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Protein

Rho GTPase-activating protein 7

Gene

DLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.3 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • lipid binding Source: InterPro
  • SH2 domain binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • apoptotic process Source: UniProtKB
  • focal adhesion assembly Source: UniProtKB
  • forebrain development Source: UniProtKB
  • heart morphogenesis Source: UniProtKB
  • hindbrain morphogenesis Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of focal adhesion assembly Source: UniProtKB
  • negative regulation of Rho protein signal transduction Source: UniProtKB
  • negative regulation of stress fiber assembly Source: UniProtKB
  • neural tube closure Source: UniProtKB
  • positive regulation of execution phase of apoptosis Source: UniProtKB
  • positive regulation of protein dephosphorylation Source: UniProtKB
  • regulation of actin cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164741-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
SIGNORiQ96QB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 7
Alternative name(s):
Deleted in liver cancer 1 protein
Short name:
DLC-1
HP protein
Rho-type GTPase-activating protein 7
START domain-containing protein 12
Short name:
StARD12
StAR-related lipid transfer protein 12
Gene namesi
Name:DLC1
Synonyms:ARHGAP7, KIAA1723, STARD12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:2897. DLC1.

Subcellular locationi

GO - Cellular componenti

  • caveola Source: UniProtKB
  • cortical actin cytoskeleton Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • nucleus Source: UniProtKB
  • ruffle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi475F → G: Abolishes interaction with EF1A1. 1 Publication1
Mutagenesisi476L → G: Abolishes interaction with EF1A1. 1 Publication1
Mutagenesisi879Y → F: Unable to displace endogenous DLC1 from focal adhesions. 1 Publication1
Mutagenesisi1114R → E: No catalytic activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi10395.
MalaCardsiDLC1.
OpenTargetsiENSG00000164741.
PharmGKBiPA27351.

Polymorphism and mutation databases

BioMutaiDLC1.
DMDMi313104315.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567071 – 1528Rho GTPase-activating protein 7Add BLAST1528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei523PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei566PhosphoserineBy similarity1
Modified residuei757PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96QB1.
PaxDbiQ96QB1.
PeptideAtlasiQ96QB1.
PRIDEiQ96QB1.

PTM databases

iPTMnetiQ96QB1.
PhosphoSitePlusiQ96QB1.

Expressioni

Tissue specificityi

Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

Gene expression databases

BgeeiENSG00000164741.
CleanExiHS_DLC1.
ExpressionAtlasiQ96QB1. baseline and differential.
GenevisibleiQ96QB1. HS.

Organism-specific databases

HPAiHPA017753.

Interactioni

Subunit structurei

Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RASA1P209367EBI-2608428,EBI-1026476

GO - Molecular functioni

  • SH2 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115667. 18 interactors.
DIPiDIP-56928N.
IntActiQ96QB1. 32 interactors.
MINTiMINT-6942866.
STRINGi9606.ENSP00000276297.

Structurei

Secondary structure

11528
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi451 – 463Combined sources13
Helixi468 – 473Combined sources6
Turni474 – 476Combined sources3
Helixi481 – 487Combined sources7
Turni488 – 490Combined sources3
Helixi493 – 509Combined sources17
Turni510 – 514Combined sources5
Helixi906 – 920Combined sources15
Helixi1080 – 1087Combined sources8
Beta strandi1088 – 1091Combined sources4
Helixi1093 – 1105Combined sources13
Turni1110 – 1114Combined sources5
Helixi1119 – 1129Combined sources11
Beta strandi1131 – 1134Combined sources4
Helixi1143 – 1156Combined sources14
Beta strandi1157 – 1159Combined sources3
Helixi1166 – 1176Combined sources11
Helixi1179 – 1181Combined sources3
Helixi1182 – 1191Combined sources10
Helixi1195 – 1213Combined sources19
Helixi1215 – 1218Combined sources4
Helixi1222 – 1234Combined sources13
Helixi1260 – 1278Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKYNMR-A451-515[»]
2GYTNMR-A451-513[»]
2KAPNMR-A454-513[»]
2LOZNMR-B811-824[»]
3KUQX-ray2.30A1074-1283[»]
5FZTX-ray2.10B904-926[»]
ProteinModelPortaliQ96QB1.
SMRiQ96QB1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96QB1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini448 – 515SAMAdd BLAST68
Domaini1078 – 1284Rho-GAPPROSITE-ProRule annotationAdd BLAST207
Domaini1314 – 1521STARTPROSITE-ProRule annotationAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni710 – 884Focal adhesion-targeting (FAT)Add BLAST175
Regioni1051 – 1073Polybasic cluster (PBR)Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi741 – 747Poly-Ser7
Compositional biasi868 – 874Poly-Ser7

Domaini

The SAM domain mediates interaction with EF1A1, and functions as an autoinhibitory regulator of RhoGAP Activity.1 Publication
The polybasic cluster is required for activation and mediates binding to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) containing membranes.1 Publication

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2200. Eukaryota.
ENOG410XQ10. LUCA.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000147792.
HOVERGENiHBG055955.
InParanoidiQ96QB1.
KOiK20632.
OMAiWVSCSTS.
OrthoDBiEOG091G00OE.
PhylomeDBiQ96QB1.
TreeFamiTF314044.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.530.20. 1 hit.
InterProiIPR028854. DLC1.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR12659:SF2. PTHR12659:SF2. 1 hit.
PfamiPF00620. RhoGAP. 1 hit.
PF07647. SAM_2. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50848. START. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q96QB1-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVAIRKRSW EEHVTHWMGQ PFNSDDRNTA CHHGLVADSL QASMEKDATL
60 70 80 90 100
NVDRKEKCVS LPDCCHGSEL RDFPGRPMGH LSKDVDENDS HEGEDQFLSL
110 120 130 140 150
EASTETLVHV SDEDNNADLC LTDDKQVLNT QGQKTSGQHM IQGAGSLEKA
160 170 180 190 200
LPIIQSNQVS SNSWGIAGET ELALVKESGE RKVTDSISKS LELCNEISLS
210 220 230 240 250
EIKDAPKVNA VDTLNVKDIA PEKQLLNSAV IAQQRRKPDP PKDENERSTC
260 270 280 290 300
NVVQNEFLDT PCTNRGLPLL KTDFGSCLLQ PPSCPNGMSA ENGLEKSGFS
310 320 330 340 350
QHQNKSPPKV KAEDGMQCLQ LKETLATQEP TDNQVRLRKR KEIREDRDRA
360 370 380 390 400
RLDSMVLLIM KLDQLDQDIE NALSTSSSPS GTPTNLRRHV PDLESGSESG
410 420 430 440 450
ADTISVNQTR VNLSSDTEST DLPSSTPVAN SGTKPKTTAI QGISEKEKAE
460 470 480 490 500
IEAKEACDWL RATGFPQYAQ LYEDFLFPID ISLVKREHDF LDRDAIEALC
510 520 530 540 550
RRLNTLNKCA VMKLEISPHR KRSDDSDEDE PCAISGKWTF QRDSKRWSRL
560 570 580 590 600
EEFDVFSPKQ DLVPGSPDDS HPKDGPSPGG TLMDLSERQE VSSVRSLSST
610 620 630 640 650
GSLPSHAPPS EDAATPRTNS VISVCSSSNL AGNDDSFGSL PSPKELSSFS
660 670 680 690 700
FSMKGHEKTA KSKTRSLLKR MESLKLKSSH HSKHKAPSKL GLIISGPILQ
710 720 730 740 750
EGMDEEKLKQ LNCVEISALN GNRINVPMVR KRSVSNSTQT SSSSSQSETS
760 770 780 790 800
SAVSTPSPVT RTRSLSACNK RVGMYLEGFD PFNQSTFNNV VEQNFKNRES
810 820 830 840 850
YPEDTVFYIP EDHKPGTFPK ALTNGSFSPS GNNGSVNWRT GSFHGPGHIS
860 870 880 890 900
LRRENSSDSP KELKRRNSSS SMSSRLSIYD NVPGSILYSS SGDLADLENE
910 920 930 940 950
DIFPELDDIL YHVKGMQRIV NQWSEKFSDE GDSDSALDSV SPCPSSPKQI
960 970 980 990 1000
HLDVDNDRTT PSDLDSTGNS LNEPEEPSEI PERRDSGVGA SLTRSNRHRL
1010 1020 1030 1040 1050
RWHSFQSSHR PSLNSVSLQI NCQSVAQMNL LQKYSLLKLT ALLEKYTPSN
1060 1070 1080 1090 1100
KHGFSWAVPK FMKRIKVPDY KDRSVFGVPL TVNVQRTGQP LPQSIQQAMR
1110 1120 1130 1140 1150
YLRNHCLDQV GLFRKSGVKS RIQALRQMNE GAIDCVNYEG QSAYDVADML
1160 1170 1180 1190 1200
KQYFRDLPEP LMTNKLSETF LQIYQYVPKD QRLQAIKAAI MLLPDENREV
1210 1220 1230 1240 1250
LQTLLYFLSD VTAAVKENQM TPTNLAVCLA PSLFHLNTLK RENSSPRVMQ
1260 1270 1280 1290 1300
RKQSLGKPDQ KDLNENLAAT QGLAHMIAEC KKLFQVPEEM SRCRNSYTEQ
1310 1320 1330 1340 1350
ELKPLTLEAL GHLGNDDSAD YQHFLQDCVD GLFKEVKEKF KGWVSYSTSE
1360 1370 1380 1390 1400
QAELSYKKVS EGPPLRLWRS VIEVPAVPEE ILKRLLKEQH LWDVDLLDSK
1410 1420 1430 1440 1450
VIEILDSQTE IYQYVQNSMA PHPARDYVVL RTWRTNLPKG ACALLLTSVD
1460 1470 1480 1490 1500
HDRAPVVGVR VNVLLSRYLI EPCGPGKSKL TYMCRVDLRG HMPEWYTKSF
1510 1520
GHLCAAEVVK IRDSFSNQNT ETKDTKSR
Length:1,528
Mass (Da):170,591
Last modified:November 30, 2010 - v4
Checksum:i5D20F29CC606302E
GO
Isoform 1 (identifier: Q96QB1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-437: Missing.
     438-450: TAIQGISEKEKAE → MCRKKPDTMILTQ

Show »
Length:1,091
Mass (Da):122,827
Checksum:i422B9D58B528E26C
GO
Isoform 3 (identifier: Q96QB1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-498: EIEAKEACDW...DFLDRDAIEA → AVKSVKLEVD...FHVAGEENIT
     499-1528: Missing.

Show »
Length:498
Mass (Da):54,552
Checksum:iAA2A500A52492F1F
GO
Isoform 4 (identifier: Q96QB1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-437: Missing.
     438-511: Missing.

Note: No experimental confirmation available.
Show »
Length:1,017
Mass (Da):114,152
Checksum:iA001B182EDE65398
GO
Isoform 5 (identifier: Q96QB1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-463: EIEAKEACDWLRAT → GKLTFWFCFLANLF
     464-1528: Missing.

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):50,890
Checksum:i299AF4E12B29EEB1
GO
Isoform 6 (identifier: Q96QB1-6) [UniParc]FASTAAdd to basket
Also known as: i-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MSVAIRKRSW...VADSLQASME → MGDPKAHVMA...IWKNTRDRRL
     46-448: Missing.

Note: Produced by alternative promoter usage. ubiquitously expressed, significantly down-regulated in multiple carcinoma cell lines. PubMed:21217778 (ABX83661/ABX83662) sequences are in conflict in positions: 49-50:EA->KP.
Show »
Length:1,125
Mass (Da):126,746
Checksum:iA93D84FF40E9B92A
GO

Sequence cautioni

The sequence AAB81637 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB21814 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43S → C in BAB14996 (PubMed:14702039).Curated1
Sequence conflicti130T → I in BAB14996 (PubMed:14702039).Curated1
Sequence conflicti571H → L in BAB21814 (PubMed:11214970).Curated1
Sequence conflicti1114R → K in AAB87700 (PubMed:9605766).Curated1
Sequence conflicti1364P → R in AAB87700 (PubMed:9605766).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05929327R → C.Corresponds to variant rs34575560dbSNPEnsembl.1
Natural variantiVAR_05929481L → V.Corresponds to variant rs3816748dbSNPEnsembl.1
Natural variantiVAR_059295254Q → H.2 PublicationsCorresponds to variant rs11203495dbSNPEnsembl.1
Natural variantiVAR_059296255N → D.3 PublicationsCorresponds to variant rs11203494dbSNPEnsembl.1
Natural variantiVAR_059297260T → I.2 PublicationsCorresponds to variant rs3816747dbSNPEnsembl.1
Natural variantiVAR_059298320Q → H.Corresponds to variant rs34591797dbSNPEnsembl.1
Natural variantiVAR_014229712N → S.2 PublicationsCorresponds to variant rs1044092dbSNPEnsembl.1
Natural variantiVAR_014230791V → M.5 PublicationsCorresponds to variant rs532841dbSNPEnsembl.1
Natural variantiVAR_014231959T → A.1 PublicationCorresponds to variant rs121908500dbSNPEnsembl.1
Natural variantiVAR_014232998H → Q.1 PublicationCorresponds to variant rs149295187dbSNPEnsembl.1
Natural variantiVAR_0142331025V → A.1 Publication1
Natural variantiVAR_0142341199E → V.2 PublicationsCorresponds to variant rs1044093dbSNPEnsembl.1
Natural variantiVAR_0142351209S → C.2 PublicationsCorresponds to variant rs1044094dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0378711 – 437Missing in isoform 1 and isoform 4. 3 PublicationsAdd BLAST437
Alternative sequenceiVSP_0538361 – 45MSVAI…QASME → MGDPKAHVMARPLRAPLRRS FSDHIRDSTARALDVIWKNT RDRRL in isoform 6. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_05383746 – 448Missing in isoform 6. 1 PublicationAdd BLAST403
Alternative sequenceiVSP_044651438 – 511Missing in isoform 4. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_037872438 – 450TAIQG…KEKAE → MCRKKPDTMILTQ in isoform 1. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_037873450 – 498EIEAK…DAIEA → AVKSVKLEVDEDKSTKGSNF SNSEVAIGLSPYTFPQKRLF HVAGEENIT in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_046331450 – 463EIEAK…WLRAT → GKLTFWFCFLANLF in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_046332464 – 1528Missing in isoform 5. 1 PublicationAdd BLAST1065
Alternative sequenceiVSP_037874499 – 1528Missing in isoform 3. 1 PublicationAdd BLAST1030

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035119 mRNA. Translation: AAB87700.1.
AF026219 mRNA. Translation: AAB81637.1. Different initiation.
AF408781
, AF408768, AF408769, AF408770, AF408771, AF408772, AF408773, AF408774, AF408775, AF408776, AF408777, AF408778, AF408779, AF408780 Genomic DNA. Translation: AAK97501.1.
AB051510 mRNA. Translation: BAB21814.1. Different initiation.
AK024774 mRNA. Translation: BAB14996.1.
AK299049 mRNA. Translation: BAG61122.1.
AC015641 Genomic DNA. No translation available.
AC019270 Genomic DNA. No translation available.
AC022844 Genomic DNA. No translation available.
AC106845 Genomic DNA. No translation available.
BC049842 mRNA. Translation: AAH49842.1.
BC054511 mRNA. Translation: AAH54511.1.
EU159199 mRNA. Translation: ABX83661.1.
EU159200 mRNA. Translation: ABX83662.1.
CCDSiCCDS55201.1. [Q96QB1-4]
CCDS5989.1. [Q96QB1-2]
CCDS5990.1. [Q96QB1-1]
CCDS5991.2. [Q96QB1-5]
CCDS83253.1. [Q96QB1-6]
RefSeqiNP_001157743.1. NM_001164271.1. [Q96QB1-4]
NP_001303597.1. NM_001316668.1. [Q96QB1-6]
NP_006085.2. NM_006094.4. [Q96QB1-1]
NP_079043.3. NM_024767.3. [Q96QB1-5]
NP_872584.2. NM_182643.2. [Q96QB1-2]
XP_005273431.1. XM_005273374.1. [Q96QB1-2]
XP_016868440.1. XM_017012951.1. [Q96QB1-2]
XP_016868441.1. XM_017012952.1. [Q96QB1-4]
UniGeneiHs.134296.
Hs.738560.

Genome annotation databases

EnsembliENST00000276297; ENSP00000276297; ENSG00000164741. [Q96QB1-2]
ENST00000316609; ENSP00000321034; ENSG00000164741. [Q96QB1-3]
ENST00000358919; ENSP00000351797; ENSG00000164741. [Q96QB1-1]
ENST00000511869; ENSP00000425878; ENSG00000164741. [Q96QB1-5]
ENST00000512044; ENSP00000422595; ENSG00000164741. [Q96QB1-6]
ENST00000520226; ENSP00000428028; ENSG00000164741. [Q96QB1-4]
GeneIDi10395.
KEGGihsa:10395.
UCSCiuc003wwk.2. human. [Q96QB1-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035119 mRNA. Translation: AAB87700.1.
AF026219 mRNA. Translation: AAB81637.1. Different initiation.
AF408781
, AF408768, AF408769, AF408770, AF408771, AF408772, AF408773, AF408774, AF408775, AF408776, AF408777, AF408778, AF408779, AF408780 Genomic DNA. Translation: AAK97501.1.
AB051510 mRNA. Translation: BAB21814.1. Different initiation.
AK024774 mRNA. Translation: BAB14996.1.
AK299049 mRNA. Translation: BAG61122.1.
AC015641 Genomic DNA. No translation available.
AC019270 Genomic DNA. No translation available.
AC022844 Genomic DNA. No translation available.
AC106845 Genomic DNA. No translation available.
BC049842 mRNA. Translation: AAH49842.1.
BC054511 mRNA. Translation: AAH54511.1.
EU159199 mRNA. Translation: ABX83661.1.
EU159200 mRNA. Translation: ABX83662.1.
CCDSiCCDS55201.1. [Q96QB1-4]
CCDS5989.1. [Q96QB1-2]
CCDS5990.1. [Q96QB1-1]
CCDS5991.2. [Q96QB1-5]
CCDS83253.1. [Q96QB1-6]
RefSeqiNP_001157743.1. NM_001164271.1. [Q96QB1-4]
NP_001303597.1. NM_001316668.1. [Q96QB1-6]
NP_006085.2. NM_006094.4. [Q96QB1-1]
NP_079043.3. NM_024767.3. [Q96QB1-5]
NP_872584.2. NM_182643.2. [Q96QB1-2]
XP_005273431.1. XM_005273374.1. [Q96QB1-2]
XP_016868440.1. XM_017012951.1. [Q96QB1-2]
XP_016868441.1. XM_017012952.1. [Q96QB1-4]
UniGeneiHs.134296.
Hs.738560.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKYNMR-A451-515[»]
2GYTNMR-A451-513[»]
2KAPNMR-A454-513[»]
2LOZNMR-B811-824[»]
3KUQX-ray2.30A1074-1283[»]
5FZTX-ray2.10B904-926[»]
ProteinModelPortaliQ96QB1.
SMRiQ96QB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115667. 18 interactors.
DIPiDIP-56928N.
IntActiQ96QB1. 32 interactors.
MINTiMINT-6942866.
STRINGi9606.ENSP00000276297.

PTM databases

iPTMnetiQ96QB1.
PhosphoSitePlusiQ96QB1.

Polymorphism and mutation databases

BioMutaiDLC1.
DMDMi313104315.

Proteomic databases

EPDiQ96QB1.
PaxDbiQ96QB1.
PeptideAtlasiQ96QB1.
PRIDEiQ96QB1.

Protocols and materials databases

DNASUi10395.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276297; ENSP00000276297; ENSG00000164741. [Q96QB1-2]
ENST00000316609; ENSP00000321034; ENSG00000164741. [Q96QB1-3]
ENST00000358919; ENSP00000351797; ENSG00000164741. [Q96QB1-1]
ENST00000511869; ENSP00000425878; ENSG00000164741. [Q96QB1-5]
ENST00000512044; ENSP00000422595; ENSG00000164741. [Q96QB1-6]
ENST00000520226; ENSP00000428028; ENSG00000164741. [Q96QB1-4]
GeneIDi10395.
KEGGihsa:10395.
UCSCiuc003wwk.2. human. [Q96QB1-2]

Organism-specific databases

CTDi10395.
DisGeNETi10395.
GeneCardsiDLC1.
HGNCiHGNC:2897. DLC1.
HPAiHPA017753.
MalaCardsiDLC1.
MIMi604258. gene.
neXtProtiNX_Q96QB1.
OpenTargetsiENSG00000164741.
PharmGKBiPA27351.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2200. Eukaryota.
ENOG410XQ10. LUCA.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000147792.
HOVERGENiHBG055955.
InParanoidiQ96QB1.
KOiK20632.
OMAiWVSCSTS.
OrthoDBiEOG091G00OE.
PhylomeDBiQ96QB1.
TreeFamiTF314044.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164741-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
SIGNORiQ96QB1.

Miscellaneous databases

ChiTaRSiDLC1. human.
EvolutionaryTraceiQ96QB1.
GeneWikiiDLC1.
GenomeRNAii10395.
PROiQ96QB1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164741.
CleanExiHS_DLC1.
ExpressionAtlasiQ96QB1. baseline and differential.
GenevisibleiQ96QB1. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.530.20. 1 hit.
InterProiIPR028854. DLC1.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR12659:SF2. PTHR12659:SF2. 1 hit.
PfamiPF00620. RhoGAP. 1 hit.
PF07647. SAM_2. 1 hit.
PF01852. START. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00234. START. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG07_HUMAN
AccessioniPrimary (citable) accession number: Q96QB1
Secondary accession number(s): B4DR10
, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q9C0E0, Q9H7A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.