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Protein
Submitted name:

MHC class I polypeptide-related sequence A

Gene

MICA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I polypeptide-related sequence AImported
Submitted name:
MHC class I polypeptide-related sequence A, isoform CRA_cImported
Submitted name:
MICAImported
Submitted name:
Stress inducible class I homologImported
Submitted name:
cDNA FLJ60820, highly similar to Homo sapiens MHC class I polypeptide-related sequence A (MICA), mRNAImported
Gene namesi
Name:MICAImported
ORF Names:hCG_2001511Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204520.12
HGNCiHGNC:7090 MICA

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204520
PharmGKBiPA30811

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501458924524 – 332Sequence analysisAdd BLAST309

Expressioni

Gene expression databases

BgeeiENSG00000204520

Interactioni

Protein-protein interaction databases

IntActiQ96QC4, 2 interactors
STRINGi9606.ENSP00000365394

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 296Ig-likeInterPro annotationAdd BLAST90

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410J8TZ Eukaryota
ENOG41118IQ LUCA
GeneTreeiENSGT00740000114936
HOGENOMiHOG000231246
HOVERGENiHBG106364
OMAiLVLQSHW
OrthoDBiEOG091G0ANY
TreeFamiTF342166

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q96QC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLAEVH
60 70 80 90 100
LDGQPFLRYD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL
110 120 130 140 150
AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETEEW
160 170 180 190 200
TVPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLESGVV
210 220 230 240 250
LRRTVPPMVN VTRSEASEGN ITVTCRASSF YPRNIILTWR QDGVSLSHDT
260 270 280 290 300
QQWGDVLPDG NGTYQTWVAT RICRGEEQRF TCYMEHSGNH STHPVPSGKV
310 320 330
LVLQSHWQTF HVSAVAAGCC YFCYYYFLCP LL
Length:332
Mass (Da):37,834
Last modified:December 1, 2001 - v1
Checksum:iA8D8C5080781CB90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645933 Genomic DNA No translation available.
AL669854 Genomic DNA No translation available.
BX005439 Genomic DNA No translation available.
BX119958 Genomic DNA No translation available.
KY500931 Genomic DNA Translation: ARB08519.1
KY500934 Genomic DNA Translation: ARB08522.1
KY500935 Genomic DNA Translation: ARB08523.1
KY500937 Genomic DNA Translation: ARB08525.1
KY500938 Genomic DNA Translation: ARB08526.1
KY500939 Genomic DNA Translation: ARB08527.1
BA000025 Genomic DNA Translation: BAB63308.1
AK299135 mRNA Translation: BAG61187.1
CH471081 Genomic DNA Translation: EAX03396.1
RefSeqiNP_001170990.1, NM_001177519.2
NP_001276081.1, NM_001289152.1
NP_001276082.1, NM_001289153.1
NP_001276083.1, NM_001289154.1
UniGeneiHs.130838

Genome annotation databases

EnsembliENST00000415525; ENSP00000416941; ENSG00000231225
ENST00000427477; ENSP00000394553; ENSG00000233051
ENST00000449934; ENSP00000413079; ENSG00000204520
ENST00000546529; ENSP00000446655; ENSG00000231225
ENST00000547767; ENSP00000447026; ENSG00000233051
GeneIDi100507436
UCSCiuc003ntk.3 human

Similar proteinsi

Entry informationi

Entry nameiQ96QC4_HUMAN
AccessioniPrimary (citable) accession number: Q96QC4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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