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Protein
Submitted name:

Multidrug resistance associated protein

Gene

MRP3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Multidrug resistance associated proteinImported
Gene namesi
Name:MRP3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5520HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12320HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15218HelicalSequence analysisAdd
BLAST
Transmembranei172 – 19019HelicalSequence analysisAdd
BLAST
Transmembranei299 – 32022HelicalSequence analysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST
Transmembranei423 – 44523HelicalSequence analysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence analysisAdd
BLAST
Transmembranei536 – 55621HelicalSequence analysisAdd
BLAST
Transmembranei965 – 99228HelicalSequence analysisAdd
BLAST
Transmembranei1012 – 103524HelicalSequence analysisAdd
BLAST
Transmembranei1110 – 112920HelicalSequence analysisAdd
BLAST
Transmembranei1194 – 121724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073669.

PTM / Processingi

Proteomic databases

PaxDbiQ96QA9.
PRIDEiQ96QA9.

Expressioni

Gene expression databases

BgeeiQ96QA9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000285238.

Chemistry

BindingDBiQ96QA9.

Structurei

3D structure databases

ProteinModelPortaliQ96QA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini312 – 594283ABC transmembrane type-1InterPro annotationAdd
BLAST
Domaini629 – 851223ABC transporterInterPro annotationAdd
BLAST
Domaini972 – 1252281ABC transmembrane type-1InterPro annotationAdd
BLAST
Domaini1291 – 1510220ABC transporterInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.UniRule annotation
Contains ABC transmembrane type-1 domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030242. ABCC3.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF221. PTHR24223:SF221. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96QA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALCGSGEL GSKFWDSNLS VHTENPDLTP CFQNSLLAWV PCIYLWVALP
60 70 80 90 100
CYLLYLRHHC RGYIILSHLS KLKMVLGVLL WCVSWADLFY SFHGLVHGRA
110 120 130 140 150
PAPVFFVTPL VVGVTMLLAT LLIQYERLQG VQSSGVLIIF WFLCVVCAIV
160 170 180 190 200
PFRSKILLAK AEGEISDPFR FTTFYIHFAL VLSALILACF REKPPFFSAK
210 220 230 240 250
NVDPNPYPET SAGFLSRLFF WWFTKMAIYG YRHPLEEKDL WSLKEEDRSQ
260 270 280 290 300
MVVQQLLEAW RKQEKQTARH KASAAPGKNA SGEDEVLLGA RPRPRKPSFL
310 320 330 340 350
KALLATFGSS FLISACFKLI QDLLSFINPQ LLSILIRFIS NPMAPSWWGF
360 370 380 390 400
LVAGLMFLCS MMQSLILQHY YHYIFVTGVK FRTGIMGVIY RKALVITNSV
410 420 430 440 450
KRASTVGEIV NLMSVDAQRF MDLAPFLNLL WSAPLQIILA IYFLWQNLGP
460 470 480 490 500
SVLAGVAFMV LLIPLNGAVA VKMRAFQVKQ MKLKDSRIKL MSEILNGIKV
510 520 530 540 550
LKLYAWEPSF LKQVEGIRQG ELQLLRTAAY LHTTTTFTWM CSPFLVTLIT
560 570 580 590 600
LWVYVYVDPN NVLDAEKAFV SVSLFNILRL PLNMLPQLIS NLTQASVSLK
610 620 630 640 650
RIQQFLSQEE LDPQSVERKT ISPGYAITIH SGTFTWAQDL PPTLHSLDIQ
660 670 680 690 700
VPKGALVAVV GPVGCGKSSL VSALLGEMEK LEGKVHMKGS VAYVPQQAWI
710 720 730 740 750
QNCTLQENVL FGKALNPKRY QQTLEACALL ADLEMLPGGD QTEIGEKGIN
760 770 780 790 800
LSGGQRQRVS LARAVYSDAD IFLLDDPLSA VDSHVAKHIF DHVIGPEGVL
810 820 830 840 850
AGKTRVLVTH GISFLPQTDF IIVLADGQVS EMGPYPALLQ RNGSFANFLC
860 870 880 890 900
NYAPDEDQGH LEDSWTALEG AEDKEALLIE DTLSNHTDLT DNDPVTYVVQ
910 920 930 940 950
KQFMRQLSAL SSDGEGQGRP VPRRHLGPSE KVQVTEAKAD GALTQEEKAA
960 970 980 990 1000
IGTVELSVFW DYAKAVGLCT TLAICLLYVG QSAAAIGANV WLSAWTNDAM
1010 1020 1030 1040 1050
ADSRQNNTSL RLGVYAALGI LQGFLVMLAA MAMAAGGIQA ARVLHQALLH
1060 1070 1080 1090 1100
NKIRSPQSFF DTTPSGRILN CFSKDIYVVD EVLAPVILML LNSFFNAIST
1110 1120 1130 1140 1150
LVVIMASTPL FTVVILPLAV LYTLVQRFYA ATSRQLKRLE SVSRSPIYSH
1160 1170 1180 1190 1200
FSETVTGASV IRAYNRSRDF EIISDTKVDA NQRSCYPYII SNRWLSIGVE
1210 1220 1230 1240 1250
FVGNCVVLFA ALFAVIGRSS LNPGLVGLSV SYSLQVTFAL NWMIRMMSDL
1260 1270 1280 1290 1300
ESNIVAVERV KEYSKTETEA PWVVEGSRPP EGWPPRGEVE FRNYSVRYRP
1310 1320 1330 1340 1350
GLDLVLRDLS LHVHGGEKVG IVGRTGAGKS SMTLCLFRIL EAAKGEIRID
1360 1370 1380 1390 1400
GLNVADIGDP ILFSGTLRMN LDPFGSYSEE DIWWALELSH LHTFVSSQPA
1410 1420 1430 1440 1450
GLDFQCSEGG ENLSVGQRQL VCLARALLRK SRILVLDEAT AAIDLETDNL
1460 1470 1480 1490 1500
IQATIRTQFD TCTVLTIAHR LNTIMDYTRV LVLDKGVVAE FDSPANLIAA
1510
RGIFYGMARD AGLA
Length:1,514
Mass (Da):167,827
Last modified:December 1, 2001 - v1
Checksum:i9920EA482B796E8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ294545
, AJ294546, AJ294547, AJ294548, AJ294549, AJ294550, AJ294551, AJ294552, AJ294553, AJ294554, AJ294555, AJ294556, AJ294557, AJ294558, AJ294559, AJ294560, AJ294561, AJ294562, AJ294563, AJ294564, AJ294565 Genomic DNA. Translation: CAC69553.1.
UniGeneiHs.463421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ294545
, AJ294546, AJ294547, AJ294548, AJ294549, AJ294550, AJ294551, AJ294552, AJ294553, AJ294554, AJ294555, AJ294556, AJ294557, AJ294558, AJ294559, AJ294560, AJ294561, AJ294562, AJ294563, AJ294564, AJ294565 Genomic DNA. Translation: CAC69553.1.
UniGeneiHs.463421.

3D structure databases

ProteinModelPortaliQ96QA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000285238.

Chemistry

BindingDBiQ96QA9.
ChEMBLiCHEMBL2073669.

Proteomic databases

PaxDbiQ96QA9.
PRIDEiQ96QA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.

Miscellaneous databases

ChiTaRSiABCC3. human.

Gene expression databases

BgeeiQ96QA9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030242. ABCC3.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF221. PTHR24223:SF221. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic organization of human MRP3 and its expression during keratinocyte differentiation."
    Kielar D., Langmann T.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ96QA9_HUMAN
AccessioniPrimary (citable) accession number: Q96QA9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: April 13, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.