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Q96QF0

- RAB3I_HUMAN

UniProt

Q96QF0 - RAB3I_HUMAN

Protein

Rab-3A-interacting protein

Gene

RAB3IP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.3 Publications

    GO - Molecular functioni

    1. protein binding Source: BHF-UCL
    2. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. cilium assembly Source: BHF-UCL
    2. Golgi to plasma membrane transport Source: BHF-UCL
    3. positive regulation of Rab GTPase activity Source: GOC
    4. protein localization to organelle Source: BHF-UCL
    5. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rab-3A-interacting protein
    Short name:
    Rab3A-interacting protein
    Alternative name(s):
    Rabin-3
    SSX2-interacting protein
    Gene namesi
    Name:RAB3IPImported
    Synonyms:RABIN8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:16508. RAB3IP.

    Subcellular locationi

    Cytoplasm. Nucleus. Cytoplasmcytoskeleton. Cell projectionlamellipodium
    Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin.

    GO - Cellular componenti

    1. centrosome Source: BHF-UCL
    2. ciliary basal body Source: BHF-UCL
    3. cytoskeleton Source: UniProtKB-SubCell
    4. cytosol Source: UniProtKB
    5. lamellipodium Source: UniProtKB-SubCell
    6. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34136.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Rab-3A-interacting proteinPRO_0000097144Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei163 – 1631Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96QF0.
    PaxDbiQ96QF0.
    PRIDEiQ96QF0.

    PTM databases

    PhosphoSiteiQ96QF0.

    Expressioni

    Tissue specificityi

    Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.2 Publications

    Gene expression databases

    ArrayExpressiQ96QF0.
    BgeeiQ96QF0.
    GenevestigatoriQ96QF0.

    Organism-specific databases

    HPAiHPA039794.

    Interactioni

    Subunit structurei

    Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BBS1Q8NFJ92EBI-747860,EBI-1805484
    RAB3IL1Q8TBN03EBI-747844,EBI-743796
    SSX2BQ163854EBI-747865,EBI-2210673
    TRAPPC10P485536EBI-747844,EBI-6160572

    Protein-protein interaction databases

    BioGridi125566. 3 interactions.
    DIPiDIP-41703N.
    IntActiQ96QF0. 30 interactions.
    MINTiMINT-237210.

    Structurei

    Secondary structure

    1
    476
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi175 – 19016
    Helixi193 – 24351

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LHXX-ray3.05C/D/E/F173-248[»]
    4LHYX-ray3.10C/D/E/F173-248[»]
    4LHZX-ray3.20C/D/E/F173-248[»]
    ProteinModelPortaliQ96QF0.
    SMRiQ96QF0. Positions 173-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili165 – 26096Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC2 family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG299882.
    HOVERGENiHBG057034.
    InParanoidiQ96QF0.
    KOiK16779.
    OMAiAPIQANA.
    OrthoDBiEOG7KSX8Q.
    PhylomeDBiQ96QF0.
    TreeFamiTF313748.

    Family and domain databases

    InterProiIPR009449. Sec2p.
    [Graphical view]
    PfamiPF06428. Sec2p. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 21 Publication (identifier: Q96QF0-1) [UniParc]FASTAAdd to Basket

    Also known as: alpha21 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT    50
    TSPSVIYRPH PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS 100
    FHVTDPAPCS TSGVTAGLTK LTTRKDNYNA EREFLQGATI TEACDGSDDI 150
    FGLSTDSLSR LRSPSVLEVR EKGYERLKEE LAKAQRELKL KDEECERLSK 200
    VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE AQGKIDVLQA 250
    EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL 300
    SVIQPIVKDC KEADLSLYNE FRLWKDEPTM DRTCPFLDKI YQEDIFPCLT 350
    FSKSELASAV LEAVENNTLS IEPVGLQPIR FVKASAVECG GPKKCALTGQ 400
    SKSCKHRIKL GDSSNYYYIS PFCRYRITSV CNFFTYIRYI QQGLVKQQDV 450
    DQMFWEVMQL RKEMSLAKLG YFKEEL 476
    Length:476
    Mass (Da):53,021
    Last modified:December 1, 2001 - v1
    Checksum:iDD77781823038F15
    GO
    Isoform 11 Publication (identifier: Q96QF0-2) [UniParc]FASTAAdd to Basket

    Also known as: alpha11 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.

    Show »
    Length:460
    Mass (Da):51,250
    Checksum:iED659E364B5C75FA
    GO
    Isoform 31 Publication (identifier: Q96QF0-3) [UniParc]FASTAAdd to Basket

    Also known as: beta11 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.
         394-411: KCALTGQSKSCKHRIKLG → SLLYVTFLHTFDTFSRDS
         412-476: Missing.

    Show »
    Length:395
    Mass (Da):43,446
    Checksum:i00E0F63E76FCEB09
    GO
    Isoform 41 Publication (identifier: Q96QF0-4) [UniParc]FASTAAdd to Basket

    Also known as: beta21 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         394-411: KCALTGQSKSCKHRIKLG → SLLYVTFLHTFDTFSRDS
         412-476: Missing.

    Show »
    Length:411
    Mass (Da):45,217
    Checksum:iB7C472F90DDD661C
    GO
    Isoform 51 Publication (identifier: Q96QF0-5) [UniParc]FASTAAdd to Basket

    Also known as: gamma11 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.
         313-320: ADLSLYNE → KMCSHWPE
         321-476: Missing.

    Show »
    Length:304
    Mass (Da):33,234
    Checksum:i6C579A473B5C0B52
    GO
    Isoform 61 Publication (identifier: Q96QF0-6) [UniParc]FASTAAdd to Basket

    Also known as: gamma21 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         313-320: ADLSLYNE → KMCSHWPE
         321-476: Missing.

    Show »
    Length:320
    Mass (Da):35,005
    Checksum:i00F8D4526DB2AEFC
    GO
    Isoform 7Curated (identifier: Q96QF0-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: Missing.
         313-331: ADLSLYNEFRLWKDEPTMD → VTHQGLSPLTLLILVSSHH
         332-476: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:315
    Mass (Da):34,270
    Checksum:iB4BCBD28A3C81394
    GO
    Isoform 8Curated (identifier: Q96QF0-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-222: Missing.

    Show »
    Length:254
    Mass (Da):28,642
    Checksum:i33D7F36AA55989C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1641P → Q in AAH59358. (PubMed:15489334)Curated
    Sequence conflicti286 – 2861N → D in BAB15391. (PubMed:14702039)Curated
    Sequence conflicti356 – 3561Missing in BAB15391. (PubMed:14702039)Curated
    Sequence conflicti464 – 4641M → V in BAB15391. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 222222Missing in isoform 8. 2 PublicationsVSP_051756Add
    BLAST
    Alternative sequencei1 – 1616Missing in isoform 1, isoform 3, isoform 5 and isoform 7. 3 PublicationsVSP_051755Add
    BLAST
    Alternative sequencei313 – 33119ADLSL…EPTMD → VTHQGLSPLTLLILVSSHH in isoform 7. 1 PublicationVSP_051758Add
    BLAST
    Alternative sequencei313 – 3208ADLSLYNE → KMCSHWPE in isoform 5 and isoform 6. 1 PublicationVSP_051757
    Alternative sequencei321 – 476156Missing in isoform 5 and isoform 6. 1 PublicationVSP_051759Add
    BLAST
    Alternative sequencei332 – 476145Missing in isoform 7. 1 PublicationVSP_051760Add
    BLAST
    Alternative sequencei394 – 41118KCALT…RIKLG → SLLYVTFLHTFDTFSRDS in isoform 3 and isoform 4. 1 PublicationVSP_051761Add
    BLAST
    Alternative sequencei412 – 47665Missing in isoform 3 and isoform 4. 1 PublicationVSP_051762Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ312896 mRNA. Translation: CAC59835.1.
    AJ312897 mRNA. Translation: CAC59836.1.
    AJ312898 mRNA. Translation: CAC59837.1.
    AJ312899 mRNA. Translation: CAC59838.1.
    AJ312900 mRNA. Translation: CAC59839.1.
    AJ312901 mRNA. Translation: CAC59840.1.
    AK026201 mRNA. Translation: BAB15391.1.
    AK027566 mRNA. Translation: BAB55202.1.
    AK027671 mRNA. Translation: BAB55283.1.
    AC025263 Genomic DNA. No translation available.
    BC015548 mRNA. Translation: AAH15548.1.
    BC059358 mRNA. Translation: AAH59358.1.
    CCDSiCCDS41811.1. [Q96QF0-4]
    CCDS44942.1. [Q96QF0-8]
    CCDS8993.1. [Q96QF0-1]
    CCDS8995.1. [Q96QF0-2]
    CCDS8996.1. [Q96QF0-3]
    RefSeqiNP_001019818.1. NM_001024647.3. [Q96QF0-8]
    NP_001265331.1. NM_001278402.1. [Q96QF0-8]
    NP_071901.2. NM_022456.4. [Q96QF0-2]
    NP_783322.1. NM_175623.3. [Q96QF0-1]
    NP_783323.1. NM_175624.3. [Q96QF0-3]
    NP_783324.1. NM_175625.3. [Q96QF0-4]
    UniGeneiHs.258209.

    Genome annotation databases

    EnsembliENST00000247833; ENSP00000247833; ENSG00000127328. [Q96QF0-2]
    ENST00000362025; ENSP00000355381; ENSG00000127328. [Q96QF0-4]
    ENST00000378815; ENSP00000368092; ENSG00000127328. [Q96QF0-7]
    ENST00000417413; ENSP00000436304; ENSG00000127328. [Q96QF0-5]
    ENST00000483530; ENSP00000419216; ENSG00000127328. [Q96QF0-3]
    ENST00000550536; ENSP00000447300; ENSG00000127328. [Q96QF0-1]
    ENST00000551641; ENSP00000448773; ENSG00000127328. [Q96QF0-8]
    ENST00000552199; ENSP00000448944; ENSG00000127328. [Q96QF0-6]
    ENST00000553099; ENSP00000448027; ENSG00000127328. [Q96QF0-8]
    GeneIDi117177.
    KEGGihsa:117177.
    UCSCiuc001svm.3. human. [Q96QF0-1]
    uc001svn.3. human. [Q96QF0-3]
    uc001svq.3. human. [Q96QF0-4]
    uc021rao.1. human. [Q96QF0-7]

    Polymorphism databases

    DMDMi71152025.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ312896 mRNA. Translation: CAC59835.1 .
    AJ312897 mRNA. Translation: CAC59836.1 .
    AJ312898 mRNA. Translation: CAC59837.1 .
    AJ312899 mRNA. Translation: CAC59838.1 .
    AJ312900 mRNA. Translation: CAC59839.1 .
    AJ312901 mRNA. Translation: CAC59840.1 .
    AK026201 mRNA. Translation: BAB15391.1 .
    AK027566 mRNA. Translation: BAB55202.1 .
    AK027671 mRNA. Translation: BAB55283.1 .
    AC025263 Genomic DNA. No translation available.
    BC015548 mRNA. Translation: AAH15548.1 .
    BC059358 mRNA. Translation: AAH59358.1 .
    CCDSi CCDS41811.1. [Q96QF0-4 ]
    CCDS44942.1. [Q96QF0-8 ]
    CCDS8993.1. [Q96QF0-1 ]
    CCDS8995.1. [Q96QF0-2 ]
    CCDS8996.1. [Q96QF0-3 ]
    RefSeqi NP_001019818.1. NM_001024647.3. [Q96QF0-8 ]
    NP_001265331.1. NM_001278402.1. [Q96QF0-8 ]
    NP_071901.2. NM_022456.4. [Q96QF0-2 ]
    NP_783322.1. NM_175623.3. [Q96QF0-1 ]
    NP_783323.1. NM_175624.3. [Q96QF0-3 ]
    NP_783324.1. NM_175625.3. [Q96QF0-4 ]
    UniGenei Hs.258209.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LHX X-ray 3.05 C/D/E/F 173-248 [» ]
    4LHY X-ray 3.10 C/D/E/F 173-248 [» ]
    4LHZ X-ray 3.20 C/D/E/F 173-248 [» ]
    ProteinModelPortali Q96QF0.
    SMRi Q96QF0. Positions 173-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125566. 3 interactions.
    DIPi DIP-41703N.
    IntActi Q96QF0. 30 interactions.
    MINTi MINT-237210.

    PTM databases

    PhosphoSitei Q96QF0.

    Polymorphism databases

    DMDMi 71152025.

    Proteomic databases

    MaxQBi Q96QF0.
    PaxDbi Q96QF0.
    PRIDEi Q96QF0.

    Protocols and materials databases

    DNASUi 117177.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247833 ; ENSP00000247833 ; ENSG00000127328 . [Q96QF0-2 ]
    ENST00000362025 ; ENSP00000355381 ; ENSG00000127328 . [Q96QF0-4 ]
    ENST00000378815 ; ENSP00000368092 ; ENSG00000127328 . [Q96QF0-7 ]
    ENST00000417413 ; ENSP00000436304 ; ENSG00000127328 . [Q96QF0-5 ]
    ENST00000483530 ; ENSP00000419216 ; ENSG00000127328 . [Q96QF0-3 ]
    ENST00000550536 ; ENSP00000447300 ; ENSG00000127328 . [Q96QF0-1 ]
    ENST00000551641 ; ENSP00000448773 ; ENSG00000127328 . [Q96QF0-8 ]
    ENST00000552199 ; ENSP00000448944 ; ENSG00000127328 . [Q96QF0-6 ]
    ENST00000553099 ; ENSP00000448027 ; ENSG00000127328 . [Q96QF0-8 ]
    GeneIDi 117177.
    KEGGi hsa:117177.
    UCSCi uc001svm.3. human. [Q96QF0-1 ]
    uc001svn.3. human. [Q96QF0-3 ]
    uc001svq.3. human. [Q96QF0-4 ]
    uc021rao.1. human. [Q96QF0-7 ]

    Organism-specific databases

    CTDi 117177.
    GeneCardsi GC12P070132.
    HGNCi HGNC:16508. RAB3IP.
    HPAi HPA039794.
    MIMi 608686. gene.
    neXtProti NX_Q96QF0.
    PharmGKBi PA34136.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299882.
    HOVERGENi HBG057034.
    InParanoidi Q96QF0.
    KOi K16779.
    OMAi APIQANA.
    OrthoDBi EOG7KSX8Q.
    PhylomeDBi Q96QF0.
    TreeFami TF313748.

    Miscellaneous databases

    GeneWikii RAB3IP.
    GenomeRNAii 117177.
    NextBioi 80133.
    PROi Q96QF0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96QF0.
    Bgeei Q96QF0.
    Genevestigatori Q96QF0.

    Family and domain databases

    InterProi IPR009449. Sec2p.
    [Graphical view ]
    Pfami PF06428. Sec2p. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP."
      de Bruijn D.R.H., dos Santos N.R., Kater-Baats E., Thijssen J., van den Berk L., Stap J., Balemans M., Schepens M., Merkx G., van Kessel A.G.
      Genes Chromosomes Cancer 34:285-298(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), INTERACTION WITH SSX2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Testis1 Publication.
    2. "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport."
      Hattula K., Furuhjelm J., Arffman A., Peranen J.
      Mol. Biol. Cell 13:3268-3280(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RAB3A; RAB8A AND RAB8B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 8).
      Tissue: Small intestineImported and TeratocarcinomaImported.
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 8).
      Tissue: BrainImported and ColonImported.
    6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."
      Yoshimura S., Gerondopoulos A., Linford A., Rigden D.J., Barr F.A.
      J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR.
    11. "A molecular network for de novo generation of the apical surface and lumen."
      Bryant D.M., Datta A., Rodriguez-Fraticelli A.E., Peraenen J., Martin-Belmonte F., Mostov K.E.
      Nat. Cell Biol. 12:1035-1045(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiRAB3I_HUMAN
    AccessioniPrimary (citable) accession number: Q96QF0
    Secondary accession number(s): B7WPJ6
    , Q6PCE4, Q96A24, Q96QE6, Q96QE7, Q96QE8, Q96QE9, Q96QF1, Q9H673
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3