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Q96QG7

- MTMR9_HUMAN

UniProt

Q96QG7 - MTMR9_HUMAN

Protein

Myotubularin-related protein 9

Gene

MTMR9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.Curated

    GO - Molecular functioni

    1. enzyme regulator activity Source: Ensembl
    2. phosphatase activity Source: InterPro
    3. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 9
    Gene namesi
    Name:MTMR9
    Synonyms:C8orf9, MTMR8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14596. MTMR9.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37904.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Myotubularin-related protein 9PRO_0000094943Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications
    Modified residuei548 – 5481Phosphoserine4 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96QG7.
    PaxDbiQ96QG7.
    PRIDEiQ96QG7.

    PTM databases

    PhosphoSiteiQ96QG7.

    Expressioni

    Tissue specificityi

    Expressed in many tissues.

    Gene expression databases

    ArrayExpressiQ96QG7.
    BgeeiQ96QG7.
    CleanExiHS_MTMR8.
    HS_MTMR9.
    GenevestigatoriQ96QG7.

    Interactioni

    Subunit structurei

    Interacts with MTMR6, MTMR7 and MTMR8.1 Publication

    Protein-protein interaction databases

    BioGridi122455. 11 interactions.
    DIPiDIP-54283N.
    IntActiQ96QG7. 7 interactions.
    MINTiMINT-6942912.
    STRINGi9606.ENSP00000221086.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QG7.
    SMRiQ96QG7. Positions 20-502.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini123 – 498376Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278929.
    HOGENOMiHOG000210599.
    HOVERGENiHBG105875.
    InParanoidiQ96QG7.
    KOiK18084.
    OMAiKCKDLRI.
    OrthoDBiEOG79PJNX.
    PhylomeDBiQ96QG7.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    [Graphical view]
    PfamiPF06602. Myotub-related. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96QG7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEFAELIKTP RVDNVVLHRP FYPAVEGTLC LTGHHLILSS RQDNTEELWL    50
    LHSNIDAIDK RFVGSLGTII IKCKDFRIIQ LDIPGMEECL NIASSIEALS 100
    TLDSITLMYP FFYRPMFEVI EDGWHSFLPE QEFELYSSAT SEWRLSYVNK 150
    EFAVCPSYPP IVTVPKSIDD EALRKVATFR HGGRFPVLSY YHKKNGMVIM 200
    RSGQPLTGTN GRRCKEDEKL INATLRAGKR GYIIDTRSLN VAQQTRAKGG 250
    GFEQEAHYPQ WRRIHKSIER YHILQESLIK LVEACNDQTH NMDRWLSKLE 300
    ASNWLTHIKE ILTTACLAAQ CIDREGASIL IHGTEGTDST LQVTSLAQII 350
    LEPRSRTIRG FEALIEREWL QAGHPFQQRC AQSAYCNTKQ KWEAPVFLLF 400
    LDCVWQILRQ FPCSFEFNEN FLIMLFEHAY ASQFGTFLGN NESERCKLKL 450
    QQKTMSLWSW VNQPSELSKF TNPLFEANNL VIWPSVAPQS LPLWEGIFLR 500
    WNRSSKYLDE AYEEMVNIIE YNKELQAKVN ILRRQLAELE TEDGMQESP 549
    Length:549
    Mass (Da):63,462
    Last modified:December 1, 2001 - v1
    Checksum:i910F7D2907F9707E
    GO
    Isoform 2 (identifier: Q96QG7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:464
    Mass (Da):53,796
    Checksum:i8F537560CE0C03E3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti194 – 1941K → R in BAA91170. (PubMed:14702039)Curated
    Sequence conflicti382 – 3821Q → L in AAH22003. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585Missing in isoform 2. 1 PublicationVSP_056209Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ297823 mRNA. Translation: CAC51114.1.
    AJ297824 Genomic DNA. Translation: CAC51115.1.
    AK000444 mRNA. Translation: BAA91170.1.
    AK294463 mRNA. Translation: BAH11777.1.
    AF131216 Genomic DNA. No translation available.
    BC022003 mRNA. Translation: AAH22003.1.
    BC034990 mRNA. Translation: AAH34990.1.
    BC093788 mRNA. Translation: AAH93788.1.
    BC101623 mRNA. Translation: AAI01624.1.
    CCDSiCCDS5979.1.
    RefSeqiNP_056273.2. NM_015458.3.
    UniGeneiHs.591395.

    Genome annotation databases

    EnsembliENST00000221086; ENSP00000221086; ENSG00000104643.
    ENST00000526292; ENSP00000433239; ENSG00000104643.
    GeneIDi66036.
    KEGGihsa:66036.
    UCSCiuc003wtm.3. human.

    Polymorphism databases

    DMDMi33112393.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ297823 mRNA. Translation: CAC51114.1 .
    AJ297824 Genomic DNA. Translation: CAC51115.1 .
    AK000444 mRNA. Translation: BAA91170.1 .
    AK294463 mRNA. Translation: BAH11777.1 .
    AF131216 Genomic DNA. No translation available.
    BC022003 mRNA. Translation: AAH22003.1 .
    BC034990 mRNA. Translation: AAH34990.1 .
    BC093788 mRNA. Translation: AAH93788.1 .
    BC101623 mRNA. Translation: AAI01624.1 .
    CCDSi CCDS5979.1.
    RefSeqi NP_056273.2. NM_015458.3.
    UniGenei Hs.591395.

    3D structure databases

    ProteinModelPortali Q96QG7.
    SMRi Q96QG7. Positions 20-502.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122455. 11 interactions.
    DIPi DIP-54283N.
    IntActi Q96QG7. 7 interactions.
    MINTi MINT-6942912.
    STRINGi 9606.ENSP00000221086.

    PTM databases

    PhosphoSitei Q96QG7.

    Polymorphism databases

    DMDMi 33112393.

    Proteomic databases

    MaxQBi Q96QG7.
    PaxDbi Q96QG7.
    PRIDEi Q96QG7.

    Protocols and materials databases

    DNASUi 66036.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221086 ; ENSP00000221086 ; ENSG00000104643 .
    ENST00000526292 ; ENSP00000433239 ; ENSG00000104643 .
    GeneIDi 66036.
    KEGGi hsa:66036.
    UCSCi uc003wtm.3. human.

    Organism-specific databases

    CTDi 66036.
    GeneCardsi GC08P011141.
    H-InvDB HIX0025669.
    HIX0034664.
    HGNCi HGNC:14596. MTMR9.
    MIMi 606260. gene.
    neXtProti NX_Q96QG7.
    PharmGKBi PA37904.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278929.
    HOGENOMi HOG000210599.
    HOVERGENi HBG105875.
    InParanoidi Q96QG7.
    KOi K18084.
    OMAi KCKDLRI.
    OrthoDBi EOG79PJNX.
    PhylomeDBi Q96QG7.
    TreeFami TF315197.

    Miscellaneous databases

    ChiTaRSi MTMR9. human.
    GeneWikii MTMR9.
    GenomeRNAii 66036.
    NextBioi 67542.
    PROi Q96QG7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96QG7.
    Bgeei Q96QG7.
    CleanExi HS_MTMR8.
    HS_MTMR9.
    Genevestigatori Q96QG7.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    [Graphical view ]
    Pfami PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and localization of a new human myotubularin-related protein gene, MTMR8, on 8p22-p23."
      Appel S., Reichwald K., Zimmermann W., Reis A., Rosenthal A., Hennies H.C.
      Genomics 75:6-8(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver and Testis.
    5. "Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions."
      Lorenzo O., Urbe S., Clague M.J.
      J. Cell Sci. 119:2953-2959(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MTMR6; MTMR7 AND MTMR8.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMTMR9_HUMAN
    AccessioniPrimary (citable) accession number: Q96QG7
    Secondary accession number(s): B7Z291
    , Q52LU3, Q8WW11, Q96QG6, Q9NX50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3