Q96QG7 (MTMR9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myotubularin-related protein 9

Gene names

Name:	MTMR9
Synonyms:	C8orf9, MTMR8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.
Subunit structure	Interacts with MTMR6, MTMR7 and MTMR8. Ref.4
Subcellular location	Cytoplasm Ref.4.
Tissue specificity	Expressed in many tissues.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Contains 1 myotubularin phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	enzyme regulator activity Inferred from electronic annotation. Source: Compara phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Myotubularin-related protein 9		PRO_0000094943
Regions
	Domain	123 – 498	376	Myotubularin phosphatase
Amino acid modifications
	Modified residue	548	1	Phosphoserine Ref.5 Ref.6 Ref.7 Ref.9
Experimental info
	Sequence conflict	194	1	K → R in BAA91170. Ref.2
	Sequence conflict	382	1	Q → L in AAH22003. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96QG7 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 910F7D2907F9707E	FASTA	549	63,462
	10 20 30 40 50 60 MEFAELIKTP RVDNVVLHRP FYPAVEGTLC LTGHHLILSS RQDNTEELWL LHSNIDAIDK 70 80 90 100 110 120 RFVGSLGTII IKCKDFRIIQ LDIPGMEECL NIASSIEALS TLDSITLMYP FFYRPMFEVI 130 140 150 160 170 180 EDGWHSFLPE QEFELYSSAT SEWRLSYVNK EFAVCPSYPP IVTVPKSIDD EALRKVATFR 190 200 210 220 230 240 HGGRFPVLSY YHKKNGMVIM RSGQPLTGTN GRRCKEDEKL INATLRAGKR GYIIDTRSLN 250 260 270 280 290 300 VAQQTRAKGG GFEQEAHYPQ WRRIHKSIER YHILQESLIK LVEACNDQTH NMDRWLSKLE 310 320 330 340 350 360 ASNWLTHIKE ILTTACLAAQ CIDREGASIL IHGTEGTDST LQVTSLAQII LEPRSRTIRG 370 380 390 400 410 420 FEALIEREWL QAGHPFQQRC AQSAYCNTKQ KWEAPVFLLF LDCVWQILRQ FPCSFEFNEN 430 440 450 460 470 480 FLIMLFEHAY ASQFGTFLGN NESERCKLKL QQKTMSLWSW VNQPSELSKF TNPLFEANNL 490 500 510 520 530 540 VIWPSVAPQS LPLWEGIFLR WNRSSKYLDE AYEEMVNIIE YNKELQAKVN ILRRQLAELE TEDGMQESP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and localization of a new human myotubularin-related protein gene, MTMR8, on 8p22-p23." Appel S., Reichwald K., Zimmermann W., Reis A., Rosenthal A., Hennies H.C. Genomics 75:6-8(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver and Testis.
[4]	"Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions." Lorenzo O., Urbe S., Clague M.J. J. Cell Sci. 119:2953-2959(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MTMR6; MTMR7 AND MTMR8.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ297823 mRNA. Translation: CAC51114.1. AJ297824 Genomic DNA. Translation: CAC51115.1. AK000444 mRNA. Translation: BAA91170.1. BC022003 mRNA. Translation: AAH22003.1. BC034990 mRNA. Translation: AAH34990.1. BC093788 mRNA. Translation: AAH93788.1. BC101623 mRNA. Translation: AAI01624.1.
IPI	IPI00102580.
RefSeq	NP_056273.2. NM_015458.3.
UniGene	Hs.591395.
3D structure databases
ProteinModelPortal	Q96QG7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96QG7. 4 interactions.
STRING	9606.ENSP00000221086.
PTM databases
PhosphoSite	Q96QG7.
Polymorphism databases
DMDM	33112393.
Proteomic databases
PaxDb	Q96QG7.
PRIDE	Q96QG7.
Protocols and materials databases
DNASU	66036.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221086; ENSP00000221086; ENSG00000104643.
GeneID	66036.
KEGG	hsa:66036.
UCSC	uc003wtm.3. human.
Organism-specific databases
CTD	66036.
GeneCards	GC08P011141.
H-InvDB	HIX0025669. HIX0034664.
HGNC	HGNC:14596. MTMR9.
MIM	606260. gene.
neXtProt	NX_Q96QG7.
PharmGKB	PA37904.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG278929.
HOGENOM	HOG000210599.
HOVERGEN	HBG105875.
InParanoid	Q96QG7.
OMA	KCKDLRI.
OrthoDB	EOG44QT0H.
PhylomeDB	Q96QG7.
Gene expression databases
ArrayExpress	Q96QG7.
Bgee	Q96QG7.
CleanEx	HS_MTMR8. HS_MTMR9.
Genevestigator	Q96QG7.
GermOnline	ENSG00000104643. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR010569. Myotub-related. IPR017906. Myotubularin_phosphatase_dom. IPR011993. PH_like_dom. [Graphical view]
Pfam	PF06602. Myotub-related. 1 hit. [Graphical view]
PROSITE	PS51339. PPASE_MYOTUBULARIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MTMR9. human.
GenomeRNAi	66036.
NextBio	67542.
SOURCE	Search...

Entry information

Entry name

MTMR9_HUMAN

Accession

Primary (citable) accession number: Q96QG7
Secondary accession number(s): Q52LU3 , Q8WW11, Q96QG6, Q9NX50

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.