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Q96QE2

- MYCT_HUMAN

UniProt

Q96QE2 - MYCT_HUMAN

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Protein
Proton myo-inositol cotransporter
Gene
SLC2A13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers.1 Publication

GO - Molecular functioni

  1. substrate-specific transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_19188. Inositol transporters.

Protein family/group databases

TCDBi2.A.1.1.25. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:SLC2A13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:15956. SLC2A13.

Subcellular locationi

Membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini98 – 12528Extracellular Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini147 – 1482Cytoplasmic Reviewed prediction
Transmembranei149 – 16921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini170 – 1789Extracellular Reviewed prediction
Transmembranei179 – 19921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini200 – 21213Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei213 – 23321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini234 – 2396Extracellular Reviewed prediction
Transmembranei240 – 26021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini261 – 32464Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei325 – 34521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini346 – 36318Extracellular Reviewed prediction
Add
BLAST
Transmembranei364 – 38421Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini385 – 3939Cytoplasmic Reviewed prediction
Transmembranei394 – 41421Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini415 – 50894Extracellular Reviewed prediction
Add
BLAST
Transmembranei509 – 52921Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini530 – 54920Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei550 – 57021Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini571 – 5733Extracellular Reviewed prediction
Transmembranei574 – 59421Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini595 – 64854Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Proton myo-inositol cotransporter
PRO_0000050456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi458 – 4581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi485 – 4851N-linked (GlcNAc...) Reviewed prediction
Modified residuei640 – 6401Phosphoserine2 Publications
Modified residuei645 – 6451Phosphoserine2 Publications

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ96QE2.
PaxDbiQ96QE2.
PRIDEiQ96QE2.

PTM databases

PhosphoSiteiQ96QE2.

Expressioni

Tissue specificityi

Predominantly expressed in the brain.1 Publication

Gene expression databases

ArrayExpressiQ96QE2.
BgeeiQ96QE2.
CleanExiHS_SLC2A13.
GenevestigatoriQ96QE2.

Organism-specific databases

HPAiHPA006584.

Structurei

3D structure databases

ProteinModelPortaliQ96QE2.
SMRiQ96QE2. Positions 98-410, 509-610.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ96QE2.
KOiK08150.
OMAiATHIGVM.
OrthoDBiEOG7VDXNV.
PhylomeDBiQ96QE2.
TreeFamiTF314916.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QE2-1 [UniParc]FASTAAdd to Basket

« Hide

MSRKASENVE YTLRSLSSLM GERRRKQPEP DAASAAGECS LLAAAESSTS    50
LQSAGAGGGG VGDLERAARR QFQQDETPAF VYVVAVFSAL GGFLFGYDTG 100
VVSGAMLLLK RQLSLDALWQ ELLVSSTVGA AAVSALAGGA LNGVFGRRAA 150
ILLASALFTA GSAVLAAANN KETLLAGRLV VGLGIGIASM TVPVYIAEVS 200
PPNLRGRLVT INTLFITGGQ FFASVVDGAF SYLQKDGWRY MLGLAAVPAV 250
IQFFGFLFLP ESPRWLIQKG QTQKARRILS QMRGNQTIDE EYDSIKNNIE 300
EEEKEVGSAG PVICRMLSYP PTRRALIVGC GLQMFQQLSG INTIMYYSAT 350
ILQMSGVEDD RLAIWLASVT AFTNFIFTLV GVWLVEKVGR RKLTFGSLAG 400
TTVALIILAL GFVLSAQVSP RITFKPIAPS GQNATCTRYS YCNECMLDPD 450
CGFCYKMNKS TVIDSSCVPV NKASTNEAAW GRCENETKFK TEDIFWAYNF 500
CPTPYSWTAL LGLILYLVFF APGMGPMPWT VNSEIYPLWA RSTGNACSSG 550
INWIFNVLVS LTFLHTAEYL TYYGAFFLYA GFAAVGLLFI YGCLPETKGK 600
KLEEIESLFD NRLCTCGTSD SDEGRYIEYI RVKGSNYHLS DNDASDVE 648
Length:648
Mass (Da):70,371
Last modified:April 20, 2010 - v3
Checksum:i07B951E20A7F46EB
GO

Sequence cautioni

The sequence AAI17118.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAI17120.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAC51116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315644 mRNA. Translation: CAC51116.1. Different initiation.
BC117117 mRNA. Translation: AAI17118.1. Different initiation.
BC117119 mRNA. Translation: AAI17120.1. Different initiation.
CCDSiCCDS8736.2.
RefSeqiNP_443117.3. NM_052885.3.
UniGeneiHs.558595.

Genome annotation databases

EnsembliENST00000280871; ENSP00000280871; ENSG00000151229.
GeneIDi114134.
KEGGihsa:114134.
UCSCiuc010skm.2. human.

Polymorphism databases

DMDMi294862502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315644 mRNA. Translation: CAC51116.1 . Different initiation.
BC117117 mRNA. Translation: AAI17118.1 . Different initiation.
BC117119 mRNA. Translation: AAI17120.1 . Different initiation.
CCDSi CCDS8736.2.
RefSeqi NP_443117.3. NM_052885.3.
UniGenei Hs.558595.

3D structure databases

ProteinModelPortali Q96QE2.
SMRi Q96QE2. Positions 98-410, 509-610.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.1.1.25. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q96QE2.

Polymorphism databases

DMDMi 294862502.

Proteomic databases

MaxQBi Q96QE2.
PaxDbi Q96QE2.
PRIDEi Q96QE2.

Protocols and materials databases

DNASUi 114134.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280871 ; ENSP00000280871 ; ENSG00000151229 .
GeneIDi 114134.
KEGGi hsa:114134.
UCSCi uc010skm.2. human.

Organism-specific databases

CTDi 114134.
GeneCardsi GC12M040051.
H-InvDB HIX0026507.
HGNCi HGNC:15956. SLC2A13.
HPAi HPA006584.
MIMi 611036. gene.
neXtProti NX_Q96QE2.
PharmGKBi PA38066.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000202868.
HOVERGENi HBG031722.
InParanoidi Q96QE2.
KOi K08150.
OMAi ATHIGVM.
OrthoDBi EOG7VDXNV.
PhylomeDBi Q96QE2.
TreeFami TF314916.

Enzyme and pathway databases

Reactomei REACT_19188. Inositol transporters.

Miscellaneous databases

GeneWikii SLC2A13.
GenomeRNAii 114134.
NextBioi 79005.
PROi Q96QE2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96QE2.
Bgeei Q96QE2.
CleanExi HS_SLC2A13.
Genevestigatori Q96QE2.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 2 hits.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain."
    Uldry M., Ibberson M., Horisberger J.-D., Chatton J.-Y., Riederer B.M., Thorens B.
    EMBO J. 20:4467-4477(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-648.
    Tissue: Brain.
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-645, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMYCT_HUMAN
AccessioniPrimary (citable) accession number: Q96QE2
Secondary accession number(s): Q17S07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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