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Q96QE2

- MYCT_HUMAN

UniProt

Q96QE2 - MYCT_HUMAN

Protein

Proton myo-inositol cotransporter

Gene

SLC2A13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    H+-myo-inositol cotransporter. Can also transport related stereoisomers.1 Publication

    GO - Molecular functioni

    1. substrate-specific transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_19188. Inositol transporters.

    Protein family/group databases

    TCDBi2.A.1.1.25. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proton myo-inositol cotransporter
    Short name:
    H(+)-myo-inositol cotransporter
    Short name:
    Hmit
    Alternative name(s):
    H(+)-myo-inositol symporter
    Solute carrier family 2 member 13
    Gene namesi
    Name:SLC2A13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:15956. SLC2A13.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38066.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 648648Proton myo-inositol cotransporterPRO_0000050456Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
    Modified residuei640 – 6401Phosphoserine2 Publications
    Modified residuei645 – 6451Phosphoserine2 Publications

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ96QE2.
    PaxDbiQ96QE2.
    PRIDEiQ96QE2.

    PTM databases

    PhosphoSiteiQ96QE2.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the brain.1 Publication

    Gene expression databases

    ArrayExpressiQ96QE2.
    BgeeiQ96QE2.
    CleanExiHS_SLC2A13.
    GenevestigatoriQ96QE2.

    Organism-specific databases

    HPAiHPA006584.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QE2.
    SMRiQ96QE2. Positions 98-410, 509-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 12528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 1482CytoplasmicSequence Analysis
    Topological domaini170 – 1789ExtracellularSequence Analysis
    Topological domaini200 – 21213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini234 – 2396ExtracellularSequence Analysis
    Topological domaini261 – 32464CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini346 – 36318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini385 – 3939CytoplasmicSequence Analysis
    Topological domaini415 – 50894ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini530 – 54920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini571 – 5733ExtracellularSequence Analysis
    Topological domaini595 – 64854CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei325 – 34521Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei364 – 38421Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei509 – 52921Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei550 – 57021Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei574 – 59421Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000202868.
    HOVERGENiHBG031722.
    InParanoidiQ96QE2.
    KOiK08150.
    OMAiATHIGVM.
    OrthoDBiEOG7VDXNV.
    PhylomeDBiQ96QE2.
    TreeFamiTF314916.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 2 hits.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96QE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKASENVE YTLRSLSSLM GERRRKQPEP DAASAAGECS LLAAAESSTS    50
    LQSAGAGGGG VGDLERAARR QFQQDETPAF VYVVAVFSAL GGFLFGYDTG 100
    VVSGAMLLLK RQLSLDALWQ ELLVSSTVGA AAVSALAGGA LNGVFGRRAA 150
    ILLASALFTA GSAVLAAANN KETLLAGRLV VGLGIGIASM TVPVYIAEVS 200
    PPNLRGRLVT INTLFITGGQ FFASVVDGAF SYLQKDGWRY MLGLAAVPAV 250
    IQFFGFLFLP ESPRWLIQKG QTQKARRILS QMRGNQTIDE EYDSIKNNIE 300
    EEEKEVGSAG PVICRMLSYP PTRRALIVGC GLQMFQQLSG INTIMYYSAT 350
    ILQMSGVEDD RLAIWLASVT AFTNFIFTLV GVWLVEKVGR RKLTFGSLAG 400
    TTVALIILAL GFVLSAQVSP RITFKPIAPS GQNATCTRYS YCNECMLDPD 450
    CGFCYKMNKS TVIDSSCVPV NKASTNEAAW GRCENETKFK TEDIFWAYNF 500
    CPTPYSWTAL LGLILYLVFF APGMGPMPWT VNSEIYPLWA RSTGNACSSG 550
    INWIFNVLVS LTFLHTAEYL TYYGAFFLYA GFAAVGLLFI YGCLPETKGK 600
    KLEEIESLFD NRLCTCGTSD SDEGRYIEYI RVKGSNYHLS DNDASDVE 648
    Length:648
    Mass (Da):70,371
    Last modified:April 20, 2010 - v3
    Checksum:i07B951E20A7F46EB
    GO

    Sequence cautioni

    The sequence AAI17118.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI17120.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAC51116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315644 mRNA. Translation: CAC51116.1. Different initiation.
    BC117117 mRNA. Translation: AAI17118.1. Different initiation.
    BC117119 mRNA. Translation: AAI17120.1. Different initiation.
    CCDSiCCDS8736.2.
    RefSeqiNP_443117.3. NM_052885.3.
    UniGeneiHs.558595.

    Genome annotation databases

    EnsembliENST00000280871; ENSP00000280871; ENSG00000151229.
    GeneIDi114134.
    KEGGihsa:114134.
    UCSCiuc010skm.2. human.

    Polymorphism databases

    DMDMi294862502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315644 mRNA. Translation: CAC51116.1 . Different initiation.
    BC117117 mRNA. Translation: AAI17118.1 . Different initiation.
    BC117119 mRNA. Translation: AAI17120.1 . Different initiation.
    CCDSi CCDS8736.2.
    RefSeqi NP_443117.3. NM_052885.3.
    UniGenei Hs.558595.

    3D structure databases

    ProteinModelPortali Q96QE2.
    SMRi Q96QE2. Positions 98-410, 509-610.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.1.1.25. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q96QE2.

    Polymorphism databases

    DMDMi 294862502.

    Proteomic databases

    MaxQBi Q96QE2.
    PaxDbi Q96QE2.
    PRIDEi Q96QE2.

    Protocols and materials databases

    DNASUi 114134.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280871 ; ENSP00000280871 ; ENSG00000151229 .
    GeneIDi 114134.
    KEGGi hsa:114134.
    UCSCi uc010skm.2. human.

    Organism-specific databases

    CTDi 114134.
    GeneCardsi GC12M040051.
    H-InvDB HIX0026507.
    HGNCi HGNC:15956. SLC2A13.
    HPAi HPA006584.
    MIMi 611036. gene.
    neXtProti NX_Q96QE2.
    PharmGKBi PA38066.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000202868.
    HOVERGENi HBG031722.
    InParanoidi Q96QE2.
    KOi K08150.
    OMAi ATHIGVM.
    OrthoDBi EOG7VDXNV.
    PhylomeDBi Q96QE2.
    TreeFami TF314916.

    Enzyme and pathway databases

    Reactomei REACT_19188. Inositol transporters.

    Miscellaneous databases

    GeneWikii SLC2A13.
    GenomeRNAii 114134.
    NextBioi 79005.
    PROi Q96QE2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96QE2.
    Bgeei Q96QE2.
    CleanExi HS_SLC2A13.
    Genevestigatori Q96QE2.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 2 hits.
    [Graphical view ]
    PRINTSi PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain."
      Uldry M., Ibberson M., Horisberger J.-D., Chatton J.-Y., Riederer B.M., Thorens B.
      EMBO J. 20:4467-4477(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-648.
      Tissue: Brain.
    3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiMYCT_HUMAN
    AccessioniPrimary (citable) accession number: Q96QE2
    Secondary accession number(s): Q17S07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3