Q96QF0 (RAB3I_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rab-3A-interacting protein
Short name=Rab3A-interacting protein

Alternative name(s):
Rabin-3
SSX2-interacting protein

Gene names

Name:	RAB3IP
Synonyms:	RABIN8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide exchange factor for RAB8A. Mediates the release of GDP from RAB8A but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Ref.2 Ref.9
Subunit structure	Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B. Ref.1 Ref.2 UniProtKB Q62739
Subcellular location	Cytoplasm. Nucleus. Cytoplasm › cytoskeleton › actin patch. Cell projection › lamellipodium. Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. Ref.1 Ref.2
Tissue specificity	Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver. Ref.1 Ref.2
Sequence similarities	Belongs to the SEC2 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell projection Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Golgi to plasma membrane transport Traceable author statement. Source: BHF-UCL cilium assembly Inferred from mutant phenotype. Source: BHF-UCL protein localization to organelle Inferred from mutant phenotype. Source: BHF-UCL protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	actin cortical patch Inferred from electronic annotation. Source: UniProtKB-SubCell centrosome Inferred from direct assay. Source: BHF-UCL cytosol Inferred from direct assay Ref.1. Source: UniProtKB lamellipodium Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule basal body Traceable author statement. Source: BHF-UCL nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BBS1	Q8NFJ9	2	EBI-747860,EBI-1805484
RAB3IL1	Q8TBN0	3	EBI-747844,EBI-743796
SSX2	Q16385	4	EBI-747865,EBI-2210673

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 Ref.1 (identifier: Q96QF0-1)

Also known as: alpha2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 Ref.1 (identifier: Q96QF0-2)

Also known as: alpha1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Isoform 3 Ref.1 (identifier: Q96QF0-3)

Also known as: beta1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     394-411: KCALTGQSKSCKHRIKLG → SLLYVTFLHTFDTFSRDS
     412-476: Missing.

Isoform 4 Ref.1 (identifier: Q96QF0-4)

Also known as: beta2;

The sequence of this isoform differs from the canonical sequence as follows:
     394-411: KCALTGQSKSCKHRIKLG → SLLYVTFLHTFDTFSRDS
     412-476: Missing.

Isoform 5 Ref.1 (identifier: Q96QF0-5)

Also known as: gamma1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     313-320: ADLSLYNE → KMCSHWPE
     321-476: Missing.

Isoform 6 Ref.1 (identifier: Q96QF0-6)

Also known as: gamma2;

The sequence of this isoform differs from the canonical sequence as follows:
     313-320: ADLSLYNE → KMCSHWPE
     321-476: Missing.

Isoform 7 (identifier: Q96QF0-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     313-331: ADLSLYNEFRLWKDEPTMD → VTHQGLSPLTLLILVSSHH
     332-476: Missing.

Note: No experimental confirmation available.

Isoform 8 (identifier: Q96QF0-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	Rab-3A-interacting protein		PRO_0000097144
Regions
	Coiled coil	165 – 260	96	Potential
Amino acid modifications
	Modified residue	163	1	Phosphoserine Ref.6 Ref.7
	Modified residue	265	1	Phosphothreonine Ref.8
	Modified residue	266	1	Phosphoserine Ref.8
	Modified residue	268	1	Phosphothreonine Ref.8
	Modified residue	288	1	Phosphoserine By similarity
	Modified residue	290	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 222	222	Missing in isoform 8.		VSP_051756
	Alternative sequence	1 – 16	16	Missing in isoform 1, isoform 3, isoform 5 and isoform 7. Ref.1		VSP_051755
	Alternative sequence	313 – 331	19	ADLSL…EPTMD → VTHQGLSPLTLLILVSSHH in isoform 7.		VSP_051758
	Alternative sequence	313 – 320	8	ADLSLYNE → KMCSHWPE in isoform 5 and isoform 6. Ref.1		VSP_051757
	Alternative sequence	321 – 476	156	Missing in isoform 5 and isoform 6. Ref.1		VSP_051759
	Alternative sequence	332 – 476	145	Missing in isoform 7.		VSP_051760
	Alternative sequence	394 – 411	18	KCALT…RIKLG → SLLYVTFLHTFDTFSRDS in isoform 3 and isoform 4. Ref.1		VSP_051761
	Alternative sequence	412 – 476	65	Missing in isoform 3 and isoform 4. Ref.1		VSP_051762
Experimental info
	Sequence conflict	164	1	P → Q in AAH59358. Ref.5
	Sequence conflict	286	1	N → D in BAB15391. Ref.3
	Sequence conflict	356	1	Missing in BAB15391. Ref.3
	Sequence conflict	464	1	M → V in BAB15391. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (alpha2) [UniParc]. Last modified December 1, 2001. Version 1. Checksum: DD77781823038F15	FASTA	476	53,021
	10 20 30 40 50 60 MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT TSPSVIYRPH 70 80 90 100 110 120 PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS FHVTDPAPCS TSGVTAGLTK 130 140 150 160 170 180 LTTRKDNYNA EREFLQGATI TEACDGSDDI FGLSTDSLSR LRSPSVLEVR EKGYERLKEE 190 200 210 220 230 240 LAKAQRELKL KDEECERLSK VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE 250 260 270 280 290 300 AQGKIDVLQA EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL 310 320 330 340 350 360 SVIQPIVKDC KEADLSLYNE FRLWKDEPTM DRTCPFLDKI YQEDIFPCLT FSKSELASAV 370 380 390 400 410 420 LEAVENNTLS IEPVGLQPIR FVKASAVECG GPKKCALTGQ SKSCKHRIKL GDSSNYYYIS 430 440 450 460 470 PFCRYRITSV CNFFTYIRYI QQGLVKQQDV DQMFWEVMQL RKEMSLAKLG YFKEEL
	Isoform 1 (alpha1) [UniParc]. Checksum: ED659E364B5C75FA	FASTA	460	51,250
	10 20 30 40 50 60 MANDPLEGFH EVNLASPTSP DLLGVYESGT QEQTTSPSVI YRPHPSALSS VPIQANALDV 70 80 90 100 110 120 SELPTQPVYS SPRRLNCAEI SSISFHVTDP APCSTSGVTA GLTKLTTRKD NYNAEREFLQ 130 140 150 160 170 180 GATITEACDG SDDIFGLSTD SLSRLRSPSV LEVREKGYER LKEELAKAQR ELKLKDEECE 190 200 210 220 230 240 RLSKVRDQLG QELEELTASL FEEAHKMVRE ANIKQATAEK QLKEAQGKID VLQAEVAALK 250 260 270 280 290 300 TLVLSSSPTS PTQEPLPGGK TPFKKGHTRN KSTSSAMSGS HQDLSVIQPI VKDCKEADLS 310 320 330 340 350 360 LYNEFRLWKD EPTMDRTCPF LDKIYQEDIF PCLTFSKSEL ASAVLEAVEN NTLSIEPVGL 370 380 390 400 410 420 QPIRFVKASA VECGGPKKCA LTGQSKSCKH RIKLGDSSNY YYISPFCRYR ITSVCNFFTY 430 440 450 460 IRYIQQGLVK QQDVDQMFWE VMQLRKEMSL AKLGYFKEEL
	Isoform 3 (beta1) [UniParc]. Checksum: 00E0F63E76FCEB09	FASTA	395	43,446
	10 20 30 40 50 60 MANDPLEGFH EVNLASPTSP DLLGVYESGT QEQTTSPSVI YRPHPSALSS VPIQANALDV 70 80 90 100 110 120 SELPTQPVYS SPRRLNCAEI SSISFHVTDP APCSTSGVTA GLTKLTTRKD NYNAEREFLQ 130 140 150 160 170 180 GATITEACDG SDDIFGLSTD SLSRLRSPSV LEVREKGYER LKEELAKAQR ELKLKDEECE 190 200 210 220 230 240 RLSKVRDQLG QELEELTASL FEEAHKMVRE ANIKQATAEK QLKEAQGKID VLQAEVAALK 250 260 270 280 290 300 TLVLSSSPTS PTQEPLPGGK TPFKKGHTRN KSTSSAMSGS HQDLSVIQPI VKDCKEADLS 310 320 330 340 350 360 LYNEFRLWKD EPTMDRTCPF LDKIYQEDIF PCLTFSKSEL ASAVLEAVEN NTLSIEPVGL 370 380 390 QPIRFVKASA VECGGPKSLL YVTFLHTFDT FSRDS
	Isoform 4 (beta2) [UniParc]. Checksum: B7C472F90DDD661C	FASTA	411	45,217
	10 20 30 40 50 60 MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT TSPSVIYRPH 70 80 90 100 110 120 PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS FHVTDPAPCS TSGVTAGLTK 130 140 150 160 170 180 LTTRKDNYNA EREFLQGATI TEACDGSDDI FGLSTDSLSR LRSPSVLEVR EKGYERLKEE 190 200 210 220 230 240 LAKAQRELKL KDEECERLSK VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE 250 260 270 280 290 300 AQGKIDVLQA EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL 310 320 330 340 350 360 SVIQPIVKDC KEADLSLYNE FRLWKDEPTM DRTCPFLDKI YQEDIFPCLT FSKSELASAV 370 380 390 400 410 LEAVENNTLS IEPVGLQPIR FVKASAVECG GPKSLLYVTF LHTFDTFSRD S
	Isoform 5 (gamma1) [UniParc]. Checksum: 6C579A473B5C0B52	FASTA	304	33,234
	10 20 30 40 50 60 MANDPLEGFH EVNLASPTSP DLLGVYESGT QEQTTSPSVI YRPHPSALSS VPIQANALDV 70 80 90 100 110 120 SELPTQPVYS SPRRLNCAEI SSISFHVTDP APCSTSGVTA GLTKLTTRKD NYNAEREFLQ 130 140 150 160 170 180 GATITEACDG SDDIFGLSTD SLSRLRSPSV LEVREKGYER LKEELAKAQR ELKLKDEECE 190 200 210 220 230 240 RLSKVRDQLG QELEELTASL FEEAHKMVRE ANIKQATAEK QLKEAQGKID VLQAEVAALK 250 260 270 280 290 300 TLVLSSSPTS PTQEPLPGGK TPFKKGHTRN KSTSSAMSGS HQDLSVIQPI VKDCKEKMCS HWPE
	Isoform 6 (gamma2) [UniParc]. Checksum: 00F8D4526DB2AEFC	FASTA	320	35,005
	10 20 30 40 50 60 MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT TSPSVIYRPH 70 80 90 100 110 120 PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS FHVTDPAPCS TSGVTAGLTK 130 140 150 160 170 180 LTTRKDNYNA EREFLQGATI TEACDGSDDI FGLSTDSLSR LRSPSVLEVR EKGYERLKEE 190 200 210 220 230 240 LAKAQRELKL KDEECERLSK VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE 250 260 270 280 290 300 AQGKIDVLQA EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL 310 320 SVIQPIVKDC KEKMCSHWPE
	Isoform 7 [UniParc]. Checksum: B4BCBD28A3C81394	FASTA	315	34,270
	10 20 30 40 50 60 MANDPLEGFH EVNLASPTSP DLLGVYESGT QEQTTSPSVI YRPHPSALSS VPIQANALDV 70 80 90 100 110 120 SELPTQPVYS SPRRLNCAEI SSISFHVTDP APCSTSGVTA GLTKLTTRKD NYNAEREFLQ 130 140 150 160 170 180 GATITEACDG SDDIFGLSTD SLSRLRSPSV LEVREKGYER LKEELAKAQR ELKLKDEECE 190 200 210 220 230 240 RLSKVRDQLG QELEELTASL FEEAHKMVRE ANIKQATAEK QLKEAQGKID VLQAEVAALK 250 260 270 280 290 300 TLVLSSSPTS PTQEPLPGGK TPFKKGHTRN KSTSSAMSGS HQDLSVIQPI VKDCKEVTHQ 310 GLSPLTLLIL VSSHH
	Isoform 8 [UniParc]. Checksum: 33D7F36AA55989C8	FASTA	254	28,642
	10 20 30 40 50 60 MVREANIKQA TAEKQLKEAQ GKIDVLQAEV AALKTLVLSS SPTSPTQEPL PGGKTPFKKG 70 80 90 100 110 120 HTRNKSTSSA MSGSHQDLSV IQPIVKDCKE ADLSLYNEFR LWKDEPTMDR TCPFLDKIYQ 130 140 150 160 170 180 EDIFPCLTFS KSELASAVLE AVENNTLSIE PVGLQPIRFV KASAVECGGP KKCALTGQSK 190 200 210 220 230 240 SCKHRIKLGD SSNYYYISPF CRYRITSVCN FFTYIRYIQQ GLVKQQDVDQ MFWEVMQLRK 250 EMSLAKLGYF KEEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP." de Bruijn D.R.H., dos Santos N.R., Kater-Baats E., Thijssen J., van den Berk L., Stap J., Balemans M., Schepens M., Merkx G., van Kessel A.G. Genes Chromosomes Cancer 34:285-298(2002) [PubMed: 12007189] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), INTERACTION WITH SSX2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport." Hattula K., Furuhjelm J., Arffman A., Peranen J. Mol. Biol. Cell 13:3268-3280(2002) [PubMed: 12221131] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RAB3A; RAB8A AND RAB8B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 8). Tissue: Small intestine and Teratocarcinoma.
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 8). Tissue: Brain and Colon.
[6]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-265; SER-266 AND THR-268, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"A molecular network for de novo generation of the apical surface and lumen." Bryant D.M., Datta A., Rodriguez-Fraticelli A.E., Peraenen J., Martin-Belmonte F., Mostov K.E. Nat. Cell Biol. 12:1035-1045(2010) [PubMed: 20890297] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ312896 mRNA. Translation: CAC59835.1. AJ312897 mRNA. Translation: CAC59836.1. AJ312898 mRNA. Translation: CAC59837.1. AJ312899 mRNA. Translation: CAC59838.1. AJ312900 mRNA. Translation: CAC59839.1. AJ312901 mRNA. Translation: CAC59840.1. AK026201 mRNA. Translation: BAB15391.1. AK027566 mRNA. Translation: BAB55202.1. AK027671 mRNA. Translation: BAB55283.1. AC025263 Genomic DNA. No translation available. BC015548 mRNA. Translation: AAH15548.1. BC059358 mRNA. Translation: AAH59358.1.
IPI	IPI00044842. IPI00395383. IPI00397214. IPI00397215. IPI00397216. IPI00397221. IPI00607662. IPI00607773.
RefSeq	NP_001019818.1. NM_001024647.2. NP_071901.2. NM_022456.3. NP_783322.1. NM_175623.2. NP_783323.1. NM_175624.2. NP_783324.1. NM_175625.2.
UniGene	Hs.258209.
3D structure databases
ProteinModelPortal	Q96QF0.
SMR	Q96QF0. Positions 172-263.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96QF0. 5 interactions.
MINT	MINT-237210.
STRING	Q96QF0.
PTM databases
PhosphoSite	Q96QF0.
Polymorphism databases
DMDM	71152025.
Proteomic databases
PRIDE	Q96QF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378809; ENSP00000368086; ENSG00000127328. ENST00000378815; ENSP00000368092; ENSG00000127328.
GeneID	117177.
KEGG	hsa:117177.
UCSC	uc001svl.1. human. uc001svm.1. human. uc001svn.1. human. uc001svp.1. human.
Organism-specific databases
CTD	117177.
GeneCards	GC12P070132.
HGNC	HGNC:16508. RAB3IP.
HPA	HPA039794.
MIM	608686. gene.
neXtProt	NX_Q96QF0.
PharmGKB	PA34136.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07562.
GeneTree	ENSGT00390000009036.
HOVERGEN	HBG057034.
InParanoid	Q96QF0.
OMA	APIQANA.
OrthoDB	EOG4X6C8J.
PhylomeDB	Q96QF0.
Gene expression databases
ArrayExpress	Q96QF0.
Bgee	Q96QF0.
Genevestigator	Q96QF0.
GermOnline	ENSG00000127328. Homo sapiens.
Family and domain databases
InterPro	IPR009449. Sec2p. [Graphical view]
Pfam	PF06428. Sec2p. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	80133.
SOURCE	Search...

Entry information

Entry name

RAB3I_HUMAN

Accession

Primary (citable) accession number: Q96QF0
Secondary accession number(s): B7WPJ6 , Q6PCE4, Q96A24, Q96QE6, Q96QE7, Q96QE8, Q96QE9, Q96QF1, Q9H673

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.