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Protein
Submitted name:

MHC class I polypeptide-related sequence A

Gene

MICA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I polypeptide-related sequence AImported
Submitted name:
MHC class I polypeptide-related sequence A, isoform CRA_cImported
Submitted name:
Stress inducible class I homologImported
Submitted name:
cDNA FLJ60820, highly similar to Homo sapiens MHC class I polypeptide-related sequence A (MICA), mRNAImported
Gene namesi
Name:MICAImported
ORF Names:hCG_2001511Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7090. MICA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 332309Sequence analysisPRO_5007715965Add
BLAST

Proteomic databases

MaxQBiQ96QC4.
PeptideAtlasiQ96QC4.

Expressioni

Gene expression databases

BgeeiENSG00000204520.

Structurei

3D structure databases

SMRiQ96QC4. Positions 24-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 29690Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410J8TZ. Eukaryota.
ENOG41118IQ. LUCA.
GeneTreeiENSGT00840000130010.
HOGENOMiHOG000231246.
HOVERGENiHBG106364.
OMAiQAFLHYD.
OrthoDBiEOG091G0ANY.
PhylomeDBiQ96QC4.
TreeFamiTF342166.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLAEVH
60 70 80 90 100
LDGQPFLRYD RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL
110 120 130 140 150
AHIKDQKEGL HSLQEIRVCE IHEDNSTRSS QHFYYDGELF LSQNLETEEW
160 170 180 190 200
TVPQSSRAQT LAMNVRNFLK EDAMKTKTHY HAMHADCLQE LRRYLESGVV
210 220 230 240 250
LRRTVPPMVN VTRSEASEGN ITVTCRASSF YPRNIILTWR QDGVSLSHDT
260 270 280 290 300
QQWGDVLPDG NGTYQTWVAT RICRGEEQRF TCYMEHSGNH STHPVPSGKV
310 320 330
LVLQSHWQTF HVSAVAAGCC YFCYYYFLCP LL
Length:332
Mass (Da):37,834
Last modified:December 1, 2001 - v1
Checksum:iA8D8C5080781CB90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645933 Genomic DNA. No translation available.
AL669854 Genomic DNA. No translation available.
BX005439 Genomic DNA. No translation available.
BX119958 Genomic DNA. No translation available.
BA000025 Genomic DNA. Translation: BAB63308.1.
AK299135 mRNA. Translation: BAG61187.1.
CH471081 Genomic DNA. Translation: EAX03396.1.
RefSeqiNP_001170990.1. NM_001177519.2.
NP_001276081.1. NM_001289152.1.
NP_001276082.1. NM_001289153.1.
NP_001276083.1. NM_001289154.1.
UniGeneiHs.130838.

Genome annotation databases

EnsembliENST00000415525; ENSP00000416941; ENSG00000231225.
ENST00000427477; ENSP00000394553; ENSG00000233051.
ENST00000449934; ENSP00000413079; ENSG00000204520.
ENST00000546529; ENSP00000446655; ENSG00000231225.
ENST00000547767; ENSP00000447026; ENSG00000233051.
GeneIDi100507436.
UCSCiuc003ntk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645933 Genomic DNA. No translation available.
AL669854 Genomic DNA. No translation available.
BX005439 Genomic DNA. No translation available.
BX119958 Genomic DNA. No translation available.
BA000025 Genomic DNA. Translation: BAB63308.1.
AK299135 mRNA. Translation: BAG61187.1.
CH471081 Genomic DNA. Translation: EAX03396.1.
RefSeqiNP_001170990.1. NM_001177519.2.
NP_001276081.1. NM_001289152.1.
NP_001276082.1. NM_001289153.1.
NP_001276083.1. NM_001289154.1.
UniGeneiHs.130838.

3D structure databases

SMRiQ96QC4. Positions 24-297.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ96QC4.
PeptideAtlasiQ96QC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415525; ENSP00000416941; ENSG00000231225.
ENST00000427477; ENSP00000394553; ENSG00000233051.
ENST00000449934; ENSP00000413079; ENSG00000204520.
ENST00000546529; ENSP00000446655; ENSG00000231225.
ENST00000547767; ENSP00000447026; ENSG00000233051.
GeneIDi100507436.
UCSCiuc003ntk.3. human.

Organism-specific databases

CTDi100507436.
HGNCiHGNC:7090. MICA.
PharmGKBiPA30811.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8TZ. Eukaryota.
ENOG41118IQ. LUCA.
GeneTreeiENSGT00840000130010.
HOGENOMiHOG000231246.
HOVERGENiHBG106364.
OMAiQAFLHYD.
OrthoDBiEOG091G0ANY.
PhylomeDBiQ96QC4.
TreeFamiTF342166.

Miscellaneous databases

ChiTaRSiMICA. human.
GenomeRNAii100507436.

Gene expression databases

BgeeiENSG00000204520.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ96QC4_HUMAN
AccessioniPrimary (citable) accession number: Q96QC4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.