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Protein

Protein yippee-like 2

Gene

YPEL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1
Metal bindingi26ZincPROSITE-ProRule annotation1
Metal bindingi79ZincPROSITE-ProRule annotation1
Metal bindingi82ZincPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein yippee-like 2
Gene namesi
Name:YPEL2
ORF Names:FKSG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000175155.8
HGNCiHGNC:18326 YPEL2
MIMi609723 gene
neXtProtiNX_Q96QA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi388403
OpenTargetsiENSG00000175155
PharmGKBiPA134978522

Polymorphism and mutation databases

BioMutaiYPEL2
DMDMi27805781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002123851 – 119Protein yippee-like 2Add BLAST119

Proteomic databases

PaxDbiQ96QA6
PeptideAtlasiQ96QA6
PRIDEiQ96QA6

PTM databases

iPTMnetiQ96QA6
PhosphoSitePlusiQ96QA6

Expressioni

Tissue specificityi

Widely expressed. Detected in fetal and adult kidney, heart, liver, lung and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000175155
CleanExiHS_YPEL2
GenevisibleiQ96QA6 HS

Organism-specific databases

HPAiHPA030501
HPA045621

Interactioni

Subunit structurei

May interact with FAM168B.

Protein-protein interaction databases

BioGridi132675, 3 interactors
IntActiQ96QA6, 4 interactors
MINTiQ96QA6
STRINGi9606.ENSP00000312272

Structurei

3D structure databases

ProteinModelPortaliQ96QA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 116YippeePROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the yippee family.Curated

Phylogenomic databases

eggNOGiKOG3399 Eukaryota
ENOG4111VJ1 LUCA
GeneTreeiENSGT00390000008364
HOGENOMiHOG000184254
HOVERGENiHBG054215
InParanoidiQ96QA6
OMAiHLATIHS
OrthoDBiEOG091G0XLE
PhylomeDBiQ96QA6
TreeFamiTF313936

Family and domain databases

InterProiView protein in InterPro
IPR034751 Yippee
IPR004910 Yippee/Mis18/Cereblon
PfamiView protein in Pfam
PF03226 Yippee-Mis18, 1 hit
PROSITEiView protein in PROSITE
PS51792 YIPPEE, 1 hit

Sequencei

Sequence statusi: Complete.

Q96QA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKMTRSKTF QAYLPSCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL
60 70 80 90 100
FNSVVNVGCG PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY
110
KEGKYIIELA HMIKDNGWD
Length:119
Mass (Da):13,577
Last modified:December 1, 2001 - v1
Checksum:i5904018C67E1A2D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098736 Genomic DNA Translation: BAD51377.1
AF305195 mRNA Translation: AAL09354.1
BC127924 mRNA Translation: AAI27925.1
BC132884 mRNA Translation: AAI32885.1
BC132886 mRNA Translation: AAI32887.1
CCDSiCCDS32695.1
RefSeqiNP_001005404.1, NM_001005404.3
XP_016880110.1, XM_017024621.1
UniGeneiHs.463613

Genome annotation databases

EnsembliENST00000312655; ENSP00000312272; ENSG00000175155
ENST00000585166; ENSP00000464285; ENSG00000175155
GeneIDi388403
KEGGihsa:388403
UCSCiuc002ixm.2 human

Similar proteinsi

Entry informationi

Entry nameiYPEL2_HUMAN
AccessioniPrimary (citable) accession number: Q96QA6
Secondary accession number(s): A0PK16
, A2RUG4, Q65ZA0, Q8N3W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health