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Q96QD8

- S38A2_HUMAN

UniProt

Q96QD8 - S38A2_HUMAN

Protein

Sodium-coupled neutral amino acid transporter 2

Gene

SLC38A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.2 Publications

    Enzyme regulationi

    Inhibited by N-methyl-D-glucamine and probably choline.1 Publication

    Kineticsi

    1. KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0)

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: Ensembl
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. glutamate secretion Source: Reactome
    3. ion transport Source: Reactome
    4. neurotransmitter secretion Source: Reactome
    5. sodium ion transport Source: UniProtKB-KW
    6. synaptic transmission Source: Reactome
    7. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.18.6.5. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Alternative name(s):
    Amino acid transporter A2
    Protein 40-9-1
    Solute carrier family 38 member 2
    System A amino acid transporter 2
    System A transporter 1
    System N amino acid transporter 2
    Gene namesi
    Name:SLC38A2
    Synonyms:ATA2, KIAA1382, SAT2, SNAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13448. SLC38A2.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes By similarity. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37773.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Sodium-coupled neutral amino acid transporter 2PRO_0000311369Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101Phosphoserine1 Publication
    Modified residuei12 – 121Phosphoserine1 Publication
    Modified residuei22 – 221Phosphoserine1 Publication
    Modified residuei55 – 551PhosphoserineBy similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ96QD8.
    PaxDbiQ96QD8.
    PeptideAtlasiQ96QD8.
    PRIDEiQ96QD8.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).3 Publications

    Inductioni

    Up-regulated upon hypertonic conditions and amino acid deprivation.3 Publications

    Gene expression databases

    ArrayExpressiQ96QD8.
    BgeeiQ96QD8.
    CleanExiHS_SAT2.
    HS_SLC38A2.
    GenevestigatoriQ96QD8.

    Organism-specific databases

    HPAiHPA035180.

    Interactioni

    Protein-protein interaction databases

    BioGridi119943. 7 interactions.
    IntActiQ96QD8. 1 interaction.
    MINTiMINT-1398587.
    STRINGi9606.ENSP00000256689.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 1025ExtracellularSequence Analysis
    Topological domaini124 – 15835CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 1889ExtracellularSequence Analysis
    Topological domaini210 – 2178CytoplasmicSequence Analysis
    Topological domaini239 – 29254ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 32916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 37121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini393 – 41321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini435 – 4362ExtracellularSequence Analysis
    Topological domaini458 – 47417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini496 – 50611ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9696Regulates protein turnover upon amino acid deprivationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236441.
    HOGENOMiHOG000013088.
    HOVERGENiHBG059571.
    InParanoidiQ96QD8.
    KOiK14207.
    OMAiYEHVESE.
    PhylomeDBiQ96QD8.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96QD8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKAEMGRFS ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN    50
    FLLESNLGKK KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG 100
    IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGYK AFGLVGKLAA 150
    SGSITMQNIG AMSSYLFIVK YELPLVIQAL TNIEDKTGLW YLNGNYLVLL 200
    VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK FQVPCPVEAA 250
    LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI 300
    FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF 350
    YEHVESELLH TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH 400
    LLCASKDFSW WRHSLITVSI LAFTNLLVIF VPTIRDIFGF IGASAASMLI 450
    FILPSAFYIK LVKKEPMKSV QKIGALFFLL SGVLVMTGSM ALIVLDWVHN 500
    APGGGH 506
    Length:506
    Mass (Da):56,026
    Last modified:December 4, 2007 - v2
    Checksum:i125C70875793D031
    GO
    Isoform 2 (identifier: Q96QD8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-100: Missing.
         101-105: IALFI → MKQNL

    Show »
    Length:406
    Mass (Da):45,179
    Checksum:iC72772C3238776CE
    GO

    Sequence cautioni

    The sequence BAD18765.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561M → V in CAC51434. 1 PublicationCurated
    Sequence conflicti273 – 2731H → R in BAA91846. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481N → K.
    Corresponds to variant rs11183450 [ dbSNP | Ensembl ].
    VAR_037235

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 100100Missing in isoform 2. 2 PublicationsVSP_029553Add
    BLAST
    Alternative sequencei101 – 1055IALFI → MKQNL in isoform 2. 2 PublicationsVSP_029554

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF259799 mRNA. Translation: AAK38510.1.
    AF298897 mRNA. Translation: AAG24618.1.
    AJ344099 mRNA. Translation: CAC51434.1.
    AB037803 mRNA. Translation: BAA92620.2.
    AK001700 mRNA. Translation: BAA91846.1.
    AK172784 mRNA. Translation: BAD18765.1. Different initiation.
    CR457267 mRNA. Translation: CAG33548.1.
    CH471111 Genomic DNA. Translation: EAW57900.1.
    CH471111 Genomic DNA. Translation: EAW57901.1.
    BC040342 mRNA. Translation: AAH40342.1.
    CCDSiCCDS8749.1. [Q96QD8-1]
    RefSeqiNP_061849.2. NM_018976.4. [Q96QD8-1]
    XP_005269040.1. XM_005268983.1. [Q96QD8-2]
    UniGeneiHs.221847.

    Genome annotation databases

    EnsembliENST00000256689; ENSP00000256689; ENSG00000134294. [Q96QD8-1]
    GeneIDi54407.
    KEGGihsa:54407.
    UCSCiuc001rpg.3. human. [Q96QD8-1]
    uc001rph.3. human. [Q96QD8-2]

    Polymorphism databases

    DMDMi162416227.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF259799 mRNA. Translation: AAK38510.1 .
    AF298897 mRNA. Translation: AAG24618.1 .
    AJ344099 mRNA. Translation: CAC51434.1 .
    AB037803 mRNA. Translation: BAA92620.2 .
    AK001700 mRNA. Translation: BAA91846.1 .
    AK172784 mRNA. Translation: BAD18765.1 . Different initiation.
    CR457267 mRNA. Translation: CAG33548.1 .
    CH471111 Genomic DNA. Translation: EAW57900.1 .
    CH471111 Genomic DNA. Translation: EAW57901.1 .
    BC040342 mRNA. Translation: AAH40342.1 .
    CCDSi CCDS8749.1. [Q96QD8-1 ]
    RefSeqi NP_061849.2. NM_018976.4. [Q96QD8-1 ]
    XP_005269040.1. XM_005268983.1. [Q96QD8-2 ]
    UniGenei Hs.221847.

    3D structure databases

    ProteinModelPortali Q96QD8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119943. 7 interactions.
    IntActi Q96QD8. 1 interaction.
    MINTi MINT-1398587.
    STRINGi 9606.ENSP00000256689.

    Chemistry

    GuidetoPHARMACOLOGYi 1170.

    Protein family/group databases

    TCDBi 2.A.18.6.5. the amino acid/auxin permease (aaap) family.

    Polymorphism databases

    DMDMi 162416227.

    Proteomic databases

    MaxQBi Q96QD8.
    PaxDbi Q96QD8.
    PeptideAtlasi Q96QD8.
    PRIDEi Q96QD8.

    Protocols and materials databases

    DNASUi 54407.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256689 ; ENSP00000256689 ; ENSG00000134294 . [Q96QD8-1 ]
    GeneIDi 54407.
    KEGGi hsa:54407.
    UCSCi uc001rpg.3. human. [Q96QD8-1 ]
    uc001rph.3. human. [Q96QD8-2 ]

    Organism-specific databases

    CTDi 54407.
    GeneCardsi GC12M046751.
    HGNCi HGNC:13448. SLC38A2.
    HPAi HPA035180.
    MIMi 605180. gene.
    neXtProti NX_Q96QD8.
    PharmGKBi PA37773.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236441.
    HOGENOMi HOG000013088.
    HOVERGENi HBG059571.
    InParanoidi Q96QD8.
    KOi K14207.
    OMAi YEHVESE.
    PhylomeDBi Q96QD8.
    TreeFami TF328787.

    Enzyme and pathway databases

    Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    ChiTaRSi SLC38A2. human.
    GeneWikii SLC38A2.
    GenomeRNAii 54407.
    NextBioi 56613.
    PROi Q96QD8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96QD8.
    Bgeei Q96QD8.
    CleanExi HS_SAT2.
    HS_SLC38A2.
    Genevestigatori Q96QD8.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A."
      Hatanaka T., Huang W., Wang H., Sugawara M., Prasad P.D., Leibach F.H., Ganapathy V.
      Biochim. Biophys. Acta 1467:1-6(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY.
      Tissue: Hepatoma.
    2. "Expression studies of the human amino acid transporter, hATA2."
      Powell J., Brock A.P., Hart I.R.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Schmidt T.
      Thesis (2001), University of Goettingen, Germany
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hepatoma and Teratocarcinoma.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    10. "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element."
      Palii S.S., Chen H., Kilberg M.S.
      J. Biol. Chem. 279:3463-3471(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    11. "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress."
      Bevilacqua E., Bussolati O., Dall'Asta V., Gaccioli F., Sala R., Gazzola G.C., Franchi-Gazzola R.
      FEBS Lett. 579:3376-3380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    12. "Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain."
      Gonzalez-Gonzalez I.M., Cubelos B., Gimenez C., Zafra F.
      Neuroscience 130:61-73(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    13. "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation."
      Gaccioli F., Huang C.C., Wang C., Bevilacqua E., Franchi-Gazzola R., Gazzola G.C., Bussolati O., Snider M.D., Hatzoglou M.
      J. Biol. Chem. 281:17929-17940(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    14. "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex."
      Melone M., Varoqui H., Erickson J.D., Conti F.
      Neuroscience 140:281-292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS38A2_HUMAN
    AccessioniPrimary (citable) accession number: Q96QD8
    Secondary accession number(s): Q6IA88
    , Q6ZMG2, Q9HAV3, Q9NVA8, Q9P2G5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3