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Q96QG7

- MTMR9_HUMAN

UniProt

Q96QG7 - MTMR9_HUMAN

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Protein
Myotubularin-related protein 9
Gene
MTMR9, C8orf9, MTMR8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Reviewed prediction.

GO - Molecular functioni

  1. enzyme regulator activity Source: Ensembl
  2. phosphatase activity Source: InterPro
  3. protein binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 9
Gene namesi
Name:MTMR9
Synonyms:C8orf9, MTMR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:14596. MTMR9.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Myotubularin-related protein 9
PRO_0000094943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei548 – 5481Phosphoserine4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96QG7.
PaxDbiQ96QG7.
PRIDEiQ96QG7.

PTM databases

PhosphoSiteiQ96QG7.

Expressioni

Tissue specificityi

Expressed in many tissues.

Gene expression databases

ArrayExpressiQ96QG7.
BgeeiQ96QG7.
CleanExiHS_MTMR8.
HS_MTMR9.
GenevestigatoriQ96QG7.

Interactioni

Subunit structurei

Interacts with MTMR6, MTMR7 and MTMR8.1 Publication

Protein-protein interaction databases

BioGridi122455. 11 interactions.
DIPiDIP-54283N.
IntActiQ96QG7. 7 interactions.
MINTiMINT-6942912.
STRINGi9606.ENSP00000221086.

Structurei

3D structure databases

ProteinModelPortaliQ96QG7.
SMRiQ96QG7. Positions 20-502.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 498376Myotubularin phosphatase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG278929.
HOGENOMiHOG000210599.
HOVERGENiHBG105875.
InParanoidiQ96QG7.
KOiK18084.
OMAiKCKDLRI.
OrthoDBiEOG79PJNX.
PhylomeDBiQ96QG7.
TreeFamiTF315197.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PfamiPF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QG7-1 [UniParc]FASTAAdd to Basket

« Hide

MEFAELIKTP RVDNVVLHRP FYPAVEGTLC LTGHHLILSS RQDNTEELWL    50
LHSNIDAIDK RFVGSLGTII IKCKDFRIIQ LDIPGMEECL NIASSIEALS 100
TLDSITLMYP FFYRPMFEVI EDGWHSFLPE QEFELYSSAT SEWRLSYVNK 150
EFAVCPSYPP IVTVPKSIDD EALRKVATFR HGGRFPVLSY YHKKNGMVIM 200
RSGQPLTGTN GRRCKEDEKL INATLRAGKR GYIIDTRSLN VAQQTRAKGG 250
GFEQEAHYPQ WRRIHKSIER YHILQESLIK LVEACNDQTH NMDRWLSKLE 300
ASNWLTHIKE ILTTACLAAQ CIDREGASIL IHGTEGTDST LQVTSLAQII 350
LEPRSRTIRG FEALIEREWL QAGHPFQQRC AQSAYCNTKQ KWEAPVFLLF 400
LDCVWQILRQ FPCSFEFNEN FLIMLFEHAY ASQFGTFLGN NESERCKLKL 450
QQKTMSLWSW VNQPSELSKF TNPLFEANNL VIWPSVAPQS LPLWEGIFLR 500
WNRSSKYLDE AYEEMVNIIE YNKELQAKVN ILRRQLAELE TEDGMQESP 549
Length:549
Mass (Da):63,462
Last modified:December 1, 2001 - v1
Checksum:i910F7D2907F9707E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941K → R in BAA91170. 1 Publication
Sequence conflicti382 – 3821Q → L in AAH22003. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ297823 mRNA. Translation: CAC51114.1.
AJ297824 Genomic DNA. Translation: CAC51115.1.
AK000444 mRNA. Translation: BAA91170.1.
BC022003 mRNA. Translation: AAH22003.1.
BC034990 mRNA. Translation: AAH34990.1.
BC093788 mRNA. Translation: AAH93788.1.
BC101623 mRNA. Translation: AAI01624.1.
CCDSiCCDS5979.1.
RefSeqiNP_056273.2. NM_015458.3.
UniGeneiHs.591395.

Genome annotation databases

EnsembliENST00000221086; ENSP00000221086; ENSG00000104643.
GeneIDi66036.
KEGGihsa:66036.
UCSCiuc003wtm.3. human.

Polymorphism databases

DMDMi33112393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ297823 mRNA. Translation: CAC51114.1 .
AJ297824 Genomic DNA. Translation: CAC51115.1 .
AK000444 mRNA. Translation: BAA91170.1 .
BC022003 mRNA. Translation: AAH22003.1 .
BC034990 mRNA. Translation: AAH34990.1 .
BC093788 mRNA. Translation: AAH93788.1 .
BC101623 mRNA. Translation: AAI01624.1 .
CCDSi CCDS5979.1.
RefSeqi NP_056273.2. NM_015458.3.
UniGenei Hs.591395.

3D structure databases

ProteinModelPortali Q96QG7.
SMRi Q96QG7. Positions 20-502.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122455. 11 interactions.
DIPi DIP-54283N.
IntActi Q96QG7. 7 interactions.
MINTi MINT-6942912.
STRINGi 9606.ENSP00000221086.

PTM databases

PhosphoSitei Q96QG7.

Polymorphism databases

DMDMi 33112393.

Proteomic databases

MaxQBi Q96QG7.
PaxDbi Q96QG7.
PRIDEi Q96QG7.

Protocols and materials databases

DNASUi 66036.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221086 ; ENSP00000221086 ; ENSG00000104643 .
GeneIDi 66036.
KEGGi hsa:66036.
UCSCi uc003wtm.3. human.

Organism-specific databases

CTDi 66036.
GeneCardsi GC08P011141.
H-InvDB HIX0025669.
HIX0034664.
HGNCi HGNC:14596. MTMR9.
MIMi 606260. gene.
neXtProti NX_Q96QG7.
PharmGKBi PA37904.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278929.
HOGENOMi HOG000210599.
HOVERGENi HBG105875.
InParanoidi Q96QG7.
KOi K18084.
OMAi KCKDLRI.
OrthoDBi EOG79PJNX.
PhylomeDBi Q96QG7.
TreeFami TF315197.

Miscellaneous databases

ChiTaRSi MTMR9. human.
GeneWikii MTMR9.
GenomeRNAii 66036.
NextBioi 67542.
PROi Q96QG7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96QG7.
Bgeei Q96QG7.
CleanExi HS_MTMR8.
HS_MTMR9.
Genevestigatori Q96QG7.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view ]
Pfami PF06602. Myotub-related. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and localization of a new human myotubularin-related protein gene, MTMR8, on 8p22-p23."
    Appel S., Reichwald K., Zimmermann W., Reis A., Rosenthal A., Hennies H.C.
    Genomics 75:6-8(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver and Testis.
  4. "Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions."
    Lorenzo O., Urbe S., Clague M.J.
    J. Cell Sci. 119:2953-2959(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MTMR6; MTMR7 AND MTMR8.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMTMR9_HUMAN
AccessioniPrimary (citable) accession number: Q96QG7
Secondary accession number(s): Q52LU3
, Q8WW11, Q96QG6, Q9NX50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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