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Q96QD8

- S38A2_HUMAN

UniProt

Q96QD8 - S38A2_HUMAN

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Protein

Sodium-coupled neutral amino acid transporter 2

Gene

SLC38A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.2 Publications

Enzyme regulationi

Inhibited by N-methyl-D-glucamine and probably choline.1 Publication

Kineticsi

  1. KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0)

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: Ensembl
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. glutamate secretion Source: Reactome
  3. ion transport Source: Reactome
  4. neurotransmitter secretion Source: Reactome
  5. sodium ion transport Source: UniProtKB-KW
  6. synaptic transmission Source: Reactome
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.18.6.5. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 2
Alternative name(s):
Amino acid transporter A2
Protein 40-9-1
Solute carrier family 38 member 2
System A amino acid transporter 2
System A transporter 1
System N amino acid transporter 2
Gene namesi
Name:SLC38A2
Synonyms:ATA2, KIAA1382, SAT2, SNAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13448. SLC38A2.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes By similarity. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Sodium-coupled neutral amino acid transporter 2PRO_0000311369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphoserine1 Publication
Modified residuei12 – 121Phosphoserine1 Publication
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei55 – 551PhosphoserineBy similarity
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ96QD8.
PaxDbiQ96QD8.
PeptideAtlasiQ96QD8.
PRIDEiQ96QD8.

Expressioni

Tissue specificityi

Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).3 Publications

Inductioni

Up-regulated upon hypertonic conditions and amino acid deprivation.3 Publications

Gene expression databases

BgeeiQ96QD8.
CleanExiHS_SAT2.
HS_SLC38A2.
ExpressionAtlasiQ96QD8. baseline and differential.
GenevestigatoriQ96QD8.

Organism-specific databases

HPAiHPA035180.

Interactioni

Protein-protein interaction databases

BioGridi119943. 7 interactions.
IntActiQ96QD8. 1 interaction.
MINTiMINT-1398587.
STRINGi9606.ENSP00000256689.

Structurei

3D structure databases

ProteinModelPortaliQ96QD8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini98 – 1025ExtracellularSequence Analysis
Topological domaini124 – 15835CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini180 – 1889ExtracellularSequence Analysis
Topological domaini210 – 2178CytoplasmicSequence Analysis
Topological domaini239 – 29254ExtracellularSequence AnalysisAdd
BLAST
Topological domaini314 – 32916CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini351 – 37121ExtracellularSequence AnalysisAdd
BLAST
Topological domaini393 – 41321CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini435 – 4362ExtracellularSequence Analysis
Topological domaini458 – 47417CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini496 – 50611ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence AnalysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence AnalysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence AnalysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence AnalysisAdd
BLAST
Transmembranei437 – 45721HelicalSequence AnalysisAdd
BLAST
Transmembranei475 – 49521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696Regulates protein turnover upon amino acid deprivationBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236441.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ96QD8.
KOiK14207.
OMAiYEHVESE.
PhylomeDBiQ96QD8.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96QD8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKAEMGRFS ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN
60 70 80 90 100
FLLESNLGKK KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG
110 120 130 140 150
IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGYK AFGLVGKLAA
160 170 180 190 200
SGSITMQNIG AMSSYLFIVK YELPLVIQAL TNIEDKTGLW YLNGNYLVLL
210 220 230 240 250
VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK FQVPCPVEAA
260 270 280 290 300
LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI
310 320 330 340 350
FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF
360 370 380 390 400
YEHVESELLH TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH
410 420 430 440 450
LLCASKDFSW WRHSLITVSI LAFTNLLVIF VPTIRDIFGF IGASAASMLI
460 470 480 490 500
FILPSAFYIK LVKKEPMKSV QKIGALFFLL SGVLVMTGSM ALIVLDWVHN

APGGGH
Length:506
Mass (Da):56,026
Last modified:December 4, 2007 - v2
Checksum:i125C70875793D031
GO
Isoform 2 (identifier: Q96QD8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.
     101-105: IALFI → MKQNL

Show »
Length:406
Mass (Da):45,179
Checksum:iC72772C3238776CE
GO

Sequence cautioni

The sequence BAD18765.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561M → V in CAC51434. 1 PublicationCurated
Sequence conflicti273 – 2731H → R in BAA91846. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481N → K.
Corresponds to variant rs11183450 [ dbSNP | Ensembl ].
VAR_037235

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 100100Missing in isoform 2. 2 PublicationsVSP_029553Add
BLAST
Alternative sequencei101 – 1055IALFI → MKQNL in isoform 2. 2 PublicationsVSP_029554

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF259799 mRNA. Translation: AAK38510.1.
AF298897 mRNA. Translation: AAG24618.1.
AJ344099 mRNA. Translation: CAC51434.1.
AB037803 mRNA. Translation: BAA92620.2.
AK001700 mRNA. Translation: BAA91846.1.
AK172784 mRNA. Translation: BAD18765.1. Different initiation.
CR457267 mRNA. Translation: CAG33548.1.
CH471111 Genomic DNA. Translation: EAW57900.1.
CH471111 Genomic DNA. Translation: EAW57901.1.
BC040342 mRNA. Translation: AAH40342.1.
CCDSiCCDS8749.1. [Q96QD8-1]
RefSeqiNP_061849.2. NM_018976.4. [Q96QD8-1]
XP_005269040.1. XM_005268983.1. [Q96QD8-2]
UniGeneiHs.221847.

Genome annotation databases

EnsembliENST00000256689; ENSP00000256689; ENSG00000134294. [Q96QD8-1]
ENST00000612232; ENSP00000482873; ENSG00000134294. [Q96QD8-2]
GeneIDi54407.
KEGGihsa:54407.
UCSCiuc001rpg.3. human. [Q96QD8-1]
uc001rph.3. human. [Q96QD8-2]

Polymorphism databases

DMDMi162416227.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF259799 mRNA. Translation: AAK38510.1 .
AF298897 mRNA. Translation: AAG24618.1 .
AJ344099 mRNA. Translation: CAC51434.1 .
AB037803 mRNA. Translation: BAA92620.2 .
AK001700 mRNA. Translation: BAA91846.1 .
AK172784 mRNA. Translation: BAD18765.1 . Different initiation.
CR457267 mRNA. Translation: CAG33548.1 .
CH471111 Genomic DNA. Translation: EAW57900.1 .
CH471111 Genomic DNA. Translation: EAW57901.1 .
BC040342 mRNA. Translation: AAH40342.1 .
CCDSi CCDS8749.1. [Q96QD8-1 ]
RefSeqi NP_061849.2. NM_018976.4. [Q96QD8-1 ]
XP_005269040.1. XM_005268983.1. [Q96QD8-2 ]
UniGenei Hs.221847.

3D structure databases

ProteinModelPortali Q96QD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119943. 7 interactions.
IntActi Q96QD8. 1 interaction.
MINTi MINT-1398587.
STRINGi 9606.ENSP00000256689.

Chemistry

GuidetoPHARMACOLOGYi 1170.

Protein family/group databases

TCDBi 2.A.18.6.5. the amino acid/auxin permease (aaap) family.

Polymorphism databases

DMDMi 162416227.

Proteomic databases

MaxQBi Q96QD8.
PaxDbi Q96QD8.
PeptideAtlasi Q96QD8.
PRIDEi Q96QD8.

Protocols and materials databases

DNASUi 54407.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256689 ; ENSP00000256689 ; ENSG00000134294 . [Q96QD8-1 ]
ENST00000612232 ; ENSP00000482873 ; ENSG00000134294 . [Q96QD8-2 ]
GeneIDi 54407.
KEGGi hsa:54407.
UCSCi uc001rpg.3. human. [Q96QD8-1 ]
uc001rph.3. human. [Q96QD8-2 ]

Organism-specific databases

CTDi 54407.
GeneCardsi GC12M046751.
HGNCi HGNC:13448. SLC38A2.
HPAi HPA035180.
MIMi 605180. gene.
neXtProti NX_Q96QD8.
PharmGKBi PA37773.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236441.
GeneTreei ENSGT00760000119147.
HOGENOMi HOG000013088.
HOVERGENi HBG059571.
InParanoidi Q96QD8.
KOi K14207.
OMAi YEHVESE.
PhylomeDBi Q96QD8.
TreeFami TF328787.

Enzyme and pathway databases

Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSi SLC38A2. human.
GeneWikii SLC38A2.
GenomeRNAii 54407.
NextBioi 56613.
PROi Q96QD8.
SOURCEi Search...

Gene expression databases

Bgeei Q96QD8.
CleanExi HS_SAT2.
HS_SLC38A2.
ExpressionAtlasi Q96QD8. baseline and differential.
Genevestigatori Q96QD8.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A."
    Hatanaka T., Huang W., Wang H., Sugawara M., Prasad P.D., Leibach F.H., Ganapathy V.
    Biochim. Biophys. Acta 1467:1-6(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY.
    Tissue: Hepatoma.
  2. "Expression studies of the human amino acid transporter, hATA2."
    Powell J., Brock A.P., Hart I.R.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Schmidt T.
    Thesis (2001), University of Goettingen, Germany
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hepatoma and Teratocarcinoma.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  10. "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element."
    Palii S.S., Chen H., Kilberg M.S.
    J. Biol. Chem. 279:3463-3471(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  11. "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress."
    Bevilacqua E., Bussolati O., Dall'Asta V., Gaccioli F., Sala R., Gazzola G.C., Franchi-Gazzola R.
    FEBS Lett. 579:3376-3380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  12. "Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain."
    Gonzalez-Gonzalez I.M., Cubelos B., Gimenez C., Zafra F.
    Neuroscience 130:61-73(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation."
    Gaccioli F., Huang C.C., Wang C., Bevilacqua E., Franchi-Gazzola R., Gazzola G.C., Bussolati O., Snider M.D., Hatzoglou M.
    J. Biol. Chem. 281:17929-17940(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  14. "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex."
    Melone M., Varoqui H., Erickson J.D., Conti F.
    Neuroscience 140:281-292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS38A2_HUMAN
AccessioniPrimary (citable) accession number: Q96QD8
Secondary accession number(s): Q6IA88
, Q6ZMG2, Q9HAV3, Q9NVA8, Q9P2G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3