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Q96QH8

- LYZL5_HUMAN

UniProt

Q96QH8 - LYZL5_HUMAN

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Protein

Sperm acrosome-associated protein 5

Gene

SPACA5

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome-associated protein 5 (EC:3.2.1.17)
Alternative name(s):
Lysozyme-like protein 5
Sperm-specific lysozyme-like protein X
Short name:
SLLP-X
Gene namesi
Name:SPACA5
Synonyms:LYZL5, SPACA5A
ORF Names:UNQ6288/PRO20753
AND
Name:SPACA5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:31353. SPACA5.
HGNC:19142. SPACA5B.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 159138Sperm acrosome-associated protein 5PRO_0000284470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 147PROSITE-ProRule annotation
Disulfide bondi51 ↔ 135PROSITE-ProRule annotation
Disulfide bondi85 ↔ 100PROSITE-ProRule annotation
Disulfide bondi96 ↔ 114PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ96QH8.

Expressioni

Gene expression databases

BgeeiQ96QH8.
CleanExiHS_SPACA5.
HS_SPACA5B.
GenevestigatoriQ96QH8.

Interactioni

Protein-protein interaction databases

BioGridi133301. 1 interaction.
STRINGi9606.ENSP00000304762.

Structurei

3D structure databases

ProteinModelPortaliQ96QH8.
SMRiQ96QH8. Positions 21-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74463.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiQ96QH8.
KOiK01185.
OMAiMTITKEM.
OrthoDBiEOG7BW0M5.
PhylomeDBiQ96QH8.
TreeFamiTF324882.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96QH8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAWGTVVVT LATLMVVTVD AKIYERCELA ARLERAGLNG YKGYGVGDWL
60 70 80 90 100
CMAHYESGFD TAFVDHNPDG SSEYGIFQLN SAWWCDNGIT PTKNLCHMDC
110 120 130 140 150
HDLLNRHILD DIRCAKQIVS SQNGLSAWTS WRLHCSGHDL SEWLKGCDMH

VKIDPKIHP
Length:159
Mass (Da):17,896
Last modified:December 1, 2001 - v1
Checksum:iDD081C9CB5946277
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261R → L in AAQ89203. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF217622 mRNA. Translation: AAQ13890.1.
AY358844 mRNA. Translation: AAQ89203.1.
Z98304 Genomic DNA. Translation: CAC41950.1.
AL356464 Genomic DNA. Translation: CAI40526.1.
CCDSiCCDS14286.1.
CCDS35238.1.
RefSeqiNP_001073369.1. NM_001079900.1.
NP_995328.2. NM_205856.3.
XP_006724593.1. XM_006724530.1.
XP_006724594.1. XM_006724531.1.
UniGeneiHs.319319.
Hs.712503.

Genome annotation databases

EnsembliENST00000304270; ENSP00000304762; ENSG00000171478.
ENST00000304355; ENSP00000305847; ENSG00000171489.
ENST00000376940; ENSP00000366139; ENSG00000171489.
GeneIDi389852.
729201.
KEGGihsa:389852.
hsa:729201.
UCSCiuc004diu.3. human.

Polymorphism databases

DMDMi74761053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF217622 mRNA. Translation: AAQ13890.1 .
AY358844 mRNA. Translation: AAQ89203.1 .
Z98304 Genomic DNA. Translation: CAC41950.1 .
AL356464 Genomic DNA. Translation: CAI40526.1 .
CCDSi CCDS14286.1.
CCDS35238.1.
RefSeqi NP_001073369.1. NM_001079900.1.
NP_995328.2. NM_205856.3.
XP_006724593.1. XM_006724530.1.
XP_006724594.1. XM_006724531.1.
UniGenei Hs.319319.
Hs.712503.

3D structure databases

ProteinModelPortali Q96QH8.
SMRi Q96QH8. Positions 21-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 133301. 1 interaction.
STRINGi 9606.ENSP00000304762.

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Polymorphism databases

DMDMi 74761053.

Proteomic databases

PRIDEi Q96QH8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304270 ; ENSP00000304762 ; ENSG00000171478 .
ENST00000304355 ; ENSP00000305847 ; ENSG00000171489 .
ENST00000376940 ; ENSP00000366139 ; ENSG00000171489 .
GeneIDi 389852.
729201.
KEGGi hsa:389852.
hsa:729201.
UCSCi uc004diu.3. human.

Organism-specific databases

CTDi 389852.
729201.
GeneCardsi GC0XP047864.
GC0XP047986.
HGNCi HGNC:31353. SPACA5.
HGNC:19142. SPACA5B.
MIMi 300593. gene.
neXtProti NX_Q96QH8.
PharmGKBi PA162404365.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74463.
GeneTreei ENSGT00550000074398.
HOGENOMi HOG000037357.
HOVERGENi HBG052297.
InParanoidi Q96QH8.
KOi K01185.
OMAi MTITKEM.
OrthoDBi EOG7BW0M5.
PhylomeDBi Q96QH8.
TreeFami TF324882.

Miscellaneous databases

NextBioi 103156.
PROi Q96QH8.
SOURCEi Search...

Gene expression databases

Bgeei Q96QH8.
CleanExi HS_SPACA5.
HS_SPACA5B.
Genevestigatori Q96QH8.

Family and domain databases

InterProi IPR001916. Glyco_hydro_22.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00062. Lys. 1 hit.
[Graphical view ]
PRINTSi PR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTi SM00263. LYZ1. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel lysozyme like human sperm-specific secretory protein SLLP-X which maps to the X chromosome."
    Mandal A., Herr J.C.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome."
    Chen Y.-T., Iseli C., Venditti C.A., Old L.J., Simpson A.J.G., Jongeneel C.V.
    Genes Chromosomes Cancer 45:392-400(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiLYZL5_HUMAN
AccessioniPrimary (citable) accession number: Q96QH8
Secondary accession number(s): Q6UWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3