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Protein

Sperm acrosome-associated protein 5

Gene

SPACA5

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome-associated protein 5 (EC:3.2.1.17)
Alternative name(s):
Lysozyme-like protein 5
Sperm-specific lysozyme-like protein X
Short name:
SLLP-X
Gene namesi
Name:SPACA5
Synonyms:LYZL5, SPACA5A
ORF Names:UNQ6288/PRO20753
AND
Name:SPACA5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:31353. SPACA5.
HGNC:19142. SPACA5B.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 159138Sperm acrosome-associated protein 5PRO_0000284470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 147PROSITE-ProRule annotation
Disulfide bondi51 ↔ 135PROSITE-ProRule annotation
Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
Disulfide bondi96 ↔ 114PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ96QH8.

Expressioni

Gene expression databases

BgeeiQ96QH8.
CleanExiHS_SPACA5.
HS_SPACA5B.
GenevestigatoriQ96QH8.

Organism-specific databases

HPAiHPA044747.
HPA047149.

Interactioni

Protein-protein interaction databases

BioGridi133301. 1 interaction.
STRINGi9606.ENSP00000304762.

Structurei

3D structure databases

ProteinModelPortaliQ96QH8.
SMRiQ96QH8. Positions 21-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74463.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ96QH8.
KOiK01185.
OMAiIGDWLCM.
OrthoDBiEOG7BW0M5.
PhylomeDBiQ96QH8.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030064. LYZL5.
[Graphical view]
PANTHERiPTHR11407:SF12. PTHR11407:SF12. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96QH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAWGTVVVT LATLMVVTVD AKIYERCELA ARLERAGLNG YKGYGVGDWL
60 70 80 90 100
CMAHYESGFD TAFVDHNPDG SSEYGIFQLN SAWWCDNGIT PTKNLCHMDC
110 120 130 140 150
HDLLNRHILD DIRCAKQIVS SQNGLSAWTS WRLHCSGHDL SEWLKGCDMH

VKIDPKIHP
Length:159
Mass (Da):17,896
Last modified:December 1, 2001 - v1
Checksum:iDD081C9CB5946277
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261R → L in AAQ89203 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217622 mRNA. Translation: AAQ13890.1.
AY358844 mRNA. Translation: AAQ89203.1.
Z98304 Genomic DNA. Translation: CAC41950.1.
AL356464 Genomic DNA. Translation: CAI40526.1.
CCDSiCCDS14286.1.
CCDS35238.1.
RefSeqiNP_001073369.1. NM_001079900.1.
NP_995328.2. NM_205856.3.
XP_006724593.1. XM_006724530.1.
XP_006724594.1. XM_006724531.1.
UniGeneiHs.319319.
Hs.712503.

Genome annotation databases

EnsembliENST00000304270; ENSP00000304762; ENSG00000171478.
ENST00000304355; ENSP00000305847; ENSG00000171489.
ENST00000376940; ENSP00000366139; ENSG00000171489.
GeneIDi389852.
729201.
KEGGihsa:389852.
hsa:729201.
UCSCiuc004diu.3. human.

Polymorphism databases

DMDMi74761053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217622 mRNA. Translation: AAQ13890.1.
AY358844 mRNA. Translation: AAQ89203.1.
Z98304 Genomic DNA. Translation: CAC41950.1.
AL356464 Genomic DNA. Translation: CAI40526.1.
CCDSiCCDS14286.1.
CCDS35238.1.
RefSeqiNP_001073369.1. NM_001079900.1.
NP_995328.2. NM_205856.3.
XP_006724593.1. XM_006724530.1.
XP_006724594.1. XM_006724531.1.
UniGeneiHs.319319.
Hs.712503.

3D structure databases

ProteinModelPortaliQ96QH8.
SMRiQ96QH8. Positions 21-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133301. 1 interaction.
STRINGi9606.ENSP00000304762.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Polymorphism databases

DMDMi74761053.

Proteomic databases

PRIDEiQ96QH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304270; ENSP00000304762; ENSG00000171478.
ENST00000304355; ENSP00000305847; ENSG00000171489.
ENST00000376940; ENSP00000366139; ENSG00000171489.
GeneIDi389852.
729201.
KEGGihsa:389852.
hsa:729201.
UCSCiuc004diu.3. human.

Organism-specific databases

CTDi389852.
729201.
GeneCardsiGC0XP047864.
GC0XP047986.
HGNCiHGNC:31353. SPACA5.
HGNC:19142. SPACA5B.
HPAiHPA044747.
HPA047149.
MIMi300593. gene.
neXtProtiNX_Q96QH8.
PharmGKBiPA162404365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74463.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ96QH8.
KOiK01185.
OMAiIGDWLCM.
OrthoDBiEOG7BW0M5.
PhylomeDBiQ96QH8.
TreeFamiTF324882.

Miscellaneous databases

NextBioi103156.
PROiQ96QH8.
SOURCEiSearch...

Gene expression databases

BgeeiQ96QH8.
CleanExiHS_SPACA5.
HS_SPACA5B.
GenevestigatoriQ96QH8.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030064. LYZL5.
[Graphical view]
PANTHERiPTHR11407:SF12. PTHR11407:SF12. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel lysozyme like human sperm-specific secretory protein SLLP-X which maps to the X chromosome."
    Mandal A., Herr J.C.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome."
    Chen Y.-T., Iseli C., Venditti C.A., Old L.J., Simpson A.J.G., Jongeneel C.V.
    Genes Chromosomes Cancer 45:392-400(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiLYZL5_HUMAN
AccessioniPrimary (citable) accession number: Q96QH8
Secondary accession number(s): Q6UWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.