Q96QF7 (ACRC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acidic repeat-containing protein

Gene names

Name:

ACRC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	691 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Potential Ref.1.
Tissue specificity	Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain. Ref.1
Sequence similarities	Belongs to the serine-aspartate repeat-containing protein (SDr) family. Contains 1 SprT-like domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 691	691	Acidic repeat-containing protein		PRO_0000317387
Regions
	Domain	522 – 677	156	SprT-like
	Compositional bias	125 – 331	207	Asp/Ser-rich
	Compositional bias	412 – 518	107	Arg/Lys/Pro-rich
Natural variations
	Natural variant	471	1	R → H. Corresponds to variant rs10217999 [ dbSNP | Ensembl ].		VAR_050634
	Natural variant	662	1	T → I. Corresponds to variant rs2280962 [ dbSNP | Ensembl ].		VAR_038520

Sequences

	Sequence		Length	Mass (Da)
	Q96QF7 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F6B63CBF9A7CE1EA	FASTA	691	76,112
	10 20 30 40 50 60 MDGCKKELPR LQEPEEDEDC YILNVQSSSD DTSGSSVARR APKRQASCIL NVQSRSGDTS 70 80 90 100 110 120 GSSVARRAPK RQASSVVVID SDSDEECHTH EEKKAKLLEI NSDDESPECC HVKPAIQEPP 130 140 150 160 170 180 IVISDDDNDD DNGNDLEVPD DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD 190 200 210 220 230 240 DNSDDSDVPD DNSDDSSDDN SDDSSDDNSD DSDVPDDKSD DSDVPDDSSD DSDVPDDSSD 250 260 270 280 290 300 DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEASDDSSD DSEASDDSSD 310 320 330 340 350 360 DSEAPDDKSD DSDVPEDKSD DSDVPDDNSD DLEVPVPAED LCNEGQIASD EEELVEAAAA 370 380 390 400 410 420 VSQHDSSDDA GEQDLGENLS KPPSDPEANP EVSERKLPTE EEPAPVVEQS GKRKSKTKTI 430 440 450 460 470 480 VEPPRKRQTK TKNIVEPPRK RQTKTKNIVE PLRKRKAKTK NVSVTPGHKK RGPSKKKPGA 490 500 510 520 530 540 AKVEKRKTRT PKCKVPGCFL QDLEKSKKYS GKNLKRNKDE LVQRIYDLFN RSVCDKKLPE 550 560 570 580 590 600 KLRIGWNNKM VKTAGLCSTG EMWYPKWRRF AKIQIGLKVC DSADRIRDTL IHEMCHAASW 610 620 630 640 650 660 LIDGIHDSHG DAWKYYARKS NRIHPELPRV TRCHNYKINY KVHYECTGCK TRIGCYTKSL 670 680 690 DTSRFICAKC KGSLVMVPLT QKDGTRIVPH V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1." Nolte D., Ramser J., Niemann S., Lehrach H., Sudbrak R., Mueller U. Neurogenetics 3:207-213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart and Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ311392 mRNA. Translation: CAC60255.1. AK097433 mRNA. Translation: BAC05051.1. BC136259 mRNA. Translation: AAI36260.1.
IPI	IPI00289929.
RefSeq	NP_443189.1. NM_052957.4.
UniGene	Hs.135167.
3D structure databases
ProteinModelPortal	Q96QF7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96QF7. 1 interaction.
PTM databases
PhosphoSite	Q96QF7.
Polymorphism databases
DMDM	74732669.
Proteomic databases
PaxDb	Q96QF7.
PRIDE	Q96QF7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373695; ENSP00000362799; ENSG00000147174. ENST00000373696; ENSP00000362800; ENSG00000147174.
GeneID	93953.
KEGG	hsa:93953.
UCSC	uc004eae.2. human.
Organism-specific databases
CTD	93953.
GeneCards	GC0XP070797.
HGNC	HGNC:15805. ACRC.
HPA	HPA023476.
MIM	300369. gene.
neXtProt	NX_Q96QF7.
PharmGKB	PA24453.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302054.
HOGENOM	HOG000033791.
HOVERGEN	HBG102033.
InParanoid	Q96QF7.
OMA	DVPDDNS.
OrthoDB	EOG473PRB.
Gene expression databases
Bgee	Q96QF7.
CleanEx	HS_ACRC.
Genevestigator	Q96QF7.
Family and domain databases
InterPro	IPR006640. SprT-like_domain. [Graphical view]
Pfam	PF10263. SprT-like. 1 hit. [Graphical view]
SMART	SM00731. SprT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	93953.
NextBio	78222.
SOURCE	Search...

Entry information

Entry name

ACRC_HUMAN

Accession

Primary (citable) accession number: Q96QF7
Secondary accession number(s): B9EG62

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.