Proton myo-inositol cotransporter - Homo sapiens (Human)

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Q96QE2 (MYCT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Proton myo-inositol cotransporter
Short name=H(+)-myo-inositol cotransporter
Short name=Hmit

Alternative name(s):
H(+)-myo-inositol symporter

Gene names

Name:

SLC2A13

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	648 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	H⁺-myo-inositol cotransporter. Can also transport related stereoisomers. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Predominantly expressed in the brain. Ref.1
Post-translational modification	Glycosylated. Ref.1
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]
Sequence caution	The sequence AAI17118.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI17120.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAC51116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular function	substrate-specific transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 648

648

Proton myo-inositol cotransporter

PRO_0000050456

Regions

Topological domain

1 – 76

Cytoplasmic Potential

Transmembrane

77 – 97

Helical; Name=1; Potential

Topological domain

98 – 125

Extracellular Potential

Transmembrane

126 – 146

Helical; Name=2; Potential

Topological domain

147 – 148

Cytoplasmic Potential

Transmembrane

149 – 169

Helical; Name=3; Potential

Topological domain

170 – 178

Extracellular Potential

Transmembrane

179 – 199

Helical; Name=4; Potential

Topological domain

200 – 212

Cytoplasmic Potential

Transmembrane

213 – 233

Helical; Name=5; Potential

Topological domain

234 – 239

Extracellular Potential

Transmembrane

240 – 260

Helical; Name=6; Potential

Topological domain

261 – 324

Cytoplasmic Potential

Transmembrane

325 – 345

Helical; Name=7; Potential

Topological domain

346 – 363

Extracellular Potential

Transmembrane

364 – 384

Helical; Name=8; Potential

Topological domain

385 – 393

Cytoplasmic Potential

Transmembrane

394 – 414

Helical; Name=9; Potential

Topological domain

415 – 508

Extracellular Potential

Transmembrane

509 – 529

Helical; Name=10; Potential

Topological domain

530 – 549

Cytoplasmic Potential

Transmembrane

550 – 570

Helical; Name=11; Potential

Topological domain

571 – 573

Extracellular Potential

Transmembrane

574 – 594

Helical; Name=12; Potential

Topological domain

595 – 648

Cytoplasmic Potential

Amino acid modifications

Modified residue

640

Phosphoserine Ref.3

Modified residue

645

Phosphoserine Ref.3 Ref.4

Glycosylation

433

N-linked (GlcNAc...) Potential

Glycosylation

458

N-linked (GlcNAc...) Potential

Glycosylation

485

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q96QE2 [UniParc].

Last modified April 20, 2010. Version 3.
Checksum: 07B951E20A7F46EB
Show »

FASTA

648

70,371

        10         20         30         40         50         60 
MSRKASENVE YTLRSLSSLM GERRRKQPEP DAASAAGECS LLAAAESSTS LQSAGAGGGG 

        70         80         90        100        110        120 
VGDLERAARR QFQQDETPAF VYVVAVFSAL GGFLFGYDTG VVSGAMLLLK RQLSLDALWQ 

       130        140        150        160        170        180 
ELLVSSTVGA AAVSALAGGA LNGVFGRRAA ILLASALFTA GSAVLAAANN KETLLAGRLV 

       190        200        210        220        230        240 
VGLGIGIASM TVPVYIAEVS PPNLRGRLVT INTLFITGGQ FFASVVDGAF SYLQKDGWRY 

       250        260        270        280        290        300 
MLGLAAVPAV IQFFGFLFLP ESPRWLIQKG QTQKARRILS QMRGNQTIDE EYDSIKNNIE 

       310        320        330        340        350        360 
EEEKEVGSAG PVICRMLSYP PTRRALIVGC GLQMFQQLSG INTIMYYSAT ILQMSGVEDD 

       370        380        390        400        410        420 
RLAIWLASVT AFTNFIFTLV GVWLVEKVGR RKLTFGSLAG TTVALIILAL GFVLSAQVSP 

       430        440        450        460        470        480 
RITFKPIAPS GQNATCTRYS YCNECMLDPD CGFCYKMNKS TVIDSSCVPV NKASTNEAAW 

       490        500        510        520        530        540 
GRCENETKFK TEDIFWAYNF CPTPYSWTAL LGLILYLVFF APGMGPMPWT VNSEIYPLWA 

       550        560        570        580        590        600 
RSTGNACSSG INWIFNVLVS LTFLHTAEYL TYYGAFFLYA GFAAVGLLFI YGCLPETKGK 

       610        620        630        640 
KLEEIESLFD NRLCTCGTSD SDEGRYIEYI RVKGSNYHLS DNDASDVE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain." Uldry M., Ibberson M., Horisberger J.-D., Chatton J.-Y., Riederer B.M., Thorens B. EMBO J. 20:4467-4477(2001) [PubMed: 11500374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-648. Tissue: Brain.
[3]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ315644 mRNA. Translation: CAC51116.1. Different initiation. BC117117 mRNA. Translation: AAI17118.1. Different initiation. BC117119 mRNA. Translation: AAI17120.1. Different initiation.
IPI	IPI00658045.
RefSeq	NP_443117.3. NM_052885.3.
UniGene	Hs.558595.
3D structure databases
ProteinModelPortal	Q96QE2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96QE2.
Protein family/group databases
TCDB	2.A.1.1.25. major facilitator superfamily (MFS).
PTM databases
PhosphoSite	Q96QE2.
Polymorphism databases
DMDM	294862502.
Proteomic databases
PRIDE	Q96QE2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280871; ENSP00000280871; ENSG00000151229. ENST00000380863; ENSP00000370244; ENSG00000151229.
GeneID	114134.
KEGG	hsa:114134.
NMPDR	fig\|9606.3.peg.7395.
UCSC	uc001rmd.1. human.
Organism-specific databases
CTD	114134.
GeneCards	GC12M040051.
H-InvDB	HIX0026507.
HGNC	HGNC:15956. SLC2A13.
HPA	HPA006584.
MIM	611036. gene.
neXtProt	NX_Q96QE2.
PharmGKB	PA38066.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08334.
GeneTree	ENSGT00590000083062.
HOGENOM	HBG744444.
HOVERGEN	HBG031722.
InParanoid	Q96QE2.
OMA	IFWAYNF.
OrthoDB	EOG4S7JPS.
PhylomeDB	Q96QE2.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q96QE2.
Bgee	Q96QE2.
CleanEx	HS_SLC2A13.
Genevestigator	Q96QE2.
GermOnline	ENSG00000151229. Homo sapiens.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
KO	K08150.
Pfam	PF00083. Sugar_tr. 2 hits. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	79005.
SOURCE	Search...

Entry information

Entry name

MYCT_HUMAN

Accession

Primary (citable) accession number: Q96QE2
Secondary accession number(s): Q17S07

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	April 20, 2010
Last modified:	January 25, 2012
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents