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Protein

Sperm acrosome-associated protein 5

Gene

SPACA5

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciZFISH:G66-33019-MONOMER.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome-associated protein 5 (EC:3.2.1.17)
Alternative name(s):
Lysozyme-like protein 5
Sperm-specific lysozyme-like protein X
Short name:
SLLP-X
Gene namesi
Name:SPACA5
Synonyms:LYZL5, SPACA5A
ORF Names:UNQ6288/PRO20753
AND
Name:SPACA5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:31353. SPACA5.
HGNC:19142. SPACA5B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171478.
ENSG00000171489.
PharmGKBiPA162404365.

Polymorphism and mutation databases

DMDMi74761053.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000028447022 – 159Sperm acrosome-associated protein 5Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 147PROSITE-ProRule annotation
Disulfide bondi51 ↔ 135PROSITE-ProRule annotation
Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
Disulfide bondi96 ↔ 114PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96QH8.
PeptideAtlasiQ96QH8.
PRIDEiQ96QH8.

PTM databases

iPTMnetiQ96QH8.
PhosphoSitePlusiQ96QH8.

Expressioni

Gene expression databases

BgeeiENSG00000171478.
CleanExiHS_SPACA5.
HS_SPACA5B.
ExpressionAtlasiQ96QH8. differential.

Organism-specific databases

HPAiHPA044747.
HPA047149.

Structurei

3D structure databases

ProteinModelPortaliQ96QH8.
SMRiQ96QH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IT6F. Eukaryota.
ENOG4111EG8. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ96QH8.
KOiK01185.
OMAiTQNLCHM.
OrthoDBiEOG091G0R9V.
PhylomeDBiQ96QH8.
TreeFamiTF324882.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030064. LYZL5.
[Graphical view]
PANTHERiPTHR11407:SF31. PTHR11407:SF31. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96QH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAWGTVVVT LATLMVVTVD AKIYERCELA ARLERAGLNG YKGYGVGDWL
60 70 80 90 100
CMAHYESGFD TAFVDHNPDG SSEYGIFQLN SAWWCDNGIT PTKNLCHMDC
110 120 130 140 150
HDLLNRHILD DIRCAKQIVS SQNGLSAWTS WRLHCSGHDL SEWLKGCDMH

VKIDPKIHP
Length:159
Mass (Da):17,896
Last modified:December 1, 2001 - v1
Checksum:iDD081C9CB5946277
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26R → L in AAQ89203 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217622 mRNA. Translation: AAQ13890.1.
AY358844 mRNA. Translation: AAQ89203.1.
Z98304 Genomic DNA. Translation: CAC41950.1.
AL356464 Genomic DNA. Translation: CAI40526.1.
CCDSiCCDS14286.1.
CCDS35238.1.
RefSeqiNP_001073369.1. NM_001079900.1.
NP_995328.2. NM_205856.3.
XP_016885001.1. XM_017029512.1.
UniGeneiHs.319319.
Hs.712503.

Genome annotation databases

EnsembliENST00000304270; ENSP00000304762; ENSG00000171478.
ENST00000304355; ENSP00000305847; ENSG00000171489.
ENST00000376940; ENSP00000366139; ENSG00000171489.
GeneIDi389852.
729201.
KEGGihsa:389852.
hsa:729201.
UCSCiuc004diu.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217622 mRNA. Translation: AAQ13890.1.
AY358844 mRNA. Translation: AAQ89203.1.
Z98304 Genomic DNA. Translation: CAC41950.1.
AL356464 Genomic DNA. Translation: CAI40526.1.
CCDSiCCDS14286.1.
CCDS35238.1.
RefSeqiNP_001073369.1. NM_001079900.1.
NP_995328.2. NM_205856.3.
XP_016885001.1. XM_017029512.1.
UniGeneiHs.319319.
Hs.712503.

3D structure databases

ProteinModelPortaliQ96QH8.
SMRiQ96QH8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

PTM databases

iPTMnetiQ96QH8.
PhosphoSitePlusiQ96QH8.

Polymorphism and mutation databases

DMDMi74761053.

Proteomic databases

PaxDbiQ96QH8.
PeptideAtlasiQ96QH8.
PRIDEiQ96QH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304270; ENSP00000304762; ENSG00000171478.
ENST00000304355; ENSP00000305847; ENSG00000171489.
ENST00000376940; ENSP00000366139; ENSG00000171489.
GeneIDi389852.
729201.
KEGGihsa:389852.
hsa:729201.
UCSCiuc004diu.5. human.

Organism-specific databases

CTDi389852.
729201.
GeneCardsiSPACA5.
SPACA5B.
HGNCiHGNC:31353. SPACA5.
HGNC:19142. SPACA5B.
HPAiHPA044747.
HPA047149.
MIMi300593. gene.
neXtProtiNX_Q96QH8.
OpenTargetsiENSG00000171478.
ENSG00000171489.
PharmGKBiPA162404365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT6F. Eukaryota.
ENOG4111EG8. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ96QH8.
KOiK01185.
OMAiTQNLCHM.
OrthoDBiEOG091G0R9V.
PhylomeDBiQ96QH8.
TreeFamiTF324882.

Enzyme and pathway databases

BioCyciZFISH:G66-33019-MONOMER.

Miscellaneous databases

PROiQ96QH8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171478.
CleanExiHS_SPACA5.
HS_SPACA5B.
ExpressionAtlasiQ96QH8. differential.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
IPR030064. LYZL5.
[Graphical view]
PANTHERiPTHR11407:SF31. PTHR11407:SF31. 1 hit.
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYZL5_HUMAN
AccessioniPrimary (citable) accession number: Q96QH8
Secondary accession number(s): Q6UWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.