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Protein

Proton myo-inositol cotransporter

Gene

SLC2A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151229-MONOMER.
ReactomeiR-HSA-429593. Inositol transporters.

Protein family/group databases

TCDBi2.A.1.1.25. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:SLC2A13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:15956. SLC2A13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 97Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini98 – 125ExtracellularSequence analysisAdd BLAST28
Transmembranei126 – 146Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini147 – 148CytoplasmicSequence analysis2
Transmembranei149 – 169Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini170 – 178ExtracellularSequence analysis9
Transmembranei179 – 199Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini200 – 212CytoplasmicSequence analysisAdd BLAST13
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 239ExtracellularSequence analysis6
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 324CytoplasmicSequence analysisAdd BLAST64
Transmembranei325 – 345Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini346 – 363ExtracellularSequence analysisAdd BLAST18
Transmembranei364 – 384Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini385 – 393CytoplasmicSequence analysis9
Transmembranei394 – 414Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini415 – 508ExtracellularSequence analysisAdd BLAST94
Transmembranei509 – 529Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini530 – 549CytoplasmicSequence analysisAdd BLAST20
Transmembranei550 – 570Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini571 – 573ExtracellularSequence analysis3
Transmembranei574 – 594Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini595 – 648CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114134.
OpenTargetsiENSG00000151229.
PharmGKBiPA38066.

Polymorphism and mutation databases

BioMutaiSLC2A13.
DMDMi294862502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504561 – 648Proton myo-inositol cotransporterAdd BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei47PhosphoserineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi458N-linked (GlcNAc...)Sequence analysis1
Glycosylationi485N-linked (GlcNAc...)Sequence analysis1
Modified residuei640PhosphoserineCombined sources1
Modified residuei645PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96QE2.
MaxQBiQ96QE2.
PaxDbiQ96QE2.
PeptideAtlasiQ96QE2.
PRIDEiQ96QE2.

PTM databases

iPTMnetiQ96QE2.
PhosphoSitePlusiQ96QE2.

Expressioni

Tissue specificityi

Predominantly expressed in the brain.1 Publication

Gene expression databases

BgeeiENSG00000151229.
CleanExiHS_SLC2A13.
ExpressionAtlasiQ96QE2. baseline and differential.
GenevisibleiQ96QE2. HS.

Organism-specific databases

HPAiHPA006584.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000280871.

Structurei

3D structure databases

ProteinModelPortaliQ96QE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ96QE2.
KOiK08150.
OMAiRKYSLMI.
OrthoDBiEOG091G046D.
PhylomeDBiQ96QE2.
TreeFamiTF314916.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKASENVE YTLRSLSSLM GERRRKQPEP DAASAAGECS LLAAAESSTS
60 70 80 90 100
LQSAGAGGGG VGDLERAARR QFQQDETPAF VYVVAVFSAL GGFLFGYDTG
110 120 130 140 150
VVSGAMLLLK RQLSLDALWQ ELLVSSTVGA AAVSALAGGA LNGVFGRRAA
160 170 180 190 200
ILLASALFTA GSAVLAAANN KETLLAGRLV VGLGIGIASM TVPVYIAEVS
210 220 230 240 250
PPNLRGRLVT INTLFITGGQ FFASVVDGAF SYLQKDGWRY MLGLAAVPAV
260 270 280 290 300
IQFFGFLFLP ESPRWLIQKG QTQKARRILS QMRGNQTIDE EYDSIKNNIE
310 320 330 340 350
EEEKEVGSAG PVICRMLSYP PTRRALIVGC GLQMFQQLSG INTIMYYSAT
360 370 380 390 400
ILQMSGVEDD RLAIWLASVT AFTNFIFTLV GVWLVEKVGR RKLTFGSLAG
410 420 430 440 450
TTVALIILAL GFVLSAQVSP RITFKPIAPS GQNATCTRYS YCNECMLDPD
460 470 480 490 500
CGFCYKMNKS TVIDSSCVPV NKASTNEAAW GRCENETKFK TEDIFWAYNF
510 520 530 540 550
CPTPYSWTAL LGLILYLVFF APGMGPMPWT VNSEIYPLWA RSTGNACSSG
560 570 580 590 600
INWIFNVLVS LTFLHTAEYL TYYGAFFLYA GFAAVGLLFI YGCLPETKGK
610 620 630 640
KLEEIESLFD NRLCTCGTSD SDEGRYIEYI RVKGSNYHLS DNDASDVE
Length:648
Mass (Da):70,371
Last modified:April 20, 2010 - v3
Checksum:i07B951E20A7F46EB
GO

Sequence cautioni

The sequence AAI17118 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI17120 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAC51116 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315644 mRNA. Translation: CAC51116.1. Different initiation.
BC117117 mRNA. Translation: AAI17118.1. Different initiation.
BC117119 mRNA. Translation: AAI17120.1. Different initiation.
CCDSiCCDS8736.2.
RefSeqiNP_443117.3. NM_052885.3.
UniGeneiHs.558595.

Genome annotation databases

EnsembliENST00000280871; ENSP00000280871; ENSG00000151229.
GeneIDi114134.
KEGGihsa:114134.
UCSCiuc010skm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315644 mRNA. Translation: CAC51116.1. Different initiation.
BC117117 mRNA. Translation: AAI17118.1. Different initiation.
BC117119 mRNA. Translation: AAI17120.1. Different initiation.
CCDSiCCDS8736.2.
RefSeqiNP_443117.3. NM_052885.3.
UniGeneiHs.558595.

3D structure databases

ProteinModelPortaliQ96QE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000280871.

Protein family/group databases

TCDBi2.A.1.1.25. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ96QE2.
PhosphoSitePlusiQ96QE2.

Polymorphism and mutation databases

BioMutaiSLC2A13.
DMDMi294862502.

Proteomic databases

EPDiQ96QE2.
MaxQBiQ96QE2.
PaxDbiQ96QE2.
PeptideAtlasiQ96QE2.
PRIDEiQ96QE2.

Protocols and materials databases

DNASUi114134.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280871; ENSP00000280871; ENSG00000151229.
GeneIDi114134.
KEGGihsa:114134.
UCSCiuc010skm.2. human.

Organism-specific databases

CTDi114134.
DisGeNETi114134.
GeneCardsiSLC2A13.
H-InvDBHIX0026507.
HGNCiHGNC:15956. SLC2A13.
HPAiHPA006584.
MIMi611036. gene.
neXtProtiNX_Q96QE2.
OpenTargetsiENSG00000151229.
PharmGKBiPA38066.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ96QE2.
KOiK08150.
OMAiRKYSLMI.
OrthoDBiEOG091G046D.
PhylomeDBiQ96QE2.
TreeFamiTF314916.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151229-MONOMER.
ReactomeiR-HSA-429593. Inositol transporters.

Miscellaneous databases

ChiTaRSiSLC2A13. human.
GeneWikiiSLC2A13.
GenomeRNAii114134.
PROiQ96QE2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151229.
CleanExiHS_SLC2A13.
ExpressionAtlasiQ96QE2. baseline and differential.
GenevisibleiQ96QE2. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 2 hits.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYCT_HUMAN
AccessioniPrimary (citable) accession number: Q96QE2
Secondary accession number(s): Q17S07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.