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Q96QF7 (ACRC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acidic repeat-containing protein
Gene names
Name:ACRC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length691 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Potential Ref.1.

Tissue specificity

Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain. Ref.1

Sequence similarities

Belongs to the serine-aspartate repeat-containing protein (SDr) family.

Contains 1 SprT-like domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 691691Acidic repeat-containing protein
PRO_0000317387

Regions

Domain522 – 677156SprT-like
Compositional bias125 – 331207Asp/Ser-rich
Compositional bias412 – 518107Arg/Lys/Pro-rich

Natural variations

Natural variant4711R → H.
Corresponds to variant rs10217999 [ dbSNP | Ensembl ].
VAR_050634
Natural variant6621T → I.
Corresponds to variant rs2280962 [ dbSNP | Ensembl ].
VAR_038520

Sequences

Sequence LengthMass (Da)Tools
Q96QF7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F6B63CBF9A7CE1EA

FASTA69176,112
        10         20         30         40         50         60 
MDGCKKELPR LQEPEEDEDC YILNVQSSSD DTSGSSVARR APKRQASCIL NVQSRSGDTS 

        70         80         90        100        110        120 
GSSVARRAPK RQASSVVVID SDSDEECHTH EEKKAKLLEI NSDDESPECC HVKPAIQEPP 

       130        140        150        160        170        180 
IVISDDDNDD DNGNDLEVPD DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD 

       190        200        210        220        230        240 
DNSDDSDVPD DNSDDSSDDN SDDSSDDNSD DSDVPDDKSD DSDVPDDSSD DSDVPDDSSD 

       250        260        270        280        290        300 
DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEASDDSSD DSEASDDSSD 

       310        320        330        340        350        360 
DSEAPDDKSD DSDVPEDKSD DSDVPDDNSD DLEVPVPAED LCNEGQIASD EEELVEAAAA 

       370        380        390        400        410        420 
VSQHDSSDDA GEQDLGENLS KPPSDPEANP EVSERKLPTE EEPAPVVEQS GKRKSKTKTI 

       430        440        450        460        470        480 
VEPPRKRQTK TKNIVEPPRK RQTKTKNIVE PLRKRKAKTK NVSVTPGHKK RGPSKKKPGA 

       490        500        510        520        530        540 
AKVEKRKTRT PKCKVPGCFL QDLEKSKKYS GKNLKRNKDE LVQRIYDLFN RSVCDKKLPE 

       550        560        570        580        590        600 
KLRIGWNNKM VKTAGLCSTG EMWYPKWRRF AKIQIGLKVC DSADRIRDTL IHEMCHAASW 

       610        620        630        640        650        660 
LIDGIHDSHG DAWKYYARKS NRIHPELPRV TRCHNYKINY KVHYECTGCK TRIGCYTKSL 

       670        680        690 
DTSRFICAKC KGSLVMVPLT QKDGTRIVPH V 

« Hide

References

« Hide 'large scale' references
[1]"ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1."
Nolte D., Ramser J., Niemann S., Lehrach H., Sudbrak R., Mueller U.
Neurogenetics 3:207-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart and Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ311392 mRNA. Translation: CAC60255.1.
AK097433 mRNA. Translation: BAC05051.1.
BC136259 mRNA. Translation: AAI36260.1.
CCDSCCDS35326.1.
RefSeqNP_443189.1. NM_052957.4.
XP_006724779.1. XM_006724716.1.
UniGeneHs.135167.

3D structure databases

ProteinModelPortalQ96QF7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96QF7. 1 interaction.

PTM databases

PhosphoSiteQ96QF7.

Polymorphism databases

DMDM74732669.

Proteomic databases

PaxDbQ96QF7.
PRIDEQ96QF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373695; ENSP00000362799; ENSG00000147174.
ENST00000373696; ENSP00000362800; ENSG00000147174.
GeneID93953.
KEGGhsa:93953.
UCSCuc004eae.2. human.

Organism-specific databases

CTD93953.
GeneCardsGC0XP070797.
HGNCHGNC:15805. ACRC.
HPAHPA023476.
MIM300369. gene.
neXtProtNX_Q96QF7.
PharmGKBPA24453.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302054.
HOGENOMHOG000033791.
HOVERGENHBG102033.
InParanoidQ96QF7.
OMATISNWAQ.
OrthoDBEOG75J0M8.
PhylomeDBQ96QF7.
TreeFamTF316140.

Gene expression databases

BgeeQ96QF7.
CleanExHS_ACRC.
GenevestigatorQ96QF7.

Family and domain databases

InterProIPR006640. SprT-like_domain.
[Graphical view]
PfamPF10263. SprT-like. 1 hit.
[Graphical view]
SMARTSM00731. SprT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiAcidic_repeat-containing_protein.
GenomeRNAi93953.
NextBio78222.
PROQ96QF7.
SOURCESearch...

Entry information

Entry nameACRC_HUMAN
AccessionPrimary (citable) accession number: Q96QF7
Secondary accession number(s): B9EG62
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM