Reviewed,
UniProtKB/Swiss-Prot Q96QF7 (ACRC_HUMAN)
Last modified
November 24, 2009.
Version 51.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Acidic repeat-containing protein | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 691 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Nucleus Potential. |
| Tissue specificity | Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain. Ref.1 |
| Sequence similarities | Belongs to the serine-aspartate repeat-containing protein (SDr) family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Polymorphism |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 691 | 691 | Acidic repeat-containing protein | PRO_0000317387 | |||||
Regions | |||||||||
| Compositional bias | 125 – 331 | 207 | Asp/Ser-rich | ||||||
| Compositional bias | 412 – 518 | 107 | Arg/Lys/Pro-rich | ||||||
Natural variations | |||||||||
| Natural variant | 471 | 1 | R → H: dbSNP rs10217999. | VAR_050634 | |||||
| Natural variant | 662 | 1 | T → I: dbSNP rs2280962. | VAR_038520 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1." Nolte D., Ramser J., Niemann S., Lehrach H., Sudbrak R., Mueller U. Neurogenetics 3:207-213(2001) [PubMed: 11714101] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Fetal brain. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.  Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart and Lung. |
Cross-references
Sequence databases | |
|---|---|
| AJ311392 mRNA. Translation: CAC60255.1. AK097433 mRNA. Translation: BAC05051.1. BC136259 mRNA. Translation: AAI36260.1. | |
| IPI | IPI00289929. |
| RefSeq | NP_443189.1. |
| UniGene | Hs.135167 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q96QF7. |
Genome annotation databases | |
| Ensembl | ENST00000373695; ENSP00000362799; ENSG00000147174; Homo sapiens. [Genome view] ENST00000373696; ENSP00000362800; ENSG00000147174; Homo sapiens. [Genome view] |
| GeneID | 93953. |
| KEGG | hsa:93953. |
| UCSC | uc004eae.1. human. |
Organism-specific databases | |
| CTD | 93953. |
| GeneCards | GC0XP070714. |
| HGNC | HGNC:15805. ACRC. |
| HPA | HPA023476. |
| MIM | 300369. gene. |
| PharmGKB | PA24453. |
| GenAtlas | Search... |
Phylogenomic databases | |
| OMA | SEAPDDN |
| OrthoDB | EOG9D299J |
Gene expression databases | |
| ArrayExpress | Q96QF7. |
| Bgee | Q96QF7. |
| CleanEx | HS_ACRC. |
| Genevestigator | Q96QF7. |
Family and domain databases | |
| InterPro | IPR019390. DUF_SprT-like. IPR006640. SprT. [Graphical view] |
| Pfam | PF10263. SprT-like. 1 hit. [Graphical view] |
| SMART | SM00731. SprT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 78222. |
| SOURCE | Search... |
Entry information
| Entry name | ACRC_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96QF7 Secondary accession number(s): B9EG62 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |
