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Q96QF7

- ACRC_HUMAN

UniProt

Q96QF7 - ACRC_HUMAN

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Protein

Acidic repeat-containing protein

Gene

ACRC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic repeat-containing protein
Gene namesi
Name:ACRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:15805. ACRC.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Acidic repeat-containing proteinPRO_0000317387Add
BLAST

Proteomic databases

PaxDbiQ96QF7.
PRIDEiQ96QF7.

PTM databases

PhosphoSiteiQ96QF7.

Expressioni

Tissue specificityi

Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain.1 Publication

Gene expression databases

BgeeiQ96QF7.
CleanExiHS_ACRC.
GenevestigatoriQ96QF7.

Organism-specific databases

HPAiHPA023476.

Interactioni

Protein-protein interaction databases

IntActiQ96QF7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96QF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini522 – 677156SprT-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi125 – 331207Asp/Ser-richAdd
BLAST
Compositional biasi412 – 518107Arg/Lys/Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 SprT-like domain.Curated

Phylogenomic databases

eggNOGiNOG302054.
GeneTreeiENSGT00440000040163.
HOGENOMiHOG000033791.
HOVERGENiHBG102033.
InParanoidiQ96QF7.
OMAiTISNWAQ.
OrthoDBiEOG75J0M8.
PhylomeDBiQ96QF7.
TreeFamiTF316140.

Family and domain databases

InterProiIPR006640. SprT-like_domain.
[Graphical view]
PfamiPF10263. SprT-like. 1 hit.
[Graphical view]
SMARTiSM00731. SprT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGCKKELPR LQEPEEDEDC YILNVQSSSD DTSGSSVARR APKRQASCIL
60 70 80 90 100
NVQSRSGDTS GSSVARRAPK RQASSVVVID SDSDEECHTH EEKKAKLLEI
110 120 130 140 150
NSDDESPECC HVKPAIQEPP IVISDDDNDD DNGNDLEVPD DNSDDSEAPD
160 170 180 190 200
DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD DNSDDSDVPD DNSDDSSDDN
210 220 230 240 250
SDDSSDDNSD DSDVPDDKSD DSDVPDDSSD DSDVPDDSSD DSEAPDDSSD
260 270 280 290 300
DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEASDDSSD DSEASDDSSD
310 320 330 340 350
DSEAPDDKSD DSDVPEDKSD DSDVPDDNSD DLEVPVPAED LCNEGQIASD
360 370 380 390 400
EEELVEAAAA VSQHDSSDDA GEQDLGENLS KPPSDPEANP EVSERKLPTE
410 420 430 440 450
EEPAPVVEQS GKRKSKTKTI VEPPRKRQTK TKNIVEPPRK RQTKTKNIVE
460 470 480 490 500
PLRKRKAKTK NVSVTPGHKK RGPSKKKPGA AKVEKRKTRT PKCKVPGCFL
510 520 530 540 550
QDLEKSKKYS GKNLKRNKDE LVQRIYDLFN RSVCDKKLPE KLRIGWNNKM
560 570 580 590 600
VKTAGLCSTG EMWYPKWRRF AKIQIGLKVC DSADRIRDTL IHEMCHAASW
610 620 630 640 650
LIDGIHDSHG DAWKYYARKS NRIHPELPRV TRCHNYKINY KVHYECTGCK
660 670 680 690
TRIGCYTKSL DTSRFICAKC KGSLVMVPLT QKDGTRIVPH V
Length:691
Mass (Da):76,112
Last modified:December 1, 2001 - v1
Checksum:iF6B63CBF9A7CE1EA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti471 – 4711R → H.
Corresponds to variant rs10217999 [ dbSNP | Ensembl ].
VAR_050634
Natural varianti662 – 6621T → I.
Corresponds to variant rs2280962 [ dbSNP | Ensembl ].
VAR_038520

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311392 mRNA. Translation: CAC60255.1.
AK097433 mRNA. Translation: BAC05051.1.
BC136259 mRNA. Translation: AAI36260.1.
CCDSiCCDS35326.1.
RefSeqiNP_443189.1. NM_052957.4.
XP_006724779.1. XM_006724716.1.
UniGeneiHs.135167.

Genome annotation databases

EnsembliENST00000373695; ENSP00000362799; ENSG00000147174.
ENST00000373696; ENSP00000362800; ENSG00000147174.
GeneIDi93953.
KEGGihsa:93953.
UCSCiuc004eae.2. human.

Polymorphism databases

DMDMi74732669.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311392 mRNA. Translation: CAC60255.1 .
AK097433 mRNA. Translation: BAC05051.1 .
BC136259 mRNA. Translation: AAI36260.1 .
CCDSi CCDS35326.1.
RefSeqi NP_443189.1. NM_052957.4.
XP_006724779.1. XM_006724716.1.
UniGenei Hs.135167.

3D structure databases

ProteinModelPortali Q96QF7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q96QF7. 1 interaction.

PTM databases

PhosphoSitei Q96QF7.

Polymorphism databases

DMDMi 74732669.

Proteomic databases

PaxDbi Q96QF7.
PRIDEi Q96QF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373695 ; ENSP00000362799 ; ENSG00000147174 .
ENST00000373696 ; ENSP00000362800 ; ENSG00000147174 .
GeneIDi 93953.
KEGGi hsa:93953.
UCSCi uc004eae.2. human.

Organism-specific databases

CTDi 93953.
GeneCardsi GC0XP070797.
HGNCi HGNC:15805. ACRC.
HPAi HPA023476.
MIMi 300369. gene.
neXtProti NX_Q96QF7.
PharmGKBi PA24453.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302054.
GeneTreei ENSGT00440000040163.
HOGENOMi HOG000033791.
HOVERGENi HBG102033.
InParanoidi Q96QF7.
OMAi TISNWAQ.
OrthoDBi EOG75J0M8.
PhylomeDBi Q96QF7.
TreeFami TF316140.

Miscellaneous databases

GeneWikii Acidic_repeat-containing_protein.
GenomeRNAii 93953.
NextBioi 78222.
PROi Q96QF7.
SOURCEi Search...

Gene expression databases

Bgeei Q96QF7.
CleanExi HS_ACRC.
Genevestigatori Q96QF7.

Family and domain databases

InterProi IPR006640. SprT-like_domain.
[Graphical view ]
Pfami PF10263. SprT-like. 1 hit.
[Graphical view ]
SMARTi SM00731. SprT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1."
    Nolte D., Ramser J., Niemann S., Lehrach H., Sudbrak R., Mueller U.
    Neurogenetics 3:207-213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart and Lung.

Entry informationi

Entry nameiACRC_HUMAN
AccessioniPrimary (citable) accession number: Q96QF7
Secondary accession number(s): B9EG62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3