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Q96QF7

- ACRC_HUMAN

UniProt

Q96QF7 - ACRC_HUMAN

Protein

Acidic repeat-containing protein

Gene

ACRC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acidic repeat-containing protein
    Gene namesi
    Name:ACRC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:15805. ACRC.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24453.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 691691Acidic repeat-containing proteinPRO_0000317387Add
    BLAST

    Proteomic databases

    PaxDbiQ96QF7.
    PRIDEiQ96QF7.

    PTM databases

    PhosphoSiteiQ96QF7.

    Expressioni

    Tissue specificityi

    Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain.1 Publication

    Gene expression databases

    BgeeiQ96QF7.
    CleanExiHS_ACRC.
    GenevestigatoriQ96QF7.

    Organism-specific databases

    HPAiHPA023476.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96QF7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QF7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini522 – 677156SprT-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi125 – 331207Asp/Ser-richAdd
    BLAST
    Compositional biasi412 – 518107Arg/Lys/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SprT-like domain.Curated

    Phylogenomic databases

    eggNOGiNOG302054.
    HOGENOMiHOG000033791.
    HOVERGENiHBG102033.
    InParanoidiQ96QF7.
    OMAiTISNWAQ.
    OrthoDBiEOG75J0M8.
    PhylomeDBiQ96QF7.
    TreeFamiTF316140.

    Family and domain databases

    InterProiIPR006640. SprT-like_domain.
    [Graphical view]
    PfamiPF10263. SprT-like. 1 hit.
    [Graphical view]
    SMARTiSM00731. SprT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96QF7-1 [UniParc]FASTAAdd to Basket

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    MDGCKKELPR LQEPEEDEDC YILNVQSSSD DTSGSSVARR APKRQASCIL    50
    NVQSRSGDTS GSSVARRAPK RQASSVVVID SDSDEECHTH EEKKAKLLEI 100
    NSDDESPECC HVKPAIQEPP IVISDDDNDD DNGNDLEVPD DNSDDSEAPD 150
    DNSDDSEAPD DNSDDSEAPD DNSDDSEAPD DNSDDSDVPD DNSDDSSDDN 200
    SDDSSDDNSD DSDVPDDKSD DSDVPDDSSD DSDVPDDSSD DSEAPDDSSD 250
    DSEAPDDSSD DSEAPDDSSD DSEAPDDSSD DSEASDDSSD DSEASDDSSD 300
    DSEAPDDKSD DSDVPEDKSD DSDVPDDNSD DLEVPVPAED LCNEGQIASD 350
    EEELVEAAAA VSQHDSSDDA GEQDLGENLS KPPSDPEANP EVSERKLPTE 400
    EEPAPVVEQS GKRKSKTKTI VEPPRKRQTK TKNIVEPPRK RQTKTKNIVE 450
    PLRKRKAKTK NVSVTPGHKK RGPSKKKPGA AKVEKRKTRT PKCKVPGCFL 500
    QDLEKSKKYS GKNLKRNKDE LVQRIYDLFN RSVCDKKLPE KLRIGWNNKM 550
    VKTAGLCSTG EMWYPKWRRF AKIQIGLKVC DSADRIRDTL IHEMCHAASW 600
    LIDGIHDSHG DAWKYYARKS NRIHPELPRV TRCHNYKINY KVHYECTGCK 650
    TRIGCYTKSL DTSRFICAKC KGSLVMVPLT QKDGTRIVPH V 691
    Length:691
    Mass (Da):76,112
    Last modified:December 1, 2001 - v1
    Checksum:iF6B63CBF9A7CE1EA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti471 – 4711R → H.
    Corresponds to variant rs10217999 [ dbSNP | Ensembl ].
    VAR_050634
    Natural varianti662 – 6621T → I.
    Corresponds to variant rs2280962 [ dbSNP | Ensembl ].
    VAR_038520

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311392 mRNA. Translation: CAC60255.1.
    AK097433 mRNA. Translation: BAC05051.1.
    BC136259 mRNA. Translation: AAI36260.1.
    CCDSiCCDS35326.1.
    RefSeqiNP_443189.1. NM_052957.4.
    XP_006724779.1. XM_006724716.1.
    UniGeneiHs.135167.

    Genome annotation databases

    EnsembliENST00000373695; ENSP00000362799; ENSG00000147174.
    ENST00000373696; ENSP00000362800; ENSG00000147174.
    GeneIDi93953.
    KEGGihsa:93953.
    UCSCiuc004eae.2. human.

    Polymorphism databases

    DMDMi74732669.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ311392 mRNA. Translation: CAC60255.1 .
    AK097433 mRNA. Translation: BAC05051.1 .
    BC136259 mRNA. Translation: AAI36260.1 .
    CCDSi CCDS35326.1.
    RefSeqi NP_443189.1. NM_052957.4.
    XP_006724779.1. XM_006724716.1.
    UniGenei Hs.135167.

    3D structure databases

    ProteinModelPortali Q96QF7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q96QF7. 1 interaction.

    PTM databases

    PhosphoSitei Q96QF7.

    Polymorphism databases

    DMDMi 74732669.

    Proteomic databases

    PaxDbi Q96QF7.
    PRIDEi Q96QF7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373695 ; ENSP00000362799 ; ENSG00000147174 .
    ENST00000373696 ; ENSP00000362800 ; ENSG00000147174 .
    GeneIDi 93953.
    KEGGi hsa:93953.
    UCSCi uc004eae.2. human.

    Organism-specific databases

    CTDi 93953.
    GeneCardsi GC0XP070797.
    HGNCi HGNC:15805. ACRC.
    HPAi HPA023476.
    MIMi 300369. gene.
    neXtProti NX_Q96QF7.
    PharmGKBi PA24453.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302054.
    HOGENOMi HOG000033791.
    HOVERGENi HBG102033.
    InParanoidi Q96QF7.
    OMAi TISNWAQ.
    OrthoDBi EOG75J0M8.
    PhylomeDBi Q96QF7.
    TreeFami TF316140.

    Miscellaneous databases

    GeneWikii Acidic_repeat-containing_protein.
    GenomeRNAii 93953.
    NextBioi 78222.
    PROi Q96QF7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96QF7.
    CleanExi HS_ACRC.
    Genevestigatori Q96QF7.

    Family and domain databases

    InterProi IPR006640. SprT-like_domain.
    [Graphical view ]
    Pfami PF10263. SprT-like. 1 hit.
    [Graphical view ]
    SMARTi SM00731. SprT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ACRC codes for a novel nuclear protein with unusual acidic repeat tract and maps to DYT3 (dystonia parkinsonism) critical interval in xq13.1."
      Nolte D., Ramser J., Niemann S., Lehrach H., Sudbrak R., Mueller U.
      Neurogenetics 3:207-213(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart and Lung.

    Entry informationi

    Entry nameiACRC_HUMAN
    AccessioniPrimary (citable) accession number: Q96QF7
    Secondary accession number(s): B9EG62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3