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Protein

UAP56-interacting factor

Gene

FYTTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.1 Publication

GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA export from nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
UAP56-interacting factor
Alternative name(s):
Forty-two-three domain-containing protein 1
Short name:
Protein 40-2-3
Gene namesi
Name:FYTTD1
Synonyms:UIF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25407. FYTTD1.

Subcellular locationi

GO - Cellular componenti

  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946373.

Polymorphism and mutation databases

BioMutaiFYTTD1.
DMDMi284018159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318UAP56-interacting factorPRO_0000287441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei16 – 161PhosphoserineCombined sources
Modified residuei23 – 231PhosphoserineCombined sources
Modified residuei61 – 611PhosphoserineCombined sources
Modified residuei118 – 1181PhosphoserineCombined sources
Cross-linki140 – 140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Cross-linki261 – 261Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96QD9.
MaxQBiQ96QD9.
PaxDbiQ96QD9.
PeptideAtlasiQ96QD9.
PRIDEiQ96QD9.
TopDownProteomicsiQ96QD9-1. [Q96QD9-1]

PTM databases

iPTMnetiQ96QD9.
PhosphoSiteiQ96QD9.

Expressioni

Tissue specificityi

Expressed in a wide variety of cancer types.1 Publication

Gene expression databases

BgeeiQ96QD9.
CleanExiHS_FYTTD1.
ExpressionAtlasiQ96QD9. baseline and differential.
GenevisibleiQ96QD9. HS.

Organism-specific databases

HPAiHPA054474.

Interactioni

Subunit structurei

Interacts with CHTOP (By similarity). Interacts with DDX39B/UAP56 and NXF1; interaction with DDX39B/UAP56 and NXF1 are mutually exclusive. Interacts with SSRP1; required for its recruitment to mRNAs.By similarity1 Publication

Protein-protein interaction databases

BioGridi123976. 70 interactions.
IntActiQ96QD9. 16 interactions.
MINTiMINT-1379576.
STRINGi9606.ENSP00000241502.

Structurei

3D structure databases

ProteinModelPortaliQ96QD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi26 – 4419UAP56-binding motifAdd
BLAST

Sequence similaritiesi

Belongs to the UIF family.Curated

Phylogenomic databases

eggNOGiENOG410II12. Eukaryota.
ENOG4111TUX. LUCA.
GeneTreeiENSGT00390000012807.
HOVERGENiHBG066549.
InParanoidiQ96QD9.
OMAiMKRDQSE.
PhylomeDBiQ96QD9.
TreeFamiTF336232.

Family and domain databases

InterProiIPR009782. FYTTD1.
[Graphical view]
PANTHERiPTHR21038. PTHR21038. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96QD9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRFGTRLVG ATATSSPPPK ARSNENLDKI DMSLDDIIKL NRKEGKKQNF
60 70 80 90 100
PRLNRRLLQQ SGAQQFRMRV RWGIQQNSGF GKTSLNRRGR VMPGKRRPNG
110 120 130 140 150
VITGLAARKT TGIRKGISPM NRPPLSDKNI EQYFPVLKRK ANLLRQNEGQ
160 170 180 190 200
RKPVAVLKRP SQLSRKNNIP ANFTRSGNKL NHQKDTRQAT FLFRRGLKVQ
210 220 230 240 250
AQLNTEQLLD DVVAKRTRQW RTSTTNGGIL TVSIDNPGAV QCPVTQKPRL
260 270 280 290 300
TRTAVPSFLT KREQSDVKKV PKGVPLQFDI NSVGKQTGMT LNERFGILKE
310
QRATLTYNKG GSRFVTVG
Length:318
Mass (Da):35,818
Last modified:January 19, 2010 - v3
Checksum:iEB2F37D1D423D13C
GO
Isoform 2 (identifier: Q96QD9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MNRFGTRLVGATATSSPPPKARSNENLDKIDMSLD → MEPSVIMGN

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):33,004
Checksum:iE6E22D967F234F82
GO
Isoform 3 (identifier: Q96QD9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: No experimental confirmation available.
Show »
Length:251
Mass (Da):28,182
Checksum:i893BA69046662EA4
GO
Isoform 4 (identifier: Q96QD9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-129: N → K
     130-318: Missing.

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,524
Checksum:iDD28E3E18E6D18F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781N → S in BAH14679 (PubMed:14702039).Curated
Sequence conflicti263 – 2631E → G in BAB55284 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871R → H.4 Publications
Corresponds to variant rs3205525 [ dbSNP | Ensembl ].
VAR_062411

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6767Missing in isoform 3. 1 PublicationVSP_038658Add
BLAST
Alternative sequencei1 – 3535MNRFG…DMSLD → MEPSVIMGN in isoform 2. 1 PublicationVSP_038659Add
BLAST
Alternative sequencei129 – 1291N → K in isoform 4. 1 PublicationVSP_038660
Alternative sequencei130 – 318189Missing in isoform 4. 1 PublicationVSP_038661Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344094 mRNA. Translation: CAC51432.1.
AL136558 mRNA. Translation: CAB66493.1.
AK027672 mRNA. Translation: BAB55284.1.
AK296283 mRNA. Translation: BAH12300.1.
AK302546 mRNA. Translation: BAH13737.1.
AK303462 mRNA. Translation: BAH13966.1.
AK315019 mRNA. Translation: BAG37509.1.
AK316308 mRNA. Translation: BAH14679.1.
CR533502 mRNA. Translation: CAG38533.1.
AC024560 Genomic DNA. No translation available.
AC055764 Genomic DNA. No translation available.
CH471252 Genomic DNA. Translation: EAW92240.1.
BC035006 mRNA. Translation: AAH35006.1.
BC039734 mRNA. Translation: AAH39734.1.
CCDSiCCDS3329.1. [Q96QD9-1]
CCDS43196.2. [Q96QD9-2]
RefSeqiNP_001011537.2. NM_001011537.2. [Q96QD9-2]
NP_115664.2. NM_032288.6. [Q96QD9-1]
UniGeneiHs.277533.

Genome annotation databases

EnsembliENST00000241502; ENSP00000241502; ENSG00000122068. [Q96QD9-1]
ENST00000415708; ENSP00000393746; ENSG00000122068. [Q96QD9-2]
ENST00000418169; ENSP00000400191; ENSG00000122068. [Q96QD9-4]
ENST00000424384; ENSP00000394631; ENSG00000122068. [Q96QD9-3]
GeneIDi84248.
KEGGihsa:84248.
UCSCiuc003fyi.3. human. [Q96QD9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344094 mRNA. Translation: CAC51432.1.
AL136558 mRNA. Translation: CAB66493.1.
AK027672 mRNA. Translation: BAB55284.1.
AK296283 mRNA. Translation: BAH12300.1.
AK302546 mRNA. Translation: BAH13737.1.
AK303462 mRNA. Translation: BAH13966.1.
AK315019 mRNA. Translation: BAG37509.1.
AK316308 mRNA. Translation: BAH14679.1.
CR533502 mRNA. Translation: CAG38533.1.
AC024560 Genomic DNA. No translation available.
AC055764 Genomic DNA. No translation available.
CH471252 Genomic DNA. Translation: EAW92240.1.
BC035006 mRNA. Translation: AAH35006.1.
BC039734 mRNA. Translation: AAH39734.1.
CCDSiCCDS3329.1. [Q96QD9-1]
CCDS43196.2. [Q96QD9-2]
RefSeqiNP_001011537.2. NM_001011537.2. [Q96QD9-2]
NP_115664.2. NM_032288.6. [Q96QD9-1]
UniGeneiHs.277533.

3D structure databases

ProteinModelPortaliQ96QD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123976. 70 interactions.
IntActiQ96QD9. 16 interactions.
MINTiMINT-1379576.
STRINGi9606.ENSP00000241502.

PTM databases

iPTMnetiQ96QD9.
PhosphoSiteiQ96QD9.

Polymorphism and mutation databases

BioMutaiFYTTD1.
DMDMi284018159.

Proteomic databases

EPDiQ96QD9.
MaxQBiQ96QD9.
PaxDbiQ96QD9.
PeptideAtlasiQ96QD9.
PRIDEiQ96QD9.
TopDownProteomicsiQ96QD9-1. [Q96QD9-1]

Protocols and materials databases

DNASUi84248.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241502; ENSP00000241502; ENSG00000122068. [Q96QD9-1]
ENST00000415708; ENSP00000393746; ENSG00000122068. [Q96QD9-2]
ENST00000418169; ENSP00000400191; ENSG00000122068. [Q96QD9-4]
ENST00000424384; ENSP00000394631; ENSG00000122068. [Q96QD9-3]
GeneIDi84248.
KEGGihsa:84248.
UCSCiuc003fyi.3. human. [Q96QD9-1]

Organism-specific databases

CTDi84248.
GeneCardsiFYTTD1.
H-InvDBHIX0003990.
HGNCiHGNC:25407. FYTTD1.
HPAiHPA054474.
MIMi616933. gene.
neXtProtiNX_Q96QD9.
PharmGKBiPA134946373.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II12. Eukaryota.
ENOG4111TUX. LUCA.
GeneTreeiENSGT00390000012807.
HOVERGENiHBG066549.
InParanoidiQ96QD9.
OMAiMKRDQSE.
PhylomeDBiQ96QD9.
TreeFamiTF336232.

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiFYTTD1. human.
GenomeRNAii84248.
PROiQ96QD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96QD9.
CleanExiHS_FYTTD1.
ExpressionAtlasiQ96QD9. baseline and differential.
GenevisibleiQ96QD9. HS.

Family and domain databases

InterProiIPR009782. FYTTD1.
[Graphical view]
PANTHERiPTHR21038. PTHR21038. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Schmidt T.
    Thesis (2001), Faculty of Biological Sciences / Goettingen, Germany
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-87.
    Tissue: Amygdala.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4), VARIANT HIS-87.
    Tissue: Placenta, Teratocarcinoma, Testis, Thalamus and Thymus.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-87.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT HIS-87.
    Tissue: Testis.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA."
    Hautbergue G.M., Hung M.L., Walsh M.J., Snijders A.P., Chang C.T., Jones R., Ponting C.P., Dickman M.J., Wilson S.A.
    Curr. Biol. 19:1918-1924(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, RNA-BINDING, INTERACTION WITH DDX39B; NXF1 AND SSRP1.
  12. "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
    Blomster H.A., Imanishi S.Y., Siimes J., Kastu J., Morrice N.A., Eriksson J.E., Sistonen L.
    J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-140.
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-61 AND SER-118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  17. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-261, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiUIF_HUMAN
AccessioniPrimary (citable) accession number: Q96QD9
Secondary accession number(s): A8MY74
, B2RCB2, B7Z3R4, B7Z7V1, B7Z8I0, B7ZAJ3, C9J7P6, C9JNG6, C9JTH3, C9JY50, Q96SL9, Q9BQI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: January 19, 2010
Last modified: July 6, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.