Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proton myo-inositol cotransporter

Gene

SLC2A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_19188. Inositol transporters.

Protein family/group databases

TCDBi2.A.1.1.25. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:SLC2A13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:15956. SLC2A13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini98 – 12528ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini147 – 1482CytoplasmicSequence Analysis
Transmembranei149 – 16921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini170 – 1789ExtracellularSequence Analysis
Transmembranei179 – 19921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini200 – 21213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini234 – 2396ExtracellularSequence Analysis
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 32464CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei325 – 34521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini346 – 36318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei364 – 38421Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini385 – 3939CytoplasmicSequence Analysis
Transmembranei394 – 41421Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini415 – 50894ExtracellularSequence AnalysisAdd
BLAST
Transmembranei509 – 52921Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini530 – 54920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei550 – 57021Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini571 – 5733ExtracellularSequence Analysis
Transmembranei574 – 59421Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini595 – 64854CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38066.

Polymorphism and mutation databases

BioMutaiSLC2A13.
DMDMi294862502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Proton myo-inositol cotransporterPRO_0000050456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
Modified residuei640 – 6401Phosphoserine2 Publications
Modified residuei645 – 6451Phosphoserine3 Publications

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ96QE2.
PaxDbiQ96QE2.
PRIDEiQ96QE2.

PTM databases

PhosphoSiteiQ96QE2.

Expressioni

Tissue specificityi

Predominantly expressed in the brain.1 Publication

Gene expression databases

BgeeiQ96QE2.
CleanExiHS_SLC2A13.
ExpressionAtlasiQ96QE2. baseline and differential.
GenevestigatoriQ96QE2.

Organism-specific databases

HPAiHPA006584.

Structurei

3D structure databases

ProteinModelPortaliQ96QE2.
SMRiQ96QE2. Positions 98-410, 509-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ96QE2.
KOiK08150.
OMAiRKYSLMI.
OrthoDBiEOG7VDXNV.
PhylomeDBiQ96QE2.
TreeFamiTF314916.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKASENVE YTLRSLSSLM GERRRKQPEP DAASAAGECS LLAAAESSTS
60 70 80 90 100
LQSAGAGGGG VGDLERAARR QFQQDETPAF VYVVAVFSAL GGFLFGYDTG
110 120 130 140 150
VVSGAMLLLK RQLSLDALWQ ELLVSSTVGA AAVSALAGGA LNGVFGRRAA
160 170 180 190 200
ILLASALFTA GSAVLAAANN KETLLAGRLV VGLGIGIASM TVPVYIAEVS
210 220 230 240 250
PPNLRGRLVT INTLFITGGQ FFASVVDGAF SYLQKDGWRY MLGLAAVPAV
260 270 280 290 300
IQFFGFLFLP ESPRWLIQKG QTQKARRILS QMRGNQTIDE EYDSIKNNIE
310 320 330 340 350
EEEKEVGSAG PVICRMLSYP PTRRALIVGC GLQMFQQLSG INTIMYYSAT
360 370 380 390 400
ILQMSGVEDD RLAIWLASVT AFTNFIFTLV GVWLVEKVGR RKLTFGSLAG
410 420 430 440 450
TTVALIILAL GFVLSAQVSP RITFKPIAPS GQNATCTRYS YCNECMLDPD
460 470 480 490 500
CGFCYKMNKS TVIDSSCVPV NKASTNEAAW GRCENETKFK TEDIFWAYNF
510 520 530 540 550
CPTPYSWTAL LGLILYLVFF APGMGPMPWT VNSEIYPLWA RSTGNACSSG
560 570 580 590 600
INWIFNVLVS LTFLHTAEYL TYYGAFFLYA GFAAVGLLFI YGCLPETKGK
610 620 630 640
KLEEIESLFD NRLCTCGTSD SDEGRYIEYI RVKGSNYHLS DNDASDVE
Length:648
Mass (Da):70,371
Last modified:April 20, 2010 - v3
Checksum:i07B951E20A7F46EB
GO

Sequence cautioni

The sequence AAI17118.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI17120.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAC51116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315644 mRNA. Translation: CAC51116.1. Different initiation.
BC117117 mRNA. Translation: AAI17118.1. Different initiation.
BC117119 mRNA. Translation: AAI17120.1. Different initiation.
CCDSiCCDS8736.2.
RefSeqiNP_443117.3. NM_052885.3.
UniGeneiHs.558595.

Genome annotation databases

EnsembliENST00000280871; ENSP00000280871; ENSG00000151229.
GeneIDi114134.
KEGGihsa:114134.
UCSCiuc010skm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315644 mRNA. Translation: CAC51116.1. Different initiation.
BC117117 mRNA. Translation: AAI17118.1. Different initiation.
BC117119 mRNA. Translation: AAI17120.1. Different initiation.
CCDSiCCDS8736.2.
RefSeqiNP_443117.3. NM_052885.3.
UniGeneiHs.558595.

3D structure databases

ProteinModelPortaliQ96QE2.
SMRiQ96QE2. Positions 98-410, 509-610.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.1.1.25. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ96QE2.

Polymorphism and mutation databases

BioMutaiSLC2A13.
DMDMi294862502.

Proteomic databases

MaxQBiQ96QE2.
PaxDbiQ96QE2.
PRIDEiQ96QE2.

Protocols and materials databases

DNASUi114134.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280871; ENSP00000280871; ENSG00000151229.
GeneIDi114134.
KEGGihsa:114134.
UCSCiuc010skm.2. human.

Organism-specific databases

CTDi114134.
GeneCardsiGC12M040152.
H-InvDBHIX0026507.
HGNCiHGNC:15956. SLC2A13.
HPAiHPA006584.
MIMi611036. gene.
neXtProtiNX_Q96QE2.
PharmGKBiPA38066.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00590000083062.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ96QE2.
KOiK08150.
OMAiRKYSLMI.
OrthoDBiEOG7VDXNV.
PhylomeDBiQ96QE2.
TreeFamiTF314916.

Enzyme and pathway databases

ReactomeiREACT_19188. Inositol transporters.

Miscellaneous databases

ChiTaRSiSLC2A13. human.
GeneWikiiSLC2A13.
GenomeRNAii114134.
NextBioi79005.
PROiQ96QE2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96QE2.
CleanExiHS_SLC2A13.
ExpressionAtlasiQ96QE2. baseline and differential.
GenevestigatoriQ96QE2.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain."
    Uldry M., Ibberson M., Horisberger J.-D., Chatton J.-Y., Riederer B.M., Thorens B.
    EMBO J. 20:4467-4477(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-648.
    Tissue: Brain.
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMYCT_HUMAN
AccessioniPrimary (citable) accession number: Q96QE2
Secondary accession number(s): Q17S07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 20, 2010
Last modified: May 27, 2015
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.