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Protein

Leucine-rich repeat-containing protein 37B

Gene

LRRC37B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 37B
Alternative name(s):
C66 SLIT-like testicular protein
Gene namesi
Name:LRRC37B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29070. LRRC37B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 905ExtracellularSequence analysisAdd BLAST878
Transmembranei906 – 926HelicalSequence analysisAdd BLAST21
Topological domaini927 – 947CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114659.
OpenTargetsiENSG00000185158.
PharmGKBiPA142671525.

Polymorphism and mutation databases

BioMutaiLRRC37B.
DMDMi296439308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000023265328 – 947Leucine-rich repeat-containing protein 37BAdd BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi358N-linked (GlcNAc...)Sequence analysis1
Glycosylationi789N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96QE4.
PeptideAtlasiQ96QE4.
PRIDEiQ96QE4.

PTM databases

iPTMnetiQ96QE4.
PhosphoSitePlusiQ96QE4.

Expressioni

Gene expression databases

BgeeiENSG00000185158.
CleanExiHS_LRRC37B.
ExpressionAtlasiQ96QE4. baseline and differential.
GenevisibleiQ96QE4. HS.

Organism-specific databases

HPAiHPA015134.
HPA015135.

Interactioni

Protein-protein interaction databases

BioGridi125332. 1 interactor.
STRINGi9606.ENSP00000340519.

Structurei

3D structure databases

ProteinModelPortaliQ96QE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati556 – 577LRR 1Add BLAST22
Repeati580 – 601LRR 2Add BLAST22
Repeati604 – 625LRR 3Add BLAST22
Repeati628 – 649LRR 4Add BLAST22
Repeati655 – 676LRR 5Add BLAST22
Repeati679 – 699LRR 6Add BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili867 – 897Sequence analysisAdd BLAST31

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000293202.
HOVERGENiHBG060837.
InParanoidiQ96QE4.
PhylomeDBiQ96QE4.
TreeFamiTF341959.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 2 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96QE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWLRFWGPW PLLTWQLLSL LVKEAQPLVW VKDPLQLTSN PLGPPEPWSS
60 70 80 90 100
RSSHLPWESP HAPAPPAAPG DFDYLGPSAS SQMSALPQEP TENLAPFLKE
110 120 130 140 150
LDSAGELPLG PEPFLAAHQD LNDKRTPEER LPEVVPLLNR DQNQALVQLP
160 170 180 190 200
RLKWVQTTDL DRAAGHQADE ILVPLDSKVS RPTKFVVSPK NLKKDLAERW
210 220 230 240 250
SLPEIVGIPH QLSKPQRQKQ TLPDDYLSMD TLYPGSLPPE LRVNADEPPG
260 270 280 290 300
PPEQVGLSQF HLEPKSQNPE TLEDIQSSSL QEEAPAQLLQ LPQEVEPSTQ
310 320 330 340 350
QEAPALPPES SMESLAQTPL NHEVTVQPPG EDQAHYNLPK FTVKPADVEV
360 370 380 390 400
TMTSEPKNET ESTQAQQEAP IQPPEEAEPS STALRTTDPP PEHPEVTLPP
410 420 430 440 450
SDKGQAQHSH LTEATVQPLD LELSITTEPT TEVKPSPTTE ETSAQPPDPG
460 470 480 490 500
LAITPEPTTE IGHSTALEKT RAPHPDQVQT LHRSLTEVTG PPTKLESSQD
510 520 530 540 550
SLVQSETAPE EQKASTSTNI CELCTCGDET LSCVGLSPKQ RLRQVPVPEP
560 570 580 590 600
DTYNGIFTTL NFQGNYISYL DGNVWKAYSW TEKLILSENY LTELPKDSFE
610 620 630 640 650
GLLYLQYLDL SCNKIRYIER QTFESLPFLQ YINLGCNLIT KLSLGTFQAW
660 670 680 690 700
HGMQFLHNLI LNRNPLTTVE DPYLFELPAL KYLDMGTTHI TLTTLKNILT
710 720 730 740 750
MTVELEKLIL PSHMACCLCQ FKNSIEAVCK TVKLHCNTAC LTNSIHCPEE
760 770 780 790 800
ASVGNPEGAF MKMLQARKQH MSTQLTIESE APSDSSGINL SGFGGDQLEI
810 820 830 840 850
QLTEQLRSLI PNEDVRKFMS HVIRTLKMEC SETHVQGSCA KLMLRTGLLM
860 870 880 890 900
KLLSEQQEAK ALNVEWDTDQ QKTNYINENM EQNEQKEQKS SELMKEVPGD
910 920 930 940
DYKNKLIFAI SVTVILIILI IIFCLIEVNS HKRASEKYKD NPSISGA
Length:947
Mass (Da):105,567
Last modified:May 18, 2010 - v3
Checksum:i2C599D50C8C637AC
GO
Isoform 2 (identifier: Q96QE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-658: Missing.

Note: No experimental confirmation available.
Show »
Length:896
Mass (Da):99,568
Checksum:i9271EA5076990C62
GO

Sequence cautioni

The sequence AAR28082 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6 – 24FWGPW…LLVKE → ITAMAPPYVATIVFTSQG in CAC44536 (PubMed:10843809).CuratedAdd BLAST19
Sequence conflicti198E → G in AAR28082 (Ref. 2) Curated1
Sequence conflicti336Y → H in AAR28082 (Ref. 2) Curated1
Sequence conflicti469K → E in AAR28082 (Ref. 2) Curated1
Sequence conflicti604Y → S in CAC44536 (PubMed:10843809).Curated1
Sequence conflicti621Q → H in CAC44536 (PubMed:10843809).Curated1
Sequence conflicti621Q → H in AAR28082 (Ref. 2) Curated1
Sequence conflicti641K → E in CAC44536 (PubMed:10843809).Curated1
Sequence conflicti702T → S in AAR28082 (Ref. 2) Curated1
Sequence conflicti772S → G in AAR28082 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054513608 – 658Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ314647 mRNA. Translation: CAC44536.1.
AY386261 mRNA. Translation: AAR28082.1. Different initiation.
AC090616 Genomic DNA. No translation available.
BC117373 mRNA. Translation: AAI17374.1.
BC143581 mRNA. Translation: AAI43582.1.
CCDSiCCDS32609.1. [Q96QE4-1]
RefSeqiNP_443120.2. NM_052888.2. [Q96QE4-1]
UniGeneiHs.514071.
Hs.568209.
Hs.738806.
Hs.744157.

Genome annotation databases

EnsembliENST00000341671; ENSP00000340519; ENSG00000185158. [Q96QE4-1]
ENST00000394713; ENSP00000378202; ENSG00000185158. [Q96QE4-1]
GeneIDi114659.
KEGGihsa:114659.
UCSCiuc060dst.1. human. [Q96QE4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ314647 mRNA. Translation: CAC44536.1.
AY386261 mRNA. Translation: AAR28082.1. Different initiation.
AC090616 Genomic DNA. No translation available.
BC117373 mRNA. Translation: AAI17374.1.
BC143581 mRNA. Translation: AAI43582.1.
CCDSiCCDS32609.1. [Q96QE4-1]
RefSeqiNP_443120.2. NM_052888.2. [Q96QE4-1]
UniGeneiHs.514071.
Hs.568209.
Hs.738806.
Hs.744157.

3D structure databases

ProteinModelPortaliQ96QE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125332. 1 interactor.
STRINGi9606.ENSP00000340519.

PTM databases

iPTMnetiQ96QE4.
PhosphoSitePlusiQ96QE4.

Polymorphism and mutation databases

BioMutaiLRRC37B.
DMDMi296439308.

Proteomic databases

PaxDbiQ96QE4.
PeptideAtlasiQ96QE4.
PRIDEiQ96QE4.

Protocols and materials databases

DNASUi114659.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341671; ENSP00000340519; ENSG00000185158. [Q96QE4-1]
ENST00000394713; ENSP00000378202; ENSG00000185158. [Q96QE4-1]
GeneIDi114659.
KEGGihsa:114659.
UCSCiuc060dst.1. human. [Q96QE4-1]

Organism-specific databases

CTDi114659.
DisGeNETi114659.
GeneCardsiLRRC37B.
H-InvDBHIX0039097.
HIX0039456.
HGNCiHGNC:29070. LRRC37B.
HPAiHPA015134.
HPA015135.
MIMi616558. gene.
neXtProtiNX_Q96QE4.
OpenTargetsiENSG00000185158.
PharmGKBiPA142671525.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000293202.
HOVERGENiHBG060837.
InParanoidiQ96QE4.
PhylomeDBiQ96QE4.
TreeFamiTF341959.

Enzyme and pathway databases

BioCyciZFISH:G66-32445-MONOMER.

Miscellaneous databases

ChiTaRSiLRRC37B. human.
GenomeRNAii114659.
PROiQ96QE4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185158.
CleanExiHS_LRRC37B.
ExpressionAtlasiQ96QE4. baseline and differential.
GenevisibleiQ96QE4. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 2 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLR37B_HUMAN
AccessioniPrimary (citable) accession number: Q96QE4
Secondary accession number(s): Q17RC9, Q5YKG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.