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Q96QE2 (MYCT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proton myo-inositol cotransporter

Short name=H(+)-myo-inositol cotransporter
Short name=Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene names
Name:SLC2A13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

H+-myo-inositol cotransporter. Can also transport related stereoisomers. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Predominantly expressed in the brain. Ref.1

Post-translational modification

Glycosylated. Ref.1

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence caution

The sequence AAI17118.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI17120.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAC51116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionsubstrate-specific transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 648648Proton myo-inositol cotransporter
PRO_0000050456

Regions

Topological domain1 – 7676Cytoplasmic Potential
Transmembrane77 – 9721Helical; Name=1; Potential
Topological domain98 – 12528Extracellular Potential
Transmembrane126 – 14621Helical; Name=2; Potential
Topological domain147 – 1482Cytoplasmic Potential
Transmembrane149 – 16921Helical; Name=3; Potential
Topological domain170 – 1789Extracellular Potential
Transmembrane179 – 19921Helical; Name=4; Potential
Topological domain200 – 21213Cytoplasmic Potential
Transmembrane213 – 23321Helical; Name=5; Potential
Topological domain234 – 2396Extracellular Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 32464Cytoplasmic Potential
Transmembrane325 – 34521Helical; Name=7; Potential
Topological domain346 – 36318Extracellular Potential
Transmembrane364 – 38421Helical; Name=8; Potential
Topological domain385 – 3939Cytoplasmic Potential
Transmembrane394 – 41421Helical; Name=9; Potential
Topological domain415 – 50894Extracellular Potential
Transmembrane509 – 52921Helical; Name=10; Potential
Topological domain530 – 54920Cytoplasmic Potential
Transmembrane550 – 57021Helical; Name=11; Potential
Topological domain571 – 5733Extracellular Potential
Transmembrane574 – 59421Helical; Name=12; Potential
Topological domain595 – 64854Cytoplasmic Potential

Amino acid modifications

Modified residue6401Phosphoserine Ref.3 Ref.5
Modified residue6451Phosphoserine Ref.3 Ref.5
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation4581N-linked (GlcNAc...) Potential
Glycosylation4851N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q96QE2 [UniParc].

Last modified April 20, 2010. Version 3.
Checksum: 07B951E20A7F46EB

FASTA64870,371
        10         20         30         40         50         60 
MSRKASENVE YTLRSLSSLM GERRRKQPEP DAASAAGECS LLAAAESSTS LQSAGAGGGG 

        70         80         90        100        110        120 
VGDLERAARR QFQQDETPAF VYVVAVFSAL GGFLFGYDTG VVSGAMLLLK RQLSLDALWQ 

       130        140        150        160        170        180 
ELLVSSTVGA AAVSALAGGA LNGVFGRRAA ILLASALFTA GSAVLAAANN KETLLAGRLV 

       190        200        210        220        230        240 
VGLGIGIASM TVPVYIAEVS PPNLRGRLVT INTLFITGGQ FFASVVDGAF SYLQKDGWRY 

       250        260        270        280        290        300 
MLGLAAVPAV IQFFGFLFLP ESPRWLIQKG QTQKARRILS QMRGNQTIDE EYDSIKNNIE 

       310        320        330        340        350        360 
EEEKEVGSAG PVICRMLSYP PTRRALIVGC GLQMFQQLSG INTIMYYSAT ILQMSGVEDD 

       370        380        390        400        410        420 
RLAIWLASVT AFTNFIFTLV GVWLVEKVGR RKLTFGSLAG TTVALIILAL GFVLSAQVSP 

       430        440        450        460        470        480 
RITFKPIAPS GQNATCTRYS YCNECMLDPD CGFCYKMNKS TVIDSSCVPV NKASTNEAAW 

       490        500        510        520        530        540 
GRCENETKFK TEDIFWAYNF CPTPYSWTAL LGLILYLVFF APGMGPMPWT VNSEIYPLWA 

       550        560        570        580        590        600 
RSTGNACSSG INWIFNVLVS LTFLHTAEYL TYYGAFFLYA GFAAVGLLFI YGCLPETKGK 

       610        620        630        640 
KLEEIESLFD NRLCTCGTSD SDEGRYIEYI RVKGSNYHLS DNDASDVE 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain."
Uldry M., Ibberson M., Horisberger J.-D., Chatton J.-Y., Riederer B.M., Thorens B.
EMBO J. 20:4467-4477(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-648.
Tissue: Brain.
[3]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ315644 mRNA. Translation: CAC51116.1. Different initiation.
BC117117 mRNA. Translation: AAI17118.1. Different initiation.
BC117119 mRNA. Translation: AAI17120.1. Different initiation.
CCDSCCDS8736.2.
RefSeqNP_443117.3. NM_052885.3.
UniGeneHs.558595.

3D structure databases

ProteinModelPortalQ96QE2.
SMRQ96QE2. Positions 98-410, 509-610.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.1.1.25. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ96QE2.

Polymorphism databases

DMDM294862502.

Proteomic databases

MaxQBQ96QE2.
PaxDbQ96QE2.
PRIDEQ96QE2.

Protocols and materials databases

DNASU114134.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280871; ENSP00000280871; ENSG00000151229.
GeneID114134.
KEGGhsa:114134.
UCSCuc010skm.2. human.

Organism-specific databases

CTD114134.
GeneCardsGC12M040051.
H-InvDBHIX0026507.
HGNCHGNC:15956. SLC2A13.
HPAHPA006584.
MIM611036. gene.
neXtProtNX_Q96QE2.
PharmGKBPA38066.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000202868.
HOVERGENHBG031722.
InParanoidQ96QE2.
KOK08150.
OMAATHIGVM.
OrthoDBEOG7VDXNV.
PhylomeDBQ96QE2.
TreeFamTF314916.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ96QE2.
BgeeQ96QE2.
CleanExHS_SLC2A13.
GenevestigatorQ96QE2.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC2A13.
GenomeRNAi114134.
NextBio79005.
PROQ96QE2.
SOURCESearch...

Entry information

Entry nameMYCT_HUMAN
AccessionPrimary (citable) accession number: Q96QE2
Secondary accession number(s): Q17S07
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM