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Protein

Sodium-coupled neutral amino acid transporter 2

Gene

SLC38A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.2 Publications

Enzyme regulationi

Inhibited by N-methyl-D-glucamine and probably choline.1 Publication

Kineticsi

  1. KM=0.39 mM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.0)

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.18.6.5. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 2
    Alternative name(s):
    Amino acid transporter A2
    Protein 40-9-1
    Solute carrier family 38 member 2
    System A amino acid transporter 2
    System A transporter 1
    System N amino acid transporter 2
    Gene namesi
    Name:SLC38A2
    Synonyms:ATA2, KIAA1382, SAT2, SNAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13448. SLC38A2.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Topological domaini98 – 1025ExtracellularSequence Analysis
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Topological domaini124 – 15835CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Topological domaini180 – 1889ExtracellularSequence Analysis
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Topological domaini210 – 2178CytoplasmicSequence Analysis
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Topological domaini239 – 29254ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST
    Topological domaini314 – 32916CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Topological domaini351 – 37121ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Topological domaini393 – 41321CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421HelicalSequence AnalysisAdd
    BLAST
    Topological domaini435 – 4362ExtracellularSequence Analysis
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Topological domaini458 – 47417CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST
    Topological domaini496 – 50611ExtracellularSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37773.

    Polymorphism and mutation databases

    BioMutai2/14/2002.
    DMDMi162416227.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Sodium-coupled neutral amino acid transporter 2PRO_0000311369Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101Phosphoserine1 Publication
    Modified residuei12 – 121Phosphoserine1 Publication
    Modified residuei22 – 221Phosphoserine1 Publication
    Modified residuei55 – 551PhosphoserineBy similarity
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ96QD8.
    PaxDbiQ96QD8.
    PeptideAtlasiQ96QD8.
    PRIDEiQ96QD8.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).3 Publications

    Inductioni

    Up-regulated upon hypertonic conditions and amino acid deprivation.3 Publications

    Gene expression databases

    BgeeiQ96QD8.
    CleanExiHS_SAT2.
    HS_SLC38A2.
    ExpressionAtlasiQ96QD8. baseline and differential.
    GenevisibleiQ96QD8. HS.

    Organism-specific databases

    HPAiHPA035180.

    Interactioni

    Protein-protein interaction databases

    BioGridi119943. 6 interactions.
    IntActiQ96QD8. 6 interactions.
    MINTiMINT-1398587.
    STRINGi9606.ENSP00000256689.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96QD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9696Regulates protein turnover upon amino acid deprivationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236441.
    GeneTreeiENSGT00760000119147.
    HOGENOMiHOG000013088.
    HOVERGENiHBG059571.
    InParanoidiQ96QD8.
    KOiK14207.
    OMAiITHLLCA.
    PhylomeDBiQ96QD8.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q96QD8-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MKKAEMGRFS ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN
    60 70 80 90 100
    FLLESNLGKK KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG
    110 120 130 140 150
    IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGYK AFGLVGKLAA
    160 170 180 190 200
    SGSITMQNIG AMSSYLFIVK YELPLVIQAL TNIEDKTGLW YLNGNYLVLL
    210 220 230 240 250
    VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK FQVPCPVEAA
    260 270 280 290 300
    LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI
    310 320 330 340 350
    FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF
    360 370 380 390 400
    YEHVESELLH TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH
    410 420 430 440 450
    LLCASKDFSW WRHSLITVSI LAFTNLLVIF VPTIRDIFGF IGASAASMLI
    460 470 480 490 500
    FILPSAFYIK LVKKEPMKSV QKIGALFFLL SGVLVMTGSM ALIVLDWVHN

    APGGGH
    Length:506
    Mass (Da):56,026
    Last modified:December 4, 2007 - v2
    Checksum:i125C70875793D031
    GO
    Isoform 2 (identifier: Q96QD8-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-100: Missing.
         101-105: IALFI → MKQNL

    Show »
    Length:406
    Mass (Da):45,179
    Checksum:iC72772C3238776CE
    GO

    Sequence cautioni

    The sequence BAD18765.1 differs from that shown. Reason: Erroneous initiation. Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561M → V in CAC51434 (Ref. 3) Curated
    Sequence conflicti273 – 2731H → R in BAA91846 (PubMed:14702039).Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481N → K.
    Corresponds to variant rs11183450 [ dbSNP | Ensembl ].
    VAR_037235

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 100100Missing in isoform 2. 2 PublicationsVSP_029553Add
    BLAST
    Alternative sequencei101 – 1055IALFI → MKQNL in isoform 2. 2 PublicationsVSP_029554

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF259799 mRNA. Translation: AAK38510.1.
    AF298897 mRNA. Translation: AAG24618.1.
    AJ344099 mRNA. Translation: CAC51434.1.
    AB037803 mRNA. Translation: BAA92620.2.
    AK001700 mRNA. Translation: BAA91846.1.
    AK172784 mRNA. Translation: BAD18765.1. Different initiation.
    CR457267 mRNA. Translation: CAG33548.1.
    CH471111 Genomic DNA. Translation: EAW57900.1.
    CH471111 Genomic DNA. Translation: EAW57901.1.
    BC040342 mRNA. Translation: AAH40342.1.
    CCDSiCCDS76551.1. [Q96QD8-2]
    CCDS8749.1. [Q96QD8-1]
    RefSeqiNP_001294865.1. NM_001307936.1. [Q96QD8-2]
    NP_061849.2. NM_018976.4. [Q96QD8-1]
    UniGeneiHs.221847.

    Genome annotation databases

    EnsembliENST00000256689; ENSP00000256689; ENSG00000134294.
    ENST00000612232; ENSP00000482873; ENSG00000134294. [Q96QD8-2]
    GeneIDi54407.
    KEGGihsa:54407.
    UCSCiuc001rpg.3. human. [Q96QD8-1]
    uc001rph.3. human. [Q96QD8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF259799 mRNA. Translation: AAK38510.1.
    AF298897 mRNA. Translation: AAG24618.1.
    AJ344099 mRNA. Translation: CAC51434.1.
    AB037803 mRNA. Translation: BAA92620.2.
    AK001700 mRNA. Translation: BAA91846.1.
    AK172784 mRNA. Translation: BAD18765.1. Different initiation.
    CR457267 mRNA. Translation: CAG33548.1.
    CH471111 Genomic DNA. Translation: EAW57900.1.
    CH471111 Genomic DNA. Translation: EAW57901.1.
    BC040342 mRNA. Translation: AAH40342.1.
    CCDSiCCDS76551.1. [Q96QD8-2]
    CCDS8749.1. [Q96QD8-1]
    RefSeqiNP_001294865.1. NM_001307936.1. [Q96QD8-2]
    NP_061849.2. NM_018976.4. [Q96QD8-1]
    UniGeneiHs.221847.

    3D structure databases

    ProteinModelPortaliQ96QD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi119943. 6 interactions.
    IntActiQ96QD8. 6 interactions.
    MINTiMINT-1398587.
    STRINGi9606.ENSP00000256689.

    Chemistry

    GuidetoPHARMACOLOGYi1170.

    Protein family/group databases

    TCDBi2.A.18.6.5. the amino acid/auxin permease (aaap) family.

    Polymorphism and mutation databases

    BioMutai2/14/2002.
    DMDMi162416227.

    Proteomic databases

    MaxQBiQ96QD8.
    PaxDbiQ96QD8.
    PeptideAtlasiQ96QD8.
    PRIDEiQ96QD8.

    Protocols and materials databases

    DNASUi54407.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000256689; ENSP00000256689; ENSG00000134294.
    ENST00000612232; ENSP00000482873; ENSG00000134294. [Q96QD8-2]
    GeneIDi54407.
    KEGGihsa:54407.
    UCSCiuc001rpg.3. human. [Q96QD8-1]
    uc001rph.3. human. [Q96QD8-2]

    Organism-specific databases

    CTDi54407.
    GeneCardsiGC12M046751.
    HGNCiHGNC:13448. SLC38A2.
    HPAiHPA035180.
    MIMi605180. gene.
    neXtProtiNX_Q96QD8.
    PharmGKBiPA37773.
    HUGEiSearch...
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiNOG236441.
    GeneTreeiENSGT00760000119147.
    HOGENOMiHOG000013088.
    HOVERGENiHBG059571.
    InParanoidiQ96QD8.
    KOiK14207.
    OMAiITHLLCA.
    PhylomeDBiQ96QD8.
    TreeFamiTF328787.

    Enzyme and pathway databases

    ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
    REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    ChiTaRSiSLC38A2. human.
    GeneWikiiSLC38A2.
    GenomeRNAii54407.
    NextBioi56613.
    PROiQ96QD8.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ96QD8.
    CleanExiHS_SAT2.
    HS_SLC38A2.
    ExpressionAtlasiQ96QD8. baseline and differential.
    GenevisibleiQ96QD8. HS.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A."
      Hatanaka T., Huang W., Wang H., Sugawara M., Prasad P.D., Leibach F.H., Ganapathy V.
      Biochim. Biophys. Acta 1467:1-6(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY.
      Tissue: Hepatoma.
    2. "Expression studies of the human amino acid transporter, hATA2."
      Powell J., Brock A.P., Hart I.R.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Schmidt T.
      Thesis (2001), University of Goettingen, Germany
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hepatoma and Teratocarcinoma.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    10. "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element."
      Palii S.S., Chen H., Kilberg M.S.
      J. Biol. Chem. 279:3463-3471(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    11. "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress."
      Bevilacqua E., Bussolati O., Dall'Asta V., Gaccioli F., Sala R., Gazzola G.C., Franchi-Gazzola R.
      FEBS Lett. 579:3376-3380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    12. "Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain."
      Gonzalez-Gonzalez I.M., Cubelos B., Gimenez C., Zafra F.
      Neuroscience 130:61-73(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    13. "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation."
      Gaccioli F., Huang C.C., Wang C., Bevilacqua E., Franchi-Gazzola R., Gazzola G.C., Bussolati O., Snider M.D., Hatzoglou M.
      J. Biol. Chem. 281:17929-17940(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    14. "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex."
      Melone M., Varoqui H., Erickson J.D., Conti F.
      Neuroscience 140:281-292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS38A2_HUMAN
    AccessioniPrimary (citable) accession number: Q96QD8
    Secondary accession number(s): Q6IA88
    , Q6ZMG2, Q9HAV3, Q9NVA8, Q9P2G5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: July 22, 2015
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.