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Q96QG7 (MTMR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotubularin-related protein 9
Gene names
Name:MTMR9
Synonyms:C8orf9, MTMR8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.

Subunit structure

Interacts with MTMR6, MTMR7 and MTMR8. Ref.4

Subcellular location

Cytoplasm Ref.4.

Tissue specificity

Expressed in many tissues.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 myotubularin phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionenzyme regulator activity

Inferred from electronic annotation. Source: Ensembl

phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Myotubularin-related protein 9
PRO_0000094943

Regions

Domain123 – 498376Myotubularin phosphatase

Amino acid modifications

Modified residue11N-acetylmethionine Ref.11 Ref.12
Modified residue5481Phosphoserine Ref.5 Ref.7 Ref.8 Ref.10

Experimental info

Sequence conflict1941K → R in BAA91170. Ref.2
Sequence conflict3821Q → L in AAH22003. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q96QG7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 910F7D2907F9707E

FASTA54963,462
        10         20         30         40         50         60 
MEFAELIKTP RVDNVVLHRP FYPAVEGTLC LTGHHLILSS RQDNTEELWL LHSNIDAIDK 

        70         80         90        100        110        120 
RFVGSLGTII IKCKDFRIIQ LDIPGMEECL NIASSIEALS TLDSITLMYP FFYRPMFEVI 

       130        140        150        160        170        180 
EDGWHSFLPE QEFELYSSAT SEWRLSYVNK EFAVCPSYPP IVTVPKSIDD EALRKVATFR 

       190        200        210        220        230        240 
HGGRFPVLSY YHKKNGMVIM RSGQPLTGTN GRRCKEDEKL INATLRAGKR GYIIDTRSLN 

       250        260        270        280        290        300 
VAQQTRAKGG GFEQEAHYPQ WRRIHKSIER YHILQESLIK LVEACNDQTH NMDRWLSKLE 

       310        320        330        340        350        360 
ASNWLTHIKE ILTTACLAAQ CIDREGASIL IHGTEGTDST LQVTSLAQII LEPRSRTIRG 

       370        380        390        400        410        420 
FEALIEREWL QAGHPFQQRC AQSAYCNTKQ KWEAPVFLLF LDCVWQILRQ FPCSFEFNEN 

       430        440        450        460        470        480 
FLIMLFEHAY ASQFGTFLGN NESERCKLKL QQKTMSLWSW VNQPSELSKF TNPLFEANNL 

       490        500        510        520        530        540 
VIWPSVAPQS LPLWEGIFLR WNRSSKYLDE AYEEMVNIIE YNKELQAKVN ILRRQLAELE 


TEDGMQESP 

« Hide

References

« Hide 'large scale' references
[1]"Identification and localization of a new human myotubularin-related protein gene, MTMR8, on 8p22-p23."
Appel S., Reichwald K., Zimmermann W., Reis A., Rosenthal A., Hennies H.C.
Genomics 75:6-8(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver and Testis.
[4]"Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions."
Lorenzo O., Urbe S., Clague M.J.
J. Cell Sci. 119:2953-2959(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MTMR6; MTMR7 AND MTMR8.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ297823 mRNA. Translation: CAC51114.1.
AJ297824 Genomic DNA. Translation: CAC51115.1.
AK000444 mRNA. Translation: BAA91170.1.
BC022003 mRNA. Translation: AAH22003.1.
BC034990 mRNA. Translation: AAH34990.1.
BC093788 mRNA. Translation: AAH93788.1.
BC101623 mRNA. Translation: AAI01624.1.
RefSeqNP_056273.2. NM_015458.3.
UniGeneHs.591395.

3D structure databases

ProteinModelPortalQ96QG7.
SMRQ96QG7. Positions 20-502.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122455. 11 interactions.
DIPDIP-54283N.
IntActQ96QG7. 7 interactions.
MINTMINT-6942912.
STRING9606.ENSP00000221086.

PTM databases

PhosphoSiteQ96QG7.

Polymorphism databases

DMDM33112393.

Proteomic databases

PaxDbQ96QG7.
PRIDEQ96QG7.

Protocols and materials databases

DNASU66036.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221086; ENSP00000221086; ENSG00000104643.
GeneID66036.
KEGGhsa:66036.
UCSCuc003wtm.3. human.

Organism-specific databases

CTD66036.
GeneCardsGC08P011141.
H-InvDBHIX0025669.
HIX0034664.
HGNCHGNC:14596. MTMR9.
MIM606260. gene.
neXtProtNX_Q96QG7.
PharmGKBPA37904.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278929.
HOGENOMHOG000210599.
HOVERGENHBG105875.
InParanoidQ96QG7.
OMAKCKDLRI.
OrthoDBEOG79PJNX.
PhylomeDBQ96QG7.
TreeFamTF315197.

Gene expression databases

ArrayExpressQ96QG7.
BgeeQ96QG7.
CleanExHS_MTMR8.
HS_MTMR9.
GenevestigatorQ96QG7.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
[Graphical view]
PfamPF06602. Myotub-related. 1 hit.
[Graphical view]
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMTMR9. human.
GeneWikiMTMR9.
GenomeRNAi66036.
NextBio67542.
PROQ96QG7.
SOURCESearch...

Entry information

Entry nameMTMR9_HUMAN
AccessionPrimary (citable) accession number: Q96QG7
Secondary accession number(s): Q52LU3 expand/collapse secondary AC list , Q8WW11, Q96QG6, Q9NX50
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM