Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DEP domain-containing protein 7

Gene

DEPDC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121690-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
DEP domain-containing protein 7
Alternative name(s):
Protein TR2/D15
Gene namesi
Name:DEPDC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29899. DEPDC7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121690.
PharmGKBiPA144596441.

Polymorphism and mutation databases

BioMutaiDEPDC7.
DMDMi74717175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077371 – 511DEP domain-containing protein 7Add BLAST511

Proteomic databases

MaxQBiQ96QD5.
PaxDbiQ96QD5.
PeptideAtlasiQ96QD5.
PRIDEiQ96QD5.
TopDownProteomicsiQ96QD5-1. [Q96QD5-1]

PTM databases

iPTMnetiQ96QD5.
PhosphoSitePlusiQ96QD5.

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Gene expression databases

BgeeiENSG00000121690.
CleanExiHS_DEPDC7.
GenevisibleiQ96QD5. HS.

Organism-specific databases

HPAiHPA015800.

Interactioni

Protein-protein interaction databases

BioGridi124854. 11 interactors.
IntActiQ96QD5. 9 interactors.
MINTiMINT-7944608.
STRINGi9606.ENSP00000241051.

Structurei

3D structure databases

ProteinModelPortaliQ96QD5.
SMRiQ96QD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 136DEPPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the DEPDC7 family.Curated
Contains 1 DEP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IKPJ. Eukaryota.
ENOG410ZQXJ. LUCA.
GeneTreeiENSGT00530000063030.
HOGENOMiHOG000112196.
HOVERGENiHBG054802.
InParanoidiQ96QD5.
PhylomeDBiQ96QD5.
TreeFamiTF328365.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96QD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVQEKAAA LNLSALHSPA HRPPGFSVAQ KPFGATYVWS SIINTLQTQV
60 70 80 90 100
EVKKRRHRLK RHNDCFVGSE AVDVIFSHLI QNKYFGDVDI PRAKVVRVCQ
110 120 130 140 150
ALMDYKVFEA VPTKVFGKDK KPTFEDSSCS LYRFTTIPNQ DSQLGKENKL
160 170 180 190 200
YSPARYADAL FKSSDIRSAS LEDLWENLSL KPANSPHVNI SATLSPQVIN
210 220 230 240 250
EVWQEETIGR LLQLVDLPLL DSLLKQQEAV PKIPQPKRQS TMVNSSNYLD
260 270 280 290 300
RGILKAYSDS QEDEWLSAAI DCLEYLPDQM VVEISRSFPE QPDRTDLVKE
310 320 330 340 350
LLFDAIGRYY SSREPLLNHL SDVHNGIAEL LVNGKTEIAL EATQLLLKLL
360 370 380 390 400
DFQNREEFRR LLYFMAVAAN PSEFKLQKES DNRMVVKRIF SKAIVDNKNL
410 420 430 440 450
SKGKTDLLVL FLMDHQKDVF KIPGTLHKIV SVKLMAIQNG RDPNRDAGYI
460 470 480 490 500
YCQRIDQRDY SNNTEKTTKD ELLNLLKTLD EDSKLSAKEK KKLLGQFYKC
510
HPDIFIEHFG D
Length:511
Mass (Da):58,310
Last modified:December 1, 2001 - v1
Checksum:iF69089ABE41AD2EA
GO
Isoform 2 (identifier: Q96QD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MATVQEKAAALNLSALHSPAHRPP → MRGLCEFYWQEFGIK

Show »
Length:502
Mass (Da):57,706
Checksum:iC4D05A4F69CDAF52
GO

Sequence cautioni

The sequence AAM22871 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66F → L in AAM22871 (Ref. 2) Curated1
Sequence conflicti273L → S in CAB53247 (PubMed:10568747).Curated1
Sequence conflicti273L → S in AAM22871 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053972192A → T.Corresponds to variant rs34161108dbSNPEnsembl.1
Natural variantiVAR_062212464T → I.1 PublicationCorresponds to variant rs17852859dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471801 – 24MATVQ…AHRPP → MRGLCEFYWQEFGIK in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245600 mRNA. Translation: CAB53247.1.
AF447588 mRNA. Translation: AAM22871.1. Different initiation.
AC107939 Genomic DNA. No translation available.
AC131263 Genomic DNA. No translation available.
AL121926 Genomic DNA. Translation: CAC48255.1.
CH471064 Genomic DNA. Translation: EAW68213.1.
BC030970 mRNA. Translation: AAH30970.1.
CCDSiCCDS41632.1. [Q96QD5-1]
CCDS41633.1. [Q96QD5-2]
RefSeqiNP_001070710.1. NM_001077242.1. [Q96QD5-1]
NP_631899.2. NM_139160.2. [Q96QD5-2]
UniGeneiHs.280990.

Genome annotation databases

EnsembliENST00000241051; ENSP00000241051; ENSG00000121690. [Q96QD5-1]
ENST00000311388; ENSP00000308971; ENSG00000121690. [Q96QD5-2]
GeneIDi91614.
KEGGihsa:91614.
UCSCiuc001mub.3. human. [Q96QD5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245600 mRNA. Translation: CAB53247.1.
AF447588 mRNA. Translation: AAM22871.1. Different initiation.
AC107939 Genomic DNA. No translation available.
AC131263 Genomic DNA. No translation available.
AL121926 Genomic DNA. Translation: CAC48255.1.
CH471064 Genomic DNA. Translation: EAW68213.1.
BC030970 mRNA. Translation: AAH30970.1.
CCDSiCCDS41632.1. [Q96QD5-1]
CCDS41633.1. [Q96QD5-2]
RefSeqiNP_001070710.1. NM_001077242.1. [Q96QD5-1]
NP_631899.2. NM_139160.2. [Q96QD5-2]
UniGeneiHs.280990.

3D structure databases

ProteinModelPortaliQ96QD5.
SMRiQ96QD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124854. 11 interactors.
IntActiQ96QD5. 9 interactors.
MINTiMINT-7944608.
STRINGi9606.ENSP00000241051.

PTM databases

iPTMnetiQ96QD5.
PhosphoSitePlusiQ96QD5.

Polymorphism and mutation databases

BioMutaiDEPDC7.
DMDMi74717175.

Proteomic databases

MaxQBiQ96QD5.
PaxDbiQ96QD5.
PeptideAtlasiQ96QD5.
PRIDEiQ96QD5.
TopDownProteomicsiQ96QD5-1. [Q96QD5-1]

Protocols and materials databases

DNASUi91614.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241051; ENSP00000241051; ENSG00000121690. [Q96QD5-1]
ENST00000311388; ENSP00000308971; ENSG00000121690. [Q96QD5-2]
GeneIDi91614.
KEGGihsa:91614.
UCSCiuc001mub.3. human. [Q96QD5-1]

Organism-specific databases

CTDi91614.
GeneCardsiDEPDC7.
H-InvDBHIX0009535.
HGNCiHGNC:29899. DEPDC7.
HPAiHPA015800.
MIMi612294. gene.
neXtProtiNX_Q96QD5.
OpenTargetsiENSG00000121690.
PharmGKBiPA144596441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKPJ. Eukaryota.
ENOG410ZQXJ. LUCA.
GeneTreeiENSGT00530000063030.
HOGENOMiHOG000112196.
HOVERGENiHBG054802.
InParanoidiQ96QD5.
PhylomeDBiQ96QD5.
TreeFamiTF328365.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121690-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.

Miscellaneous databases

GenomeRNAii91614.
PROiQ96QD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121690.
CleanExiHS_DEPDC7.
GenevisibleiQ96QD5. HS.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEPD7_HUMAN
AccessioniPrimary (citable) accession number: Q96QD5
Secondary accession number(s): G5E941
, Q8N602, Q8NCU9, Q9UGK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.