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Q96QF0

- RAB3I_HUMAN

UniProt

Q96QF0 - RAB3I_HUMAN

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Protein
Rab-3A-interacting protein
Gene
RAB3IP, RABIN8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.3 Publications

GO - Molecular functioni

  1. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB
  2. protein binding Source: BHF-UCL

GO - Biological processi

  1. Golgi to plasma membrane transport Source: BHF-UCL
  2. cilium assembly Source: BHF-UCL
  3. protein localization to organelle Source: BHF-UCL
  4. protein transport Source: UniProtKB-KW
  5. regulation of Rab GTPase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-3A-interacting protein
Short name:
Rab3A-interacting protein
Alternative name(s):
Rabin-3
SSX2-interacting protein
Gene namesi
Name:RAB3IP
Synonyms:RABIN8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:16508. RAB3IP.

Subcellular locationi

Cytoplasm. Nucleus. Cytoplasmcytoskeleton. Cell projectionlamellipodium
Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin.2 Publications

GO - Cellular componenti

  1. centrosome Source: BHF-UCL
  2. ciliary basal body Source: BHF-UCL
  3. cytoskeleton Source: UniProtKB-SubCell
  4. cytosol Source: UniProtKB
  5. lamellipodium Source: UniProtKB-SubCell
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Rab-3A-interacting protein
PRO_0000097144Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei163 – 1631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96QF0.
PaxDbiQ96QF0.
PRIDEiQ96QF0.

PTM databases

PhosphoSiteiQ96QF0.

Expressioni

Tissue specificityi

Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.2 Publications

Gene expression databases

ArrayExpressiQ96QF0.
BgeeiQ96QF0.
GenevestigatoriQ96QF0.

Organism-specific databases

HPAiHPA039794.

Interactioni

Subunit structurei

Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BBS1Q8NFJ92EBI-747860,EBI-1805484
RAB3IL1Q8TBN03EBI-747844,EBI-743796
SSX2BQ163854EBI-747865,EBI-2210673
TRAPPC10P485536EBI-747844,EBI-6160572

Protein-protein interaction databases

BioGridi125566. 2 interactions.
DIPiDIP-41703N.
IntActiQ96QF0. 30 interactions.
MINTiMINT-237210.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi175 – 19016
Helixi193 – 24351

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LHXX-ray3.05C/D/E/F173-248[»]
4LHYX-ray3.10C/D/E/F173-248[»]
4LHZX-ray3.20C/D/E/F173-248[»]
ProteinModelPortaliQ96QF0.
SMRiQ96QF0. Positions 173-248.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili165 – 26096 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the SEC2 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG299882.
HOVERGENiHBG057034.
InParanoidiQ96QF0.
KOiK16779.
OMAiAPIQANA.
OrthoDBiEOG7KSX8Q.
PhylomeDBiQ96QF0.
TreeFamiTF313748.

Family and domain databases

InterProiIPR009449. Sec2p.
[Graphical view]
PfamiPF06428. Sec2p. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 21 Publication (identifier: Q96QF0-1) [UniParc]FASTAAdd to Basket

Also known as: alpha2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT    50
TSPSVIYRPH PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS 100
FHVTDPAPCS TSGVTAGLTK LTTRKDNYNA EREFLQGATI TEACDGSDDI 150
FGLSTDSLSR LRSPSVLEVR EKGYERLKEE LAKAQRELKL KDEECERLSK 200
VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE AQGKIDVLQA 250
EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL 300
SVIQPIVKDC KEADLSLYNE FRLWKDEPTM DRTCPFLDKI YQEDIFPCLT 350
FSKSELASAV LEAVENNTLS IEPVGLQPIR FVKASAVECG GPKKCALTGQ 400
SKSCKHRIKL GDSSNYYYIS PFCRYRITSV CNFFTYIRYI QQGLVKQQDV 450
DQMFWEVMQL RKEMSLAKLG YFKEEL 476
Length:476
Mass (Da):53,021
Last modified:December 1, 2001 - v1
Checksum:iDD77781823038F15
GO
Isoform 11 Publication (identifier: Q96QF0-2) [UniParc]FASTAAdd to Basket

Also known as: alpha1

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:460
Mass (Da):51,250
Checksum:iED659E364B5C75FA
GO
Isoform 31 Publication (identifier: Q96QF0-3) [UniParc]FASTAAdd to Basket

Also known as: beta1

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     394-411: KCALTGQSKSCKHRIKLG → SLLYVTFLHTFDTFSRDS
     412-476: Missing.

Show »
Length:395
Mass (Da):43,446
Checksum:i00E0F63E76FCEB09
GO
Isoform 41 Publication (identifier: Q96QF0-4) [UniParc]FASTAAdd to Basket

Also known as: beta2

The sequence of this isoform differs from the canonical sequence as follows:
     394-411: KCALTGQSKSCKHRIKLG → SLLYVTFLHTFDTFSRDS
     412-476: Missing.

Show »
Length:411
Mass (Da):45,217
Checksum:iB7C472F90DDD661C
GO
Isoform 51 Publication (identifier: Q96QF0-5) [UniParc]FASTAAdd to Basket

Also known as: gamma1

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     313-320: ADLSLYNE → KMCSHWPE
     321-476: Missing.

Show »
Length:304
Mass (Da):33,234
Checksum:i6C579A473B5C0B52
GO
Isoform 61 Publication (identifier: Q96QF0-6) [UniParc]FASTAAdd to Basket

Also known as: gamma2

The sequence of this isoform differs from the canonical sequence as follows:
     313-320: ADLSLYNE → KMCSHWPE
     321-476: Missing.

Show »
Length:320
Mass (Da):35,005
Checksum:i00F8D4526DB2AEFC
GO
Isoform 7 (identifier: Q96QF0-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     313-331: ADLSLYNEFRLWKDEPTMD → VTHQGLSPLTLLILVSSHH
     332-476: Missing.

Note: No experimental confirmation available.

Show »
Length:315
Mass (Da):34,270
Checksum:iB4BCBD28A3C81394
GO
Isoform 8 (identifier: Q96QF0-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.

Show »
Length:254
Mass (Da):28,642
Checksum:i33D7F36AA55989C8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 222222Missing in isoform 8.
VSP_051756Add
BLAST
Alternative sequencei1 – 1616Missing in isoform 1, isoform 3, isoform 5 and isoform 7. 1 Publication
VSP_051755Add
BLAST
Alternative sequencei313 – 33119ADLSL…EPTMD → VTHQGLSPLTLLILVSSHH in isoform 7.
VSP_051758Add
BLAST
Alternative sequencei313 – 3208ADLSLYNE → KMCSHWPE in isoform 5 and isoform 6. 1 Publication
VSP_051757
Alternative sequencei321 – 476156Missing in isoform 5 and isoform 6. 1 Publication
VSP_051759Add
BLAST
Alternative sequencei332 – 476145Missing in isoform 7.
VSP_051760Add
BLAST
Alternative sequencei394 – 41118KCALT…RIKLG → SLLYVTFLHTFDTFSRDS in isoform 3 and isoform 4. 1 Publication
VSP_051761Add
BLAST
Alternative sequencei412 – 47665Missing in isoform 3 and isoform 4. 1 Publication
VSP_051762Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641P → Q in AAH59358. 1 Publication
Sequence conflicti286 – 2861N → D in BAB15391. 1 Publication
Sequence conflicti356 – 3561Missing in BAB15391. 1 Publication
Sequence conflicti464 – 4641M → V in BAB15391. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ312896 mRNA. Translation: CAC59835.1.
AJ312897 mRNA. Translation: CAC59836.1.
AJ312898 mRNA. Translation: CAC59837.1.
AJ312899 mRNA. Translation: CAC59838.1.
AJ312900 mRNA. Translation: CAC59839.1.
AJ312901 mRNA. Translation: CAC59840.1.
AK026201 mRNA. Translation: BAB15391.1.
AK027566 mRNA. Translation: BAB55202.1.
AK027671 mRNA. Translation: BAB55283.1.
AC025263 Genomic DNA. No translation available.
BC015548 mRNA. Translation: AAH15548.1.
BC059358 mRNA. Translation: AAH59358.1.
CCDSiCCDS41811.1. [Q96QF0-4]
CCDS44942.1. [Q96QF0-8]
CCDS8993.1. [Q96QF0-1]
CCDS8995.1. [Q96QF0-2]
CCDS8996.1. [Q96QF0-3]
RefSeqiNP_001019818.1. NM_001024647.3. [Q96QF0-8]
NP_001265331.1. NM_001278402.1. [Q96QF0-8]
NP_071901.2. NM_022456.4. [Q96QF0-2]
NP_783322.1. NM_175623.3. [Q96QF0-1]
NP_783323.1. NM_175624.3. [Q96QF0-3]
NP_783324.1. NM_175625.3. [Q96QF0-4]
UniGeneiHs.258209.

Genome annotation databases

EnsembliENST00000247833; ENSP00000247833; ENSG00000127328. [Q96QF0-2]
ENST00000325555; ENSP00000323349; ENSG00000127328. [Q96QF0-8]
ENST00000362025; ENSP00000355381; ENSG00000127328. [Q96QF0-4]
ENST00000378815; ENSP00000368092; ENSG00000127328. [Q96QF0-7]
ENST00000417413; ENSP00000436304; ENSG00000127328. [Q96QF0-5]
ENST00000483530; ENSP00000419216; ENSG00000127328. [Q96QF0-3]
ENST00000550536; ENSP00000447300; ENSG00000127328. [Q96QF0-1]
ENST00000551641; ENSP00000448773; ENSG00000127328. [Q96QF0-8]
ENST00000552199; ENSP00000448944; ENSG00000127328. [Q96QF0-6]
ENST00000553099; ENSP00000448027; ENSG00000127328. [Q96QF0-8]
GeneIDi117177.
KEGGihsa:117177.
UCSCiuc001svm.3. human. [Q96QF0-1]
uc001svn.3. human. [Q96QF0-3]
uc001svq.3. human. [Q96QF0-4]
uc021rao.1. human. [Q96QF0-7]

Polymorphism databases

DMDMi71152025.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ312896 mRNA. Translation: CAC59835.1 .
AJ312897 mRNA. Translation: CAC59836.1 .
AJ312898 mRNA. Translation: CAC59837.1 .
AJ312899 mRNA. Translation: CAC59838.1 .
AJ312900 mRNA. Translation: CAC59839.1 .
AJ312901 mRNA. Translation: CAC59840.1 .
AK026201 mRNA. Translation: BAB15391.1 .
AK027566 mRNA. Translation: BAB55202.1 .
AK027671 mRNA. Translation: BAB55283.1 .
AC025263 Genomic DNA. No translation available.
BC015548 mRNA. Translation: AAH15548.1 .
BC059358 mRNA. Translation: AAH59358.1 .
CCDSi CCDS41811.1. [Q96QF0-4 ]
CCDS44942.1. [Q96QF0-8 ]
CCDS8993.1. [Q96QF0-1 ]
CCDS8995.1. [Q96QF0-2 ]
CCDS8996.1. [Q96QF0-3 ]
RefSeqi NP_001019818.1. NM_001024647.3. [Q96QF0-8 ]
NP_001265331.1. NM_001278402.1. [Q96QF0-8 ]
NP_071901.2. NM_022456.4. [Q96QF0-2 ]
NP_783322.1. NM_175623.3. [Q96QF0-1 ]
NP_783323.1. NM_175624.3. [Q96QF0-3 ]
NP_783324.1. NM_175625.3. [Q96QF0-4 ]
UniGenei Hs.258209.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4LHX X-ray 3.05 C/D/E/F 173-248 [» ]
4LHY X-ray 3.10 C/D/E/F 173-248 [» ]
4LHZ X-ray 3.20 C/D/E/F 173-248 [» ]
ProteinModelPortali Q96QF0.
SMRi Q96QF0. Positions 173-248.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125566. 2 interactions.
DIPi DIP-41703N.
IntActi Q96QF0. 30 interactions.
MINTi MINT-237210.

PTM databases

PhosphoSitei Q96QF0.

Polymorphism databases

DMDMi 71152025.

Proteomic databases

MaxQBi Q96QF0.
PaxDbi Q96QF0.
PRIDEi Q96QF0.

Protocols and materials databases

DNASUi 117177.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000247833 ; ENSP00000247833 ; ENSG00000127328 . [Q96QF0-2 ]
ENST00000325555 ; ENSP00000323349 ; ENSG00000127328 . [Q96QF0-8 ]
ENST00000362025 ; ENSP00000355381 ; ENSG00000127328 . [Q96QF0-4 ]
ENST00000378815 ; ENSP00000368092 ; ENSG00000127328 . [Q96QF0-7 ]
ENST00000417413 ; ENSP00000436304 ; ENSG00000127328 . [Q96QF0-5 ]
ENST00000483530 ; ENSP00000419216 ; ENSG00000127328 . [Q96QF0-3 ]
ENST00000550536 ; ENSP00000447300 ; ENSG00000127328 . [Q96QF0-1 ]
ENST00000551641 ; ENSP00000448773 ; ENSG00000127328 . [Q96QF0-8 ]
ENST00000552199 ; ENSP00000448944 ; ENSG00000127328 . [Q96QF0-6 ]
ENST00000553099 ; ENSP00000448027 ; ENSG00000127328 . [Q96QF0-8 ]
GeneIDi 117177.
KEGGi hsa:117177.
UCSCi uc001svm.3. human. [Q96QF0-1 ]
uc001svn.3. human. [Q96QF0-3 ]
uc001svq.3. human. [Q96QF0-4 ]
uc021rao.1. human. [Q96QF0-7 ]

Organism-specific databases

CTDi 117177.
GeneCardsi GC12P070132.
HGNCi HGNC:16508. RAB3IP.
HPAi HPA039794.
MIMi 608686. gene.
neXtProti NX_Q96QF0.
PharmGKBi PA34136.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299882.
HOVERGENi HBG057034.
InParanoidi Q96QF0.
KOi K16779.
OMAi APIQANA.
OrthoDBi EOG7KSX8Q.
PhylomeDBi Q96QF0.
TreeFami TF313748.

Miscellaneous databases

GeneWikii RAB3IP.
GenomeRNAii 117177.
NextBioi 80133.
PROi Q96QF0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96QF0.
Bgeei Q96QF0.
Genevestigatori Q96QF0.

Family and domain databases

InterProi IPR009449. Sec2p.
[Graphical view ]
Pfami PF06428. Sec2p. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP."
    de Bruijn D.R.H., dos Santos N.R., Kater-Baats E., Thijssen J., van den Berk L., Stap J., Balemans M., Schepens M., Merkx G., van Kessel A.G.
    Genes Chromosomes Cancer 34:285-298(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), INTERACTION WITH SSX2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport."
    Hattula K., Furuhjelm J., Arffman A., Peranen J.
    Mol. Biol. Cell 13:3268-3280(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RAB3A; RAB8A AND RAB8B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 8).
    Tissue: Small intestine and Teratocarcinoma.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 8).
    Tissue: Brain and Colon.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."
    Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J., Barr F.A.
    J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR.
  11. "A molecular network for de novo generation of the apical surface and lumen."
    Bryant D.M., Datta A., Rodriguez-Fraticelli A.E., Peraenen J., Martin-Belmonte F., Mostov K.E.
    Nat. Cell Biol. 12:1035-1045(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiRAB3I_HUMAN
AccessioniPrimary (citable) accession number: Q96QF0
Secondary accession number(s): B7WPJ6
, Q6PCE4, Q96A24, Q96QE6, Q96QE7, Q96QE8, Q96QE9, Q96QF1, Q9H673
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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