000304762.

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    Polymorphism databases

    DMDMi 74761053.

    Proteomic databases

    PRIDEi Q96QH8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304270 ; ENSP00000304762 ; ENSG00000171478 .
    ENST00000304355 ; ENSP00000305847 ; ENSG00000171489 .
    ENST00000376940 ; ENSP00000366139 ; ENSG00000171489 .
    GeneIDi 389852.
    729201.
    KEGGi hsa:389852.
    hsa:729201.
    UCSCi uc004diu.3. human.

    Organism-specific databases

    CTDi 389852.
    729201.
    GeneCardsi GC0XP047864.
    GC0XP047986.
    HGNCi HGNC:31353. SPACA5.
    HGNC:19142. SPACA5B.
    MIMi 300593. gene.
    neXtProti NX_Q96QH8.
    PharmGKBi PA162404365.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74463.
    HOGENOMi HOG000037357.
    HOVERGENi HBG052297.
    InParanoidi Q96QH8.
    KOi K01185.
    OMAi MTITKEM.
    OrthoDBi EOG7BW0M5.
    PhylomeDBi Q96QH8.
    TreeFami TF324882.

    Miscellaneous databases

    NextBioi 103156.
    PROi Q96QH8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96QH8.
    CleanExi HS_SPACA5.
    HS_SPACA5B.
    Genevestigatori Q96QH8.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel lysozyme like human sperm-specific secretory protein SLLP-X which maps to the X chromosome."
      Mandal A., Herr J.C.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome."
      Chen Y.-T., Iseli C., Venditti C.A., Old L.J., Simpson A.J.G., Jongeneel C.V.
      Genes Chromosomes Cancer 45:392-400(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiLYZL5_HUMAN
    AccessioniPrimary (citable) accession number: Q96QH8
    Secondary accession number(s): Q6UWD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3