Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acidic repeat-containing protein

Gene

GCNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic repeat-containing protein1 Publication
Alternative name(s):
Germ cell nuclear antigen1 Publication
Gene namesi
Name:GCNAImported
Synonyms:ACRC1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147174.11.
HGNCiHGNC:15805. GCNA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi93953.
OpenTargetsiENSG00000147174.
PharmGKBiPA24453.

Polymorphism and mutation databases

BioMutaiACRC.
DMDMi74732669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173871 – 691Acidic repeat-containing proteinAdd BLAST691

Proteomic databases

PaxDbiQ96QF7.
PeptideAtlasiQ96QF7.
PRIDEiQ96QF7.

PTM databases

iPTMnetiQ96QF7.
PhosphoSitePlusiQ96QF7.

Expressioni

Tissue specificityi

Expressed in germ cells of the testis (at protein level) (PubMed:27718356). Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain (PubMed:11714101).2 Publications

Gene expression databases

BgeeiENSG00000147174.
CleanExiHS_ACRC.
GenevisibleiQ96QF7. HS.

Organism-specific databases

HPAiHPA023476.

Interactioni

Protein-protein interaction databases

IntActiQ96QF7. 1 interactor.
STRINGi9606.ENSP00000362799.

Structurei

3D structure databases

ProteinModelPortaliQ96QF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini522 – 677SprT-likeAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 331Asp/Ser-richAdd BLAST207
Compositional biasi412 – 518Arg/Lys/Pro-richAdd BLAST107

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3854. Eukaryota.
ENOG4110GS5. LUCA.
GeneTreeiENSGT00440000040163.
HOGENOMiHOG000033791.
HOVERGENiHBG102033.
InParanoidiQ96QF7.
OMAiHEYCHLA.
OrthoDBiEOG091G0CMN.
PhylomeDBiQ96QF7.
TreeFamiTF316140.

Family and domain databases

InterProiView protein in InterPro
IPR006640. SprT-like_domain.
PfamiView protein in Pfam
PF10263. SprT-like. 1 hit.
SMARTiView protein in SMART
SM00731. SprT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96QF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGCKKELPR LQEPEEDEDC YILNVQSSSD DTSGSSVARR APKRQASCIL
60 70 80 90 100
NVQSRSGDTS GSSVARRAPK RQASSVVVID SDSDEECHTH EEKKAKLLEI
110 120 130 140 150
NSDDESPECC HVKPAIQEPP IVISDDDNDD DNGNDLEVPD DNSDDSEAPD
160 170 180 190 200
DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD DNSDDSDVPD DNSDDSSDDN
210 220 230 240 250
SDDSSDDNSD DSDVPDDKSD DSDVPDDSSD DSDVPDDSSD DSEAPDDSSD
260 270 280 290 300
DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEASDDSSD DSEASDDSSD
310 320 330 340 350
DSEAPDDKSD DSDVPEDKSD DSDVPDDNSD DLEVPVPAED LCNEGQIASD
360 370 380 390 400
EEELVEAAAA VSQHDSSDDA GEQDLGENLS KPPSDPEANP EVSERKLPTE
410 420 430 440 450
EEPAPVVEQS GKRKSKTKTI VEPPRKRQTK TKNIVEPPRK RQTKTKNIVE
460 470 480 490 500
PLRKRKAKTK NVSVTPGHKK RGPSKKKPGA AKVEKRKTRT PKCKVPGCFL
510 520 530 540 550
QDLEKSKKYS GKNLKRNKDE LVQRIYDLFN RSVCDKKLPE KLRIGWNNKM
560 570 580 590 600
VKTAGLCSTG EMWYPKWRRF AKIQIGLKVC DSADRIRDTL IHEMCHAASW
610 620 630 640 650
LIDGIHDSHG DAWKYYARKS NRIHPELPRV TRCHNYKINY KVHYECTGCK
660 670 680 690
TRIGCYTKSL DTSRFICAKC KGSLVMVPLT QKDGTRIVPH V
Length:691
Mass (Da):76,112
Last modified:December 1, 2001 - v1
Checksum:iF6B63CBF9A7CE1EA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050634471R → H. Corresponds to variant dbSNP:rs10217999Ensembl.1
Natural variantiVAR_038520662T → I. Corresponds to variant dbSNP:rs2280962Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311392 mRNA. Translation: CAC60255.1.
AK097433 mRNA. Translation: BAC05051.1.
BC136259 mRNA. Translation: AAI36260.1.
CCDSiCCDS35326.1.
RefSeqiNP_443189.1. NM_052957.4.
XP_006724779.1. XM_006724716.3.
XP_011529366.1. XM_011531064.1.
XP_016885454.1. XM_017029965.1.
UniGeneiHs.135167.

Genome annotation databases

EnsembliENST00000373695; ENSP00000362799; ENSG00000147174.
ENST00000373696; ENSP00000362800; ENSG00000147174.
GeneIDi93953.
KEGGihsa:93953.
UCSCiuc004eae.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACRC_HUMAN
AccessioniPrimary (citable) accession number: Q96QF7
Secondary accession number(s): B9EG62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families