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Protein

Protein yippee-like 2

Gene

YPEL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi79ZincPROSITE-ProRule annotation1
Metal bindingi82ZincPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yippee-like 2
Gene namesi
Name:YPEL2
ORF Names:FKSG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18326. YPEL2.

Subcellular locationi

  • Nucleusnucleolus 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi388403.
OpenTargetsiENSG00000175155.
PharmGKBiPA134978522.

Polymorphism and mutation databases

BioMutaiYPEL2.
DMDMi27805781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002123851 – 119Protein yippee-like 2Add BLAST119

Proteomic databases

PaxDbiQ96QA6.
PeptideAtlasiQ96QA6.
PRIDEiQ96QA6.

PTM databases

iPTMnetiQ96QA6.
PhosphoSitePlusiQ96QA6.

Expressioni

Tissue specificityi

Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000175155.
CleanExiHS_YPEL2.
GenevisibleiQ96QA6. HS.

Organism-specific databases

HPAiHPA030501.
HPA045621.

Interactioni

Subunit structurei

May interact with FAM168B.

Protein-protein interaction databases

BioGridi132675. 2 interactors.
IntActiQ96QA6. 4 interactors.
MINTiMINT-2815052.
STRINGi9606.ENSP00000312272.

Structurei

3D structure databases

ProteinModelPortaliQ96QA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 116YippeePROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the yippee family.Curated

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiQ96QA6.
OMAiFCGAHLC.
OrthoDBiEOG090A0EA4.
PhylomeDBiQ96QA6.
TreeFamiTF313936.

Family and domain databases

InterProiView protein in InterPro
IPR004910. Yippee/Mis18/Cereblon.
PfamiView protein in Pfam
PF03226. Yippee-Mis18. 1 hit.
PROSITEiView protein in PROSITE
PS51792. YIPPEE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96QA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKMTRSKTF QAYLPSCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY
110
KEGKYIIELA HMIKDNGWD
Length:119
Mass (Da):13,577
Last modified:December 1, 2001 - v1
Checksum:i5904018C67E1A2D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098736 Genomic DNA. Translation: BAD51377.1.
AF305195 mRNA. Translation: AAL09354.1.
BC127924 mRNA. Translation: AAI27925.1.
BC132884 mRNA. Translation: AAI32885.1.
BC132886 mRNA. Translation: AAI32887.1.
CCDSiCCDS32695.1.
RefSeqiNP_001005404.1. NM_001005404.3.
XP_016880110.1. XM_017024621.1.
UniGeneiHs.463613.

Genome annotation databases

EnsembliENST00000312655; ENSP00000312272; ENSG00000175155.
ENST00000585166; ENSP00000464285; ENSG00000175155.
GeneIDi388403.
KEGGihsa:388403.
UCSCiuc002ixm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098736 Genomic DNA. Translation: BAD51377.1.
AF305195 mRNA. Translation: AAL09354.1.
BC127924 mRNA. Translation: AAI27925.1.
BC132884 mRNA. Translation: AAI32885.1.
BC132886 mRNA. Translation: AAI32887.1.
CCDSiCCDS32695.1.
RefSeqiNP_001005404.1. NM_001005404.3.
XP_016880110.1. XM_017024621.1.
UniGeneiHs.463613.

3D structure databases

ProteinModelPortaliQ96QA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132675. 2 interactors.
IntActiQ96QA6. 4 interactors.
MINTiMINT-2815052.
STRINGi9606.ENSP00000312272.

PTM databases

iPTMnetiQ96QA6.
PhosphoSitePlusiQ96QA6.

Polymorphism and mutation databases

BioMutaiYPEL2.
DMDMi27805781.

Proteomic databases

PaxDbiQ96QA6.
PeptideAtlasiQ96QA6.
PRIDEiQ96QA6.

Protocols and materials databases

DNASUi388403.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312655; ENSP00000312272; ENSG00000175155.
ENST00000585166; ENSP00000464285; ENSG00000175155.
GeneIDi388403.
KEGGihsa:388403.
UCSCiuc002ixm.2. human.

Organism-specific databases

CTDi388403.
DisGeNETi388403.
GeneCardsiYPEL2.
HGNCiHGNC:18326. YPEL2.
HPAiHPA030501.
HPA045621.
MIMi609723. gene.
neXtProtiNX_Q96QA6.
OpenTargetsiENSG00000175155.
PharmGKBiPA134978522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3399. Eukaryota.
ENOG4111VJ1. LUCA.
GeneTreeiENSGT00390000008364.
HOGENOMiHOG000184254.
HOVERGENiHBG054215.
InParanoidiQ96QA6.
OMAiFCGAHLC.
OrthoDBiEOG090A0EA4.
PhylomeDBiQ96QA6.
TreeFamiTF313936.

Miscellaneous databases

ChiTaRSiYPEL2. human.
GenomeRNAii388403.
PROiQ96QA6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175155.
CleanExiHS_YPEL2.
GenevisibleiQ96QA6. HS.

Family and domain databases

InterProiView protein in InterPro
IPR004910. Yippee/Mis18/Cereblon.
PfamiView protein in Pfam
PF03226. Yippee-Mis18. 1 hit.
PROSITEiView protein in PROSITE
PS51792. YIPPEE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYPEL2_HUMAN
AccessioniPrimary (citable) accession number: Q96QA6
Secondary accession number(s): A0PK16
, A2RUG4, Q65ZA0, Q8N3W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: February 15, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.