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Protein

Serine/threonine-protein phosphatase 1 regulatory subunit 10

Gene

PPP1R10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri906 – 934C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  • protein import into nucleus Source: ProtInc
  • transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS06311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 1 regulatory subunit 10
Alternative name(s):
MHC class I region proline-rich protein CAT53
PP1-binding protein of 114 kDa
Phosphatase 1 nuclear targeting subunit
Protein FB19
p99
Gene namesi
Name:PPP1R10
Synonyms:CAT53, FB19, PNUTS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9284. PPP1R10.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

  • Note: Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).By similarity

GO - Cellular componenti

  • chromatin Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
  • PTW/PP1 phosphatase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5514.
OpenTargetsiENSG00000204569.
ENSG00000206489.
ENSG00000227804.
ENSG00000230995.
ENSG00000231737.
ENSG00000235291.
ENSG00000238104.
PharmGKBiPA33612.

Polymorphism and mutation databases

BioMutaiPPP1R10.
DMDMi61214507.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000715101 – 940Serine/threonine-protein phosphatase 1 regulatory subunit 10Add BLAST940

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256PhosphothreonineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei665Omega-N-methylarginineCombined sources1
Modified residuei693Omega-N-methylarginineCombined sources1
Modified residuei738Omega-N-methylarginineBy similarity1

Post-translational modificationi

Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ96QC0.
MaxQBiQ96QC0.
PaxDbiQ96QC0.
PeptideAtlasiQ96QC0.
PRIDEiQ96QC0.
TopDownProteomicsiQ96QC0.

PTM databases

iPTMnetiQ96QC0.
PhosphoSitePlusiQ96QC0.

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.2 Publications

Gene expression databases

BgeeiENSG00000204569.
CleanExiHS_PPP1R10.
ExpressionAtlasiQ96QC0. baseline and differential.
GenevisibleiQ96QC0. HS.

Organism-specific databases

HPAiCAB025501.
HPA047248.
HPA056756.

Interactioni

Subunit structurei

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi111506. 43 interactors.
DIPiDIP-39343N.
IntActiQ96QC0. 18 interactors.
MINTiMINT-1197376.
STRINGi9606.ENSP00000365694.

Structurei

3D structure databases

ProteinModelPortaliQ96QC0.
SMRiQ96QC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 147TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 348Interaction with TOX4By similarityAdd BLAST348
Regioni382 – 450Essential for PPP1CA inhibitionBy similarityAdd BLAST69
Regioni388 – 417Necessary for interaction with PPP1CABy similarityAdd BLAST30
Regioni393 – 408Necessary for interaction with PPP1CC1 PublicationAdd BLAST16
Regioni418 – 619Interaction with WDR82By similarityAdd BLAST202

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi420 – 423PP1-binding motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi304 – 310Poly-Lys7
Compositional biasi540 – 904Gly-richAdd BLAST365

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri906 – 934C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGTC. Eukaryota.
ENOG410XP4M. LUCA.
GeneTreeiENSGT00530000063820.
HOGENOMiHOG000049285.
HOVERGENiHBG053646.
InParanoidiQ96QC0.
KOiK17552.
OMAiGHRSHEG.
OrthoDBiEOG091G07K1.
PhylomeDBiQ96QC0.
TreeFamiTF105541.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
4.10.1000.10. 1 hit.
InterProiIPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF90229. SSF90229. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGPIDPKE LLKGLDSFLN RDGEVKSVDG ISKIFSLMKE ARKMVSRCTY
60 70 80 90 100
LNILLQTRSP EILVKFIDVG GYKLLNNWLT YSKTTNNIPL LQQILLTLQH
110 120 130 140 150
LPLTVDHLKQ NNTAKLVKQL SKSSEDEELR KLASVLVSDW MAVIRSQSST
160 170 180 190 200
QPAEKDKKKR KDEGKSRTTL PERPLTEVKA ETRAEEAPEK KREKPKSLRT
210 220 230 240 250
TAPSHAKFRS TGLELETPSL VPVKKNASTV VVSDKYNLKP IPLKRQSNVA
260 270 280 290 300
APGDATPPAE KKYKPLNTTP NATKEIKVKI IPPQPMEGLG FLDALNSAPV
310 320 330 340 350
PGIKIKKKKK VLSPTAAKPS PFEGKTSTEP STAKPSSPEP APPSEAMDAD
360 370 380 390 400
RPGTPVPPVE VPELMDTASL EPGALDAKPV ESPGDPNQLT RKGRKRKSVT
410 420 430 440 450
WPEEGKLREY FYFELDETER VNVNKIKDFG EAAKREILSD RHAFETARRL
460 470 480 490 500
SHDNMEEKVP WVCPRPLVLP SPLVTPGSNS QERYIQAERE KGILQELFLN
510 520 530 540 550
KESPHEPDPE PYEPIPPKLI PLDEECSMDE TPYVETLEPG GSGGSPDGAG
560 570 580 590 600
GSKLPPVLAN LMGSMGAGKG PQGPGGGGIN VQEILTSIMG SPNSHPSEEL
610 620 630 640 650
LKQPDYSDKI KQMLVPHGLL GPGPIANGFP PGGPGGPKGM QHFPPGPGGP
660 670 680 690 700
MPGPHGGPGG PVGPRLLGPP PPPRGGDPFW DGPGDPMRGG PMRGGPGPGP
710 720 730 740 750
GPYHRGRGGR GGNEPPPPPP PFRGARGGRS GGGPPNGRGG PGGGMVGGGG
760 770 780 790 800
HRPHEGPGGG MGNSSGHRPH EGPGGGMGSG HRPHEGPGGS MGGGGGHRPH
810 820 830 840 850
EGPGGGISGG SGHRPHEGPG GGMGAGGGHR PHEGPGGSMG GSGGHRPHEG
860 870 880 890 900
PGHGGPHGHR PHDVPGHRGH DHRGPPPHEH RGHDGPGHGG GGHRGHDGGH
910 920 930 940
SHGGDMSNRP VCRHFMMKGN CRYENNCAFY HPGVNGPPLP
Length:940
Mass (Da):99,058
Last modified:December 1, 2001 - v1
Checksum:i49EE42961D734121
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225K → E in CAA73697 (PubMed:9784381).Curated1
Sequence conflicti861P → L in CAA73697 (PubMed:9784381).Curated1
Sequence conflicti875P → Q in CAA73697 (PubMed:9784381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051747173R → P.Corresponds to variant rs16897725dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13247 mRNA. Translation: CAA73697.1.
AJ544537 mRNA. Translation: CAD67521.1.
BA000025 Genomic DNA. Translation: BAB63324.1.
AB088097 Genomic DNA. Translation: BAC54929.1.
AL662800 Genomic DNA. Translation: CAI18160.1.
AL662825 Genomic DNA. Translation: CAI17838.1.
BX248507 Genomic DNA. Translation: CAI18567.1.
CCDSiCCDS4681.1.
PIRiJE0291.
RefSeqiNP_002705.2. NM_002714.3.
XP_006715193.1. XM_006715130.2.
XP_011513024.1. XM_011514722.1.
XP_016866484.1. XM_017010995.1.
UniGeneiHs.106019.

Genome annotation databases

EnsembliENST00000376511; ENSP00000365694; ENSG00000204569.
ENST00000383586; ENSP00000373080; ENSG00000206489.
ENST00000420949; ENSP00000413554; ENSG00000230995.
ENST00000424446; ENSP00000407181; ENSG00000231737.
ENST00000426299; ENSP00000389299; ENSG00000235291.
ENST00000429597; ENSP00000407310; ENSG00000238104.
ENST00000449113; ENSP00000416060; ENSG00000227804.
GeneIDi5514.
KEGGihsa:5514.
UCSCiuc003nqn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13247 mRNA. Translation: CAA73697.1.
AJ544537 mRNA. Translation: CAD67521.1.
BA000025 Genomic DNA. Translation: BAB63324.1.
AB088097 Genomic DNA. Translation: BAC54929.1.
AL662800 Genomic DNA. Translation: CAI18160.1.
AL662825 Genomic DNA. Translation: CAI17838.1.
BX248507 Genomic DNA. Translation: CAI18567.1.
CCDSiCCDS4681.1.
PIRiJE0291.
RefSeqiNP_002705.2. NM_002714.3.
XP_006715193.1. XM_006715130.2.
XP_011513024.1. XM_011514722.1.
XP_016866484.1. XM_017010995.1.
UniGeneiHs.106019.

3D structure databases

ProteinModelPortaliQ96QC0.
SMRiQ96QC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111506. 43 interactors.
DIPiDIP-39343N.
IntActiQ96QC0. 18 interactors.
MINTiMINT-1197376.
STRINGi9606.ENSP00000365694.

PTM databases

iPTMnetiQ96QC0.
PhosphoSitePlusiQ96QC0.

Polymorphism and mutation databases

BioMutaiPPP1R10.
DMDMi61214507.

Proteomic databases

EPDiQ96QC0.
MaxQBiQ96QC0.
PaxDbiQ96QC0.
PeptideAtlasiQ96QC0.
PRIDEiQ96QC0.
TopDownProteomicsiQ96QC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376511; ENSP00000365694; ENSG00000204569.
ENST00000383586; ENSP00000373080; ENSG00000206489.
ENST00000420949; ENSP00000413554; ENSG00000230995.
ENST00000424446; ENSP00000407181; ENSG00000231737.
ENST00000426299; ENSP00000389299; ENSG00000235291.
ENST00000429597; ENSP00000407310; ENSG00000238104.
ENST00000449113; ENSP00000416060; ENSG00000227804.
GeneIDi5514.
KEGGihsa:5514.
UCSCiuc003nqn.3. human.

Organism-specific databases

CTDi5514.
DisGeNETi5514.
GeneCardsiPPP1R10.
H-InvDBHIX0165052.
HIX0166290.
HIX0166579.
HIX0166833.
HIX0167082.
HIX0167322.
HIX0167569.
HGNCiHGNC:9284. PPP1R10.
HPAiCAB025501.
HPA047248.
HPA056756.
MIMi603771. gene.
neXtProtiNX_Q96QC0.
OpenTargetsiENSG00000204569.
ENSG00000206489.
ENSG00000227804.
ENSG00000230995.
ENSG00000231737.
ENSG00000235291.
ENSG00000238104.
PharmGKBiPA33612.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGTC. Eukaryota.
ENOG410XP4M. LUCA.
GeneTreeiENSGT00530000063820.
HOGENOMiHOG000049285.
HOVERGENiHBG053646.
InParanoidiQ96QC0.
KOiK17552.
OMAiGHRSHEG.
OrthoDBiEOG091G07K1.
PhylomeDBiQ96QC0.
TreeFamiTF105541.

Enzyme and pathway databases

BioCyciZFISH:HS06311-MONOMER.

Miscellaneous databases

ChiTaRSiPPP1R10. human.
GeneWikiiPPP1R10.
GenomeRNAii5514.
PROiQ96QC0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204569.
CleanExiHS_PPP1R10.
ExpressionAtlasiQ96QC0. baseline and differential.
GenevisibleiQ96QC0. HS.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
4.10.1000.10. 1 hit.
InterProiIPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF90229. SSF90229. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP1RA_HUMAN
AccessioniPrimary (citable) accession number: Q96QC0
Secondary accession number(s): O00405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.